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2. 发明申请

WO2009024534A2 JAPANESE ENCEPHALITIS VIRUS (JEV) AND TICK-BORNE ENCEPHALITIS VIRUS (TBEV) PEPTIDES STIMULATING HUMAN T CELL RESPONSES 审中-公开
标题翻译： JAPANESE ENCEPHALITIS VIRUS（JEV）和TICK-BORNE ENCEPHALITIS VIRUS（TBEV）PEPTIDES刺激人类T细胞应答
公开(公告)号：WO2009024534A2
公开(公告)日：2009-02-26
申请号：PCT/EP2008060705
申请日：2008-08-14
申请人： INTERCELL AG , SCHARNAGL NICOLE , KLADE CHRISTOPH
发明人： SCHARNAGL NICOLE , KLADE CHRISTOPH
IPC分类号： C07K14/18 , A61K39/12 , A61K39/42
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/70 , C12N2770/24122 , C12N2770/24134
摘要： The present invention provides means for the development of diagnostic assays and pharmaceutical compositions to identify, treat or prevent infections caused by JEV or TBEV. More particularly, the invention relates to T cell epitopes, fragments or variants thereof, complexes comprising said T cell epitopes and at least one additional compound, nucleic acids encoding said T cell epitopes, and T cells specifically recognizing said T cell epitopes, which can be used for said diagnostic assays and pharmaceutical compositions. The invention also relates to pharmaceutical compositions comprising said T cell epitope, complex, nucleic acid, and/or T cell for the treatment or prevention of an infection with JEV and/or TBEV. Furthermore, the present invention provides methods for immunizing an animal or human against an infection with JEV and/or TBEV, and methods for stimulating an immune response in an animal or human against an infection with JEV and/or TBEV. In yet other aspects, the invention provide methods for diagnosing an infection with JEV and/or TBEV and methods for monitoring the immune response of a subject to a JEV vaccine or a TBEV vaccine.
摘要翻译：本发明提供用于鉴定，治疗或预防由JEV或TBEV引起的感染的诊断测定和药物组合物开发的方法。更具体地，本发明涉及T细胞表位，其片段或变体，包含所述T细胞表位和至少一种另外的化合物的复合物，编码所述T细胞表位的核酸和特异性识别所述T细胞表位的T细胞，其可以是用于所述诊断测定和药物组合物。本发明还涉及包含用于治疗或预防感染JEV和/或TBEV的所述T细胞表位，复合物，核酸和/或T细胞的药物组合物。此外，本发明提供了用于免疫动物或人免受JEV和/或TBEV感染的方法，以及用于刺激动物或人体免疫应答以防止JEV和/或TBEV感染的方法。在其它方面，本发明提供用于诊断JEV和/或TBEV的感染的方法以及用于监测受试者对JEV疫苗或TBEV疫苗的免疫应答的方法。

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