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1. 发明申请

WO1998029397A1 FUSED PYRIMIDINE COMPOUNDS AND MEDICINAL USE THEREOF 审中-公开
标题翻译：熔融吡嗪化合物及其药物用途
公开(公告)号：WO1998029397A1
公开(公告)日：1998-07-09
申请号：PCT/JP1997004782
申请日：1997-12-22
申请人： YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. , TANAKA, Hiroshi , SEIO, Koji , KIMURA, Koreichi , MINOGUCHI, Masanori , UEHATA, Masayoshi , KOHARA, Toshiyuki , OHASHI, Yoshitaka , MORIO, Yasunori , YAMAGAMI, Keiji
发明人： YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD.
IPC分类号： C07D239/94
CPC分类号： C07D487/04 , C07D239/94 , C07D239/95 , C07D495/04
摘要： Fused pyrimidine compounds represented by general formula (I), pharmaceutically acceptable salts thereof or hydrates of the same, drugs containing the compounds of general formula (I), pharmaceutically acceptable salts thereof or hydrates of the same, and medicinal compositions containing the compounds of general formula (I), pharmaceutically acceptable salts thereof or hydrates of the same, wherein each symbol is as defined in the specification. Because of having an excellent CRF receptor antagonism, these compounds are useful as drugs, in particular, remedies for human depression, eating disturbance including dietary negativism and overeating, Alzheimer's disease, schizophrenia, Parkinson's disease, Huntington's chorea, amyotrophic lateral sclerosis, mania, psychophysiologic disorder, senile dementia, panic disorder, cerebral attack, inflammation in autoimmune diseases such as rheumatoid arthritis, pain, obesity, Gilles de la Tourette's disease, alcohol dependence, climacteric disturbance and premenstrual tension syndrome, cardiac circulatory drugs such as hypotensive drugs, immunopotentiators, immunosuppressors and drugs for improving the conditions of patients in intensive care units (ICU).
摘要翻译：由通式（I）表示的稠合嘧啶化合物，其药学上可接受的盐或其水合物，含有通式（I）的化合物的药物，其药学上可接受的盐或其水合物，以及含有一般化合物的药物组合物式（I），其药学上可接受的盐或其水合物，其中每个符号如说明书中所定义。由于具有优异的CRF受体拮抗作用，这些化合物可用作药物，特别是用于人类抑郁症，饮食障碍，饮食消极反应和暴饮暴食，阿尔茨海默病，精神分裂症，帕金森病，亨廷顿舞蹈病，肌萎缩性侧索硬化，躁狂症，心理生理疾病，老年性痴呆，恐慌症，脑部发作，自身免疫性疾病如类风湿性关节炎，疼痛，肥胖，杜伊勒图雷特氏病，酒精依赖性，更年期障碍和经前期紧张综合征，心脏循环药物如降血压药物，免疫增强剂，免疫抑制剂和药物，用于改善重症监护病房（ICU）患者的病情。

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