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1. 发明申请

WO2008050276A1 THERMAL IMAGING FEEDBACK FOR OPTIMIZING RADIO FREQUENCY ABLATION THERAPY 审中-公开
标题翻译：用于优化无线电频率消除治疗的热成像反馈
公开(公告)号：WO2008050276A1
公开(公告)日：2008-05-02
申请号：PCT/IB2007/054269
申请日：2007-10-19
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , SAVERY, David L.M. , HALL, Christopher S.
发明人： SAVERY, David L.M. , HALL, Christopher S.
IPC分类号： A61B18/00
CPC分类号： A61B18/1206 , A61B5/015 , A61B2018/00577
摘要： The invention relates to methods and systems for monitoring and regulating radio frequency ablation therapy in order to maximize effectiveness of treatment. The invention uses an imaging scanner to provide feedback regarding location and extent of a treated volume. The feedback is used as input data for control of intensity, duration, and/or placement of radio frequency treatment. Control of treatment parameters is automatic and/or modulated by an operator.
摘要翻译：本发明涉及用于监测和调节射频消融治疗的方法和系统，以便最大化治疗的有效性。本发明使用成像扫描器来提供关于处理体积的位置和程度的反馈。反馈用作控制射频治疗的强度，持续时间和/或放置的输入数据。治疗参数的控制由操作者自动和/或调制。

2. 发明申请

WO2009007582A2 METHOD FOR RHEOLOGICAL CHARACTERIZATION OF A VISCOELASTIC MEDIUM 审中-公开
标题翻译：粘弹性介质的流变特性的方法
公开(公告)号：WO2009007582A2
公开(公告)日：2009-01-15
申请号：PCT/FR2008051129
申请日：2008-06-23
申请人： SUPER SONIC IMAGINE , CENTRE NAT RECH SCIENT , SINKUS RALPH , TANTER MICKAEL , FINK MATHIAS , BERCOFF JEREMY , SAVERY DAVID
发明人： SINKUS RALPH , TANTER MICKAEL , FINK MATHIAS , BERCOFF JEREMY , SAVERY DAVID
IPC分类号： G01N29/024 , A61B5/055 , A61B8/08 , G01N29/032 , G01N29/06 , G01N29/07 , G01N29/11 , G01N29/44 , G01S7/52 , G01S15/89
CPC分类号： G01N29/032 , A61B8/08 , A61B8/485 , G01N29/024 , G01N29/06 , G01N29/07 , G01N29/11 , G01N2203/0094 , G01N2291/02475 , G01N2291/02483 , G01N2291/02491 , G01N2291/02827 , G01S7/52038 , G01S15/8906
摘要： Method for rheological characterization of a viscoelastic medium, comprising the following steps: (a) an excitation step during which a vibratory excitation is generated in the viscoelastic medium leading to a deformation of the medium, (b) a deformation measurement step during which the deformation of the medium caused by the excitation is observed, (c) and a characterization step during which at least one non-zero power parameter y is determined such that a rheological parameter of the medium x is equal to x(f ) = a + b.fy, where f is the frequency, a is a real number and b a non-zero scale parameter. It is thus possible to obtain mapping of the power parameter y.
摘要翻译：粘弹性介质的流变学表征方法，包括以下步骤：（a）在粘弹性介质中产生振动激发导致介质变形的激发步骤，（b）变形测量步骤，其中变形观察到由激励引起的介质的（c）和表征步骤，其中确定至少一个非零功率参数y，使得介质x的流变参数等于x（f）= a + b .fy，其中f是频率，a是实数和ba非零比例参数。因此，可以获得功率参数y的映射。

3. 发明申请

WO2007015179A1 ULTRASOUND MONITORING AND FEEDBACK FOR MAGNETIC HYPERTHERMIA 审中-公开
标题翻译：超声波超声波监测和反馈
公开(公告)号：WO2007015179A1
公开(公告)日：2007-02-08
申请号：PCT/IB2006/052371
申请日：2006-07-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , RAJU, Balasundar , SAVERY, David
发明人： RAJU, Balasundar , SAVERY, David
IPC分类号： A61N1/40
CPC分类号： A61N1/406 , A61B2017/00084 , A61B2090/378
摘要： A method and system of magnetic hyperthermia control using ultrasound thermometry, the method comprising: acquiring a reference set of ultrasound data corresponding to a tissue of interest (121); applying a plurality of magnetic nanoparticles (210) at the tissue of interest (121); applying an electromagnetic field based on a set of operating parameters to initiate the hyperthermia; acquiring another set of ultrasound data corresponding to the tissue of interest (121); and determining a temperature change based on the reference set of ultrasound data and the other set of ultrasound data.
摘要翻译：一种使用超声波测温法进行磁热疗控制的方法和系统，所述方法包括：获取对应于感兴趣组织的超声数据的参考集合（121）; 在感兴趣的组织（121）上施加多个磁性纳米颗粒（210）; 基于一组操作参数施加电磁场以启动热疗; 获取对应于感兴趣组织的另一组超声数据（121）; 以及基于超声数据的参考集合和另一组超声数据来确定温度变化。

4. 发明申请

WO2009007582A3 PROCEDE DE CARACTERISATION RHEOLOGIQUE D'UN MILIEU VISCOELASTIQUE 审中-公开
公开(公告)号：WO2009007582A3
公开(公告)日：2009-01-15
申请号：PCT/FR2008/051129
申请日：2008-06-23
申请人： SUPER SONIC IMAGINE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS - , SINKUS, Ralph , TANTER, Mickaël , FINK, Mathias , BERCOFF, Jeremy , SAVERY, David
发明人： SINKUS, Ralph , TANTER, Mickaël , FINK, Mathias , BERCOFF, Jeremy , SAVERY, David
IPC分类号： G01N29/024 , G01N29/032 , G01N29/06 , G01N29/07 , G01N29/11 , A61B8/08 , G01S7/52 , G01S15/89
摘要： Procédé de caractérisation rhéologique d'un milieu viscoélastique, comprenant les étapes suivantes : (a) une étape d'excitation au cours de laquelle on génère, dans le milieu viscoélastique, une excitation vibratoire engendrant une déformation du milieu, (b) une étape de mesure de déformation au cours de laquelle on observe la déformation du milieu engendrée par l ' excitation, (c) et une étape de caractérisation au cours de laquelle on détermine au moins un paramètre de puissance y non nul tel qu'un paramètre rhéologique du milieu x soit égal à x(f ) = a + b.f y , où f est la fréquence, a est un nombre réel et b un paramètre d'échelle non nul. On peut ainsi obtenir une cartographie du paramètre de puissance y.

5. 发明申请

WO2008139245A1 METHOD AND DEVICE FOR MEASURING A MEAN VALUE OF VISCO-ELASTICITY OF A REGION OF INTEREST 审中-公开
标题翻译：用于测量感兴趣区域的粘弹性的平均值的方法和装置
公开(公告)号：WO2008139245A1
公开(公告)日：2008-11-20
申请号：PCT/IB2007/002746
申请日：2007-05-16
申请人： SUPER SONIC IMAGINE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , BERCOFF, Jeremy , SAVERY, David , TANTER, MickaëL , GENNISON, Jean-Luc , FINK, Mathias , COHEN-BACRIE, Claude
发明人： BERCOFF, Jeremy , SAVERY, David , TANTER, MickaëL , GENNISON, Jean-Luc , FINK, Mathias , COHEN-BACRIE, Claude
IPC分类号： A61B8/08
CPC分类号： A61B8/485 , A61B5/0051 , A61B8/08 , A61B8/4483 , G01S7/52036 , G01S7/52042 , G01S15/8927
摘要： The invention relates to a method for measuring a mean visco-elasticity value for a soft material. Said method using a single probe carrying at least one transducer comprises the steps of : a) inducing, in a constraint zone, at least one burst of mechanical vibrations in order to generate internal shear waves in the tissue propagating from said constraint zone into the tissue, bl) measuring, with said transducer, the transient tissue displacements in at least one first measurement zone in the tissue, said first measurement zone being located away from said constraint zone, c) estimating a mean visco-elasticity of the region of the tissue situated between the constraint zone and the first measurement zone from said measured transient tissue displacements of the tissue in the first measurement zone.
摘要翻译：本发明涉及一种用于测量软材料的平均粘弹性值的方法。使用携带至少一个换能器的单个探针的所述方法包括以下步骤：a）在约束区域中诱导至少一个机械振动爆发，以便在从所述约束区传播到组织中的组织中产生内部剪切波，b1）用所述换能器测量组织中的至少一个第一测量区域中的瞬时组织位移，所述第一测量区域远离所述约束区域，c）估计组织区域的平均粘弹性位于所述约束区域和所述第一测量区域之间，所述第一测量区域中的所述组织的测量的瞬时组织位移。

6. 发明申请

WO2008124923A1 METHOD AND SYSTEM OF ULTRASOUND SCATTERER CHARACTERIZATION 审中-公开
标题翻译：超声波扫描仪特征的方法与系统
公开(公告)号：WO2008124923A1
公开(公告)日：2008-10-23
申请号：PCT/CA2008/000673
申请日：2008-04-10
申请人： CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL , CLOUTIER, Guy , YU, François , FRANCESCHINI, Emilie , SAVERY, David
发明人： CLOUTIER, Guy , YU, François , FRANCESCHINI, Emilie , SAVERY, David
IPC分类号： G01N29/44 , A61B8/08 , G01N29/46
CPC分类号： G01N29/069 , A61B8/06 , A61B8/13 , G01N29/4418 , G01N29/4472 , G01N2291/014 , G01N2291/02408 , G01N2291/02416 , G01N2291/02466 , G01N2291/02836 , G01S7/52036
摘要： A method for characterizing ultrasound scatterers in a medium comprising providing ultrasound data representing a region of interest comprising a plurality of scatterers in a medium, the plurality of scatterers including clusters of scatterer sub-units, the scatterers having a physical property value to be estimated and the scatterer sub-units having at least one known physical parameter value; modelling the ultrasound data using an at least second order function of a spatial organization parameter defining the spatial organization of the scatterers; and estimating the physical property value of the scatterers from the modelled ultrasound data and the at least one known physical parameter of the sub-units by a regression of the spatial organization parameter as a function of frequency. A system for characterizing ultrasound scatterers is also included.
摘要翻译：一种用于表征介质中的超声波散射体的方法，包括提供表示在介质中包括多个散射体的感兴趣区域的超声波数据，所述多个散射体包括散射体子单元的簇，所述散射体具有要估计的物理属性值，具有至少一个已知物理参数值的散射体子单元; 使用定义散射体的空间组织的空间组织参数的至少二阶函数对超声数据建模; 以及通过作为频率的函数的空间组织参数的回归，从建模的超声数据和子单元的至少一个已知物理参数估计散射体的物理属性值。还包括用于表征超声波散射体的系统。

7. 发明申请

WO2008050072A3 METHOD FOR GENERATING MECHANICAL WAVES BY CREATING AN INTERFACIAL ACOUSTIC RADIATION FORCE 审中-公开
标题翻译：通过创建接口声辐射力产生机械波的方法
公开(公告)号：WO2008050072A3
公开(公告)日：2008-06-19
申请号：PCT/FR2007052247
申请日：2007-10-25
申请人： SUPER SONIC IMAGINE , PERNOT MATHIEU , SAVERY DAVID , BERCOFF JEREMY , COHEN-BACRIE CLAUDE
发明人： PERNOT MATHIEU , SAVERY DAVID , BERCOFF JEREMY , COHEN-BACRIE CLAUDE
IPC分类号： G10K11/30
CPC分类号： G10K11/30
摘要： The present invention relates to a method for generating mechanical waves in a viscous-elastic medium (11), that comprises the step of generating an acoustic radiation force (15) in the viscous-elastic medium (11) by the application of acoustic waves focused on an interface (13) separating two areas (11, 14) having different acoustic properties.
摘要翻译：本发明涉及一种用于在粘性弹性介质（11）中产生机械波的方法，该方法包括通过施加聚焦的声波在粘性弹性介质（11）中产生声辐射力（15）的步骤在分离具有不同声学特性的两个区域（11,14）的界面（13）上。

8. 发明申请

WO2008038182A2 DETERMINATION OF OPTICAL ABSORPTION COEFFICIENTS 审中-公开
标题翻译：光学吸收系数的测定
公开(公告)号：WO2008038182A2
公开(公告)日：2008-04-03
申请号：PCT/IB2007053763
申请日：2007-09-18
申请人： KONINKL PHILIPS ELECTRONICS NV , SAVERY DAVID , JANKOVIC LADISLAV , ANAND AJAY
发明人： SAVERY DAVID , JANKOVIC LADISLAV , ANAND AJAY
IPC分类号： G01N29/24 , A61B5/00 , G01N21/17 , G01N21/47
CPC分类号： G01N29/2418 , A61B5/0059 , A61B5/0095 , A61B8/08 , G01N21/1702 , G01N21/4795 , G01N2021/1706 , G01N2291/02466 , G01N2291/02475
摘要： The invention relates to an examination apparatus and a method for the determination of optical coefficients, particularly of the optical absorption coefficient (µa) in an object (1) like the body of a patient. The apparatus comprises an ultrasonic scanner (20) for recording first and second pulse echoes before and after the object (1) has been illuminated with a heating light beam (11) from a (e.g. laser) light source (10). An evaluation unit (30) determines a map of temperature increase (?T(r)) caused by the heating light beam (11) inside the object (1) based on apparent displacements showing up between the second and first pulse echoes. Furthermore, the evaluation of locally adjacent temperature increases inside the object (1) allows to determine a map of the effective scattering coefficient (µeff(r)), from which the distribution of light intensity (I(r)) inside the object (1) can be calculated. Finally, the desired optical absorption coefficient (µa) at a measuring location (r) can be determined from the light intensity and the temperature increase at this location.
摘要翻译：本发明涉及一种用于确定像患者身体的物体（1）中的光学系数，特别是光学吸收系数（μa）的检查装置和方法。该装置包括用于在来自（例如激光）光源（10）的加热光束（11）照射物体（1）之前和之后记录第一和第二脉冲回波的超声波扫描器（20）。评估单元（30）基于在第二和第一脉冲回波之间显示的表观位移来确定由对象（1）内部的加热光束（11）引起的温度升高（ΔT（r））的映射。此外，物体（1）内的局部相邻温度升高的评估允许确定物体（1）内的光强度（I（r））的分布的有效散射系数（μeff（r））的映射）可以计算。最后，测量位置（r）所需的光学吸收系数（μa）可以从光强度和该位置的温度升高来确定。

9. 发明申请

WO2008038182A3 ULTRASONIC DETERMINATION OF OPTICAL ABSORPTION COEFFICIENTS 审中-公开
公开(公告)号：WO2008038182A3
公开(公告)日：2008-04-03
申请号：PCT/IB2007/053763
申请日：2007-09-18
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , SAVERY, David , JANKOVIC, Ladislav , ANAND, Ajay
发明人： SAVERY, David , JANKOVIC, Ladislav , ANAND, Ajay
IPC分类号： G01N29/24 , A61B5/00 , G01N21/17 , G01N21/47
摘要： The invention relates to an examination apparatus and a method for the determination of optical coefficients, particularly of the optical absorption coefficient (μa) in an object (1) like the body of a patient. The apparatus comprises an ultrasonic scanner (20) for recording first and second pulse echoes before and after the object (1) has been illuminated with a heating light beam (11) from a (e.g. laser) light source (10). An evaluation unit (30) determines a map of temperature increase (ΔT(r)) caused by the heating light beam (11) inside the object (1) based on apparent displacements showing up between the second and first pulse echoes. Furthermore, the evaluation of locally adjacent temperature increases inside the object (1) allows to determine a map of the effective scattering coefficient (μeff(r)), from which the distribution of light intensity (I(r)) inside the object (1) can be calculated. Finally, the desired optical absorption coefficient (μa) at a measuring location (r) can be determined from the light intensity and the temperature increase at this location.

10. 发明申请

WO2006087649A1 METHOD AND APPARATUS FOR THE VISUALIZATION OF THE FOCUS GENERATED USING FOCUSED ULTRASOUND 审中-公开
标题翻译：使用聚焦超声波生成聚焦的方法和装置
公开(公告)号：WO2006087649A1
公开(公告)日：2006-08-24
申请号：PCT/IB2006/050382
申请日：2006-02-06
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , HALL, Christopher , SOKKA, Shunmugavelu , SAVERY, David, L.M. , CHIN, Chien, T. , AVERKIOU, Michalakis
发明人： HALL, Christopher , SOKKA, Shunmugavelu , SAVERY, David, L.M. , CHIN, Chien, T. , AVERKIOU, Michalakis
IPC分类号： A61N7/02
CPC分类号： A61N7/02 , A61B17/22029 , A61B17/2256 , A61B2090/378
摘要： The present invention relates to monitoring the focus of a therapeutic transducer in an interactive real-time manner by turning off the ultrasound transmits of the imaging transducer but continuing to receive in all directions with an imaging probe in order to identify the therapeutic beam focus. The therapeutic focused beam acts as the only transmit and as long as there is a scatterer at the focus, a strong receive signal will be generated to identify the focus.
摘要翻译：本发明涉及通过关闭成像换能器的超声波传感器而以成像探针在所有方向继续接收以便识别治疗束聚焦来以交互式实时方式来监测治疗换能器的焦点。治疗聚焦光束作为唯一的传输，并且只要在聚焦处存在散射体，将产生强接收信号以识别焦点。

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