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1. 发明申请

WO2008134450A2 BROAD-SPECTRUM ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY OF LACTOBACILLUS JOHNSONII D115 审中-公开
标题翻译：乳杆菌JOHNSONII D115的广谱抗菌和抗真菌活性
公开(公告)号：WO2008134450A2
公开(公告)日：2008-11-06
申请号：PCT/US2008/061452
申请日：2008-04-24
申请人： Kemin Industries, Inc. , YEO, Wee Ming , SE, Chea-yun , YONG, Fui-fong , TAN, Hai-meng , TEO, Alex Yeow-lim
发明人： SE, Chea-yun , YONG, Fui-fong , TAN, Hai-meng , TEO, Alex Yeow-lim
IPC分类号： C12N1/20 , A61K35/74 , A61P31/04
CPC分类号： C12R1/225 , A23K10/18 , A23L33/135 , A61K35/747 , A61L2/00 , C12N1/20 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475
摘要： The present invention demonstrated the potential use of Lactobacillus johnsonii D115 as a probiotic, as a prophylactic agent or as a surface treatment of materials against human and animal pathogens such as Brachyspira pilosicoli, Brachyspira hyodysenteriae, Shigella sonnei, Vibrio cholera, Vibrio parahaemolyticus, Campylobacter jejuni, Streptococcus pneumoniae, Enterococcus faecalis, Enterococcus faecium, Clostridium perfringens, Yersinia enterocolitica, Escherichia coli, Klebbsiella pneumoniae, Staphylococcus aureus, Salmonella spp., Bacillus cereus, Aspergillus niger and Fusarium chlamydosporum. The proteineous antimicrobial compound was partially characterized and found to be heat tolerant up to 121°C for 15 min, and acid tolerant up to pH1 for 30 min at 40°C. The compound is also stable to enzymatic digestion, being able to retain more than 60% antimicrobial activity when treated with pepsin and trypsin.
摘要翻译：本发明证明了约翰逊乳杆菌D115作为益生菌作为预防剂或作为对人和动物病原体的材料的表面处理的潜在用途，例如Brachyspira pilosicoli，猪痢疾短螺杆菌，志贺氏菌，霍乱弧菌，副溶血弧弧菌，空肠弯曲杆菌，肺炎链球菌，粪肠球菌，屎肠球菌，产气荚膜梭菌，小肠结肠炎耶尔森菌，大肠杆菌，肺炎克雷伯菌，金黄色葡萄球菌，沙门氏菌，蜡状芽孢杆菌，黑曲霉和衣原体枯萎病。蛋白质抗微生物化合物被部分表征，发现耐受温度高达121℃，持续15分钟，在40℃耐酸性达到pH1 30分钟。该化合物对于酶消化也是稳定的，当用胃蛋白酶和胰蛋白酶处理时能够保持超过60％的抗微生物活性。

2. 发明申请

WO2007064741A2 THE USE OF BACILLUS PB6 FOR THE PROPHYLAXIS OR TREATMENT OF GASTROINTESTINAL AND IMMUNO-RELATED DISEASES 审中-公开
标题翻译： BACILLUS PB6用于预防或治疗胃肠疾病和免疫相关疾病的使用
公开(公告)号：WO2007064741A2
公开(公告)日：2007-06-07
申请号：PCT/US2006/045755
申请日：2006-11-29
申请人： KEMIN INDUSTRIES, INC. , VARGHESE, Jerry , SAS, Benedikt , VAN HEMEL, Johan , VANDENKERCKHOVE, Jan , PEYS, Eric , TAN, Hai Meng , SE, Chea-yun , RAMCHAND, Chaniyilparampu
发明人： SAS, Benedikt , VAN HEMEL, Johan , VANDENKERCKHOVE, Jan , PEYS, Eric , TAN, Hai Meng , SE, Chea-yun , RAMCHAND, Chaniyilparampu
IPC分类号： A61K31/74
CPC分类号： A61K35/742 , A23L33/135 , A61K38/164 , C12R1/07 , C12R1/125
摘要： Bacteria of the sp. Bacillus that produce a lipopeptide are found to be effective in the treatment and prophylaxis of gastro-intestinal disease when administered as a probiotic. In particular, a strain of Bacillus bacteria identified as PB6 is useful for the treatment of Antibiotic Associated Diarrhea (AAD) or the more serious condition Clostridium difficile associated diarrhea (CDAD) when administered as a probiotic. Additionally, these bacteria have been found efficient for the treatment of immunorelated diseases such as Inflammatory Bowel Disease (IBD).
摘要翻译：细菌发现产生脂肽的芽孢杆菌在作为益生菌施用时可有效地治疗和预防胃肠道疾病。特别地，当作为益生菌施用时，鉴定为PB6的芽孢杆菌菌株可用于治疗抗生素相关性腹泻（AAD）或更严重的艰难梭菌相关性腹泻（CDAD）。另外，已经发现这些细菌对于治疗免疫反应性疾病如炎症性肠病（IBD）是有效的。

3. 发明申请

WO2007044340A3 PRODUCTION OF ORGANIC AND INORGANIC SELENIUM COMPOUNDS BY LACTIC ACID BACTERIA 审中-公开
公开(公告)号：WO2007044340A3
公开(公告)日：2007-04-19
申请号：PCT/US2006/038652
申请日：2006-10-04
申请人： KEMIN INDUSTRIES, INC. , TEO, Alex, Yeow-Lim , HON, Sook-Mei , SE, Chea-Yun , TAN, Hai Meng
发明人： TEO, Alex, Yeow-Lim , HON, Sook-Mei , SE, Chea-Yun , TAN, Hai Meng
IPC分类号： C12P13/12 , C12N1/20
摘要： A novel strain of lactic acid bacteria was found to be heat resistant and able to grow in a sulfur-limiting medium (SLM) containing a high concentration of sodium selenite. The microorganism is a non-spore forming and Gram-positive coccus, which is identified with > 90% confidence using the API biochemical and sugar fermentation tests, ribotyoing and 16S rRNA sequencing as Pediococcus pentosaceus SP80. In the current study, P. pentosaceus SP80 grown on SLM containing 250 ppm sodium selenite produced both organic and inorganic forms of selenium. Selenium-enriched bacteria are useful as a source of selenium for supplementing the diets of animals and humans. Animals fed efficacious amounts of the selenium-enriched bacteria show improved feed conversion rates and higher levels of glutathione peroxidase activity in heart, kidney and liver tissues indicating an increased absorption and retention of selenium over control diets.

4. 发明申请

WO2008134450A3 BROAD-SPECTRUM ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY OF LACTOBACILLUS JOHNSONII D115 审中-公开
标题翻译：乳杆菌JOHNSONII D115的广谱抗菌和抗真菌活性
公开(公告)号：WO2008134450A3
公开(公告)日：2010-01-21
申请号：PCT/US2008061452
申请日：2008-04-24
申请人： KEMIN IND INC , SE CHEA-YUN , YONG FUI-FONG , TAN HAI-MENG , YEO WEE MING , TEO ALEX YEOW-LIM
发明人： SE CHEA-YUN , YONG FUI-FONG , TAN HAI-MENG , YEO WEE MING , TEO ALEX YEOW-LIM
IPC分类号： C12N1/20 , A23L29/00 , A61K35/74 , A61P31/04
CPC分类号： C12R1/225 , A23K10/18 , A23L33/135 , A61K35/747 , A61L2/00 , C12N1/20
摘要： The present invention demonstrated the potential use of Lactobacillus johnsonii D115 as a probiotic, as a prophylactic agent or as a surface treatment of materials against human and animal pathogens such as Brachyspira pilosicoli, Brachyspira hyodysenteriae, Shigella sonnei, Vibrio cholera, Vibrio parahaemolyticus, Campylobacter jejuni, Streptococcus pneumoniae, Enterococcus faecalis, Enterococcus faecium, Clostridium perfringens, Yersinia enterocolitica, Escherichia coli, Klebbsiella pneumoniae, Staphylococcus aureus, Salmonella spp., Bacillus cereus, Aspergillus niger and Fusarium chlamydosporum. The proteineous antimicrobial compound was partially characterized and found to be heat tolerant up to 121°C for 15 min, and acid tolerant up to pH1 for 30 min at 40°C. The compound is also stable to enzymatic digestion, being able to retain more than 60% antimicrobial activity when treated with pepsin and trypsin.
摘要翻译：本发明证明了约翰逊乳杆菌D115作为益生菌作为预防剂或作为对人和动物病原体的材料的表面处理的潜在用途，例如Brachyspira pilosicoli，猪痢疾短螺杆菌，志贺氏菌，霍乱弧菌，副溶血弧弧菌，空肠弯曲杆菌，肺炎链球菌，粪肠球菌，屎肠球菌，产气荚膜梭菌，小肠结肠炎耶尔森菌，大肠杆菌，肺炎克雷伯菌，金黄色葡萄球菌，沙门氏菌，蜡状芽孢杆菌，黑曲霉和衣原体枯萎病。蛋白质抗微生物化合物被部分表征，发现耐受温度高达121℃，持续15分钟，在40℃耐酸性达到pH1 30分钟。该化合物对于酶消化也是稳定的，当用胃蛋白酶和胰蛋白酶处理时能够保持超过60％的抗微生物活性。

5. 发明申请

WO2007064741A3 THE USE OF BACILLUS PB6 FOR THE PROPHYLAXIS OR TREATMENT OF GASTROINTESTINAL AND IMMUNO-RELATED DISEASES 审中-公开
标题翻译： BACILLUS PB6用于预防或治疗胃肠道疾病和免疫相关疾病
公开(公告)号：WO2007064741A3
公开(公告)日：2008-05-08
申请号：PCT/US2006045755
申请日：2006-11-29
申请人： KEMIN IND INC , SAS BENEDIKT , VAN HEMEL JOHAN , VANDENKERCKHOVE JAN , PEYS ERIC , TAN HAI MENG , SE CHEA-YUN , RAMCHAND CHANIYILPARAMPU , VARGHESE JERRY
发明人： SAS BENEDIKT , VAN HEMEL JOHAN , VANDENKERCKHOVE JAN , PEYS ERIC , TAN HAI MENG , SE CHEA-YUN , RAMCHAND CHANIYILPARAMPU , VARGHESE JERRY
IPC分类号： A01N63/00
CPC分类号： A61K35/742 , A23L33/135 , A61K38/164 , C12R1/07 , C12R1/125
摘要： Bacteria of the sp. Bacillus that produce a lipopeptide are found to be effective in the treatment and prophylaxis of gastro-intestinal disease when administered as a probiotic. In particular, a strain of Bacillus bacteria identified as PB6 is useful for the treatment of Antibiotic Associated Diarrhea (AAD) or the more serious condition Clostridium difficile associated diarrhea (CDAD) when administered as a probiotic. Additionally, these bacteria have been found efficient for the treatment of immunorelated diseases such as Inflammatory Bowel Disease (IBD).
摘要翻译： sp。的细菌。发现产生脂肽的芽孢杆菌当作为益生菌施用时在治疗和预防胃肠疾病方面是有效的。具体而言，鉴定为PB6的芽孢杆菌属细菌菌株在作为益生菌施用时可用于治疗抗生素相关性腹泻（AAD）或更严重的病症性艰难梭菌相关性腹泻（CDAD）。此外，这些细菌已被发现有效治疗免疫相关疾病，如炎症性肠病（IBD）。

6. 发明申请

WO2007064741A8 THE USE OF BACILLUS PB6 FOR THE PROPHYLAXIS OR TREATMENT OF GASTROINTESTINAL AND IMMUNO-RELATED DISEASES 审中-公开
标题翻译： BACILLUS PB6用于预防或治疗胃肠疾病和免疫相关疾病的使用
公开(公告)号：WO2007064741A8
公开(公告)日：2008-01-31
申请号：PCT/US2006045755
申请日：2006-11-29
申请人： KEMIN IND INC , SAS BENEDIKT , VAN HEMEL JOHAN , VANDENKERCKHOVE JAN , PEYS ERIC , TAN HAI MENG , SE CHEA-YUN , RAMCHAND CHANIYILPARAMPU , VARGHESE JERRY
发明人： SAS BENEDIKT , VAN HEMEL JOHAN , VANDENKERCKHOVE JAN , PEYS ERIC , TAN HAI MENG , SE CHEA-YUN , RAMCHAND CHANIYILPARAMPU , VARGHESE JERRY
IPC分类号： A61K31/74
CPC分类号： A61K35/742 , A23L33/135 , A61K38/164 , C12R1/07 , C12R1/125
摘要： Bacteria of the sp. Bacillus that produce a lipopeptide are found to be effective in the treatment and prophylaxis of gastro-intestinal disease when administered as a probiotic. In particular, a strain of Bacillus bacteria identified as PB6 is useful for the treatment of Antibiotic Associated Diarrhea (AAD) or the more serious condition Clostridium difficile associated diarrhea (CDAD) when administered as a probiotic. Additionally, these bacteria have been found efficient for the treatment of immunorelated diseases such as Inflammatory Bowel Disease (IBD).
摘要翻译：细菌发现产生脂肽的芽孢杆菌在作为益生菌施用时可有效地治疗和预防胃肠道疾病。特别地，当作为益生菌施用时，鉴定为PB6的芽孢杆菌菌株可用于治疗抗生素相关性腹泻（AAD）或更严重的艰难梭菌相关性腹泻（CDAD）。另外，已经发现这些细菌对于治疗免疫反应性疾病如炎症性肠病（IBD）是有效的。

7. 发明申请

WO2007044340A2 PRODUCTION OF ORGANIC AND INORGANIC SELENIUM COMPOUNDS BY LACTIC ACID BACTERIA 审中-公开
标题翻译：有机酸和无机硒化合物的生产通过酸性细菌
公开(公告)号：WO2007044340A2
公开(公告)日：2007-04-19
申请号：PCT/US2006038652
申请日：2006-10-04
申请人： KEMIN IND INC , TEO ALEX YEOW-LIM , HON SOOK-MEI , SE CHEA-YUN , TAN HAI MENG
发明人： TEO ALEX YEOW-LIM , HON SOOK-MEI , SE CHEA-YUN , TAN HAI MENG
IPC分类号： A61K35/74 , C12N1/20
CPC分类号： C12R1/01 , A23K10/16 , A23K20/30 , A23K50/75 , A61K33/04 , A61K35/747 , C12N1/20
摘要： A novel strain of lactic acid bacteria was found to be heat resistant and able to grow in a sulfur-limiting medium (SLM) containing a high concentration of sodium selenite. The microorganism is a non-spore forming and Gram-positive coccus, which is identified with > 90% confidence using the API biochemical and sugar fermentation tests, ribotyoing and 16S rRNA sequencing as Pediococcus pentosaceus SP80. In the current study, P. pentosaceus SP80 grown on SLM containing 250 ppm sodium selenite produced both organic and inorganic forms of selenium. Selenium-enriched bacteria are useful as a source of selenium for supplementing the diets of animals and humans. Animals fed efficacious amounts of the selenium-enriched bacteria show improved feed conversion rates and higher levels of glutathione peroxidase activity in heart, kidney and liver tissues indicating an increased absorption and retention of selenium over control diets.
摘要翻译：发现一种新的乳酸菌菌株是耐热的，能够在含有高浓度亚硒酸钠的限硫介质（SLM）中生长。微生物是非孢子形成和革兰氏阳性球菌，其使用API生物化学和糖发酵测试，核糖体发酵和16S rRNA测序作为戊糖片球菌SP80鉴定为> 90％的置信度。在目前的研究中，在含有250ppm亚硒酸钠的SLM上生长的戊酸蜡状芽孢杆菌SP80产生有机和无机形式的硒。富含硒的细菌可用作补充动物和人类饮食的硒来源。喂食有效量的富硒细菌的动物显示出改善的饲料转化率和在心脏，肾脏和肝脏组织中更高水平的谷胱甘肽过氧化物酶活性，表明硒在对照饮食上的吸收和保留率增加。

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