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1. 发明专利

CA2185568C CHLAMYDIA VACCINES AND PROCESS 未知
公开(公告)号：CA2185568C
公开(公告)日：2001-07-03
申请号：CA2185568
申请日：1995-02-28
申请人： MACDONALD ALEX BRUCE , WHITTUM-HUDSON JUDITH A , SALTZMAN WILLIAM MARK
发明人： MACDONALD ALEX BRUCE , WHITTUM-HUDSON JUDITH A , SALTZMAN WILLIAM MARK
IPC分类号： A61K38/00 , A61K39/00 , C07K16/42 , A61K39/395 , A61K39/40
摘要： A genus specific chlamydia oral or injectable vaccine is provided which comp rises an anti-idiotype antibody capable of producing in an animal an anti-idiotypic antibody or Fab fragment thereof enclosed in mic rospheres formed of a pharmacologically acceptable polym er is capable of producing in an animal an anti-anti-iodotypic immune response (serum antibody, secretory antibody or T-cell responsee) which recognizes a glycolipid exoantigen (GLXA) of chlamydia. The oral or injectab le vaccine is produced from an idiotypic antibody to GLX A which, in turn, is utilized to produce the anti-idiotypic antibody.

2. 发明专利

CA2185568A1 CHLAMYDIA VACCINES AND PROCESS 未知
公开(公告)号：CA2185568A1
公开(公告)日：1995-09-21
申请号：CA2185568
申请日：1995-02-28
申请人： MACDONALD ALEX BRUCE , WHITTUM HUDSON JUDITH A , SALTZMAN WILLIAM MARK
发明人： MACDONALD ALEX BRUCE , WHITTUM-HUDSON JUDITH A , SALTZMAN WILLIAM MARK
IPC分类号： A61K38/00 , A61K39/00 , C07K16/42 , A61K39/395 , A61K39/40
摘要： A genus specific chlamydia oral or injectable vaccine is provided which comp rises an anti-idiotype antibody capable of producing in an animal an anti-idiotypic antibody or Fab fragment thereof enclosed in mic rospheres formed of a pharmacologically acceptable polym er is capable of producing in an animal an anti-anti-iodotypic immune response (serum antibody, secretory antibody or T-cell responsee) which recognizes a glycolipid exoantigen (GLXA) of chlamydia. The oral or injectab le vaccine is produced from an idiotypic antibody to GLX A which, in turn, is utilized to produce the anti-idiotypic antibody.

3. 发明申请

WO2006080951A8 TARGETED AND HIGH DENSITY DRUG LOADED POLYMERIC MATERIALS 审中-公开
标题翻译：目标和高密度药物负载聚合材料
公开(公告)号：WO2006080951A8
公开(公告)日：2008-08-14
申请号：PCT/US2005023444
申请日：2005-06-30
申请人： UNIV YALE , SALTZMAN WILLIAM MARK , FAHMY TAREK , FONG PETER
发明人： SALTZMAN WILLIAM MARK , FAHMY TAREK , FONG PETER
IPC分类号： A61K9/14 , A61K9/50
CPC分类号： A61K39/39 , A61K9/0019 , A61K9/0048 , A61K9/1641 , A61K9/1647 , A61K9/167 , A61K9/5153 , A61K9/5192 , A61K47/6937 , A61K2039/542 , A61K2039/55555 , A61K2039/6087 , Y10S977/773
摘要： Polymeric delivery devices have been developed which combine high loading/high density of molecules to be delivered with the option of targeting. As used herein, "high density" refers to microparticles having a high density of ligands or coupling agents, which is in the range of 1000-10,000,000, more peferably between 10,000 and 1,000,000 ligands per square micron of microparticle surface area. A general method for incorporating molecules into the surface of biocompatible polymers using materials with an HLB of less than 10, more preferably less than 5, such as fatty acids, has been developed. Because of its ease, generality and flexibility, this method has widespread utility in modifying the surface of polymeric materials for applications in drug delivery and tissue engineering, as well other fields. Targeted polymeric microparticles have also been developed which encapsulate therapeutic compounds such as drugs, cellular materials or components, and antigens, and have targeting ligands directly bound to the microparticle surface. Preferred applications include use in tissue engineering matrices, wound dressings, bone repair or regeneration materials, and other applications where the microparticles are retained at the site of application or implantation. Another preferred application is in the use of microparticles to deliver anti-proliferation agents to the lining of blood vessels following angioplasty, transplantation or bypass surgery to prevent or decrease restenosis, and in cancer therapy. In still another application, the microparticles are used to treat or prevent macular degeneration when administered to the eye, where agents such as complement inhibitors are administered.
摘要翻译：已经开发了聚合物递送装置，其结合了高载体/高密度的待分配的分子与靶向选择。如本文所用，“高密度”是指具有高密度配体或偶联剂的微粒，其在1000-10000,000范围内，更优选在10,000至1,000,000个配体/平方微米的微粒表面积之间。已经开发了使用HLB小于10，更优选小于5的材料如脂肪酸将分子掺入生物相容性聚合物的表面的一般方法。由于其易于，通用性和灵活性，该方法在改性聚合材料表面的广泛用途中用于药物递送和组织工程等领域。还已经开发了靶向的聚合物微粒，其包封诸如药物，细胞材料或组分和抗原的治疗化合物，并且具有直接结合到微粒表面的靶向配体。优选的应用包括用于组织工程基质，伤口敷料，骨修复或再生材料以及微粒保留在施用或植入部位的其它应用。另一个优选的应用是在血管成形术，移植或旁路手术之后使用微粒将抗增殖剂递送到血管的衬里以预防或减少再狭窄以及在癌症治疗中。在另一个应用中，当施用于眼睛时，微粒用于治疗或预防黄斑变性，其中施用诸如补体抑制剂的药剂。

4. 发明申请

WO1995024922A1 CHLAMYDIA VACCINES AND PROCESS 审中-公开
标题翻译： CHLAMYDIA疫苗和过程
公开(公告)号：WO1995024922A1
公开(公告)日：1995-09-21
申请号：PCT/US1995002459
申请日：1995-02-28
申请人： MacDONALD, Alex, Bruce , WHITTUM-HUDSON, Judith, A. , SALTZMAN, William, Mark
IPC分类号： A61K39/00
CPC分类号： C07K16/4233 , A61K38/00 , A61K39/00
摘要： A genus specific chlamydia oral or injectable vaccine is provided which comprises an anti-idiotype antibody capable of producing in an animal an anti-idiotypic antibody or Fab fragment thereof enclosed in microspheres formed of a pharmacologically acceptable polymer is capable of producing in an animal an anti-anti-idiotypic immune response (serum antibody, secretory antibody or T-cell responsee) which recognizes a glycolipid exoantigen (GLXA) of chlamydia. The oral or injectable vaccine is produced from an idiotypic antibody to GLXA which, in turn, is utilized to produce the anti-idiotypic antibody.
摘要翻译：提供一种特异性衣原体口服或注射疫苗，其包含能够在动物体内产生抗独特型抗体或包封在由药理学上可接受的聚合物形成的微球中的Fab片段的抗独特型抗体，其能够在动物体内产生抗独特型抗体 - 独特型免疫应答（血清抗体，分泌抗体或T细胞应答），其识别衣原体的糖脂外源抗原（GLXA）。口服或注射疫苗由GLXA的独特型抗体产生，其又用于产生抗独特型抗体。

5. 发明申请

WO2006080951A3 TARGETED AND HIGH DENSITY DRUG LOADED POLYMERIC MATERIALS 审中-公开
标题翻译：目标和高密度药物负载聚合材料
公开(公告)号：WO2006080951A3
公开(公告)日：2007-12-27
申请号：PCT/US2005023444
申请日：2005-06-30
申请人： UNIV YALE , SALTZMAN WILLIAM MARK , FAHMY TAREK , FONG PETER
发明人： SALTZMAN WILLIAM MARK , FAHMY TAREK , FONG PETER
IPC分类号： A61K9/14 , A61K9/50
CPC分类号： A61K39/39 , A61K9/0019 , A61K9/0048 , A61K9/1641 , A61K9/1647 , A61K9/167 , A61K9/5153 , A61K9/5192 , A61K47/6937 , A61K2039/542 , A61K2039/55555 , A61K2039/6087 , Y10S977/773
摘要： Polymeric delivery devices have been developed which combine high loading/high density of molecules to be delivered with the option of targeting. As used herein, "high density" refers to microparticles having a high density of ligands or coupling agents, which is in the range of 1000-10,000,000, more peferably between 10,000 and 1,000,000 ligands per square micron of microparticle surface area. A general method for incorporating molecules into the surface of biocompatible polymers using materials with an HLB of less than 10, more preferably less than 5, such as fatty acids, has been developed. Because of its ease, generality and flexibility, this method has widespread utility in modifying the surface of polymeric materials for applications in drug delivery and tissue engineering, as well other fields. Targeted polymeric microparticles have also been developed which encapsulate therapeutic compounds such as drugs, cellular materials or components, and antigens, and have targeting ligands directly bound to the microparticle surface. Preferred applications include use in tissue engineering matrices, wound dressings, bone repair or regeneration materials, and other applications where the microparticles are retained at the site of application or implantation. Another preferred application is in the use of microparticles to deliver anti-proliferation agents to the lining of blood vessels following angioplasty, transplantation or bypass surgery to prevent or decrease restenosis, and in cancer therapy. In still another application, the microparticles are used to treat or prevent macular degeneration when administered to the eye, where agents such as complement inhibitors are administered.
摘要翻译：已经开发了聚合物递送装置，其将高载体/高密度的待分配的分子与靶向选择相结合。如本文所用，“高密度”是指具有高密度配体或偶联剂的微粒，其在1000-10000,000范围内，更优选在10,000至1,000,000个配体/平方微米的微粒表面积之间。已经开发了使用HLB小于10，更优选小于5的材料如脂肪酸将分子掺入生物相容性聚合物的表面的一般方法。由于其易于通用性和灵活性，该方法在改性聚合物材料的表面上具有广泛的用途，用于药物递送和组织工程以及其他领域的应用。还开发了靶向的聚合物微粒，其包封诸如药物，细胞材料或组分和抗原的治疗化合物，并且具有直接结合到微粒表面的靶向配体。优选的应用包括用于组织工程基质，伤口敷料，骨修复或再生材料以及微粒保留在施用或植入部位的其它应用。另一个优选的应用是在血管成形术，移植或旁路手术之后使用微粒将抗增殖剂递送到血管的衬里以预防或减少再狭窄以及在癌症治疗中。在另一个应用中，当施用于眼睛时，微粒用于治疗或预防黄斑变性，其中施用诸如补体抑制剂的药剂。

6. 发明申请

WO2011053989A3 PROCESS OF TRANSFECTION OF MUTAGENIC AND RECOMBINANT NUCLEIC ACIDS TO CELLS BY POLYMERIC MATERIALS LOADED THEREWITH 审中-公开
标题翻译：通过加载聚合物将MUTAGENIC和重组核酸转移到细胞的过程
公开(公告)号：WO2011053989A3
公开(公告)日：2012-03-01
申请号：PCT/US2010055142
申请日：2010-11-02
申请人： UNIV YALE , SALTZMAN WILLIAM MARK , GLAZER PETER M , CHIN JOANNA , MCNEER NICOLE
发明人： SALTZMAN WILLIAM MARK , GLAZER PETER M , CHIN JOANNA , MCNEER NICOLE
IPC分类号： A61K9/16 , A61K9/00 , A61K9/50 , A61K9/51 , A61K47/00 , C12N15/00
CPC分类号： C12N15/88 , A61K9/0019 , A61K9/1647 , A61K9/19
摘要： Polymeric rnicroparticles are used to deliver recombinagenic or mutagenic nucleic acid molecules such as donor nucleic acid alone, or in combination with triplex forming molecules, to induce a site-specific mutation in the target DNA. Target cells endocytose the particles, releasing the nucleic acid molecules inside of the cell, where they induce mutagenesis or recombination at a target site. The examples demonstrate that triplex forming oligonucleotides, preferably PNAs, preferably in combination with a donor nucleotide molecule, can be encapsulated into polymeric microparticles, which are delivered into cells. Results demonstrate significantly greatly levels of uptake and expression, and less cytotoxicity, as compared to direct transfer of the nucleic acid molecules into the cell by nucleofection.
摘要翻译：聚合物颗粒用于递送重组或诱变核酸分子，例如单独的供体核酸，或与形成三链体的分子组合，以在靶DNA中诱导位点特异性突变。靶细胞吞噬颗粒，释放细胞内的核酸分子，在靶区域诱导诱变或重组。这些实施例表明，三重形成寡核苷酸，优选PNA，优选与供体核苷酸分子组合，可以被包封到聚合物微粒中，其被递送到细胞中。与通过核转染将核酸分子直接转移到细胞中相比，结果显示出显着的摄取和表达水平以及更少的细胞毒性。

7. 发明申请

WO2011053989A2 POLYMERIC MATERIALS LOADED WITH MUTAGENIC AND RECOMBINAGENIC NUCLEIC ACIDS 审中-公开
标题翻译：用MUTAGENIC和重组生物核酸装载的聚合材料
公开(公告)号：WO2011053989A2
公开(公告)日：2011-05-05
申请号：PCT/US2010/055142
申请日：2010-11-02
申请人： YALE UNIVERSITY , SALTZMAN, William, Mark , GLAZER, Peter, M. , CHIN, Joanna , McNEER, Nicole
发明人： SALTZMAN, William, Mark , GLAZER, Peter, M. , CHIN, Joanna , McNEER, Nicole
IPC分类号： A61K48/00
CPC分类号： C12N15/88 , A61K9/0019 , A61K9/1647 , A61K9/19
摘要： Polymeric rnicroparticles are used to deliver recombinagenic or mutagenic nucleic acid molecules such as donor nucleic acid alone, or in combination with triplex forming molecules, to induce a site-specific mutation in the target DNA. Target cells endocytose the particles, releasing the nucleic acid molecules inside of the cell, where they induce mutagenesis or recombination at a target site. The examples demonstrate that triplex forming oligonucleotides, preferably PNAs, preferably in combination with a donor nucleotide molecule, can be encapsulated into polymeric microparticles, which are delivered into cells. Results demonstrate significantly greatly levels of uptake and expression, and less cytotoxicity, as compared to direct transfer of the nucleic acid molecules into the cell by nucleofection.
摘要翻译：聚合物颗粒用于递送重组或诱变核酸分子，例如单独的供体核酸，或与形成三链体的分子组合，以在靶DNA中诱导位点特异性突变。靶细胞吞噬颗粒，释放细胞内的核酸分子，在靶区域诱导诱变或重组。这些实施例表明，三重形成寡核苷酸，优选PNA，优选与供体核苷酸分子组合，可以被包封到聚合物微粒中，其被递送到细胞中。与通过核转染将核酸分子直接转移到细胞中相比，结果显示出显着的摄取和表达水平以及更少的细胞毒性。

8. 发明申请

WO2006080951A2 TARGETED AND HIGH DENSITY DRUG LOADED POLYMERIC MATERIALS 审中-公开
标题翻译：目标和高密度药物负载聚合材料
公开(公告)号：WO2006080951A2
公开(公告)日：2006-08-03
申请号：PCT/US2005/023444
申请日：2005-06-30
申请人： YALE UNIVERSITY , SALTZMAN, William, Mark , FAHMY, Tarek , FONG, Peter
发明人： SALTZMAN, William, Mark , FAHMY, Tarek , FONG, Peter
IPC分类号： A61K38/18 , A61F2/00 , A61K9/14
CPC分类号： A61K39/39 , A61K9/0019 , A61K9/0048 , A61K9/1641 , A61K9/1647 , A61K9/167 , A61K9/5153 , A61K9/5192 , A61K47/6937 , A61K2039/542 , A61K2039/55555 , A61K2039/6087 , Y10S977/773
摘要： Polymeric delivery devices have been developed which combine high loading/high density of molecules to be delivered with the option of targeting. As used herein, “high density” refers to microparticles having a high density of ligands or coupling agents, which is in the range of 1000-10,000,000, more peferably between 10,000 and 1,000,000 ligands per square micron of microparticle surface area. A general method for incorporating molecules into the surface of biocompatible polymers using materials with an HLB of less than 10, more preferably less than 5, such as fatty acids, has been developed. Because of its ease, generality and flexibility, this method has widespread utility in modifying the surface of polymeric materials for applications in drug delivery and tissue engineering, as well other fields. Targeted polymeric microparticles have also been developed which encapsulate therapeutic compounds such as drugs, cellular materials or components, and antigens, and have targeting ligands directly bound to the microparticle surface. Preferred applications include use in tissue engineering matrices, wound dressings, bone repair or regeneration materials, and other applications where the microparticles are retained at the site of application or implantation. Another preferred application is in the use of microparticles to deliver anti-proliferation agents to the lining of blood vessels following angioplasty, transplantation or bypass surgery to prevent or decrease restenosis, and in cancer therapy. In still another application, the microparticles are used to treat or prevent macular degeneration when administered to the eye, where agents such as complement inhibitors are administered.
摘要翻译：已经开发了聚合物递送装置，其结合了高载体/高密度的待分配的分子与靶向选择。如本文所用，“高密度”是指具有高密度配体或偶联剂的微粒，其在1000-10000,000范围内，更优选在10,000至1,000,000个配体/平方微米的微粒表面积之间。已经开发了使用HLB小于10，更优选小于5的材料如脂肪酸将分子掺入生物相容性聚合物的表面的一般方法。由于其易于，通用性和灵活性，该方法在改性聚合材料表面的广泛用途中用于药物递送和组织工程等领域。还已经开发了靶向的聚合物微粒，其包封诸如药物，细胞材料或组分和抗原的治疗化合物，并且具有直接结合到微粒表面的靶向配体。优选的应用包括用于组织工程基质，伤口敷料，骨修复或再生材料以及微粒保留在施用或植入部位的其它应用。另一个优选的应用是在血管成形术，移植或旁路手术之后使用微粒将抗增殖剂递送到血管的衬里以预防或减少再狭窄以及在癌症治疗中。在另一个应用中，当施用于眼睛时，微粒用于治疗或预防黄斑变性，其中施用诸如补体抑制剂的药剂。

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