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1. 发明申请

WO2005009379A3 POLYPEPTIDES FOR INDUCING A PROTECTIVE IMMUNE RESPONSE AGAINST STAPHYLOCOCCUS AUREUS 审中-公开
标题翻译：用于诱导针对斑马鱼的保护性免疫应答的多肽
公开(公告)号：WO2005009379A3
公开(公告)日：2006-11-30
申请号：PCT/US2004023523
申请日：2004-07-22
申请人： MERCK & CO INC , ANDERSON ANNALIESA S , JANSEN KATHRIN UTE , KELLY ROSEMARIE , SCHULTZ LOREN D , MONTGOMERY DONNA L , MCCLEMENTS WILLIAM L
发明人： ANDERSON ANNALIESA S , JANSEN KATHRIN UTE , KELLY ROSEMARIE , SCHULTZ LOREN D , MONTGOMERY DONNA L , MCCLEMENTS WILLIAM L
IPC分类号： A61K39/02 , A01N37/18 , A61K20060101 , A61K39/00 , A61K39/085 , A61K39/09 , C07K1/00 , C07K2/00 , C07K14/31 , C12N15/31
CPC分类号： A61K39/085 , C07K14/31 , C07K2319/35
摘要： The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1, uses of such polypeptides, and expression systems for producing such polypeptides. SEQ ID NO: 1 is a truncated derivative of a full length S. aureus polypeptide. The full-length polypeptide is referred to herein as full-length "ORF0657n". Polypeptides containing the amino acid sequence of SEQ ID NO: 1 were found to produce a protective immune response against S. aureus .
摘要翻译：本发明的特征在于包含与SEQ ID NO：1结构相关的氨基酸序列的多肽，这种多肽的用途以及用于产生这种多肽的表达系统。 SEQ ID NO：1是全长S的截短衍生物。金黄色葡萄球菌多肽。全长多肽在本文中称为全长“ORF0657n”。发现含有SEQ ID NO：1的氨基酸序列的多肽产生针对S的保护性免疫应答。金黄色葡萄球菌的。

2. 发明申请

WO2005047315A2 OPTIMIZED EXPRESSION OF HPV 58 L1 IN YEAST 审中-公开
标题翻译：优化HPV 58 L1在YEAST中的表达
公开(公告)号：WO2005047315A2
公开(公告)日：2005-05-26
申请号：PCT/US2004/037372
申请日：2004-11-10
申请人： MERCK & CO., INC. , BRYAN, Janine, T. , BROWNLOW, Michelle, K. , SCHULTZ, Loren, D. , WANG, Xin-Min , JANSEN, Kathrin, U.
发明人： BRYAN, Janine, T. , BROWNLOW, Michelle, K. , SCHULTZ, Loren, D. , WANG, Xin-Min , JANSEN, Kathrin, U.
IPC分类号： C07K14/025
CPC分类号： C07K14/005 , A61K48/00 , A61K2039/5256 , A61K2039/5258 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2800/22
摘要： Synthetic DNA molecules encoding the HPV58 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV58 L1 protein, wherein said polynucleotides are codon-optimized for high level expression in a yeast cell. The synthetic molecules may be used to produce HPV58 virus-like particles (VLPs), and to produce vaccines and pharmaceutical compositions comprising the HPV58 VLPs. The vaccines of the present invention provide effective immunoprophylaxis against papillomavirus infection through neutralizing antibody and cell-mediated immunity and are also useful for treatment of existing HPV infections.
摘要翻译：提供编码HPV58 L1蛋白的合成DNA分子。具体地，本发明提供了编码HPV58L1蛋白的多核苷酸，其中所述多核苷酸在酵母细胞中用于高水平表达的密码子优化。合成分子可用于产生HPV58病毒样颗粒（VLP），以及产生包含HPV58 VLP的疫苗和药物组合物。本发明的疫苗通过中和抗体和细胞介导的免疫提供对乳头瘤病毒感染的有效免疫预防性，并且也可用于治疗现有的HPV感染。

3. 发明申请

WO2005032586A1 OPTIMIZED EXPRESSION OF HPV 45 L1 IN YEAST 审中-公开
标题翻译：优化HPV 45 L1在YEAST中的表达
公开(公告)号：WO2005032586A1
公开(公告)日：2005-04-14
申请号：PCT/US2004/031326
申请日：2004-09-24
申请人： MERCK & CO., INC. , BRYAN, Jaine, T. , BROWNLOW, Michelle, K. , SCHULTZ, Loren, D. , JANSEN, Kathrin, U.
发明人： BRYAN, Jaine, T. , BROWNLOW, Michelle, K. , SCHULTZ, Loren, D. , JANSEN, Kathrin, U.
IPC分类号： A61K39/12
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/5258 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034
摘要： Synthetic DNA molecules encoding the HPV45 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV45 L1 protein, wherein said polynucleotides have been codon-optimized for high level expression in a yeast cell. The synthetic molecules may be used to produce HPV45 virus-like particles (VLPs), and to produce vaccines and pharmaceutical compositions comprising the HPV45 VLPs. The vaccines of the present invention provide effective immunoprophylaxis against papillomavirus infection through neutralizing antibody and cell-mediated immunity.
摘要翻译：提供了编码HPV45 L1蛋白的合成DNA分子。具体地，本发明提供了编码HPV45 L1蛋白的多核苷酸，其中所述多核苷酸已被密码子优化用于酵母细胞中的高水平表达。合成分子可用于产生HPV45病毒样颗粒（VLP），以及产生包含HPV45 VLP的疫苗和药物组合物。本发明的疫苗通过中和抗体和细胞介导的免疫来提供对乳头瘤病毒感染的有效免疫预防。

4. 发明申请

WO2004084831A3 OPTIMIZED EXPRESSION OF HPV 31 L1 IN YEAST 审中-公开
标题翻译： HPV 31 L1在酵母中的优化表达
公开(公告)号：WO2004084831A3
公开(公告)日：2004-11-11
申请号：PCT/US2004008677
申请日：2004-03-19
申请人： MERCK & CO INC , JANSEN KATHRIN U , SCHULTZ LOREN D , NEEPER MICHAEL P , MARKUS HENRY Z
发明人： JANSEN KATHRIN U , SCHULTZ LOREN D , NEEPER MICHAEL P , MARKUS HENRY Z
IPC分类号： A61J1/03 , A61J7/04 , A61K20060101 , A61K31/66 , A61K31/675 , C07K14/025 , C12N15/33 , C12P20060101 , C12P21/06
CPC分类号： C07K14/005 , A61J1/035 , A61J7/04 , A61K31/66 , A61K31/675 , A61K2039/5258 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2800/22
摘要： Synthetic DNA molecules encoding the HPV31 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV31 L1 protein, wherein said polynucleotides are free from internal transcription termination signals that are recognized by yeast. Also provided are synthetic polynucleotides encoding HPV31 L1 wherein the polynucleotides have been codon-optimized for high level expression in a yeast cell. The synthetic molecules may be used to produce HPV31 virus-like particles (VLPs), and to produce vaccines and pharmaceutical compositions comprising the HPV31 VLPs. The vaccines of the present invention provide effective immunoprophylaxis against papillomavirus infection through neutralizing antibody and cell-mediated immunity.
摘要翻译：提供了编码HPV31 L1蛋白的合成DNA分子。具体而言，本发明提供了编码HPV31 L1蛋白的多核苷酸，其中所述多核苷酸不含由酵母识别的内部转录终止信号。还提供了编码HPV31L1的合成多核苷酸，其中所述多核苷酸已经被密码子优化以在酵母细胞中高水平表达。合成分子可用于产生HPV31病毒样颗粒（VLP），并用于产生包含HPV31 VLP的疫苗和药物组合物。本发明的疫苗通过中和抗体和细胞介导的免疫性提供对抗乳头瘤病毒感染的有效免疫预防。

5. 发明申请

WO2004084831A2 OPTIMIZED EXPRESSION OF HPV 31 L1 IN YEAST 审中-公开
标题翻译：优化HPV 31 L1在YEAST中的表达
公开(公告)号：WO2004084831A2
公开(公告)日：2004-10-07
申请号：PCT/US2004/008677
申请日：2004-03-19
申请人： MERCK & CO. INC. , JANSEN, Kathrin, U. , SCHULTZ, Loren, D. , NEEPER, Michael, P. , MARKUS, Henry, Z.
发明人： JANSEN, Kathrin, U. , SCHULTZ, Loren, D. , NEEPER, Michael, P. , MARKUS, Henry, Z.
IPC分类号： A61K
CPC分类号： C07K14/005 , A61J1/035 , A61J7/04 , A61K31/66 , A61K31/675 , A61K2039/5258 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2800/22
摘要： Synthetic DNA molecules encoding the HPV31 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV31 L1 protein, wherein said polynucleotides are free from internal transcription termination signals that are recognized by yeast. Also provided are synthetic polynucleotides encoding HPV31 L1 wherein the polynucleotides have been codon-optimized for high level expression in a yeast cell. The synthetic molecules may be used to produce HPV31 virus-like particles (VLPs), and to produce vaccines and pharmaceutical compositions comprising the HPV31 VLPs. The vaccines of the present invention provide effective immunoprophylaxis against papillomavirus infection through neutralizing antibody and cell-mediated immunity.
摘要翻译：提供编码HPV31 L1蛋白的合成DNA分子。具体地，本发明提供编码HPV31 L1蛋白的多核苷酸，其中所述多核苷酸不含被酵母识别的内部转录终止信号。还提供了编码HPV31 L1的合成多核苷酸，其中多核苷酸已被密码子优化用于酵母细胞中的高水平表达。合成分子可用于产生HPV31病毒样颗粒（VLP），以及生产包含HPV31 VLP的疫苗和药物组合物。本发明的疫苗通过中和抗体和细胞介导的免疫来提供对乳头瘤病毒感染的有效免疫预防。

6. 发明申请

WO2005009379A2 POLYPEPTIDES FOR INDUCING A PROTECTIVE IMMUNE RESPONSE AGAINST STAPHYLOCOCCUS AUREUS 审中-公开
标题翻译：诱导针对维生素A的保护性免疫应答的多肽
公开(公告)号：WO2005009379A2
公开(公告)日：2005-02-03
申请号：PCT/US2004/023523
申请日：2004-07-22
申请人： MERCK & CO., INC. , ANDERSON, Annaliesa, S. , JANSEN, Kathrin Ute , KELLY, Rosemarie , SCHULTZ, Loren, D. , MONTGOMERY, Donna, L. , MCCLEMENTS, William, L.
发明人： ANDERSON, Annaliesa, S. , JANSEN, Kathrin Ute , KELLY, Rosemarie , SCHULTZ, Loren, D. , MONTGOMERY, Donna, L. , MCCLEMENTS, William, L.
IPC分类号： A61K
CPC分类号： A61K39/085 , C07K14/31 , C07K2319/35
摘要： The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1, uses of such polypeptides, and expression systems for producing such polypeptides. SEQ ID NO: 1 is a truncated derivative of a full length S. aureus polypeptide. The full-length polypeptide is referred to herein as full-length “ORF0657n”. Polypeptides containing the amino acid sequence of SEQ ID NO: 1 were found to produce a protective immune response against S. aureus .
摘要翻译：本发明的特征在于包含与SEQ ID NO：1结构相关的氨基酸序列的多肽，这种多肽的用途以及用于产生此类多肽的表达系统。 SEQ ID NO：1是全长金黄色葡萄球菌多肽的截短衍生物。全长多肽在本文中称为全长“ORF0657n”。发现含有SEQ ID NO：1的氨基酸序列的多肽产生针对金黄色葡萄球菌的保护性免疫应答。

7. 发明申请

WO1996015247A1 PURIFIED PAPILLOMAVIRUS PROTEINS 审中-公开
标题翻译：纯化的斑马鱼蛋白
公开(公告)号：WO1996015247A1
公开(公告)日：1996-05-23
申请号：PCT/US1995015027
申请日：1995-11-13
申请人： MERCK & CO., INC. , LEHMAN, Ernest, D. , COOK, James, C., III , GEORGE, Hugh, A. , HOFMANN, Kathryn, J. , JANSEN, Kathrin, U. , JOYCE, Joseph, G. , MARKUS, Henry, Z. , SCHULTZ, Loren, D.
发明人： MERCK & CO., INC.
IPC分类号： C12N15/37
CPC分类号： C07K14/005 , A61K39/00 , C12N2710/20022 , C12N2710/20023
摘要： The present invention is directed to purified recombinant proteins of papillomaviruses (PV) and methods of making, measuring, using and formulating the same.
摘要翻译：本发明涉及乳头瘤病毒（PV）的纯化重组蛋白及其制备，测定，使用和制备方法。

8. 发明申请

WO1995031558A1 PROCESS FOR PRODUCING HBV SURFACE PROTEINS 审中-公开
标题翻译：生产HBV表面蛋白的方法
公开(公告)号：WO1995031558A1
公开(公告)日：1995-11-23
申请号：PCT/US1995006061
申请日：1995-05-12
申请人： MERCK & CO., INC. , MARKUS, Henry, Z. , SCHULTZ, Loren, D. , SHAW, Alan, R.
发明人： MERCK & CO., INC.
IPC分类号： C12N15/63
CPC分类号： C07K14/005 , A61K39/00 , C12N15/81 , C12N2730/10122
摘要： In order to produce hepatitis B virus (HBV) surface proteins in the form of particles with substantially reduced entrapped carbohydrate content, DNA encoding the HBV surface proteins was expressed in a recombinant yeast strains which are deficient in their ability to glycosylate proteins and/or has mutations in protease genes. These yeast strains produce P24 with substantially reduced sub-P24 proteolytic breakdown products when compared with P24 produced in "wild-type" yeast cells. These particles are useful as a vaccine for both the active and passive treatment or prevention of disease and/or infection caused by HBV or other agents serologically related to HBV. The processes disclosed herein utilizing these strains of yeast more efficiently produce P24.
摘要翻译：为了产生具有显着降低的包含碳水化合物含量的颗粒形式的乙型肝炎病毒（HBV）表面蛋白质，编码HBV表面蛋白的DNA在重组酵母菌株中表达，所述重组酵母菌株的蛋白质糖基化和/或具有蛋白酶基因突变。当与“野生型”酵母细胞中产生的P24相比时，这些酵母菌株产生具有显着降低的亚P24蛋白水解分解产物的P24。这些颗粒可用作活性和被动治疗或预防HBV或与HBV血清学相关的其他试剂引起的疾病和/或感染的疫苗。利用这些酵母菌株本文公开的方法更有效地产生P24。

9. 发明申请

WO1993025676A1 METHOD FOR INCREASING PRODUCTION OF DISULFIDE BONDED RECOMBINANT PROTEINS BY SACCHAROMYCES CEREVISIAE 审中-公开
标题翻译：通过SACCHAROMCES CERECISE增加生产分离的重组蛋白的方法
公开(公告)号：WO1993025676A1
公开(公告)日：1993-12-23
申请号：PCT/US1993005318
申请日：1993-06-02
申请人： MERCK & CO., INC. , UNIVERSITY OF KENT AT CANTERBURY , TUITE, Michael, F. , FREEDMAN, Robert, B. , SCHULTZ, Loren, D. , ELLIS, Ronald, W. , MARKUS, Henry, Z. , MONTGOMERY, Donna, L.
发明人： MERCK & CO., INC. , UNIVERSITY OF KENT AT CANTERBURY
IPC分类号： C12N15/09
CPC分类号： C12N9/90 , C07K14/811 , C07K14/815 , C12N15/81
摘要： Disclosed is a process for increasing the yield of disulfide bonded recombinant proteins produced by yeast, especially recombinant secreted proteins. The enzyme protein disulfide isomerase (PDI) catalyzes the formation of disulfide bonds in secretory and cell-surface proteins. We disclose the construction of recombinant strains of the yeast Saccharomyces cerevisiae which overproduce either human PDI or yeast PDI in a regulated fashion. These strains show greatly increased secretion of disulfide bonded proteins of potential therapeutic significance. These strains have the potential to increase the production of various disulfide bonded proteins.
摘要翻译：公开了一种增加由酵母，特别是重组分泌蛋白质产生的二硫键合重组蛋白的产率的方法。酶蛋白二硫键异构酶（PDI）催化分泌和细胞表面蛋白中二硫键的形成。我们公开了以规定的方式过量产生人PDI或酵母PDI的酵母酿酒酵母重组菌株的构建。这些菌株显示出显着增加的二硫键合蛋白的分泌具有潜在的治疗意义。这些菌株有可能增加各种二硫键合蛋白的产生。

10. 发明申请

WO2003018055A1 VACCINE USING PAPILLOMA VIRUS E PROTEINS DELIVERED BY VIRAL VECTOR 审中-公开
标题翻译：使用由病毒载体递送的斑马鱼病毒蛋白的疫苗
公开(公告)号：WO2003018055A1
公开(公告)日：2003-03-06
申请号：PCT/US2002/026965
申请日：2002-08-19
申请人： MERCK & CO., INC. , HUANG, Lingyi , JANSEN, Kathrin, U. , MC CLEMENTS, William, L. , MONTEIRO, Juanita , SCHULTZ, Loren, D. , TOBERY, Timothy , WANG, Xin-Min , CHEN, Ling
发明人： HUANG, Lingyi , JANSEN, Kathrin, U. , MC CLEMENTS, William, L. , MONTEIRO, Juanita , SCHULTZ, Loren, D. , TOBERY, Timothy , WANG, Xin-Min , CHEN, Ling
IPC分类号： A61K39/12
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/585 , A61K2039/70 , C12N2710/10343 , C12N2710/20022 , C12N2710/20034
摘要： Cell-mediated immune response to a papillomavirus infection can be induced by vaccination with DNA encoding papillomavirus E genes. E genes can both prevent the occurrence of papillomavirus disease, and treat disease states. Canine papillomavirus (COPV) E genes which are codon-optimized to enhance expression in host cells are also given.
摘要翻译：细胞介导的对乳头瘤病毒感染的免疫应答可以通过用编码乳头瘤病毒E基因的DNA接种来诱导。 E基因既可以预防乳头瘤病毒发生，又可以治疗疾病。还给出了密码子优化以增强宿主细胞中表达的犬乳头状瘤病毒（COPV）E基因。

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