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1. 发明专利

SK279329B6 STABLE HYDRATED CEPHALOSPORIN DRY POWDER, METHOD OF ITS PREPARATION AND FORMULATION THEREOF 未知
公开(公告)号：SK279329B6
公开(公告)日：1998-10-07
申请号：SK131194
申请日：1993-04-30
申请人： JOHNSON DONALD A. , WEARLEY LORRAINE , GALEOS REBECCA , SEQUEIRA JOEL A.
发明人： JOHNSON DONALD A , WEARLEY LORRAINE , GALEOS REBECCA , SEQUEIRA JOEL A
IPC分类号： A61J3/02 , A61K9/00 , A61K9/14 , A61K31/545 , A61K47/00 , A61K47/34 , A61P31/04
摘要： A pharmaceutical composition for oral dosage in the form of suspension in water contains from 65 to 150 mg/g of hydrated ceftibuten with from 7 to 14 percent by weight of water, from 0,30 to 0,50 mg/g of polysorbate, 80, 0,60 to 1,0 mg/g of simethicone, 12 to 20 mg/g of xanthane resin, 8 to 12 mg/g silicon dioxide, 14 to 22 mg/g titanium dioxide, 3 to 19 mg/g of a water soluble preservative, 3 to 5 mg/g of taste improving additive with fruit flavour and a sweetener or sweetening agent in an amount which is left to 1 g. This composition is prepared by mixing ingredients thereof or its pharmaceutically acceptable salts at the room temperature and normal humidity with the dry, pharmaceutically acceptable carriers. The mixture is subsequently transferred into sealable storage containers that are light-impenetrable with a capacity no more than 5 percent by volume of oxygen. The pharmaceutical composition contains antibacterially effective amount of the agent with sterile water which form a suspension being stable against sedimentation during an elapse of at least 3 hours, preferably 24 hours.

2. 发明专利

CA1307207C STEROID LOTION 未知
公开(公告)号：CA1307207C
公开(公告)日：1992-09-08
申请号：CA567221
申请日：1988-05-19
申请人： SEQUEIRA JOEL A
发明人： SEQUEIRA JOEL A , MUNAYYER FARAH J , GALEOS REBECCA
IPC分类号： A61K9/08 , A61K9/00 , A61K9/107 , A61K31/56 , A61K31/565 , A61K31/57 , A61K47/00 , A61K47/10 , A61K47/38 , A61P29/00
摘要： An improved lotion formulation for the topical administration of corticosteroids in a hydro-alcoholic base containing propylene glycol.

3. 发明申请

WO2004020289A1 PROCESS FOR PRODUCING METERED DOSE INHALER FORMULATIONS 审中-公开
标题翻译：生产计量剂量吸入剂制剂的方法
公开(公告)号：WO2004020289A1
公开(公告)日：2004-03-11
申请号：PCT/US2003/026512
申请日：2003-08-26
申请人： SCHERING CORPORATION , CHAUDHRY, Saeed , SHARPE, Stefan, A. , BERRY, Julianne , SEQUEIRA, Joel, A.
发明人： CHAUDHRY, Saeed , SHARPE, Stefan, A. , BERRY, Julianne , SEQUEIRA, Joel, A.
IPC分类号： B65B31/00
CPC分类号： B65B3/003 , A61M11/04 , A61M15/0065 , B65B31/003
摘要： Disclosed are methods of introducing a suspension or solution of a medicament, preferably mometasone furoate anhydrous, into a metered dose inhaler container, said container having a valve attached thereto, said method comprising the steps of introducing mometasone furoate anhydrous, a surfactant and a chlorflourocarbon free propellant into a vessel that is held under pressure to form a suspension or solution, circulating said suspension or solution from the vessel through a line which includes a filling head, bringing said filling head into communication with said metered dose inhaler container through said valve of said metered dose inhaler container, introducing a quantity of such suspension or solution into the container from the filling head of the line through said valve of said metered dose inhaler container, withdrawing said filling head from said metered dose inhaler container, and sealing said metered dose inhaler container, as well as the products produced thereby having an improved particle size distribution of the active ingredients in metered dose inhalers.
摘要翻译：公开了将药物（优选无糠酸莫米松）的悬浮液或溶液引入计量剂量吸入器容器中的方法，所述容器具有附着于其上的阀，所述方法包括以下步骤：将无糠酸莫米松，无表面活性剂和无氯氟碳推进剂进入保持在压力下以形成悬浮液或溶液的容器中，使所述悬浮液或溶液从容器循环通过包括填充头的管线，使所述填充头通过所述的所述阀的所述阀门与所述计量吸入器容器连通计量剂量吸入器容器，通过所述计量吸入器容器的所述阀从管线的填充头将一定数量的这种悬浮液或溶液引入容器中，从所述计量吸入器容器中取出所述填充头，并密封所述计量剂量吸入器集装箱，以及由此生产的产品改进计量吸入器中活性成分的粒度分布。

4. 发明申请

WO2004018025A1 PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：药物组合物
公开(公告)号：WO2004018025A1
公开(公告)日：2004-03-04
申请号：PCT/US2003/026272
申请日：2003-08-21
申请人： SCHERING CORPORATION , SHARPE, Stefan, A. , SEQUEIRA, Joel, A.
发明人： SHARPE, Stefan, A. , SEQUEIRA, Joel, A.
IPC分类号： A61M15/00
CPC分类号： A61K9/008 , A61K9/0075 , A61K9/124 , A61K9/145 , A61K31/58 , A61M11/001 , A61M15/00 , Y10T29/49908
摘要： Disclosed are aerosolized formulations for the treatment of asthma that contain mometasone furoate and processes for preparing the same.
摘要翻译：公开了用于治疗含有糠酸莫米他松的哮喘的雾化制剂及其制备方法。

5. 发明申请

WO2006105401A2 MEDICAMENTS AND METHODS COMBINING AN ANTICHOLINERGIC, A CORTICOSTEROID, AND A LONG ACTING BETA AGONIST 审中-公开
标题翻译：药物和方法联合抗胆碱药物，角质甾醇药物和长期治疗药物
公开(公告)号：WO2006105401A2
公开(公告)日：2006-10-05
申请号：PCT/US2006/011924
申请日：2006-03-30
申请人： SCHERING CORPORATION , SEQUEIRA, Joel, A. , YANG, Tsong-Toh
发明人： SEQUEIRA, Joel, A. , YANG, Tsong-Toh
CPC分类号： A61K31/58 , A61K9/0073 , A61K31/40 , A61K31/46 , A61K31/47 , A61K45/06 , A61K2300/00
摘要： Disclosed are inhalable medicaments and methods based on an anticholinergic in combination with a corticosteroid, and a long acting beta agonist, for simultaneous or sequential administration in the prevention or treatment of a respiratory, inflammatory or obstructive airway disease. In addition, disclosed are inhalable medicaments and methods based on combinations of an anticholinergic and a corticosteroid; an anticholinergic and a long acting beta agonist; or a corticosteroid and a long acting beta agonist, for simultaneous or sequential administration in the prevention or treatment of a respiratory, inflammatory or obstructive airway disease. Also disclosed are inhalable medicaments and methods comprising a phosphodiesterase IV inhibitor for administration in the prevention or treatment of a respiratory, inflammatory or obstructive airway disease.
摘要翻译：公开了基于抗胆碱能药物与皮质类固醇联合的可吸入药物和方法以及长效β激动剂，用于同时或连续施用以预防或治疗呼吸道，炎性或阻塞性气道疾病。此外，公开了基于抗胆碱能药和皮质类固醇组合的可吸入药物和方法; 抗胆碱能药和长效β激动剂; 或皮质类固醇和长效β激动剂，用于同时或连续施用以预防或治疗呼吸道，炎性或阻塞性气道疾病。还公开了可吸入药物和方法，其包含用于预防或治疗呼吸道，炎性或阻塞性气道疾病的磷酸二酯酶IV抑制剂。

6. 发明申请

WO03037312A2 RIBAVIRIN SYRUP FORMULATIONS 审中-公开
标题翻译： RIBAVIRIN SYRUP制剂
公开(公告)号：WO03037312A2
公开(公告)日：2003-05-08
申请号：PCT/US0234898
申请日：2002-10-31
申请人： SCHERING CORP , HEIMBECHER SUSAN K , SEQUEIRA JOEL A
发明人： HEIMBECHER SUSAN K , SEQUEIRA JOEL A
IPC分类号： A61K9/08 , A61K9/00 , A61K31/00 , A61K31/7056 , A61K47/10 , A61K47/12 , A61K47/26 , A61P31/14
CPC分类号： A61K9/0095 , A61K31/7056
摘要： A liquid formulation comprising ribavirin having a longer shelf life and improved taste is disclosed.
摘要翻译：公开了包含具有更长保质期和改善味道的利巴韦林的液体制剂。

7. 发明申请

WO2006105401A3 MEDICAMENTS AND METHODS COMBINING AN ANTICHOLINERGIC, A CORTICOSTEROID, AND A LONG ACTING BETA AGONIST 审中-公开
标题翻译：药物和方法联合抗胆碱药物，角质甾醇药物和长期治疗药物
公开(公告)号：WO2006105401A3
公开(公告)日：2007-06-21
申请号：PCT/US2006011924
申请日：2006-03-30
申请人： SCHERING CORP , SEQUEIRA JOEL A , YANG TSONG-TOH
发明人： SEQUEIRA JOEL A , YANG TSONG-TOH
IPC分类号： A61K45/06 , A61K9/12 , A61K45/00 , A61P11/00
CPC分类号： A61K31/58 , A61K9/0073 , A61K31/40 , A61K31/46 , A61K31/47 , A61K45/06 , A61K2300/00
摘要： Disclosed are inhalable medicaments and methods based on an anticholinergic in combination with a corticosteroid, and a long acting beta agonist, for simultaneous or sequential administration in the prevention or treatment of a respiratory, inflammatory or obstructive airway disease. In addition, disclosed are inhalable medicaments and methods based on combinations of an anticholinergic and a corticosteroid; an anticholinergic and a long acting beta agonist; or a corticosteroid and a long acting beta agonist, for simultaneous or sequential administration in the prevention or treatment of a respiratory, inflammatory or obstructive airway disease. Also disclosed are inhalable medicaments and methods comprising a phosphodiesterase IV inhibitor for administration in the prevention or treatment of a respiratory, inflammatory or obstructive airway disease.
摘要翻译：公开了基于抗胆碱能药物与皮质类固醇联合的可吸入药物和方法以及长效β激动剂，用于同时或连续施用以预防或治疗呼吸道，炎性或阻塞性气道疾病。此外，公开了基于抗胆碱能药和皮质类固醇组合的可吸入药物和方法; 抗胆碱能药和长效β激动剂; 或皮质类固醇和长效β激动剂，用于同时或连续施用以预防或治疗呼吸道，炎性或阻塞性气道疾病。还公开了可吸入药物和方法，其包含用于预防或治疗呼吸道，炎性或阻塞性气道疾病的磷酸二酯酶IV抑制剂。

8. 发明申请

WO2003020253A2 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF ASTHMA 审中-公开
标题翻译：用于治疗哮喘的药物组合物
公开(公告)号：WO2003020253A2
公开(公告)日：2003-03-13
申请号：PCT/US2002/027336
申请日：2002-08-27
申请人： SCHERING CORPORATION , SEQUEIRA, Joel, A. , SHARPE, Stefan, A. , HART, John, L.
发明人： SEQUEIRA, Joel, A. , SHARPE, Stefan, A. , HART, John, L.
IPC分类号： A61K31/00
CPC分类号： A61K9/008 , A61K31/58 , A61K2300/00
摘要： Disclosed are aerosolized formulations for the treatment of asthma that contain mometasone furoate and formoterol fumarate and processes for preparing the same.
摘要翻译：公开了用于治疗含有糠酸莫米松和富马酸福莫特罗的哮喘的气雾化制剂及其制备方法。

9. 发明申请

WO1991008733A1 STABLE CREAM AND LOTION BASES FOR LIPOPHILIC DRUG COMPOSITIONS 审中-公开
标题翻译：稳定的乳酪和油脂组合物
公开(公告)号：WO1991008733A1
公开(公告)日：1991-06-27
申请号：PCT/US1990007228
申请日：1990-12-14
申请人： SCHERING CORPORATION , MUNAYYER, Farah, J. , SEQUEIRA, Joel, A.
发明人： SCHERING CORPORATION
IPC分类号： A61K09/06
CPC分类号： A61K9/0014 , A61K47/22 , Y10S514/887 , Y10S514/937 , Y10S514/938
摘要： A cosmetically elegant, physically and chemically stable base in the form of an oil-in-water emulsion for use in cream and lotion lipophilic drug containing pharmaceutical compositions containing at least one lipophilic drug and an effective amount of N-methyl-2-pyrrolidone is disclosed.
摘要翻译：一种化妆品优雅的物理和化学稳定的基质，其用于含有至少一种亲脂性药物和有效量的N-甲基-2-吡咯烷酮的乳膏和洗剂亲脂性药物含药物组合物形式的水包油乳液，披露。

10. 发明申请

WO2005041931A3 PHARMACEUTICAL AEROSOL COMPOSITIONS 审中-公开
标题翻译：药用气溶胶组合物
公开(公告)号：WO2005041931A3
公开(公告)日：2006-04-06
申请号：PCT/US2004034359
申请日：2004-10-18
申请人： SCHERING CORP , BERRY JULIANNE , SHERWOOD JILL K , CHAUDHRY SAEED , SEQUEIRA JOEL A
发明人： BERRY JULIANNE , SHERWOOD JILL K , CHAUDHRY SAEED , SEQUEIRA JOEL A
IPC分类号： A61K9/12 , A61K9/00 , A61K9/14 , A61K31/58 , A61L9/04 , A61M11/00 , A61P11/06
CPC分类号： A61K9/008 , A61K9/12 , A61K9/124 , A61K31/58 , A61K2300/00
摘要： Disclosed are metered dose inhalers having a metering valve to deliver a dose containing an aerosol suspension formulation, said aerosol suspension formulation comprising: an effective amount of Mometasone Furoate, Formoterol or a combination thereof; a suspension medium selected from the group consisting of 1,1,1,2,3,3,3,-heptafluoropropane, 1,1,1,2-tetrafluoroethane; and a solvent that is ethanol; wherein said formulation contains less than about 500 µg of non-volatile residue as measured by ultraviolet spectroscopy.
摘要翻译：公开了具有计量阀以计量含有气溶胶悬浮液制剂的计量剂量吸入器，所述气溶胶悬浮液制剂包含：有效量的糠酸莫米松，福莫特罗或其组合; 选自1,1,1,2,3,3,3， - 七氟丙烷，1,1,1,2-四氟乙烷的悬浮介质; 和乙醇的溶剂; 其中所述制剂包含小于约500μg的通过紫外光谱测量的非挥发性残余物。

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