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1. 发明申请

WO2003066054A1 CATIONIC POLYMERS FOR USE IN THERAPEUTIC AGENT DELIVERY 审中-公开
标题翻译：用于治疗药物递送的阳离子聚合物
公开(公告)号：WO2003066054A1
公开(公告)日：2003-08-14
申请号：PCT/US2003/002706
申请日：2003-01-31
申请人： INTRADIGM CORPORATION , SCARIA, Puthupparampil, V. , ANSARI, Aslam, M. , WOODLE, Martin, C.
发明人： SCARIA, Puthupparampil, V. , ANSARI, Aslam, M. , WOODLE, Martin, C.
IPC分类号： A61K31/47
CPC分类号： A61K31/47 , A61K31/765 , A61K31/785 , A61K39/39 , A61K48/0041 , A61K2039/55555 , Y02A50/401
摘要： The invention provides novel nucleic acid delivery vehicles that can, for example, be administered to a subject repeatedly to effectively deliver one or more therapeutic drugs or nucleic acid molecules or polypeptides to a cell or tissue. The drug or gene delivery vehicles can be used, for instance, as part of the therapeutic and/or preventative vaccine, and/or as well as any other therapeutic regimen that involves an ongoing use of a therapeutic drug or nucleic acid molecule or polypeptide.
摘要翻译：本发明提供新的核酸递送载体，其可以例如重复施用于受试者以有效地将一种或多种治疗药物或核酸分子或多肽递送至细胞或组织。药物或基因递送载体可以用作例如治疗和/或预防性疫苗的一部分，和/或以及涉及持续使用治疗药物或核酸分子或多肽的任何其它治疗方案。

2. 发明申请

WO2006110813A3 COMPOSITION AND METHODS OF RNAI THERAPEUTICS FOR TREATMENT OF CANCER AND OTHER NEOVASCULARIZATION DISEASES 审中-公开
标题翻译：用于治疗癌症和其他新生血管疾病的RNAI治疗剂的组合物和方法
公开(公告)号：WO2006110813A3
公开(公告)日：2007-11-15
申请号：PCT/US2006013645
申请日：2006-04-12
申请人： INTRADIGM CORP , LUI YIJIA , YANG LU PATRICK , SCARIA PUTHUPPARAMPIL V , SCHIFFELERS RAYMOND , TANG QUINN Q , WOODLE MARTIN C , XIE FRANK YUEFENG , XU JUN , ZHOU QIN
发明人： LUI YIJIA , YANG LU PATRICK , SCARIA PUTHUPPARAMPIL V , SCHIFFELERS RAYMOND , TANG QUINN Q , WOODLE MARTIN C , XIE FRANK YUEFENG , XU JUN , ZHOU QIN
IPC分类号： A61K31/70 , C12N15/113
CPC分类号： A61K48/00 , A61K9/0019 , A61K9/0048 , A61K9/5146 , A61K31/70 , C12N15/1136 , C12N15/1138 , C12N2310/14 , C12N2310/53 , C12N2320/31 , C12N2320/32
摘要： Compositions and methods are provided for treatment of diseases involving unwanted neovascularization (NV). The invention provides treatments that control NV through selective inhibition of pro-angiogenic biochemical pathways, including inhibition of the VEGF pathway gene expression and inhibition localized at pathological NV tissues. Tissue targeted nanoparticle compositions comprising polymer conjugates and nucleic acid molecules that induce RNA interference (RNAi) are provided. The nanoparticle compositions of the invention can be used alone or in combination with other therapeutic agents such as VEGF pathway antagonists. The compositions and methods can be used for the treatment of NV diseases such as cancer, ocular disease, arthritis, and inflammatory diseases.
摘要翻译：提供组合物和方法用于治疗涉及不想要的新血管形成（NV）的疾病。本发明提供通过选择性抑制促血管生成生物化学途径来控制NV的治疗，包括VEGF通路基因表达的抑制和局部在病理性NV组织的抑制。提供了包含聚合物缀合物和诱导RNA干扰（RNAi）的核酸分子的组织靶向纳米颗粒组合物。本发明的纳米颗粒组合物可以单独使用或与其它治疗剂如VEGF途径拮抗剂组合使用。组合物和方法可用于治疗NV疾病如癌症，眼病，关节炎和炎性疾病。

3. 发明申请

WO2006110813A2 COMPOSITION AND METHODS OF RNAI THERAPEUTICS FOR TREATMENT OF CANCER AND OTHER NEOVASCULARIZATION DISEASES 审中-公开
标题翻译：用于治疗癌症和其他新生血管疾病的RNAI治疗剂的组合物和方法
公开(公告)号：WO2006110813A2
公开(公告)日：2006-10-19
申请号：PCT/US2006/013645
申请日：2006-04-12
申请人： INTRADIGM CORPORATION , LUI, Yijia , YANG LU, Patrick , SCARIA, Puthupparampil, V. , SCHIFFELERS, Raymond , TANG, Quinn, Q. , WOODLE, Martin, C. , XIE, Frank, Yuefeng , XU, Jun , ZHOU, Qin
发明人： LUI, Yijia , YANG LU, Patrick , SCARIA, Puthupparampil, V. , SCHIFFELERS, Raymond , TANG, Quinn, Q. , WOODLE, Martin, C. , XIE, Frank, Yuefeng , XU, Jun , ZHOU, Qin
IPC分类号： A61K48/00
CPC分类号： A61K48/00 , A61K9/0019 , A61K9/0048 , A61K9/5146 , A61K31/70 , C12N15/1136 , C12N15/1138 , C12N2310/14 , C12N2310/53 , C12N2320/31 , C12N2320/32
摘要： Compositions and methods are provided for treatment of diseases involving unwanted neovascularization (NV). The invention provides treatments that control NV through selective inhibition of pro-angiogenic biochemical pathways, including inhibition of the VEGF pathway gene expression and inhibition localized at pathological NV tissues. Tissue targeted nanoparticle compositions comprising polymer conjugates and nucleic acid molecules that induce RNA interference (RNAi) are provided. The nanoparticle compositions of the invention can be used alone or in combination with other therapeutic agents such as VEGF pathway antagonists. The compositions and methods can be used for the treatment of NV diseases such as cancer, ocular disease, arthritis, and inflammatory diseases.
摘要翻译：提供组合物和方法用于治疗涉及不想要的新血管形成（NV）的疾病。本发明提供通过选择性抑制促血管生成生物化学途径来控制NV的治疗，包括VEGF通路基因表达的抑制和局部在病理性NV组织的抑制。提供了包含聚合物缀合物和诱导RNA干扰（RNAi）的核酸分子的组织靶向纳米颗粒组合物。本发明的纳米颗粒组合物可以单独使用或与其它治疗剂如VEGF途径拮抗剂组合使用。组合物和方法可用于治疗NV疾病如癌症，眼病，关节炎和炎性疾病。

4. 发明申请

WO2004013310A2 METHODS OF DOWN REGULATING TARGET GENE EXPRESSION IN VIVO BY INTRODUCTION OF INTERFERING RNA 审中-公开
标题翻译：介导干扰RNA减量调节靶基因表达的方法
公开(公告)号：WO2004013310A2
公开(公告)日：2004-02-12
申请号：PCT/US2003/024587
申请日：2003-08-06
申请人： INTRADIGM CORPORATION , SCARIA, Puthupparampil, V. , WOODLE, Martin, C. , LU, Patrick, Y. , TANG, Qingquan , XU, Jun , XIE, Frank, Y.
发明人： SCARIA, Puthupparampil, V. , WOODLE, Martin, C. , LU, Patrick, Y. , TANG, Qingquan , XU, Jun , XIE, Frank, Y.
IPC分类号： C12N
CPC分类号： A61K48/00 , C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2310/351 , C12N2310/3513 , C12N2310/53 , C12N2320/32
摘要： Methods and compositions are provided for down regulation of target gene expression in vivo by RNA interference. The methods are useful for target discovery and validation of gene-based drug development, and for treatment of human diseases.
摘要翻译：提供了通过RNA干扰下调体内靶基因表达的方法和组合物。这些方法对目标发现和基因基础药物开发验证以及人类疾病治疗有用。

5. 发明申请

WO2004013310A3 METHODS OF DOWN REGULATING TARGET GENE EXPRESSION IN VIVO BY INTRODUCTION OF INTERFERING RNA 审中-公开
标题翻译：通过介导干扰RNA降低调节目标基因表达的方法
公开(公告)号：WO2004013310A3
公开(公告)日：2004-08-26
申请号：PCT/US0324587
申请日：2003-08-06
申请人： INTRADIGM CORP , SCARIA PUTHUPPARAMPIL V , WOODLE MARTIN C , LU PATRICK Y , TANG QINGQUAN , XU JUN , XIE FRANK Y
发明人： SCARIA PUTHUPPARAMPIL V , WOODLE MARTIN C , LU PATRICK Y , TANG QINGQUAN , XU JUN , XIE FRANK Y
IPC分类号： C12N15/09 , A61K9/08 , A61K9/10 , A61K31/7105 , A61K35/76 , A61K47/34 , A61K47/42 , A61K48/00 , A61P29/00 , A61P31/00 , A61P35/00 , A61P43/00 , C12N15/11 , C07H21/02 , C07H21/04 , C12N15/85 , C12N15/86 , C12P19/34 , C12Q1/68
CPC分类号： A61K48/00 , C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2310/351 , C12N2310/3513 , C12N2310/53 , C12N2320/32
摘要： Methods and compositions are provided for down regulation of target gene expression in vivo by RNA interference. The methods are useful for target discovery and validation of gene-based drug development, and for treatment of human diseases.
摘要翻译：提供了通过RNA干扰在体内下调靶基因表达的方法和组合物。该方法可用于基于基因的药物开发和人类疾病治疗的靶发现和验证。

6. 发明申请

WO2003066069A1 POLYMERS FOR DELIVERING PEPTIDES AND SMALL MOLECULES IN VIVO 审中-公开
标题翻译：聚合物在体内递送肽和小分子
公开(公告)号：WO2003066069A1
公开(公告)日：2003-08-14
申请号：PCT/US2003/002710
申请日：2003-01-31
申请人： INTRADIGM CORPORATION , ANSARI, Aslam, M. , SCARIA, Puthupparampil, V. , WOODLE, Martin, C.
发明人： ANSARI, Aslam, M. , SCARIA, Puthupparampil, V. , WOODLE, Martin, C.
IPC分类号： A61K31/74
CPC分类号： C08G63/08 , A61K31/74 , A61K47/64 , C08G63/912 , C08G65/329 , C08G73/0233 , C08L2203/02
摘要： Certain hydrophilic polymers, such as a polyoxazoline, when conjugated to a polypeptide or small molecule agent, can enhance the bioavailability of the agent when administered in vivo . Accordingly, hydrophilic polymers of the invention can be used as a delivery vehicle to treat any number of disorders and/or confer a myriad of therapeutic benefits to a subject.
摘要翻译：当与多肽或小分子试剂缀合时，某些亲水性聚合物例如聚恶唑啉可以在体内施用时增强试剂的生物利用度。因此，本发明的亲水性聚合物可用作递送载体以治疗任何数量的病症和/或赋予受试者无数的治疗益处。

7. 发明申请

WO2003066068A1 HPMA-POLYAMINE CONJUGATES AND USES THEREFORE 审中-公开
标题翻译： HPMA-聚氨酯结合物及其用途
公开(公告)号：WO2003066068A1
公开(公告)日：2003-08-14
申请号：PCT/US2003/002707
申请日：2003-01-31
申请人： INTRADIGM CORPORATION , GHANDEHARI, Hamidreza , WOODLE, Martin, C. , SCARIA, Puthupparampil, V. , NAN, Anjan
发明人： GHANDEHARI, Hamidreza , WOODLE, Martin, C. , SCARIA, Puthupparampil, V. , NAN, Anjan
IPC分类号： A61K31/74
CPC分类号： C07K5/021 , A61K31/74 , A61K47/58 , C07K5/1008 , C07K5/1027 , C12N15/87 , C12N2810/405
摘要： The inventions provide compositions and methods for nucleic acid delivery comprising HPMA conjugated to a polyamine. These compositions have the benefit of the steric hindrance of HPMA and the nucleic acid binding capability of a polyamine. Useful polyamines for this purpose include spermine, spermidine and their analogues, and DFMO. These polyamines have the ability not only to bind nucleic acids, but also have anti-cancer effects themselves. The compounds provided can also include ligand binding domains, such as vascular endothelial growth factors, somatostatin and somatostatin analogs, transferring, melanotropin, ApoE and ApoE peptides, von Willebrand's factor and von Willebrand's factor peptides, adenoviral fiber protein and adenoviral fiber protein peptides, PD 1 and PD 1 peptides, EGF and EGF peptides, RGD peptides, CCK peptides, antibody and antibody fragments, folate, pyridoxyl and sialyl-LewisX and chemical analogs. Methods for using these compositions to achieve a therapeutic effect, including for vaccination, are also provided.
摘要翻译：本发明提供了包含与多胺缀合的HPMA的核酸递送的组合物和方法。这些组合物具有HPMA的空间位阻和多胺的核酸结合能力的益处。有用的多胺用于此目的包括精胺，亚精胺及其类似物，以及DFMO。这些多胺不仅具有结合核酸的能力，而且还具有抗癌作用。所提供的化合物还可以包括配体结合域，例如血管内皮生长因子，生长抑素和生长抑素类似物，转移，黑素素，ApoE和ApoE肽，血管性血友病因子和血管性血友病因子肽，腺病毒纤维蛋白和腺病毒纤维蛋白肽，PD 1和PD 1肽，EGF和EGF肽，RGD肽，CCK肽，抗体和抗体片段，叶酸，吡哆醛和唾液酸-LXXX和化学类似物。还提供了使用这些组合物来实现治疗效果的方法，包括用于疫苗接种。

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