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1. 发明申请

WO2008001224A2 POLYPEPTIDES FROM NEISSERIA MENINGITIDIS 审中-公开
标题翻译：来自NEISSERIA MENINGITIDIS的多肽
公开(公告)号：WO2008001224A2
公开(公告)日：2008-01-03
申请号：PCT/IB2007/002838
申请日：2007-06-29
申请人： NOVARTIS AG , THE INSTITUTE FOR GENOMIC RESEARCH , RAPPUOLI, Rino , FRASER, Claire , PIZZA, Mariagrazia , SCARSELLI, Maria , SERRUTO, Davide , TETELIN, Hervé
发明人： RAPPUOLI, Rino , FRASER, Claire , PIZZA, Mariagrazia , SCARSELLI, Maria , SERRUTO, Davide , TETELIN, Hervé
CPC分类号： C07K14/22 , A61K38/00
摘要： Various specific meningococcal proteins are disclosed. The invention provides related polypeptides, nucleic acids, antibodies and methods. These can all be usedin medicine for treating or preventing disease and/or infection caused by meningococcus, such as bacterial meningitis.
摘要翻译：公开了各种具体的脑膜炎球菌蛋白质。本发明提供了相关的多肽，核酸，抗体和方法。这些都可以用于治疗或预防由脑膜炎球菌引起的疾病和/或感染的药物，例如细菌性脑膜炎。

2. 发明申请

WO2012032498A2 DEVELOPMENTS IN MENINGOCOCCAL OUTER MEMBRANE VESICLES 审中-公开
标题翻译：肉眼外膜的发展
公开(公告)号：WO2012032498A2
公开(公告)日：2012-03-15
申请号：PCT/IB2011/053957
申请日：2011-09-09
申请人： NOVARTIS AG , SERRUTO, Davide , PIZZA, Mariagrazia , DELANY, Isobel
发明人： SERRUTO, Davide , PIZZA, Mariagrazia , DELANY, Isobel
IPC分类号： A61K39/095 , C12N1/00
CPC分类号： A61K39/095 , A61K2039/523 , C07K14/22 , C12N1/20 , C12N1/38 , C12N9/1085 , C12Y205/01072
摘要： A first aspect of the invention provides meningococcal outer membrane vesicles in which NHBA is over-expressed. A second aspect of the invention provides meningococcal outer membrane vesicles in which NadA is over-expressed. A third aspect of the invention provides a panel of bacterial strains, each member of which is isogenic except for a single gene which in each strain encodes a different variant of an antigen of interest.
摘要翻译：本发明的第一方面提供脑膜炎球菌外膜囊泡，其中NHBA过度表达。本发明的第二方面提供其中NadA过度表达的脑膜炎球菌外膜囊泡。本发明的第三方面提供了一组细菌菌株，其每个成员都是同基因的，除了在每个菌株中编码感兴趣抗原的不同变体的单个基因。

3. 发明申请

WO2005106009A3 LACTOFERRIN CLEAVAGE OF NEISSERIAL PROTEINS 审中-公开
公开(公告)号：WO2005106009A3
公开(公告)日：2006-03-30
申请号：PCT/IB2005001446
申请日：2005-04-28
申请人： CHIRON SRL , SERRUTO DAVIDE , ARICO MARIA
发明人： SERRUTO DAVIDE , ARICO MARIA
IPC分类号： A61K39/095 , C07H21/00 , C07K14/22 , C12P21/06
CPC分类号： A61K39/095 , C07K14/22
摘要： Meningococcal antigens are cleaved by human lactoferrin. The invention is based on the identification of the cleavage products of this reaction, and provides a method for cleaving a neisserial polypeptide, comprising the step of mixing the polypeptide with a lactoferrin enzyme. The invention also provides polypeptides obtainable by this process (i.e. the cleavage products of the lactoferrin digestion) which might be useful in the preparation of anti-meningococcal vaccines. Proteins of particular interest are meningococcal proteins 287 and App.
摘要翻译：脑膜炎球菌抗原被人乳铁蛋白切割。本发明基于该反应的切割产物的鉴定，并提供了切割奈司多肽的方法，包括将多肽与乳铁蛋白酶混合的步骤。本发明还提供可通过该方法获得的多肽（即乳铁蛋白消化的切割产物），其可用于制备抗脑膜炎球菌疫苗。特别感兴趣的蛋白质是脑膜炎球菌蛋白质287和App。

4. 发明申请

WO2005106009A2 LACTOFERRIN CLEAVAGE OF NEISSERIAL PROTEINS 审中-公开
公开(公告)号：WO2005106009A2
公开(公告)日：2005-11-10
申请号：PCT/IB2005/001446
申请日：2005-04-28
申请人： CHIRON SRL , SERRUTO, Davide , ARICO, Maria
发明人： SERRUTO, Davide , ARICO, Maria
IPC分类号： C12P21/06
CPC分类号： A61K39/095 , C07K14/22
摘要： Meningococcal antigens are cleaved by human lactoferrin. The invention is based on the identification of the cleavage products of this reaction, and provides a method for cleaving a neisserial polypeptide, comprising the step of mixing the polypeptide with a lactoferrin enzyme. The invention also provides polypeptides obtainable by this process (i.e. the cleavage products of the lactoferrin digestion). Proteins of particular interest are meningococcal proteins 287 and App.
摘要翻译：脑膜炎球菌抗原被人乳铁蛋白切割。本发明基于该反应的切割产物的鉴定，并提供了切割奈司多肽的方法，包括将多肽与乳铁蛋白酶混合的步骤。本发明还提供可通过该方法获得的多肽（即乳铁蛋白消化的切割产物）。特别感兴趣的蛋白质是脑膜炎球菌蛋白质287和App。

5. 发明申请

WO2004019977A2 IMPROVED BACTERIAL OUTER MEMBRANE VESICLES 审中-公开
标题翻译：改进的细菌外膜VESICLES
公开(公告)号：WO2004019977A2
公开(公告)日：2004-03-11
申请号：PCT/IB2003/004293
申请日：2003-09-01
申请人： CHIRON SRL , PIZZA, Mariagrazia , SERRUTO, Davide , RAPPUOLI, Rini
发明人： PIZZA, Mariagrazia , SERRUTO, Davide , RAPPUOLI, Rini
IPC分类号： A61K39/095
CPC分类号： A61K39/095 , A61K2039/55555 , C07K14/22 , C12N1/06 , C12N1/20 , C12N13/00
摘要： Existing methods of meningococcal OMV preparation involve the use of detergent during disruption of the bacterial membrane. According to the invention, membrane disruption is performed substantially in the absence of detergent. The resulting OMVs which retain important bacterial immunogenic components, particularly (i) the protective NspA surface protein, (ü) protein NMB2132 and (iii) protein NMB 1870.A Typical process involves the following steps: (a) treating bacterial cells in the substantial absence of detergent; (b) centrifuging the composition from step (a) to separate the outer membrane vesicles from treated cells and cell debris, and collecting the supernatant; (c) performing a high speed centrifugation of the supernatant from step (b) and collecting the outer membrane vesicles in a pellet; (d) re-dispersing the pellet from step (c) in a buffer; (e) performing a second high speed centrifugation in accordance with step (c), collecting the outer membrane vesicles in a pellet; (f) re-dispersing the pellet from step (e) in an aqueous medium.
摘要翻译：脑膜炎球菌OMV制剂的现有方法涉及在细菌膜破坏期间使用洗涤剂。根据本发明，膜破坏基本上在没有洗涤剂的情况下进行。所产生的OMV保留重要的细菌免疫原性成分，特别是（i）保护性NspA表面蛋白（ü）蛋白NMB2132和（iii）蛋白NMB1870.A典型的方法包括以下步骤：（a）不含洗涤剂; （b）将来自步骤（a）的组合物离心以将外膜囊泡与经处理的细胞和细胞碎片分离，并收集上清液; （c）对来自步骤（b）的上清液进行高速离心并将颗粒中的外膜囊泡收集; （d）将来自步骤（c）的沉淀物重新分散在缓冲液中; （e）根据步骤（c）进行第二高速离心，将外膜囊泡收集在颗粒中; （f）将来自步骤（e）的沉淀物重新分散在水性介质中。

6. 发明申请

WO2012032498A3 MENINGOCOCCUS OVEREXPRESSING NADA AND/OR NHBA AND OUTER MEMBRANE VESICLES DERIVED THEREFROM 审中-公开
标题翻译：超氧化物歧化酶和/或NHBA和外膜衍生物
公开(公告)号：WO2012032498A3
公开(公告)日：2012-05-03
申请号：PCT/IB2011053957
申请日：2011-09-09
申请人： NOVARTIS AG , SERRUTO DAVIDE , PIZZA MARIAGRAZIA , DELANY ISOBEL
发明人： SERRUTO DAVIDE , PIZZA MARIAGRAZIA , DELANY ISOBEL
IPC分类号： A61K39/095 , C12N1/00
CPC分类号： A61K39/095 , A61K2039/523 , C07K14/22 , C12N1/20 , C12N1/38 , C12N9/1085 , C12Y205/01072
摘要： A first aspect of the invention provides meningococcal outer membrane vesicles in which NHBA is over-expressed. A second aspect of the invention provides meningococcal outer membrane vesicles in which NadA is over-expressed. A third aspect of the invention provides a panel of bacterial strains, each member of which is isogenic except for a single gene which in each strain encodes a different variant of an antigen of interest.
摘要翻译：本发明的第一方面提供脑膜炎球菌外膜囊泡，其中NHBA过度表达。本发明的第二方面提供其中NadA过度表达的脑膜炎球菌外膜囊泡。本发明的第三方面提供了一组细菌菌株，其每个成员都是同基因的，除了在每个菌株中编码感兴趣抗原的不同变体的单个基因。

7. 发明申请

WO2008001224A3 POLYPEPTIDES FROM NEISSERIA MENINGITIDIS 审中-公开
标题翻译：来自NEISSERIA MENINGITIDIS的多糖
公开(公告)号：WO2008001224A3
公开(公告)日：2008-07-10
申请号：PCT/IB2007002838
申请日：2007-06-29
申请人： NOVARTIS AG , CRAIG J VENTER INST INC , RAPPUOLI RINO , FRASER CLAIRE , PIZZA MARIAGRAZIA , SCARSELLI MARIA , SERRUTO DAVIDE , TETELIN HERVE
发明人： RAPPUOLI RINO , FRASER CLAIRE , PIZZA MARIAGRAZIA , SCARSELLI MARIA , SERRUTO DAVIDE , TETELIN HERVE
IPC分类号： C07K14/22
CPC分类号： C07K14/22 , A61K38/00
摘要： Various specific meningococcal proteins are disclosed. The invention provides related polypeptides, nucleic acids, antibodies and methods. These can all be usedin medicine for treating or preventing disease and/or infection caused by meningococcus, such as bacterial meningitis.
摘要翻译：公开了各种特定的脑膜炎球菌蛋白质。本发明提供了相关多肽，核酸，抗体和方法。这些都可以用于治疗或预防由脑膜炎球菌引起的疾病和/或感染的细菌性脑膜炎的药物。

8. 发明申请

WO2004019977A3 IMPROVED BACTERIAL OUTER MEMBRANE VESICLES 审中-公开
标题翻译：改进的细菌外膜膜
公开(公告)号：WO2004019977A3
公开(公告)日：2004-07-15
申请号：PCT/IB0304293
申请日：2003-09-01
申请人： CHIRON SRL , PIZZA MARIAGRAZIA , SERRUTO DAVIDE , RAPPUOLI RINI
发明人： PIZZA MARIAGRAZIA , SERRUTO DAVIDE , RAPPUOLI RINI
IPC分类号： A61K9/00 , A61K39/095 , C12N1/06 , A61K39/104 , A61K39/112
CPC分类号： A61K39/095 , A61K2039/55555 , C07K14/22 , C12N1/06 , C12N1/20 , C12N13/00
摘要： Existing methods of meningococcal OMV preparation involve the use of detergent during disruption of the bacterial membrane. According to the invention, membrane disruption is performed substantially in the absence of detergent. The resulting OMVs which retain important bacterial immunogenic components, particularly (i) the protective NspA surface protein, (ü) protein NMB2132 and (iii) protein NMB 1870.A Typical process involves the following steps: (a) treating bacterial cells in the substantial absence of detergent; (b) centrifuging the composition from step (a) to separate the outer membrane vesicles from treated cells and cell debris, and collecting the supernatant; (c) performing a high speed centrifugation of the supernatant from step (b) and collecting the outer membrane vesicles in a pellet; (d) re-dispersing the pellet from step (c) in a buffer; (e) performing a second high speed centrifugation in accordance with step (c), collecting the outer membrane vesicles in a pellet; (f) re-dispersing the pellet from step (e) in an aqueous medium.
摘要翻译：现有的脑膜炎球菌OMV制备方法涉及在破坏细菌膜期间使用去污剂。根据本发明，膜破裂基本上在不含洗涤剂的情况下进行。（i）保护性NspA表面蛋白质，（ü）蛋白质NMB2132和（iii）蛋白质NMB 1870.典型的方法包括以下步骤：（a）处理大量的细菌免疫原性组分没有洗涤剂; （b）离心步骤（a）的组合物以从处理的细胞和细胞碎片中分离外膜囊泡，并收集上清液; （c）对来自步骤（b）的上清液进行高速离心并将外膜囊泡收集在沉淀中; （d）将来自步骤（c）的颗粒重新分散在缓冲液中; （e）根据步骤（c）进行第二次高速离心，收集沉淀中的外膜囊泡; （f）将来自步骤（e）的粒料再分散在含水介质中。

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