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1. 发明申请

WO2004016247A1 PROCESS FOR COATING A PHARMACEUTICAL PARTICLE 审中-公开
标题翻译：涂敷药物颗粒的方法
公开(公告)号：WO2004016247A1
公开(公告)日：2004-02-26
申请号：PCT/US2003/025883
申请日：2003-08-14
申请人： E.I. DU PONT DE NEMOURS AND COMPANY , BERGER, Larry, L , GANGRADE, Nutan , ZHAO, Qian, Qui , DALZIEL, Sean, Mark , SCHURR, George, A. , FRIEDMAN, Thomas , TROUT, Torence, John, Jr.
发明人： BERGER, Larry, L , GANGRADE, Nutan , ZHAO, Qian, Qui , DALZIEL, Sean, Mark , SCHURR, George, A. , FRIEDMAN, Thomas , TROUT, Torence, John, Jr.
IPC分类号： A61K9/14
CPC分类号： A61K9/2081 , A61K9/4866 , A61K9/5026 , A61K9/5047 , B01J2/006
摘要： A process of coating to create pharmaceutical particles is disclosed. The coating can enhance the pharmaceutical particle by providing a controlled release barrier, moisture barrier, surface modifying agent, wetting agent, flowability or fluidizing agent, hydrophobicity or hydrophilicity agent, flavor masking agent, odor masking agent, release control agent, or coloring agent; or an inert particle can be coated with a pharmaceutically active liquid. Also disclosed are coated pharmaceutical particles made by one of the processes of the invention.
摘要翻译：公开了一种涂覆以产生药物颗粒的方法。涂层可以通过提供控制释放屏障，防潮，表面改性剂，润湿剂，流动性或流化剂，疏水性或亲水性剂，风味掩蔽剂，气味掩蔽剂，释放控制剂或着色剂来增强药物颗粒。或者可以用药物活性液体涂覆惰性颗粒。还公开了通过本发明的方法之一制备的包衣药物颗粒。

2. 发明申请

WO2007053584A1 TITANIUM DIOXIDE FINISHING PROCESS 审中-公开
标题翻译：二氧化钛精加工工艺
公开(公告)号：WO2007053584A1
公开(公告)日：2007-05-10
申请号：PCT/US2006/042389
申请日：2006-10-31
申请人： E. I. DU PONT DE NEMOURS AND COMPANY , DIEMER, Russell, Bertrum, Jr. , EATON, Alan, Roger , SUBRAMANIAN, Narayanan, Sankara , TAYLOR, Stephen, William , SCHURR, George, A. , ZIMMERMAN, David, A.
发明人： DIEMER, Russell, Bertrum, Jr. , EATON, Alan, Roger , SUBRAMANIAN, Narayanan, Sankara , TAYLOR, Stephen, William , SCHURR, George, A. , ZIMMERMAN, David, A.
IPC分类号： C09C1/36 , C09C3/04 , C01G23/047
CPC分类号： C01G23/07 , B82Y30/00 , C01G23/075 , C01G23/08 , C01P2004/62 , C01P2004/64 , C01P2006/80 , C09C1/3607
摘要： This disclosure relates to process for producing titanium dioxide (TiO 2 ) pigments, comprising the following steps: a) oxidizing a mixture of titanium tetrahalide and a rutile forming agent, such as aluminum halide, present in the vapor phase and in the presence of a nucleant to form a gaseous suspension comprising titanium dioxide particles; b) passing the gaseous suspension to a cooling conduit; c) introducing scouring material into the cooling conduit; wherein the particles of the scouring material have a diameter in the range of about 0.25 mm to about 12.7 mm; d) separating the vapor phase to form a powder comprising the titanium dioxide particles and the scouring material; and e) simultaneously subjecting the powder to substantially uniform heating at a temperature of about 3000C to about 6000C and reducing the size of the titanium dioxide particles and the particles of the scouring material in the powder to a mean particle size of about 50 nm to about 1000 nm, whereby the titanium dioxide pigment has a chloride content of less than about 500 ppm. The so treated powder may have a residual free chlorine content of less than about 1 ppm. The Figure is a simplified flow diagram of one embodiment of the process of the disclosure wherein feedstreams comprising oxygen, titanium tetrachloride, a nucleant and a rutile forming agent are introduced to an oxidation zone 10 wherein, in the vapor phase, the titanium tetrachloride is oxidized to form a gaseous suspension comprising titanium dioxide particles, the gaseous suspension is transferred to a cooling conduit 12 wherein the gaseous suspension is contacted with scouring material to form a cooled product having a solid phase and a vapor phase. The vapor phase is separated from the solid phase via separator 14 to form a powder comprising titanium dioxide particles and the scouring material which is passed to a particle size reducing unit 16. The powder withdrawn from the unit can be subjected to surface treating in finishing unit 18.
摘要翻译：本公开涉及生产二氧化钛（TiO 2）颜料的方法，包括以下步骤：a）氧化存在于蒸气中的四卤化钛和金红石形成剂如卤化铝的混合物并在成核剂存在下形成包含二氧化钛颗粒的气态悬浮液; b）将气态悬浮液通入冷却管道; c）将精练材料引入冷却管道; 其中所述精练材料的颗粒的直径在约0.25mm至约12.7mm的范围内; d）分离气相以形成包含二氧化钛颗粒和洗涤材料的粉末; 和e）在约300℃至约600℃的温度下同时对粉末进行基本均匀的加热，并将粉末中的二氧化钛颗粒和冲刷材料的颗粒的尺寸减小至约50nm至约的平均粒度 1000nm，由此二氧化钛颜料的氯化物含量小于约500ppm。如此处理的粉末可具有小于约1ppm的残余游离氯含量。该图是本公开方法的一个实施方案的简化流程图，其中将包含氧，四氯化钛，成核剂和金红石形成剂的进料流引入氧化区10，其中在气相中四氯化钛被氧化为了形成包含二氧化钛颗粒的气态悬浮液，将气态悬浮液转移到冷却导管12中，其中气态悬浮液与冲刷材料接触以形成具有固相和气相的冷却产物。通过分离器14将气相与固相分离，形成包含二氧化钛颗粒和洗涤材料的粉末，该粉末材料通过粒径减小单元16.从单元排出的粉末可以在整理单元中进行表面处理 18。

3. 发明申请

WO2004016720A3 COATED POLYUNSATURATED FATTY ACID-CONTAINING PARTICLES AND COATED LIQUID PHARMACEUTICAL-CONTAINING PARTICLES 审中-公开
标题翻译：包衣的含脂肪的含脂肪颗粒和包衣液体含药颗粒
公开(公告)号：WO2004016720A3
公开(公告)日：2004-04-08
申请号：PCT/US0325873
申请日：2003-08-14
申请人： DU PONT , DALZIEL SEAN MARK , FRIEDMANN THOMAS E , SCHURR GEORGE A
发明人： DALZIEL SEAN MARK , FRIEDMANN THOMAS E , SCHURR GEORGE A
IPC分类号： A23L2/39 , A23L1/00 , A23L1/30 , A61K9/14 , A61K9/16 , A61K9/50 , B01J2/00 , B05D1/02 , B05D7/00 , A23B9/14 , A23P1/08
CPC分类号： A61K9/5089 , A23K40/30 , A23L33/12 , A23P10/30 , A23P10/35 , A23V2002/00 , A61K9/1611 , A61K9/501 , A61K9/5057 , A61K9/5078 , A23V2200/224 , A23V2250/1882 , A23V2250/5488
摘要： A process for coating a PUFA (polyunsaturated fatty acid) carrier particle or carrier matrix with a liquid coating material comprising the steps of metering a liquid coating mixture (20) into a flow restrictor (14) concurrently with introducing a stream of gas such as nitrogen via inlet (22) to provide a turbulent flow zone at the outlet of the flow restrictor concomitantly the PUFA carrier particle of carrier matrix (30) is introduced into the turbulent zone via hopper (28) whereby the FUFA particle or carrier particle is coated by the atomized coating material providing a coated PUFA particle.
摘要翻译：一种用液体涂料涂覆PUFA（多不饱和脂肪酸）载体颗粒或载体基质的方法，包括以下步骤：将液体涂料混合物（20）计量到流动限制器（14）中，同时引入气流如氮气通过入口（22），以在限流器的出口处提供湍流区域，同时通过料斗（28）将载体基质（30）的PUFA载体颗粒引入湍流区域，由此FUFA颗粒或载体颗粒被提供涂覆的PUFA颗粒的雾化涂料。

4. 发明申请

WO2004026950A3 SOLID FLOWABLE POWDER WITH HIGH LIQUID LOADING 审中-公开
标题翻译：具有高液体载荷的固体流动性粉末
公开(公告)号：WO2004026950A3
公开(公告)日：2004-07-01
申请号：PCT/US0325882
申请日：2003-08-14
申请人： DU PONT , DALZIEL SEAN MARK , GAI PRATIBHA LAXMAN , FRIEDMANN THOMAS E , ZHAO QIAN QUI , SCHURR GEORGE A
发明人： DALZIEL SEAN MARK , GAI PRATIBHA LAXMAN , FRIEDMANN THOMAS E , ZHAO QIAN QUI , SCHURR GEORGE A
IPC分类号： A61K9/14 , B01J2/00 , B05D7/00 , C08K20060101
CPC分类号： A61K9/143 , B01J2/006 , B82Y30/00
摘要： A process of manufacturing compositions comprised of carrier particles under 100 nm that have been loaded to a level of greater that 60% by weight with a liquid comprising metering the liquid into a flow restrictor, injecting a gas stream through the flow restrictor to atomize the liquid and create a zone of turbulence at the outlet end of a flow restrictor, and introducing particles through a hopper (28) into the zone of turbulence to mix the particles with atomized liquid thereby loading the particles with the liquid. The hopper (28) includes metering device for accurately metering the particles at a particular ratio to the liquid feed from liquid inlet line (16). The highly-liquid-loaded particles can be further coated or encapsulated with functional coating or encapsulating materials.
摘要翻译：一种制造组合物的方法，该组合物由100nm以下的载体颗粒组成，该载体颗粒已经用包括将液体计量到限流器中的液体加载至大于60重量％的水平，将气流注入流量限制器以雾化液体并在流量限制器的出口端产生湍流区域，并将颗粒通过料斗（28）引入湍流区域，以将颗粒与雾化液体混合，从而将颗粒与液体一起加载。料斗（28）包括用于以与从液体入口管线（16）的液体进料的特定比例精确计量颗粒的计量装置。高度液体负载的颗粒可以用功能性涂层或包封材料进一步涂覆或包封。

5. 发明申请

WO2004016509A2 PROCESS FOR ENCAPSULATING A FOOD PARTICLE TO PRESERVE VOLATILES AND PREVENT OXIDATION 审中-公开
标题翻译：食用颗粒保护挥发物并防止氧化的方法
公开(公告)号：WO2004016509A2
公开(公告)日：2004-02-26
申请号：PCT/US2003/025868
申请日：2003-08-14
申请人： E.I. DU PONT DE NEMOURS AND COMPANY , DALZIEL, Sean, Mark , FRIEDMANN, Thomas , SCHURR, George, A.
发明人： DALZIEL, Sean, Mark , FRIEDMANN, Thomas , SCHURR, George, A.
IPC分类号： B65D
CPC分类号： A23F5/14 , A23L27/72 , A23P10/30 , A23P10/35 , A23V2002/00 , B01J13/04 , A23V2200/224 , A23V2250/1578 , A23V2250/628 , A23V2250/61
摘要： A process for encapsulating a food particle is disclosed. The encapsulation material encasing the food particle inhibits volatiles such as aromas, moisture, and flavors from diffusing out of the food particle and inhibits undesirable environmental volatiles from diffusing into the food particle, thereby preserving freshness. Additionally, the resulting encapsulated food particle is less susceptible to oxidation than an unencapsulated food particle. Also disclosed are encapsulated food particles made by the process of the invention.
摘要翻译：公开了一种用于包封食品颗粒的方法。包封食品颗粒的包封材料抑制挥发物如芳香，水分和风味从食物颗粒中扩散出来，并抑制不期望的环境挥发物扩散到食物颗粒中，从而保持新鲜度。另外，所得到的包封食品颗粒比未包封的食品颗粒更不易氧化。还公开了通过本发明的方法制备的包封食品颗粒。

6. 发明申请

WO2004026950A2 SOLID FLOWABLE POWDER WITH HIGH LIQUID LOADING 审中-公开
标题翻译：具有高液体载荷的固体流动性粉末
公开(公告)号：WO2004026950A2
公开(公告)日：2004-04-01
申请号：PCT/US2003/025882
申请日：2003-08-14
申请人： E.I. DU PONT DE NEMOURS AND COMPANY , DALZIEL, Sean, Mark , GAI, Pratibha, Laxman , FRIEDMANN, Thomas, E , ZHAO, Qian, Qui , SCHURR, George, A.
发明人： DALZIEL, Sean, Mark , GAI, Pratibha, Laxman , FRIEDMANN, Thomas, E , ZHAO, Qian, Qui , SCHURR, George, A.
IPC分类号： C08K
CPC分类号： A61K9/143 , B01J2/006 , B82Y30/00
摘要： A process of manufacturing compositions comprised of carrier particles under 100nm that have been loaded to a level of greater than 60% by weight with a liquid. The highly-liquid-loaded particles can be further coated or encapsulated with functional coating or encapsulating materials.
摘要翻译：制备由100nm载体颗粒组成的组合物的方法，该载体颗粒已经用液体装载到大于60重量％的水平。高度液体负载的颗粒可以用功能性涂层或包封材料进一步涂覆或包封。

7. 发明申请

WO2004016288A1 COATED SOY PRODUCT AND METHOD FOR COATING 审中-公开
标题翻译：包衣大豆产品和涂料方法
公开(公告)号：WO2004016288A1
公开(公告)日：2004-02-26
申请号：PCT/US2003/025884
申请日：2003-08-14
申请人： E.I. DU PONT DE NEMOURS AND COMPANY , DALZIEL, Sean, Mark , FRIEDMANN, Thomas , SCHURR, George, A.
发明人： DALZIEL, Sean, Mark , FRIEDMANN, Thomas , SCHURR, George, A.
IPC分类号： A61K47/00
CPC分类号： A23B9/14 , A21D2/266 , A21D2/36 , A23J3/16 , A23K20/147 , A23K40/30 , A23K50/40 , A23L5/42 , A23L7/198 , A23L11/07 , A23L33/185 , A23P10/30 , A23P10/35 , A23P20/10 , A23P20/11 , A23P20/18 , A23V2002/00 , A23V2200/22 , A23V2250/628 , A23V2250/5488 , A23V2250/18 , A23V2250/1842
摘要： A process for coating a soy product or flour is described in which the moisture level of the coated soy product is substantially the same as the moisture level of the uncoated soy product. Coated soy products or coated flours made using the process of the invention are also disclosed.
摘要翻译：描述了涂覆大豆制品或面粉的方法，其中包衣大豆制品的水分含量与未包衣的大豆制品的水分含量基本相同。还公开了使用本发明的方法制备的涂覆的大豆制品或涂覆的面粉。

8. 发明申请

WO2002102167A1 PROCESS FOR DRY COATING A FOOD PARTICLE OR ENCAPSULATING A FROZEN LIQUID PARTICLE 审中-公开
标题翻译：干燥涂层食品颗粒或加入冷冻液体颗粒的方法
公开(公告)号：WO2002102167A1
公开(公告)日：2002-12-27
申请号：PCT/US2002/019431
申请日：2002-06-19
申请人： E.I. DU PONT DE NEMOURS AND COMPANY , DALZIEL, Sean, M. , FRIEDMANN, Thomas, E. , SCHURR, George, A.
发明人： DALZIEL, Sean, M. , FRIEDMANN, Thomas, E. , SCHURR, George, A.
IPC分类号： A23B9/14
CPC分类号： A23G3/346 , A23G3/0089 , A23G3/2092 , A23G9/24 , A23G9/52 , A23G2220/20 , A23L3/361 , A23L7/122 , A23L27/72 , A23P10/30 , A23P10/35 , A23P20/10 , A23P20/11 , A23P20/15 , A23P20/18
摘要： A process for dry coating a food particle having a size in the range from about 0.5 mm to about 20.0 mm is disclosed. The resulting coated food particle has a moisture level that is substantially the same as the moisture level of the uncoated food particle. A process for encapsulating a frozen liquid particle having a size in the range from 5 micrometers to 5 millimeters with a liquid coating material is also disclosed. Also disclosed are coated food particles and encapsulate frozen liquid particles made by one of the processes of the invention.
摘要翻译：公开了一种用于干燥涂覆尺寸在约0.5mm至约20.0mm范围内的食品颗粒的方法。所得到的包衣食品颗粒的水分含量基本上与未涂覆食品颗粒的水分含量相同。还公开了一种用液体涂料将大小在5微米至5毫米范围内的冷冻液体颗粒包封的方法。还公开了包衣食品颗粒并包封由本发明的方法之一制成的冷冻液体颗粒。

9. 发明申请

WO2004016509A3 FOOD PARTICAL ENCAPSULATION PRESERVING VOLATILES AND PREVENTING OXIDATION 审中-公开
标题翻译：保护挥发性物质和预防氧化的食物颗粒保护
公开(公告)号：WO2004016509A3
公开(公告)日：2004-10-14
申请号：PCT/US0325868
申请日：2003-08-14
申请人： DU PONT , DALZIEL SEAN MARK , FRIEDMANN THOMAS , SCHURR GEORGE A
发明人： DALZIEL SEAN MARK , FRIEDMANN THOMAS , SCHURR GEORGE A
IPC分类号： A23B4/00 , A23B9/14 , A23F5/14 , A23L1/00 , A23L1/22 , A23P1/08 , B01J13/04 , B65D20060101 , B65D1/00
CPC分类号： A23F5/14 , A23L27/72 , A23P10/30 , A23P10/35 , A23V2002/00 , B01J13/04 , A23V2200/224 , A23V2250/1578 , A23V2250/628 , A23V2250/61
摘要： A process for encapsulating a solid food particle with a liquid encapsulating material comprising the steps of metering and encapsulation mixture (20) into a flow restrictor (14) concurrently a gas stream is introduced at inlet (22) into the flow restrictor there by atomizing the liquid encapsulating material and creating a turbulent flow zone at the oulet of the flow restrictor (14). Concomitant with metering the encapsulating material with the gas stream, solid food particulate (30) is introduced via hopper(28) to the turbulent zone at the outlet of the flow restrictor (14) wherein the solid food particles are encapsulating by the atomized encapsulating material, the encapsulated food particle inhibits environmental volatiles from diffusing into the food product while preventing oxidation of the food.
摘要翻译：用液体封装材料包封固体食物颗粒的方法包括以下步骤：将入口（22）计量并将混合物（20）同时包封在流量限制器（14）中，并通过雾化液体封装材料，并在流量限制器（14）的底部产生湍流区域。伴随着用气流计量封装材料，固体食物颗粒（30）通过料斗（28）引入流量限制器（14）的出口处的湍流区域，其中固体食物颗粒被雾化的包封材料，包封的食品颗粒抑制环境挥发物扩散到食品中，同时防止食物的氧化。

10. 发明申请

WO2004016720A2 COATED POLYUNSATURATED FATTY ACID-CONTAINING PARTICLES AND COATED LIQUID PHARMACEUTICAL-CONTAINING PARTICLES 审中-公开
标题翻译：包衣的含脂肪的含脂肪颗粒和包衣液体含药颗粒
公开(公告)号：WO2004016720A2
公开(公告)日：2004-02-26
申请号：PCT/US2003/025873
申请日：2003-08-14
申请人： E.I. DU PONT DE NEMOURS AND COMPANY , DALZIEL, Sean, Mark , FRIEDMANN, Thomas, E. , SCHURR, George, A.
发明人： DALZIEL, Sean, Mark , FRIEDMANN, Thomas, E. , SCHURR, George, A.
IPC分类号： C10M
CPC分类号： A61K9/5089 , A23K40/30 , A23L33/12 , A23P10/30 , A23P10/35 , A23V2002/00 , A61K9/1611 , A61K9/501 , A61K9/5057 , A61K9/5078 , A23V2200/224 , A23V2250/1882 , A23V2250/5488
摘要： A process for coating a polyunsaturated fatty acid (PUFA)-containing carrier particle or a PUFA matrix particle, or a liquid pharmaceutical-containing carrier particle or a liquid pharmaceutical matrix particle. Also disclosed are such particles made by the process of the invention and foods, pharmaceuticals, beverages, nutritional supplements, infant formula, pet food and animal feed which incorporate such particles.
摘要翻译：一种用于包覆含多不饱和脂肪酸（PUFA）载体颗粒或PUFA基质颗粒或含液体药物载体颗粒或液体药物基质颗粒的方法。还公开了通过本发明的方法制备的这样的颗粒和包含这种颗粒的食品，药物，饮料，营养补充剂，婴儿配方食品，宠物食品和动物饲料。

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