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1. 发明专利

AU2002318441A1 SLIDE STAINER WITH CONTROLLED FLUID FLOW 未知
公开(公告)号：AU2002318441A1
公开(公告)日：2004-01-19
申请号：AU2002318441
申请日：2002-06-28
申请人： SHAH PREYAS SARABHAI
发明人： SHAH PREYAS SARABHAI
IPC分类号： G01N35/00

2. 发明申请

WO2012082678A3 TISSUE PROCESSOR 审中-公开
标题翻译：组织加工商
公开(公告)号：WO2012082678A3
公开(公告)日：2014-04-24
申请号：PCT/US2011064531
申请日：2011-12-13
申请人： SHAH PREYAS
发明人： SHAH PREYAS
IPC分类号： G01N21/00 , B29C65/00 , G01N31/00 , G01N33/00
CPC分类号： G01N1/30 , A01N1/0242 , G01N1/312 , G01N35/00732 , G01N35/0092 , G01N35/025
摘要： A tissue processing system includes a plurality of processing stations. Each processing station includes a plurality of tissue receiving areas that are each configured to accommodate a tissue sample as well as physically isolate that tissue sample from other tissue samples at other receiving areas of the same processing station. Each processing station is configured to separately and individually process the tissue sample at each receiving area to either reduce or eliminate any potential for cross- contamination between the tissue samples undergoing processing at the same processing station. For each receiving area of each processing station, the system is configured to immerse a tissue sample at a particular receiving area in processing fluid for a pre-determined time according to a pre-defined protocol that is based upon parameters of that tissue sample.
摘要翻译：纸巾处理系统包括多个处理站。每个处理站包括多个组织接收区域，每个组织接收区域被配置为容纳组织样本，并且将该组织样本与来自同一处理站的其他接收区域处的其他组织样本物理隔离。每个处理站被配置为在每个接收区域处单独处理组织样本，以减少或消除在同一处理站进行处理的组织样本之间的交叉污染的任何可能性。对于每个处理站的每个接收区域，系统被配置为根据基于该组织样本的参数的预定义协议将组织样本浸入处理流体中的预定时间的处理流体中。

3. 发明申请

WO2020123319A2 METHODS OF USING MASTER / COPY ARRAYS FOR SPATIAL DETECTION 审中-公开
公开(公告)号：WO2020123319A2
公开(公告)日：2020-06-18
申请号：PCT/US2019/065096
申请日：2019-12-06
申请人： 10X GENOMICS, INC. , SHAH, Preyas
发明人： SHAH, Preyas
IPC分类号： C12Q1/6837 , C12Q1/6841
摘要： This disclosure provides methods for spatial profiling of biological analytes present in a biological sample. Methods include generating feature arrays using a master/copy format using recessed arrays, and methods for using such arrays. For example spatially-tagged analyte capture analytes can be used in spatial detection in methods to determine the location of analytes (e.g., proteins) in biological samples.

5. 发明申请

WO2012166776A1 ROTARY TISSUE PROCESSOR WITH CONFIGURABLE STATIONS 审中-公开
标题翻译：带配置台的旋转组织处理器
公开(公告)号：WO2012166776A1
公开(公告)日：2012-12-06
申请号：PCT/US2012/039955
申请日：2012-05-30
申请人： SHAH, Preyas
发明人： SHAH, Preyas
IPC分类号： G01N33/48 , G01N1/28
CPC分类号： G01N1/312 , G01N35/04 , G01N2035/0441
摘要： A configurable tissue processing system is disclosed that includes a plurality of configurable tissue processing stations, each station configured to receive tissue samples and selectively configurable to heat, agitate and apply either a positive pressure or a vacuum pressure to the received tissue samples; a transport mechanism that is configured to transport the tissue samples between the plurality of configurable tissue processing stations; and a control unit coupled to the plurality of configurable tissue processing stations and to the transport mechanism, the control unit controlling the transport mechanism to selectively position the tissue samples in the plurality of configurable tissue processing stations, and the control unit configuring each of the plurality of configurable tissue processing stations to heat, agitate and apply either a positive pressure or a vacuum pressure to the received samples. Also disclosed is a method of configuring the plurality of tissue processing stations.
摘要翻译：公开了一种可配置的组织处理系统，其包括多个可配置的组织处理站，每个站被配置为接收组织样本并且选择性地配置为对所接收的组织样本进行加热，搅动和施加正压力或真空压力; 运送机构，其构造成在所述多个可配置组织处理站之间传送所述组织样本; 以及控制单元，其耦合到所述多个可配置组织处理站和所述传送机构，所述控制单元控制所述传送机构以选择性地将所述组织样本定位在所述多个可配置组织处理站中，并且所述控制单元配置所述多个的可配置组织处理站来加热，搅拌并向接收到的样品施加正压或真空压力。还公开了一种配置多个组织处理站的方法。

6. 发明申请

WO2004003570A1 SLIDE STAINER WITH CONTROLLED FLUID FLOW 审中-公开
标题翻译：具有控制流体流动的滑块
公开(公告)号：WO2004003570A1
公开(公告)日：2004-01-08
申请号：PCT/US2002/020495
申请日：2002-06-28
申请人： SHAH, Preyas, Sarabhai
发明人： SHAH, Preyas, Sarabhai
IPC分类号： G01N35/00
CPC分类号： G01N1/312 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165
摘要： An automated slide stainer (100) with fluid flow control. The fluid flow control controls the flow rate of fluid, e.g., water, applied to at least one slide (104) by the slide stainer. In an automated slide stainer (100) that applies reagents to slides to stain biological specimens (105) on the slides (104), the flow rate controlled fluid can be used to adequately rinse the slides without damaging the biological specimens contained on the slides.
摘要翻译：具有流体流动控制的自动滑动染色器（100）。流体流量控制器通过滑动染色器控制施加到至少一个载玻片（104）的流体（例如水）的流速。在将试剂施加到载玻片（104）上的染色生物样品（105）上的自动化载玻片染色器（100）中，可以使用流速控制的流体来充分冲洗载玻片而不损坏包含在载片上的生物样品。

7. 发明申请

WO2020123305A3 GENERATING CAPTURE PROBES FOR SPATIAL ANALYSIS 审中-公开
公开(公告)号：WO2020123305A3
公开(公告)日：2020-06-18
申请号：PCT/US2019/065013
申请日：2019-12-06
申请人： 10X GENOMICS, INC. , SCHNALL-LEVIN, Michael , RAMACHANDRAN IYER, Eswar Prasad , YIN, Yifeng , SHAH, Preyas , MCDERMOTT, Geoffrey , LOWE, Adam , DELANEY, Joshua , TENTORI, Augusto Manuel , BHARADWAJ, Rajiv , GIACOMELLO, Stefania , GAGNON, Alex , FREY, Meghan , BENT, Zachary , BORGSTROM, Erik Leonard Henrik
发明人： SCHNALL-LEVIN, Michael , RAMACHANDRAN IYER, Eswar Prasad , YIN, Yifeng , SHAH, Preyas , MCDERMOTT, Geoffrey , LOWE, Adam , DELANEY, Joshua , TENTORI, Augusto Manuel , BHARADWAJ, Rajiv , GIACOMELLO, Stefania , GAGNON, Alex , FREY, Meghan , BENT, Zachary , BORGSTROM, Erik Leonard Henrik
IPC分类号： C12Q1/6837 , C12Q1/6841
摘要： The present disclosure relates to compositions and methods for generating capture probes on a substrate for identifying the location of analytes in a biological sample.

8. 发明申请

WO2005000157A2 APPARATUS AND METHOD FOR PROVIDING RAPID COMPRESSION TO AT LEAST ONE APPENDAGE 审中-公开
标题翻译：提供至少一个附件的快速压缩的装置和方法
公开(公告)号：WO2005000157A2
公开(公告)日：2005-01-06
申请号：PCT/US2004/017597
申请日：2004-06-03
申请人： RUSHABH INSTRUMENTS, LLC , SHAH, Preyas , HIGGINS, Mark
发明人： SHAH, Preyas , HIGGINS, Mark
IPC分类号： A61F
CPC分类号： A61H31/00 , A61H9/0078 , A61H31/006 , A61H2201/0103 , A61H2201/1246 , A61H2201/165 , A61H2201/5007 , A61H2230/06
摘要： Methods and apparatus for providing rapid compression to at least one appendage positioned within an inflatable sleeve are disclosed. Rapid compression is provided by filling the inflatable sleeve containing the appendage with a gas. A portion of the gas is then repeatedly withdrawn and inserted back into the inflatable sleeve to apply a compression therapy to the at least one appendage.
摘要翻译：公开了用于向定位在可充气套筒内的至少一个附肢提供快速压缩的方法和装置。通过用气体填充包含附件的充气套筒来提供快速压缩。然后重复抽出一部分气体并将其插回充气套管中，以对至少一个附件施加压缩治疗。

9. 发明申请

WO2020123319A3 METHODS OF USING MASTER / COPY ARRAYS FOR SPATIAL DETECTION 审中-公开
公开(公告)号：WO2020123319A3
公开(公告)日：2020-06-18
申请号：PCT/US2019/065096
申请日：2019-12-06
申请人： 10X GENOMICS, INC. , SHAH, Preyas
发明人： SHAH, Preyas
IPC分类号： C12Q1/6837 , C12Q1/6841
摘要： This disclosure provides methods for spatial profiling of biological analytes present in a biological sample. Methods include generating feature arrays using a master/copy format using recessed arrays, and methods for using such arrays. For example spatially-tagged analyte capture analytes can be used in spatial detection in methods to determine the location of analytes (e.g., proteins) in biological samples.

10. 发明申请

WO2020123318A1 RESOLVING SPATIAL ARRAYS USING DECONVOLUTION 审中-公开
公开(公告)号：WO2020123318A1
公开(公告)日：2020-06-18
申请号：PCT/US2019/065081
申请日：2019-12-06
申请人： 10X GENOMICS, INC. , FRENZ, Lucas , SHAH, Preyas , HINDSON, Benjamin , IYER, Eswar Prasad, Ramachandran
发明人： FRENZ, Lucas , SHAH, Preyas , HINDSON, Benjamin , IYER, Eswar Prasad, Ramachandran
IPC分类号： C12Q1/6837 , C12Q1/6841
摘要： Methods for determining a location of a feature on an array include: (a) providing a first array with a first plurality of features immobilized on a first substrate; (b) providing a second array with a second plurality of features immobilized on a second substrate; (c) aligning the first array with the second array; (d) hybridizing a first barcoded oligonucleotide of the first array to a second barcoded oligonucleotide of the second array, thereby producing a combined nucleic acid that includes first and second spatial barcodes; (e) determining all or a portion of the sequence of the combined nucleic acid; and (f) identifying the second barcoded oligonucleotide associated with the first barcoded oligonucleotide in the combined nucleic acid, and determining the location of a second feature in the second array.

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