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1. 发明申请

WO1998015530A1 INDOLE DERIVATIVES 审中-公开
标题翻译： INDOLE DORIVATIVES
公开(公告)号：WO1998015530A1
公开(公告)日：1998-04-16
申请号：PCT/JP1997003592
申请日：1997-10-07
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , YAMASAKI, Noritsugu , IMOTO, Takafumi , MURAI, Yoshiyuki , HIRAMURA, Takahiro , ONOMURA, Osamu , NISHIKAWA, Masahiro , OKU, Teruo , SAWADA, Kouzou , KAYAKIRI, Hiroshi
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D209/08
CPC分类号： C07D401/06 , C07D209/08 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D417/06 , C07D417/10 , C07D417/12 , C07D417/14
摘要： Novel indole derivatives represented by general formula (V) or pharmaceutically acceptable salts thereof. Because of having hypoglycemic or PDE5-inhibitory activities, these compouds or salts thereof are useful as remedies for impaired glucose tolerance, diabetes, complication of diabetes, insulin resistant syndrome, hyperlipidemia, atherosclerosis, cardiovascular diseases, hyper glycemia, hypertension; diseases characterized by angina pectoris, high blood pressure, pulmonary hypertension, congestive heart failure, glomerular diseases, tubular interstitial diseases, renal insufficiency, atherosclerosis, angiostenosis, peripheral vascular diseases, cerebral stroke, chronic reversible obstructive diseases, allergic rhinitis, urticaria, glaucoma or intestinal motility disorders; sexual impotence, complication of diabetes, osteoporosis, nephritis, cancerous cachexia or post-PTCA reconstriction, wherein R13 to R15 represent each: 1) hydrogen, 2) lower alkyl, lower alkylthio or lower alkoxy-substituted lower alkyl, or 3) lower alkyl, hydroxy, hydroxylated lower alkyl, lower alkyloxy, etc. bonded to or substituted by aryl or a heterocycle; provided that R13 to R15 do not represent hydrogen at the same time; R16 represents: 1) hydrogen, or 2) lower alkyl; and R17 represents optionally esterified carboxy.
摘要翻译：由通式（V）表示的新型吲哚衍生物或其药学上可接受的盐。由于具有低血糖或PDE5抑制活性，这些化合物或其盐可用作葡萄糖耐量降低，糖尿病，糖尿病并发症，胰岛素抵抗综合征，高脂血症，动脉粥样硬化，心血管疾病，高血糖症，高血压症的补救措施; 特征为心绞痛，高血压，肺动脉高压，充血性心力衰竭，肾小球疾病，肾小管间质疾病，肾功能不全，动脉粥样硬化，血管狭窄症，外周血管疾病，脑中风，慢性可逆性阻塞性疾病，过敏性鼻炎，荨麻疹，青光眼或肠蠕动障碍; 性功能障碍，糖尿病并发症，骨质疏松症，肾炎，癌性恶病质或PTCA后重建，其中R13至R15各自表示：1）氢，2）低级烷基，低级烷硫基或低级烷氧基取代的低级烷基，或3）低级烷基，羟基，羟基化的低级烷基，低级烷氧基等，与芳基或杂环结合或取代; 条件是R13至R15不同时代表氢; R16表示：1）氢，或2）低级烷基; R 17代表任意酯化的羧基。

2. 发明申请

WO1997024334A1 BENZIMIDAZOLE DERIVATIVES 审中-公开
标题翻译：苯并咪唑衍生物
公开(公告)号：WO1997024334A1
公开(公告)日：1997-07-10
申请号：PCT/JP1996003858
申请日：1996-12-27
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , YAMASAKI, Noritsugu , IMOTO, Takafumi , MURAI, Yoshiyuki , HIRAMURA, Takahiro , OKU, Teruo , SAWADA, Kouzou
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D235/08
CPC分类号： C07D401/06 , C07D209/08 , C07D235/08 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D417/06 , C07D417/10 , C07D417/12 , C07D417/14
摘要： Novel benzimidazole derivatives represented by general formula (I) or pharmaceutically acceptable salts thereof wherein R3 represents carboxy, esterified carboxy, carboxamide, amino, amido or sulfonyl. Because of having hypoglycemic or PDE5 inhibitory effects, these compounds or salts thereof are useful as remedies for impaired glucose tolerance, diabetes, complications of diabetes, insulin resistant syndrome, hyperlipidemia, atherosclerosis, cardiovascular diseases, hyperglycemia, hypertension, angina pectoris, pulmonary hypertension, congestive heart failure, glomerular diseases, tubular interstitial diseases, renal failure, angiostenosis, peripheral vascular disease, apoplexy, chronic reversible obstructive diseases, allergic rhinitis, urticaria, glaucoma, diseases characterized by abnormality in intestinal motility, sexual impotence, nephritis, cancerous cachexia, or post-PCTA reconstriction.
摘要翻译：由通式（I）表示的新型苯并咪唑衍生物或其药学上可接受的盐，其中R 3表示羧基，酯化羧基，羧酰胺，氨基，酰氨基或磺酰基。由于具有低血糖或PDE5抑制作用，这些化合物或其盐可用作葡萄糖耐量减低，糖尿病，糖尿病并发症，胰岛素抵抗综合征，高脂血症，动脉粥样硬化，心血管疾病，高血糖症，高血压，心绞痛，肺动脉高压，充血性心力衰竭，肾小球疾病，管状间质性疾病，肾衰竭，血管狭窄症，外周血管疾病，中风，慢性可逆性阻塞性疾病，过敏性鼻炎，荨麻疹，青光眼，肠蠕动异常特征性疾病，性阳ence，肾炎，癌性恶病质，或后PCTA重新约束。

3. 发明专利

JPS54143757A CABLE BENDER 失效
公开(公告)号：JPS54143757A
公开(公告)日：1979-11-09
申请号：JP5108878
申请日：1978-04-28
申请人： SUMITOMO ELECTRIC INDUSTRIES , SAWADA KOUZOU
发明人： TERADA YOSHINOBU , SAWADA JIYUNICHIROU
IPC分类号： B21D7/06 , H02G1/06
摘要： PURPOSE:To contrive the miniaturization, the prevention against the danger of breaking and damage, the reduction of number of kinds of supports, and the simplification of the operation, by connecting the arm and the rotatable bench with the pantograph mechanism, and by supporring the cable on the arm through the chain. CONSTITUTION:The bender 10 is constituted of a pair of arms 11, 11', connected by the pins 12 crossing each other, the links 14, 14', connected to the tip of arms 11, 11', by the pins 13, 13', the pin 15 connecting tips of the links 14, 14', and the bench 16 rotatably supported by the pin 15. The spring 17 is placed between the pins 12, 15, and the pantograph mechanism constituted of the arm and the link is folded. Besides, the hydraulic jack 18 for lifting a pin 13' is rotatably attached to the arm 11. The pin 19 is fixed to the tip of the arm; the chain is passed through the metallic pipes 22, 22', fixed to the stationary metallic plates 21, 21', at both ends of the flexible plate 20; this chain is hooked on above pin 19 as the belt type means, etc., so as to support the cable.

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