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2. 发明专利

AU2020206777A1 Porous material with microscale features 未知
公开(公告)号：AU2020206777A1
公开(公告)日：2021-09-02
申请号：AU2020206777
申请日：2020-01-09
申请人： KOFFLER YACOV M , PAWELEC KENDELL M , SAILOR MICHAEL , SAKAMOTO JEFFREY S , UNIV MICHIGAN REGENTS , TUSZYNSKI MARK H , UNIVERSITY OF CALIFORNIA SAN DIEGO , ZUIDEMA JONATHAN
发明人： TUSZYNSKI MARK H , SAKAMOTO JEFFREY S , PAWELEC KENDELL M , KOFFLER YACOV M , SAILOR MICHAEL , ZUIDEMA JONATHAN
IPC分类号： A61L27/56 , B29C59/02 , C08J5/18
摘要： Provided herein is technology relating to materials having microscale and/or nanoscale features and particularly, but not exclusively, to porous materials comprising microscale features, methods for producing porous materials comprising microscale features, drug delivery vehicles, and related kits, systems, and uses.

3. 发明专利

CA3126026A1 POROUS MATERIAL WITH MICROSCALE FEATURES 未知
公开(公告)号：CA3126026A1
公开(公告)日：2020-07-16
申请号：CA3126026
申请日：2020-01-09
申请人： UNIV MICHIGAN REGENTS , UNIV OF CALIFORNIA SAN DIEGO , TUSZYNSKI MARK H , SAKAMOTO JEFFREY S , PAWELEC KENDELL M , KOFFLER YACOV M , SAILOR MICHAEL , ZUIDEMA JONATHAN
发明人： TUSZYNSKI MARK H , SAKAMOTO JEFFREY S , PAWELEC KENDELL M , KOFFLER YACOV M , SAILOR MICHAEL , ZUIDEMA JONATHAN
IPC分类号： B32B3/10 , B29C59/02 , C08J5/18
摘要： Provided herein is technology relating to materials having microscale and/or nanoscale features and particularly, but not exclusively, to porous materials comprising microscale features, methods for producing porous materials comprising microscale features, drug delivery vehicles, and related kits, systems, and uses.

4. 发明申请

WO2012151306A3 ELECTROADSORPTION AND CHARGE BASED BIOMOLECULE SEPARATION AND DETECTION IN POROUS SENSORS 审中-公开
标题翻译：多孔传感器中的电吸收和电荷分离生物分离与检测
公开(公告)号：WO2012151306A3
公开(公告)日：2013-03-28
申请号：PCT/US2012036163
申请日：2012-05-02
申请人： UNIV CALIFORNIA , SAILOR MICHAEL J , CHEN MICHELLE Y
发明人： SAILOR MICHAEL J , CHEN MICHELLE Y
IPC分类号： G01N27/02 , G01N21/45 , G01N35/00
CPC分类号： G01N27/447
摘要： Electroadsorption and charged based biomolecule separation, concentration and detection with porous biosensors. In preferred embodiments, a potential is applied to a porous electrode to separate and concentrate molecules from solution. The bimolecular analytes are captured by the porous electrode itself, the same electrode that is used to generate the electric field for electroadsorption. In additional preferred embodiments, pH of the solution is adjusted to separate and concentrate biomolecules. Setting the pH equal to the protein isoelectric point was determined by the inventors to maximize concentration of biomolecules into the porous biosensor. The methods include simultaneously optically detecting charged molecules captured by the porous electrode. Methods of the invention are benign to biomolecules of interest, which are demonstrated to retain a high percentage of their activity after being released from the biosensor. Methods of the invention provide label-free detection. Advantageously, small voltages and ultrasmall volumes of solution are used in methods of the invention.
摘要翻译：电吸收和带电的生物分子分离，浓度和多孔生物传感器的检测。在优选的实施方案中，将电位施加到多孔电极以从溶液中分离和浓缩分子。双分子分析物被多孔电极本身捕获，这是用于产生电吸附电场的相同电极。在另外的优选实施方案中，调节溶液的pH以分离和浓缩生物分子。通过发明人确定等于蛋白质等电点的pH以使生物分子的浓度最大化到多孔生物传感器中。所述方法包括同时光学检测由多孔电极捕获的带电分子。本发明的方法对于感兴趣的生物分子是良性的，其被证明在从生物传感器释放后保留其高活性百分比。本发明的方法提供无标记检测。有利地，在本发明的方法中使用小电压和超小体积的溶液。

5. 发明申请

WO2010008876A3 METHOD FOR PREPARATION OF MICELLAR HYBRID NANOPARTICLES FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS AND COMPOSITIONS THEREOF 审中-公开
标题翻译：制备用于治疗和诊断应用的胶束杂合纳米颗粒的方法及其组合物
公开(公告)号：WO2010008876A3
公开(公告)日：2010-05-14
申请号：PCT/US2009048404
申请日：2009-06-24
申请人： UNIV CALIFORNIA , MASSACHUSETTS INST TECHNOLOGY , SAILOR MICHAEL J , BHATIA SANGEETA N , ROUSLAHTI ERKKI , PARK JI-HO , VON MALTZAHN GEOFFREY A
发明人： SAILOR MICHAEL J , BHATIA SANGEETA N , ROUSLAHTI ERKKI , PARK JI-HO , VON MALTZAHN GEOFFREY A
IPC分类号： A61K9/127 , A61K49/06 , A61P35/00
CPC分类号： A61K9/1271 , A61K49/0002 , A61K49/0019 , A61K49/0067 , A61K49/0082 , A61K49/1806 , A61K49/1839 , A61K49/1887
摘要： The disclosure provides a long-circulating, micellar hybrid nanoparticles (MHN) that contain MN, QD, and the anti-cancer drug doxorubicin (DOX) within a single polyethylene glycol (PEG) -phospholipid micelle and provide the first examples of simultaneous targeted drug delivery and dual-mode NIR- fluorescent and MR imaging of diseased tissue in vitro and in vivo.
摘要翻译：本公开提供了在单一聚乙二醇（PEG） - 磷脂胶束内含有MN，QD和抗癌药物多柔比星（DOX）的长循环，胶束混合纳米颗粒（MHN），并提供了同时靶向药物的第一实例在体外和体内递送和双模NIR荧光和病变组织的MR成像。

6. 发明申请

WO2008027090A2 CONTROL OF MATERIALS AND POROUS MAGNETIC PARTICLES 审中-公开
标题翻译：材料和多孔磁性颗粒的控制
公开(公告)号：WO2008027090A2
公开(公告)日：2008-03-06
申请号：PCT/US2007011727
申请日：2007-05-16
申请人： UNIV CALIFORNIA , SAILOR MICHAEL J , PARK JI-HO , DERFUS AUSTIN M , SEGAL ESTER , VECCHIO KENNETH S , BHATIA SANGEETA N
发明人： SAILOR MICHAEL J , PARK JI-HO , DERFUS AUSTIN M , SEGAL ESTER , VECCHIO KENNETH S , BHATIA SANGEETA N
IPC分类号： H01J37/02
CPC分类号： H01F1/0063 , B01J2219/00466 , B01J2219/00495 , B01J2219/005 , B01J2219/00502 , B01J2219/00563 , B01J2219/00576 , B01L3/502761 , B01L3/502792 , B01L7/52 , B01L2300/0896 , B01L2300/1816 , B01L2400/0415 , B01L2400/043 , B82Y25/00 , B82Y30/00
摘要： The present invention uses externally applied electromagnetic stimulus to control and heat porous magnetic particles and material associated with the particles. The particles contain magnetic material, such as superparamagnetic iron oxide and are associated with a material. Application of a DC magnetic field allows them to be moved with their associated material, and application of an AC RF electromagnetic field allows them to be heated with their associated material. The material can be associated with the particles by being contained in the pores of the particles, or in other cases the particles can adhere to the associated material, which can be an aqueous droplet. The present invention also provides a multi-layer porous magnetic particle. The particle includes a host layer having pores sized to accept magnetic nanoparticles. Magnetic nanoparticles are infused within pores of the host layer. An encoding layer includes pores that define a spectral code. The pores in the encoding layer are sized to substantially exclude the magnetic nanoparticles. The encoding layer can also be a multi-layer, exhibiting, for example, a complex spectral code.
摘要翻译：本发明使用外部施加的电磁刺激来控制和加热与颗粒相关联的多孔磁性颗粒和材料。颗粒含有磁性材料，例如超顺磁性氧化铁，并与材料相关联。 DC磁场的应用允许它们与其相关材料一起移动，并且AC RF电磁场的应用允许它们与其相关材料一起被加热。该材料可以通过包含在颗粒的孔中与颗粒相关联，或者在其它情况下，颗粒可以附着到可以是水性液滴的相关材料上。本发明还提供一种多层多孔磁性颗粒。颗粒包括具有尺寸以接受磁性纳米颗粒的孔的主体层。磁性纳米颗粒注入主体层的孔内。编码层包括限定光谱代码的孔。编码层中的孔的大小被确定为基本排除磁性纳米颗粒。编码层也可以是多层，表现出例如复谱谱。

7. 发明申请

WO2007008211A3 MAGNETIC POROUS PHOTONIC CRYSTAL PARTICLES AND METHOD OF MAKING 审中-公开
标题翻译：磁性多孔光子晶体颗粒及其制备方法
公开(公告)号：WO2007008211A3
公开(公告)日：2007-05-31
申请号：PCT/US2005025383
申请日：2005-07-18
申请人： UNIV CALIFORNIA , SAILOR MICHAEL J , LI YANGYANG , TRUJILLO NATHAN , DORVEE JASON
发明人： SAILOR MICHAEL J , LI YANGYANG , TRUJILLO NATHAN , DORVEE JASON
IPC分类号： H01L21/00 , B28B19/00 , H01F1/06 , H01F7/00 , H01F10/00 , H01F13/00
CPC分类号： G01N21/31 , B22F1/0003 , B22F1/025 , B22F2998/10 , B82Y20/00 , G02B6/1225 , G02B26/004 , G02F1/09 , H01F1/0063 , Y10S977/838 , Y10S977/96 , Y10S977/962 , Y10T428/29 , Y10T428/2982 , Y10T428/2991 , Y10T428/31 , Y10T428/32 , B22F3/114 , B22F9/04
摘要： The invention produces porous particles that produce a predetermined optical response and that may be manipulated magnetically. A preferred particle of the invention has a porous structure (12) that produces a predetermined optical response and magnetic material (14) adhered to the particle. Another preferred particle is amphiphilic. The optical response provided by a particle of the invention enables particles of the invention to be used in sensing, labeling, signaling, display and many other applications. The magnetic nature of the present magnetic particles permits the particles themselves to be manipulated, e.g., vibrated, moved, and re-oriented. The porous particles can also be used to control, move, and/or deliver small volumes of liquids and solids associated with the particles.
摘要翻译：本发明产生产生预定光学响应且可以磁性操作的多孔颗粒。本发明的优选颗粒具有产生预定光学响应的多孔结构（12）和粘附到颗粒上的磁性材料（14）。另一个优选的颗粒是两亲性的。由本发明的颗粒提供的光学响应使得本发明的颗粒可用于感测，标记，信号传递，显示和许多其它应用。本磁性颗粒的磁性使颗粒本身受到操纵，例如振动，移动和重新取向。多孔颗粒也可用于控制，移动和/或传送与颗粒相关的小体积的液体和固体。

8. 发明申请

WO2005062866A2 OPTICALLY ENCODED PARTICLES, SYSTEM AND HIGH-THROUGHPUT SCREENING 审中-公开
标题翻译：光学编码的颗粒，系统和高通量筛选
公开(公告)号：WO2005062866A2
公开(公告)日：2005-07-14
申请号：PCT/US2004/043001
申请日：2004-12-21
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , SAILOR, Michael, J. , MEADE, Shawn, O.
发明人： SAILOR, Michael, J. , MEADE, Shawn, O.
CPC分类号： C40B20/08 , B01J19/0046 , B01J2219/00497 , B01J2219/005 , B01J2219/0054 , B01J2219/00547 , B01J2219/00554 , B01J2219/0056 , B01J2219/00565 , B01J2219/00576 , B01J2219/00596 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B82Y20/00 , C40B20/04 , C40B30/04 , C40B40/06 , C40B40/10 , C40B40/12 , C40B40/18 , C40B50/14 , C40B70/00
摘要： The invention concerns a particle (10, 10a) having a code from a library of codes embedded in its physical structure by refractive index changes between different regions of the particle. In preferred embodiments, a thin film possesses porosity that varies in a manner to produce a code detectable in the reflectivity spectrum. An assay detection method uses such a particle and detects a spectral shift in the presence of an analyte. Additional embodiments are disclosed including additional features.
摘要翻译：本发明涉及一种具有通过嵌入其物理结构中的代码库的代码的粒子（10,10a），其通过颗粒的不同区域之间的折射率变化。在优选实施例中，薄膜具有以产生在反射率谱中可检测的代码的方式变化的孔隙率。测定检测方法使用这样的颗粒并在存在分析物的情况下检测光谱偏移。公开了另外的实施例，其包括附加特征。

9. 发明申请

WO2012149312A1 TIME-GATED FLUORESCENCE IMAGING WITH SI-CONTAINING PARTICLES 审中-公开
标题翻译：具有含SI颗粒的时域荧光成像
公开(公告)号：WO2012149312A1
公开(公告)日：2012-11-01
申请号：PCT/US2012/035447
申请日：2012-04-27
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , SAILOR, Michael, J. , GU, Luo , HALL, David, J. , MATTREY, Robert
发明人： SAILOR, Michael, J. , GU, Luo , HALL, David, J. , MATTREY, Robert
IPC分类号： G01N21/64 , G01N33/52
CPC分类号： A61K49/0021 , A61B5/0071 , G01N21/6408 , G01N21/6456 , G01N21/6489 , G01N33/54346 , G01N2021/6432
摘要： A method for imaging leverages the fluorescence lifetime of a fluorescent Si -containing particle to distinguish from background fluorescence. A particle is introduced into tissue. An excitation light pulse is applied to excite luminescence from the fluorescent Si-containing particle. Time-gated measuring of a responsive luminescence signal identifies the particle. In preferred embodiments the particle is coated or encapsulated with an organic material. The fluorescence lifetime of particles can be controlled during manufacture, such as by oxidation levels, quenching treatments, or by aging. This permits introducing and using groups of particles in imaging that have unique lifetimes and multiple time gating can be used to identify different particles or to monitor the change in lifetime of a single set of particles as they respond to a biochemical stimulus. The particles can also be functionalized for affinity to particular tissues and can be loaded with treatment molecules.
摘要翻译：用于成像的方法利用含荧光Si的颗粒的荧光寿命来区分背景荧光。将颗粒引入组织。施加激发光脉冲以激发来自荧光含Si颗粒的发光。响应发光信号的时间门控测量识别粒子。在优选的实施方案中，颗粒被涂覆或用有机材料包封。颗粒的荧光寿命可以在制造过程中进行控制，例如通过氧化水平，淬火处理或老化来控制。这允许在成像中引入和使用具有独特寿命的颗粒群，并且可以使用多次浇注来识别不同的颗粒或者在响应于生化刺激时监测单组颗粒的寿命的变化。颗粒也可以被功能化以对特定组织的亲和力并且可以加载治疗分子。

10. 发明申请

WO2008027090A3 CONTROL OF MATERIALS AND POROUS MAGNETIC PARTICLES 审中-公开
公开(公告)号：WO2008027090A3
公开(公告)日：2008-03-06
申请号：PCT/US2007/011727
申请日：2007-05-16
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , SAILOR, Michael, J. , PARK, Ji-Ho , DERFUS, Austin, M. , SEGAL, Ester , VECCHIO, Kenneth, S. , BHATIA, Sangeeta, N.
发明人： SAILOR, Michael, J. , PARK, Ji-Ho , DERFUS, Austin, M. , SEGAL, Ester , VECCHIO, Kenneth, S. , BHATIA, Sangeeta, N.
IPC分类号： H01L21/00 , G01N17/00
摘要： The present invention uses externally applied electromagnetic stimulus to control and heat porous magnetic particles and material associated with the particles. The particles contain magnetic material, such as superparamagnetic iron oxide and are associated with a material. Application of a DC magnetic field allows them to be moved with their associated material, and application of an AC RF electromagnetic field allows them to be heated with their associated material. The material can be associated with the particles by being contained in the pores of the particles, or in other cases the particles can adhere to the associated material, which can be an aqueous droplet. The present invention also provides a multi-layer porous magnetic particle. The particle includes a host layer having pores sized to accept magnetic nanoparticles. Magnetic nanoparticles are infused within pores of the host layer. An encoding layer includes pores that define a spectral code. The pores in the encoding layer are sized to substantially exclude the magnetic nanoparticles. The encoding layer can also be a multi-layer, exhibiting, for example, a complex spectral code.

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