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1. 发明申请

WO2010002888A3 ANGIOPLASTY AND TISSUE ABLATION APPARATUS AND METHOD 审中-公开
公开(公告)号：WO2010002888A3
公开(公告)日：2010-01-07
申请号：PCT/US2009/049251
申请日：2009-06-30
申请人： MEDWAVES, INC. , ORMSBY, Theodore, C. , LEUNG, George , SHEN, Gwo, Jenn
发明人： ORMSBY, Theodore, C. , LEUNG, George , SHEN, Gwo, Jenn
IPC分类号： A61B18/18 , A61M25/10
摘要： A coaxial cable apparatus which transmits radio frequency (RF) energy for the ablation of biological tissues has inner and outer coaxial conductors extending substantially the entire length of the cable from a proximal end portion to a distal end portion. An RF antenna is disposed at the distal end portion of the cable and transmits RF energy for ablation of a tissue region to be treated. An angioplasty balloon is disposed over the RF antenna and communicates with a fluid supply and extraction passageway extending through the cable to allow the balloon to be inflated for an angioplasty procedure including tissue ablation, and to be deflated after the procedure is complete.

2. 发明申请

WO2008005668A3 RADIO-FREQUENCY BASED CATHETER SYSTEM AND METHOD FOR ABLATING BIOLOGICAL TISSUES 审中-公开
标题翻译：基于无线电频率的导管系统及其生物组织研究方法
公开(公告)号：WO2008005668A3
公开(公告)日：2008-10-30
申请号：PCT/US2007071121
申请日：2007-06-13
申请人： MEDWAVES INC , ORMSBY THEODORE C , LEUNG GEORGE L , SHEN GWO JENN , CHU PETER , LAW MING-FAN
发明人： ORMSBY THEODORE C , LEUNG GEORGE L , SHEN GWO JENN , CHU PETER , LAW MING-FAN
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B18/18 , A61B18/1815 , A61B2017/00256 , A61B2017/003 , A61B2018/00666 , A61B2018/00678 , A61B2018/00702 , A61B2018/00779 , A61B2018/00785 , A61B2018/00791 , A61B2018/00946
摘要： A radio-frequency based catheter system and method for ablating biological tissues within the body vessel of a patient comprises a radio-frequency ("RF") generator (616) for selectively generating a high frequency RF energy signal in a deployable catheter (500) having an RF transmission line, an RF antenna (250) mounted on the distal portion of the catheter, and a temperature sensor (520) also mounted on a distal portion of the catheter for detecting temperature adjacent an ablation site. A control system (610) adjusts the RF energy signal so that the detected temperature is at or close to a selected temperature setting or within a selected temperature range.
摘要翻译：用于消除患者体内血液中的生物组织的基于射频的导管系统和方法包括用于在可展开的导管（500）中选择性地产生高频RF能量信号的射频（“RF”）发生器（616）具有RF传输线，安装在导管的远端部分上的RF天线（250）和还安装在导管的远端部分上的温度传感器（520），用于检测消融部位附近的温度。控制系统（610）调节RF能量信号，使得检测到的温度处于或接近所选择的温度设置或者在选定的温度范围内。

3. 发明申请

WO9414954A3 KDO ALDOLASE AND CONDENSATION REACTIONS EMPLOYED THEREWITH 审中-公开
标题翻译： KDO ALDOLASE和冷凝反应
公开(公告)号：WO9414954A3
公开(公告)日：1994-09-29
申请号：PCT/US9312367
申请日：1993-12-17
申请人： SCRIPPS RESEARCH INST , WONG CHI HUEY , SUGAI TAKESHI , SHEN GWO JENN
发明人： WONG CHI-HUEY , SUGAI TAKESHI , SHEN GWO-JENN
IPC分类号： C07H7/027 , C12N9/88 , C12P7/58 , C12P9/00 , C12P19/02 , C07H7/02 , C12N1/20
CPC分类号： C12P19/02 , C07H7/027 , C12N9/88 , C12P7/58 , C12P9/00 , Y10S435/822
摘要： Aureobacterium barkerei strain KDO-37-2 (ATCC 49977) KDO aldolase (EC 4.1.2.23) isolated therefrom are disclosed. The DKDO aldolase is further disclosed to have a broad substrate specificity with respect to its reverse reaction, i.e. the condensation of aldoses with pyruvate to form a wide range of 2-keto-3-deoxy-onic acids, including 2-keto-3-deoxy-nonulosonic acid, 2-keto-3-deoxy-octulosonic acid, 2-keto-3-deoxy-heptulosonic acid, and 2-keto-3-deoxy-hexulosonic acid. In particular, 3-deoxy-D-manno-2-octulosonic acid (D-KDO), a vital component of lipopolysaccharides found in the bacterial outer membrane may be synthesized from D-arabinose and pyruvate in 67 % yield. Additionally, protected forms of the KDO aldolase products, e.g. hexaacetyl 2-keto-3-deoxy-nonulosonic acid and pentaacetyl 2-keto-3-deoxy-octulosonic acid, may be decarboxylated to form the corresponding 2-deoxy-aldoses, e.g. 2-deoxy-octulose and 2-deoxy-heptulose respectively.
摘要翻译：公开了从其分离的巴氏杆菌菌株KDO-37-2（ATCC 49977）和KDO醛缩酶（EC 4.1.2.23）。进一步公开KDO醛缩酶相对于其逆反应具有广泛的底物特异性，即醛糖与丙酮酸的缩合形成宽范围的2-酮-3-脱氧酸，包括2-酮-3- 脱氧 - 非酮酸，2-酮-3-脱氧 - 八环酮酸，2-酮-3-脱氧 - 庚酮酸和2-酮-3-脱氧 - 己酸。特别地，在D-细菌外膜中发现的脂多糖的重要组分3-脱氧-D-壬烯-2-辛酮酸（D-KDO）可由D-阿拉伯糖和丙酮酸合成，产率67％。另外，保护形式的KDO醛缩酶产物，例如，六乙酰基2-酮-3-脱氧 - 非酮缩酮酸和五乙酰基2-酮-3-脱氧 - 八环酮酸可以脱羧以形成相应的2-脱氧醛糖，例如。 2-脱氧 - 八酮糖和2-脱氧 - 七氟醚。

4. 发明申请

WO1994014954A2 KDO ALDOLASE AND CONDENSATION REACTIONS EMPLOYED THEREWITH 审中-公开
标题翻译： KDO ALDOLASE和冷凝反应
公开(公告)号：WO1994014954A2
公开(公告)日：1994-07-07
申请号：PCT/US1993012367
申请日：1993-12-17
申请人： THE SCRIPPS RESEARCH INSTITUTE , WONG, Chi-Huey , SUGAI, Takeshi , SHEN, Gwo-Jenn
发明人： THE SCRIPPS RESEARCH INSTITUTE
IPC分类号： C12N09/88
CPC分类号： C12P19/02 , C07H7/027 , C12N9/88 , C12P7/58 , C12P9/00 , Y10S435/822
摘要： Aureobacterium barkerei strain KDO-37-2 (ATCC 49977) KDO aldolase (EC 4.1.2.23) isolated therefrom are disclosed. The DKDO aldolase is further disclosed to have a broad substrate specificity with respect to its reverse reaction, i.e. the condensation of aldoses with pyruvate to form a wide range of 2-keto-3-deoxy-onic acids, including 2-keto-3-deoxy-nonulosonic acid, 2-keto-3-deoxy-octulosonic acid, 2-keto-3-deoxy-heptulosonic acid, and 2-keto-3-deoxy-hexulosonic acid. In particular, 3-deoxy-D-manno-2-octulosonic acid (D-KDO), a vital component of lipopolysaccharides found in the bacterial outer membrane may be synthesized from D-arabinose and pyruvate in 67 % yield. Additionally, protected forms of the KDO aldolase products, e.g. hexaacetyl 2-keto-3-deoxy-nonulosonic acid and pentaacetyl 2-keto-3-deoxy-octulosonic acid, may be decarboxylated to form the corresponding 2-deoxy-aldoses, e.g. 2-deoxy-octulose and 2-deoxy-heptulose respectively.
摘要翻译：公开了从其分离的巴氏杆菌菌株KDO-37-2（ATCC 49977）KDO醛缩酶（EC 4.1.2.23）。进一步公开了DKDO醛缩酶对于其逆反应具有广泛的底物特异性，即醛糖与丙酮酸的缩合形成宽范围的2-酮-3-脱氧酸，包括2-酮-3- 脱氧 - 非酮酸，2-酮-3-脱氧 - 八环酮酸，2-酮-3-脱氧 - 庚酮酸和2-酮-3-脱氧 - 己酸。特别地，在D-细菌外膜中发现的脂多糖的重要组分3-脱氧-D-壬烯-2-辛酮酸（D-KDO）可由D-阿拉伯糖和丙酮酸合成，产率67％。另外，保护形式的KDO醛缩酶产物，例如，六乙酰基2-酮-3-脱氧 - 非酮酸和五乙酰基2-酮-3-脱氧 - 八环酸可以脱羧以形成相应的2-脱氧醛糖，例如， 2-脱氧 - 八酮糖和2-脱氧 - 七氟醚。

5. 发明申请

WO2010121040A3 ELECTRICALLY TUNABLE TISSUE ABLATION SYSTEM AND METHOD 审中-公开
标题翻译：电动可控组织吸收系统和方法
公开(公告)号：WO2010121040A3
公开(公告)日：2011-03-31
申请号：PCT/US2010031259
申请日：2010-04-15
申请人： MEDWAVES INC , ORMSBY THEODORE , CHUNG RUSSELL , LEUNG GEORGE , SHEN GWO JENN
发明人： ORMSBY THEODORE , CHUNG RUSSELL , LEUNG GEORGE , SHEN GWO JENN
IPC分类号： A61B18/18 , A61B17/3205
CPC分类号： A61B18/18 , A61B18/1815 , A61B2018/1869
摘要： An ablation system which transmits radio frequency (RF) energy for the ablation of biological tissues has a transmission line and an RF antenna disposed at the distal portion of the transmission line. An RF signal generator supplies RF energy to the proximal end of the cable for transmission to the antenna, and an electrically tunable transformer is connected between the signal generator and the antenna. The transformer is tuned based on detection of the reflected power level from the antenna so as to reduce or minimize reflected power, thereby increasing RF energy coupling between the antenna and tissue.
摘要翻译：传输用于生物组织消融的射频（RF）能量的消融系统具有设置在传输线的远端部分的传输线和RF天线。 RF信号发生器将RF能量提供给电缆的近端以传输到天线，并且电可变变压器连接在信号发生器和天线之间。基于从天线的反射功率电平的检测来调整变压器，以便减少或最小化反射功率，从而增加天线和组织之间的RF能量耦合。

6. 发明申请

WO2010121040A2 ELECTRICALLY TUNABLE TISSUE ABLATION SYSTEM AND METHOD 审中-公开
标题翻译：电动可控组织吸收系统和方法
公开(公告)号：WO2010121040A2
公开(公告)日：2010-10-21
申请号：PCT/US2010/031259
申请日：2010-04-15
申请人： MEDWAVES, INC. , ORMSBY, Theodore , CHUNG, Russell , LEUNG, George , SHEN, Gwo Jenn
发明人： ORMSBY, Theodore , CHUNG, Russell , LEUNG, George , SHEN, Gwo Jenn
IPC分类号： A61B18/18 , A61B17/3205
CPC分类号： A61B18/18 , A61B18/1815 , A61B2018/1869
摘要： An ablation system which transmits radio frequency (RF) energy for the ablation of biological tissues has a transmission line and an RF antenna disposed at the distal portion of the transmission line. An RF signal generator supplies RF energy to the proximal end of the cable for transmission to the antenna, and an electrically tunable transformer is connected between the signal generator and the antenna. The transformer is tuned based on detection of the reflected power level from the antenna so as to reduce or minimize reflected power, thereby increasing RF energy coupling between the antenna and tissue.
摘要翻译：传输用于生物组织消融的射频（RF）能量的消融系统具有设置在传输线的远端部分的传输线和RF天线。 RF信号发生器将RF能量提供给电缆的近端以传输到天线，并且电可变变压器连接在信号发生器和天线之间。基于从天线的反射功率电平的检测来调整变压器，以便减少或最小化反射功率，从而增加天线和组织之间的RF能量耦合。

7. 发明申请

WO2008051708A2 ABLATION CATHETER APPARATUS WITH ONE OR MORE ELECTRODES 审中-公开
标题翻译：具有一个或多个电极的消融导管设备
公开(公告)号：WO2008051708A2
公开(公告)日：2008-05-02
申请号：PCT/US2007/080819
申请日：2007-10-09
申请人： MEDWAVES, INC. , ORMSBY, Theodore C. , LEUNG, George L. , SHEN, Gwo Jenn , CHU, Peter
发明人： ORMSBY, Theodore C. , LEUNG, George L. , SHEN, Gwo Jenn , CHU, Peter
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B2017/003 , A61B2018/00839 , A61B2018/00916 , A61B2018/00946 , A61B2018/183
摘要： A radio frequency (RF) ablation catheter has a flexible distal end portion so that it can be deflected to position an antenna disposed in the distal end portion adjacent a tissue site to be treated. At least one electrical conductor is coupled to the antenna and extends through the catheter to the proximal end of the catheter to a connector at the proximal end of the catheter for connection to a power supply for the RF antenna. At least one electrode is disposed at the distal end portion of the catheter and electrically coupled to the proximal end connector for connection to a monitor. The electrode is of a flexible, electrically conductive material such as conductive polymer material. The electrode may be an electrocardiogram (ECG) electrode.
摘要翻译：射频（RF）消融导管具有柔性远端部分，使得其可偏转以将设置在远端部分中的天线定位在待治疗的组织部位附近。至少一个电导体联接到天线并且穿过导管延伸到导管的近端到位于导管近端的连接器，用于连接到RF天线的电源。至少一个电极设置在导管的远端部分处并电耦合到近端连接器以连接到监视器。电极是柔性的导电材料，例如导电聚合物材料。电极可以是心电图（ECG）电极。

8. 发明申请

WO2010121047A3 RADIO FREQUENCY BASED ABLATION SYSTEM AND METHOD WITH DIELECTRIC TRANSFORMER 审中-公开
公开(公告)号：WO2010121047A3
公开(公告)日：2010-10-21
申请号：PCT/US2010/031266
申请日：2010-04-15
申请人： MEDWAVES, INC. , ORMSBY, Theodore , CHUNG, Russell , LEUNG, George , SHEN, Gwo Jenn
发明人： ORMSBY, Theodore , CHUNG, Russell , LEUNG, George , SHEN, Gwo Jenn
IPC分类号： A61B18/18 , A61B17/3205
摘要： An ablation device which transmits radio frequency (RF) energy for the ablation of biological tissues has elongate inner and outer coaxial conductors extending from a proximal portion to a distal portion. An RF antenna is disposed at the distal portion of the device and transmits RF energy for ablation of a tissue region to be treated. Reflection of energy from the tissue or the ablation point is reduced by providing multiple layers of dielectric media about the antenna, or by providing a gradual transition point from the conductors to the antenna tip, by means of a longitudinally stepped dielectric layer transformer.

9. 发明申请

WO2010002888A2 ANGIOPLASTY AND TISSUE ABLATION APPARATUS AND METHOD 审中-公开
标题翻译： ANGIOPLASTY和组织吸收装置和方法
公开(公告)号：WO2010002888A2
公开(公告)日：2010-01-07
申请号：PCT/US2009049251
申请日：2009-06-30
申请人： MEDWAVES INC , ORMSBY THEODORE C , LEUNG GEORGE , SHEN GWO JENN
发明人： ORMSBY THEODORE C , LEUNG GEORGE , SHEN GWO JENN
IPC分类号： A61B18/18 , A61M25/10
CPC分类号： A61F2/958 , A61B18/1492 , A61B18/1815 , A61B2018/00214 , A61B2018/0022 , A61B2018/00422 , A61B2018/1846 , A61B2018/1853 , A61B2018/1861
摘要： A coaxial cable apparatus which transmits radio frequency (RF) energy for the ablation of biological tissues has inner and outer coaxial conductors extending substantially the entire length of the cable from a proximal end portion to a distal end portion. An RF antenna is disposed at the distal end portion of the cable and transmits RF energy for ablation of a tissue region to be treated. An angioplasty balloon is disposed over the RF antenna and communicates with a fluid supply and extraction passageway extending through the cable to allow the balloon to be inflated for an angioplasty procedure including tissue ablation, and to be deflated after the procedure is complete.
摘要翻译：传输用于生物组织消融的射频（RF）能量的同轴电缆装置具有从近端部分到远端部分的大致整个长度的电缆的内部和外部同轴导线。 RF天线设置在电缆的远端部分，并且传输RF能量以消除待治疗的组织区域。血管成形术球囊设置在RF天线上方，并与延伸穿过电缆的流体供应和提取通道连通，以允许气囊膨胀用于包括组织消融的血管成形术程序，并且在手术完成后被放气。

10. 发明申请

WO2008051708A3 ABLATION CATHETER APPARATUS WITH ONE OR MORE ELECTRODES 审中-公开
标题翻译：具有一个或多个电极的吸引器设备
公开(公告)号：WO2008051708A3
公开(公告)日：2008-06-19
申请号：PCT/US2007080819
申请日：2007-10-09
申请人： MEDWAVES INC , ORMSBY THEODORE C , LEUNG GEORGE L , SHEN GWO JENN , CHU PETER
发明人： ORMSBY THEODORE C , LEUNG GEORGE L , SHEN GWO JENN , CHU PETER
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B2017/003 , A61B2018/00839 , A61B2018/00916 , A61B2018/00946 , A61B2018/183
摘要： A radio frequency (RF) ablation catheter has a flexible distal end portion so that it can be deflected to position an antenna disposed in the distal end portion adjacent a tissue site to be treated. At least one electrical conductor is coupled to the antenna and extends through the catheter to the proximal end of the catheter to a connector at the proximal end of the catheter for connection to a power supply for the RF antenna. At least one electrode is disposed at the distal end portion of the catheter and electrically coupled to the proximal end connector for connection to a monitor. The electrode is of a flexible, electrically conductive material such as conductive polymer material. The electrode may be an electrocardiogram (ECG) electrode.
摘要翻译：射频（RF）消融导管具有柔性的远端部分，使得其可被偏转以定位邻近待治疗组织部位的远端部分中的天线。至少一个电导体被耦合到天线并且延伸穿过导管到导管的近端到在导管的近端处的连接器，用于连接到用于RF天线的电源。至少一个电极设置在导管的远端部分处并且电耦合到近端连接器以连接到监视器。电极是柔性的导电材料，例如导电聚合物材料。电极可以是心电图（ECG）电极。

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