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1. 发明申请

WO2003006444A2 SUBSTITUTED AMIDES, SULFONAMIDES AND UREAS USEFUL FOR INHIBITING KINASE ACTIVITY 审中-公开
标题翻译：用于抑制激酶活性的替代氨基酸，磺酰胺和尿酸
公开(公告)号：WO2003006444A2
公开(公告)日：2003-01-23
申请号：PCT/US2002/021525
申请日：2002-07-09
申请人： AVENTIS PHARMACEUTICALS INC. , SAFAR, Pavel , WALSER, Armin , SHIMSHOCK, Stephen, J.
发明人： SAFAR, Pavel , WALSER, Armin , SHIMSHOCK, Stephen, J.
IPC分类号： C07D295/12
CPC分类号： C07D295/135 , A61K38/00 , C07C257/18 , C07D211/62 , C07D401/06 , C07D401/12 , C07D405/12 , C07D405/14 , C07K5/0207 , C07K5/021
摘要： Amide, sulfonamide and urea compounds having an inhibitory effect on Src kinase including enantiomers, stereoisomers and tautomers thereof, as well as pharmaceutically acceptable salts or solvates of said compound, said compound having the general structure shown in Formulae (I) and (II).
摘要翻译：酰胺，对Src激酶具有抑制作用的磺酰胺和脲化合物，包括对映异构体，立体异构体和互变异构体，以及所述化合物的药学上可接受的盐或溶剂合物，所述化合物具有式（I）和（II）所示的一般结构。

2. 发明申请

WO2006012256A3 FKBP BINDING COMPOSITION AND PHARMACEUTICAL USE THEREOF 审中-公开
标题翻译： FKBP结合组合物及其药物用途
公开(公告)号：WO2006012256A3
公开(公告)日：2006-04-27
申请号：PCT/US2005022360
申请日：2005-06-24
申请人： AVENTIS PHARMA INC , KOSLEY JR RAYMOND W , BARON BRUCE , JIMONET PATRICK , JURCAK JOHN G , SHIMSHOCK STEPHEN J , ZHAO XU-YANG , SHER ROSY , MUELLER PAUL J , BEALL JENNIFER , BARRAGUE MATTHIEU , GUILES JOSEPH W
发明人： KOSLEY JR RAYMOND W , BARON BRUCE , JIMONET PATRICK , JURCAK JOHN G , SHIMSHOCK STEPHEN J , ZHAO XU-YANG , SHER ROSY , MUELLER PAUL J , BEALL JENNIFER , BARRAGUE MATTHIEU , GUILES JOSEPH W
IPC分类号： C07D211/96 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/445 , A61P25/00 , A61P25/28 , C07D401/12 , C07D405/12 , C07D409/14
CPC分类号： C07D409/14 , C07D211/96 , C07D401/12 , C07D405/12
摘要： A composition for binding FKBP proteins is disclosed, along with a method of treating conditions associated with neuronal degeneration, wherein said composition comprises a compound of Formula (I), wherein, R, R
摘要翻译：公开了一种用于结合FKBP蛋白的组合物，以及治疗与神经元变性相关的病症的方法，其中所述组合物包含式（I）化合物，其中R 1，R 2，

3. 发明申请

WO2006081343A1 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS 审中-公开
标题翻译： 2-PHENYL-INDOLES作为PROSTAGLANDIN D2受体拮抗剂
公开(公告)号：WO2006081343A1
公开(公告)日：2006-08-03
申请号：PCT/US2006/002736
申请日：2006-01-25
申请人： AVENTIS PHARMACEUTICALS INC. , HARRIS, Keith, J. , LANG, Hans-Jochen , MATHEW, Rose, M. , SHIMSHOCK, Stephen, J. , NIEDUZAK, Thaddeus, R. , JACKSON, Sharon , YANG, Zhaoxia , BORDEAU, Kenneth, J.
发明人： HARRIS, Keith, J. , LANG, Hans-Jochen , MATHEW, Rose, M. , SHIMSHOCK, Stephen, J. , NIEDUZAK, Thaddeus, R. , JACKSON, Sharon , YANG, Zhaoxia , BORDEAU, Kenneth, J.
IPC分类号： C07D209/12 , C07D209/18 , C07D209/22 , C07D209/24 , C07D413/06 , A61K31/404 , A61K31/405 , A61K31/4245 , A61P11/00
CPC分类号： C07D209/12 , C07D209/18 , C07D209/22 , C07D209/24 , C07D405/12 , C07D413/06
摘要： The present invention is directed to a compound of Formula (XVI) wherein R, R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and n are as defined herein, or a pharmaceutically acceptable salt, hydrate, or solvate thereof, a pharmaceutically acceptable prodrug thereof, or a pharmaceutically acceptable salt, hydrate or solvate of the prodrug, a pharmaceutical composition comprising a pharmaceutically effective amount of one or more compounds according to Formula (XVI) in admixture with a pharmaceutically acceptable carrier, a method of treating a patient suffering from a PGD2-mediated disorder including, but not limited to, allergic disease (such as allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, bronchitis, urticaria, eczema, diseases accompanied by itch (such as atopic dermatitis and urticaria), diseases (such as cataract, retinal detachment, inflammation, infection and sleeping disorders) which are generated secondarily as a result of behavior accompanied by itch (such as scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis and the like by administering to said patient a pharmaceutically effective amount of a compound according to Formula (XVI).
摘要翻译：本发明涉及式（ⅩⅥ）的化合物，其中R 1，R 2，R 3，R 4，R 4， 5，R 6，R 7和n如本文所定义，或其药学上可接受的盐，水合物或溶剂合物，其药学上可接受的前药，或药学上可接受的盐，水合物或溶剂合物，包含药学上有效量的一种或多种根据式（XVI）的化合物与药学上可接受的载体混合的药物组合物，治疗患有PGD2的患者的方法包括但不限于过敏性疾病（如过敏性鼻炎，过敏性结膜炎，特应性皮炎，支气管哮喘和食物过敏），系统性肥大细胞增多症，伴有系统性肥大细胞活化的疾病，过敏反应，支气管收缩，支气管炎，荨麻疹，湿疹，伴有瘙痒的疾病（如特应性皮炎和荨麻疹），伴随瘙痒的行为（如搔抓和殴打），炎症，慢性阻塞性肺疾病，局部缺血再灌注损伤等二次产生的疾病（如白内障，视网膜脱离，炎症，感染和睡眠障碍），脑血管意外，慢性类风湿性关节炎，胸膜炎，溃疡性结肠炎等，通过向所述患者施用药学有效量的根据式（XVI）的化合物。

4. 发明申请

WO2006012256A2 FKBP BINDING COMPOSITION AND PHARMACEUTICAL USE THEREOF 审中-公开
标题翻译： FKBP结合组合物及其药物用途
公开(公告)号：WO2006012256A2
公开(公告)日：2006-02-02
申请号：PCT/US2005/022360
申请日：2005-06-24
申请人： AVENTIS PHARMACEUTICALS INC. , KOSLEY, JR., Raymond, W. , BARON, Bruce , JIMONET, Patrick , JURCAK, John, G. , SHIMSHOCK, Stephen, J. , ZHAO, Xu-Yang , SHER, Rosy , MUELLER, Paul, J. , BEALL, Jennifer , BARRAGUE, Matthieu , GUILES, Joseph, W.
发明人： KOSLEY, JR., Raymond, W. , BARON, Bruce , JIMONET, Patrick , JURCAK, John, G. , SHIMSHOCK, Stephen, J. , ZHAO, Xu-Yang , SHER, Rosy , MUELLER, Paul, J. , BEALL, Jennifer , BARRAGUE, Matthieu , GUILES, Joseph, W.
IPC分类号： C07D211/96 , C07D401/12 , C07D405/12 , C07D409/14 , A61K31/445 , A61K31/453 , A61K31/454 , A61K31/4545 , A61P25/00 , A61P25/28
CPC分类号： C07D409/14 , C07D211/96 , C07D401/12 , C07D405/12
摘要： A composition for binding FKBP proteins is disclosed, along with a method of treating conditions associated with neuronal degeneration, wherein said composition comprises a compound of Formula (I), wherein, R, R 1 , R 2 , R 3 and X are as defined herein.
摘要翻译：公开了一种用于结合FKBP蛋白的组合物，以及治疗与神经元变性相关的病症的方法，其中所述组合物包含式（I）化合物，其中R 1，R 1，R 2 > 2，R 3和X如本文所定义。

5. 发明申请

WO2003006444A3 SUBSTITUTED AMIDES, SULFONAMIDES AND UREAS USEFUL FOR INHIBITING KINASE ACTIVITY 审中-公开
公开(公告)号：WO2003006444A3
公开(公告)日：2003-01-23
申请号：PCT/US2002/021525
申请日：2002-07-09
申请人： AVENTIS PHARMACEUTICALS INC. , SAFAR, Pavel , WALSER, Armin , SHIMSHOCK, Stephen, J.
发明人： SAFAR, Pavel , WALSER, Armin , SHIMSHOCK, Stephen, J.
IPC分类号： C07D295/12
摘要： Amide, sulfonamide and urea compounds having an inhibitory effect on Src kinase including enantiomers, stereoisomers and tautomers thereof, as well as pharmaceutically acceptable salts or solvates of said compound, said compound having the general structure shown in Formulae (I) and (II).

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