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1. 发明专利

IL180985A N-HYDROXY-4-{5-[4-(5-ISOPROPYL-2-METHYL-1,3-THIAZOL-4-YL)PHENOXY]PENTOXY}BENZAMIDINE BIS(METHANESULFONATE), A METHOD FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS AND ORAL FORMULATIONS THEREOF 未知
公开(公告)号：IL180985A
公开(公告)日：2012-02-29
申请号：IL18098507
申请日：2007-01-25
申请人： DONG WHA PHARM CO LTD , LEE JIN SOO , RYU JEI MAN , AHN SEOK HOON , JIN YOUNG GOO , SHIN DONG HYUK , CHO EUN HEE , SEONG SEUNG KYOO , CHO SOON KI , JEON CHAN SEOK , LEE KI YOUNG , JUNG SE HYUN
发明人： LEE JIN SOO , RYU JEI MAN , AHN SEOK HOON , JIN YOUNG GOO , SHIN DONG HYUK , CHO EUN HEE , SEONG SEUNG KYOO , CHO SOON KI , JEON CHAN SEOK , LEE KI YOUNG , JUNG SE HYUN
摘要： Disclosed is an N-Hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy} benzamidine 2 methansulfonic acid salt, which has excellent bioavailability. Also disclosed are a method of preparing the compound and a pharmaceutical composition comprising the compound.

2. 发明专利

IL180524A PROCESS FOR PREPARING N-HYDROXY-4-{5-[4-(5-ISOPROPYL-2-METHYL-1,3-THIAZOL-4-YL)-PHENOXY]-PENTOXY}-BENZAMIDINE 未知
公开(公告)号：IL180524A
公开(公告)日：2011-12-29
申请号：IL18052407
申请日：2007-01-03
申请人： DONG WHA PHARM CO LTD , LEE JIN SOO , AHN SEOK HOON , JIN YOUNG GOO , PARK JAE HOON , SHIN DONG HYUK , CHO EUN HEE , CHANG HWAN BONG , JUNG YOUNG HO
发明人： LEE JIN SOO , AHN SEOK HOON , JIN YOUNG GOO , PARK JAE HOON , SHIN DONG HYUK , CHO EUN HEE , CHANG HWAN BONG , JUNG YOUNG HO
摘要： This invention relates to an improved method of preparing N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}benzamidine.

3. 发明公开

EP3444332A1 MEDIUM ADDITION KIT FOR CULTURING NK CELLS AND NK CELL CULTURING METHOD USING KIT 审中-公开
公开(公告)号：EP3444332A1
公开(公告)日：2019-02-20
申请号：EP16890777.2
申请日：2016-12-28
申请人： Shin, Dong Hyuk
发明人： Shin, Dong Hyuk
IPC分类号： C12N5/0783 , C07K16/28
摘要： The present invention relates to a method for culturing natural killer cells (NK cells) applied to immune therapy and, more particularly, to a medium addition kin for culturing NK cells with which lymphocytes derived from human peripheral blood can be cultured to effectively amplify and activate NK cells, which have an outstanding therapeutic effect on malignant tumors, while remarkably increasing the share of NK cells, and an NK cell culturing method using the kit.

4. 发明公开

EP3929988A1 DISPLAY PANEL AND MANUFACTURING METHOD THEREFOR 审中-公开
公开(公告)号：EP3929988A1
公开(公告)日：2021-12-29
申请号：EP19915767.8
申请日：2019-09-03
申请人： ELK Corporation , Shin, Dong Hyuk
发明人： SHIN, Dong Hyuk
IPC分类号： H01L27/15 , H01L33/00 , H01L21/768
摘要： A manufacturing method of a display panel for a micro LED display includes providing a substrate, a plurality of micro LEDs formed on the substrate, a switching circuit formed on an upper surface of the substrate to control the micro LEDs, a plurality of upper electrodes formed on one side of the upper surface of the substrate to correspond to an end of the switching circuit, a driving circuit unit formed on a lower surface of the substrate, and a plurality of lower electrodes formed on one side of the lower surface of the substrate to correspond to the driving circuit unit, forming a first mask formed with a connecting slit connecting the upper electrodes and the lower electrodes via an upper surface, a side surface, and a lower surface of the substrate, forming a first mask formed with a connecting slit connecting the upper electrodes and the lower electrodes via an upper surface, a side surface, and a lower surface of the substrate, and forming a metal connection pattern connecting the upper electrodes and the lower electrodes on the substrate by removing the first mask.

5. 发明申请

WO2011083955A3 METHOD FOR MANUFACTURING CRYSTALLINE FORM (I) OF CLOPIDOGREL HYDROGEN SULPHATE 审中-公开
标题翻译：制造氯吡格雷硫酸氢盐结晶形式（I）的方法
公开(公告)号：WO2011083955A3
公开(公告)日：2011-12-08
申请号：PCT/KR2011000038
申请日：2011-01-05
申请人： DONG WHA PHARM CO LTD , OH YOON SEOK , SHIN DONG HYUK , JUNG JIN YONG
发明人： OH YOON SEOK , SHIN DONG HYUK , JUNG JIN YONG
IPC分类号： C07D495/04 , C07D495/02
CPC分类号： C07D495/04
摘要： The present invention provides a method for manufacturing a crystalline form (I) of clopidogrel hydrogen sulphate(clopidogrel hydrogen sulfate), including reacting a clopidogrel free base with concentrated sulfuric acid in the presence of a mixed solvent containing water in an amount of 4 to 14% by weight based on the weight of the clopidogrel free base and 2-butanol.
摘要翻译：本发明提供氯吡格雷硫酸氢盐（氯吡格雷硫酸氢盐）的结晶形式（I）的制造方法，其包括使氯吡格雷游离碱与浓硫酸在含有4至14的水的混合溶剂存在下反应基于氯吡格雷游离碱和2-丁醇的重量的重量％。

6. 发明申请

WO2011008015A3 WAFER-DICING METHOD 审中-公开
标题翻译：波形法
公开(公告)号：WO2011008015A3
公开(公告)日：2011-04-21
申请号：PCT/KR2010004562
申请日：2010-07-14
申请人： INATECH CO LTD , SHIN DONG HYUK , LEE GIL YOUNG
发明人： SHIN DONG HYUK , LEE GIL YOUNG
IPC分类号： H01L21/78 , H01L21/301
CPC分类号： H01L21/67092 , B23K26/0624 , B23K26/364 , B23K26/40 , B23K2203/50
摘要： The present invention relates to a wafer-dicing method for separating a wafer into a plurality of semiconductor dies, comprising: a step of forming a cutting guide groove, involving irradiating femtosecond pulse laser beams, having a pulse duration of 1 picosecond or less, onto the wafer attached to a stretchable dicing tape to form cutting guide grooves into a predetermined pattern on one surface of the wafer; a cracking step of cracking the wafer from ends of the cutting guide grooves toward the other surface of the wafer; and a dicing tape stretching step of stretching the dicing tape to separate the plurality of semiconductor dies from each other.
摘要翻译：本发明涉及一种用于将晶片分离成多个半导体晶片的晶片切割方法，包括：将具有1皮秒或更短脉冲持续时间的飞秒脉冲激光束照射到切割引导槽的步骤，所述晶片附接到可拉伸的切割带，以在所述晶片的一个表面上形成预定图案的切割引导槽; 将晶片从切割引导槽的端部朝向晶片的另一表面开裂的破裂步骤; 以及切割带拉伸步骤，用于拉伸切割带以将多个半导体管芯彼此分离。

7. 发明申请

WO2008096987A1 NOVEL IMATINIB CAMSYLATE AND METHOD FOR PREPARING THEREOF 审中-公开
标题翻译：新型樟脑磺酸钠及其制备方法
公开(公告)号：WO2008096987A1
公开(公告)日：2008-08-14
申请号：PCT/KR2008/000639
申请日：2008-02-01
申请人： DONG WHA PHARMACEUTICAL IND. CO. LTD. , OH, Yoon Seok , LIM, Jae Kyung , SHIN, Dong Hyuk , SEONG, Seung Kyoo , LEE, Sang Ho , LEE, Hak Soo , CHO, Eun Hee , RYU, Jei Man
发明人： OH, Yoon Seok , LIM, Jae Kyung , SHIN, Dong Hyuk , SEONG, Seung Kyoo , LEE, Sang Ho , LEE, Hak Soo , CHO, Eun Hee , RYU, Jei Man
IPC分类号： C07D401/14
CPC分类号： C07D401/04
摘要： The present invention relates to a novel imatinib camsylate and a method for preparing the same. Imatinib camsylate according to the present invention has a faster absorption rate and higher absorption concentration in terms of pharmacokinetics, and further has excellent water solubility, as compared to commercially available imatinib mesylate.
摘要翻译：本发明涉及新颖的伊马替尼樟脑磺酸盐及其制备方法。与市售的甲磺酸伊马替尼相比，本发明的伊马替尼樟脑磺酸盐在药代动力学方面具有更快的吸收速率和更高的吸收浓度，并且还具有优异的水溶性。

8. 发明申请

WO2006031038A1 A METHOD FOR PREPARING RADIOACTIVE FILM 审中-公开
标题翻译：一种制备放射性薄膜的方法
公开(公告)号：WO2006031038A1
公开(公告)日：2006-03-23
申请号：PCT/KR2005/002999
申请日：2005-09-12
申请人： DONG WHA PHARM. IND. CO., LTD. , KOREA ATOMIC ENERGY RESEARCH INSTITUTE , RYU, Jei-Man , KIM, Yu-Eun , SEONG, Seung-Kyoo , SHIN, Dong-Hyuk , CHO, Byung-Ho , SONG, Young-Jun , PARK, Kyung-Bae , SHIN, Byung-Chul
发明人： RYU, Jei-Man , KIM, Yu-Eun , SEONG, Seung-Kyoo , SHIN, Dong-Hyuk , CHO, Byung-Ho , SONG, Young-Jun , PARK, Kyung-Bae , SHIN, Byung-Chul
IPC分类号： C08J5/18
CPC分类号： A61K51/1279 , C08J5/18 , C08J2375/04 , C08K3/16 , C08K3/28
摘要： The present invention relates to a method for preparing a radioactive film for local radioactive treatment. More particularly, the present invention relates to a method for preparing a radioactive film comprising the steps of; dissolving 0.1 ~ 14.5 weight % of a stable nuclide and 13 ~ 32.5 weight % of a film-forming base for the total amount of a solvent in the solvent; applying a stable nuclide solution on a release paper by a coater and drying; and irradiating a stable nuclide film with neutrons in a nuclear reactor. A method for preparing a radioactive film according to the present invention provides a radioactive film having a uniform distribution of radionuclides and an even thickness. Therefore, the therapeutic efficacy of the radioactive film for selective treatment of a lesion may be maximized by attaching the radioactive film on a patient' s skin or a mucous membrane and by direct radioactive radiation.
摘要翻译：本发明涉及一种用于局部放射性处理的放射性膜的制备方法。更具体地，本发明涉及一种制备放射性膜的方法，包括以下步骤：将0.1〜14.5重量％的稳定核素和13〜32.5重量％的成膜基质溶解在溶剂中的溶剂的总量; 通过涂布机将稳定的核素溶液施加在剥离纸上并干燥; 并在核反应堆中用中子照射稳定的核素膜。根据本发明的制备放射性膜的方法提供了具有均匀分布的放射性核素的均匀厚度的放射性膜。因此，通过将放射性膜附着在患者的皮肤或粘膜上以及通过直接放射性辐射，可以使放射性膜用于选择性治疗病变的治疗功效最大化。

9. 发明申请

WO2005125283A1 FLEXIBLE EL DOME SHEET AND FLEXIBLE EL DOME SHEET KEYPAD USING THE SAME 审中-公开
标题翻译：柔性薄片和柔性EL圆点表键盘使用它
公开(公告)号：WO2005125283A1
公开(公告)日：2005-12-29
申请号：PCT/KR2005/000716
申请日：2005-03-14
申请人： EL KOREA CORPORATION , SHIN, Dong Hyuk , BAE, Kwang Hyuk
发明人： SHIN, Dong Hyuk , BAE, Kwang Hyuk
IPC分类号： H05B33/00
CPC分类号： H01H13/83 , H01H13/7006 , H01H2205/026 , H01H2219/018
摘要： A flexible EL dome sheet uses a polymer insulation layer having a thickness of 5 to 50 gm as a substrate, and therefore, the thickness of the flexible EL dome sheet is 50 to 150 gm. The flexible EL dome sheet comprises a flexible EL sheet having key patterns formed thereon and metal or poly domes attached to the EL sheet. Since the flexible EL sheet and the metal or poly domes are used, the flexible EL dome sheet has excellent flexibility and durability, and an additional process for silicon molding is not necessary. Furthermore, the tactile feel of the flexible EL dome sheet keypad is improved. Electric connection between an EL driver of a flexible printed circuit board and the flexible EL sheet is achieved using a contact pad terminal structure, whereby no additional connector is necessary, and therefore, an FPC connecting process is not required.
摘要翻译：柔性EL圆顶片使用厚度为5〜50gm的聚合物绝缘层作为基板，因此柔性EL圆顶片的厚度为50〜150gm。柔性EL圆顶片包括其上形成有键图案的柔性EL片和附着到EL片的金属或多晶圆顶。由于使用柔性EL片和金属或多晶圆顶，因此柔性EL圆顶片具有优异的柔性和耐久性，并且不需要额外的硅成型工艺。此外，改善了柔性EL圆顶板键盘的触感。柔性印刷电路板的EL驱动器与柔性EL片之间的电连接使用接触垫端子结构实现，由此不需要额外的连接器，因此不需要FPC连接工艺。

10. 发明申请

WO0138306A9 NOVEL 3-NITROPYRIDINE DERIVATIVES AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES 审中-公开
标题翻译：新型3-硝基吡啶衍生物和含有衍生物的药物组合物
公开(公告)号：WO0138306A9
公开(公告)日：2003-06-19
申请号：PCT/KR0001365
申请日：2000-11-27
申请人： DONG WHA PHARM IND CO LTD , YOON SUNG JUNE , LEE SANG WOOK , KIM NAM DOO , PARK YONG KYUN , LEE GEUN HYUNG , KIM JONG WOO , PARK SANG JIN , PARK HEE JEOUNG , SHIN DONG HYUK
发明人： YOON SUNG JUNE , LEE SANG WOOK , KIM NAM DOO , PARK YONG KYUN , LEE GEUN HYUNG , KIM JONG WOO , PARK SANG JIN , PARK HEE JEOUNG , SHIN DONG HYUK
IPC分类号： C07D401/12 , C07D213/16
CPC分类号： C07D401/12
摘要： The present invention relates to novel 3-nitropyridine derivatives and the pharmaceutical compositions containing said derivatives, and more specifically, to 3-nitropyridine derivatives and their pharmaceutically acceptable salts, the process for preparing them, and the pharmaceutical compositions containing said compounds as active ingredients. In particular, said 3-nitropyridine derivatives of the present invention, due to their inhibitory activity against the proliferation of human immunodeficiency virus (HIV) as well as hepatitis B virus (HBV), can be used as a therapeutic agent as well as a preventive agent for hepatitis B and acquired immune deficiency syndrome (AIDS).
摘要翻译：本发明涉及新的3-硝基吡啶衍生物和含有所述衍生物，更具体地涉及3-硝基吡啶衍生物及其药学上可接受的盐的药物组合物，其制备方法和含有所述化合物作为活性成分的药物组合物。特别地，本发明的所述3-硝基吡啶衍生物由于其对人类免疫缺陷病毒（HIV）以及乙型肝炎病毒（HBV）的增殖的抑制活性可用作治疗剂以及预防性乙型肝炎的代理人和获得性免疫缺陷综合征（AIDS）。

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