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1. 发明申请

WO2009073611A2 METHOD OF CHARACTERIZING PHASE TRANSFORMATIONS IN SHAPE MEMORY MATERIALS 审中-公开
标题翻译：在形状记忆材料中表征相变的方法
公开(公告)号：WO2009073611A2
公开(公告)日：2009-06-11
申请号：PCT/US2008085144
申请日：2008-12-01
申请人： COOK INC , SABIN CORP , MAGNUSON MARK A , LIU FRANK J
发明人： MAGNUSON MARK A , LIU FRANK J
IPC分类号： G01N25/48
CPC分类号： G01N25/4866
摘要： A method of characterizing phase transformations of a shape memory material specimen entails recording data from the specimen during heating and cooling. The temperature of the specimen is changed in a first direction to a first temperature sufficient to define a first inflection and a second inflection in the data being recorded. The temperature of the specimen is changed in a second direction to a second temperature sufficient to define a third inflection in the data. The third inflection is formed by overlapping primary and secondary sub-inflections. The temperature of the specimen is changed in the first direction to a third temperature sufficient to define the first inflection but not sufficient to define the second inflection. The temperature of the specimen is then changed in the second direction to a fourth temperature sufficient to define the secondary sub-inflection in the data being recorded.
摘要翻译：表征形状记忆材料样本的相变的方法需要在加热和冷却期间从样品记录数据。样本的温度在第一方向上变化到足以限定正在记录的数据中的第一拐点和第二拐点的第一温度。样本的温度在第二方向上变化到足以限定数据中的第三个拐点的第二温度。第三个拐点是通过重叠的次级次级变换形成的。样本的温度在第一方向上变化到足以限定第一拐点但不足以限定第二拐点的第三温度。然后将样品的温度在第二方向上改变到足以限定正在记录的数据中的次级副拐点的第四温度。

2. 发明申请

WO2011031857A3 SUBSTRATE SURFACE MODIFICATION UTILIZING A DENSIFIED FLUID AND A SURFACE MODIFIER 审中-公开
标题翻译：使用致密流体和表面改性剂进行基底表面改性
公开(公告)号：WO2011031857A3
公开(公告)日：2011-09-29
申请号：PCT/US2010048268
申请日：2010-09-09
申请人： SABIN CORP , LIU JIAN-LIN , DEMARS BRUCE J
发明人： LIU JIAN-LIN , DEMARS BRUCE J
IPC分类号： A61L29/14 , A61L29/16
CPC分类号： A61M25/0009 , A61L29/04 , A61L29/085 , A61L29/14 , A61L2400/10
摘要： Described are methods for modifying the surface properties of a polymer substrate by exposing the substrate to a densified fluid and a surface modifying agent. The densified fluid may be densified carbon dioxide and the surface modifying agent may be one which reduces the surface tension of the polymer substrate, for example as incorporated into a medical device such as a catheter.
摘要翻译：描述了通过将基材暴露于致密流体和表面改性剂来改变聚合物基材的表面性质的方法。致密化的流体可以是致密化的二氧化碳，并且表面改性剂可以是降低聚合物基材表面张力的表面改性剂，例如掺入诸如导管的医疗装置中。

3. 发明申请

WO2010059542A1 METHOD OF FORMING REINFORCED TUBING 审中-公开
标题翻译：形成加强管道的方法
公开(公告)号：WO2010059542A1
公开(公告)日：2010-05-27
申请号：PCT/US2009064519
申请日：2009-11-16
申请人： SABIN CORP , DREWES DAVID A JR , BAKER BRETT O
发明人： DREWES DAVID A JR , BAKER BRETT O
IPC分类号： B29C47/02 , A61M25/00 , B29C33/34 , B29C53/38 , B32B15/08 , F16L9/133
CPC分类号： B32B37/00 , A61M25/0012 , A61M25/005 , B05D1/00 , B29C47/00 , B29C47/0026 , B29C53/12 , B29C66/8122 , B29D23/001 , B29K2071/00 , B29K2077/00 , B29L2009/005 , B29L2031/7542 , B32B1/08 , B32B7/12 , B32B27/08 , B32B27/285 , B32B27/32 , B32B27/322 , B32B27/34 , B32B27/40 , B32B2250/24 , B32B2307/412 , B32B2307/714 , B32B2307/736 , B32B2535/00 , F16L11/081 , B29K2827/18
摘要： A method of forming a reinforced tubular medical device in a continuous operation, and a medical device formed by the continuous method. An elongated core capable of movement about a line is provided. An elongated tubular member is formed around a moving length of the core by extruding a coating of a functionalized polymer around the moving core length, applying a reinforcing member to an outer surface of the functionalized polymer coating along the moving length, and extruding a polymeric outer jacket over the functionalized polymer and reinforcing member along the moving length, such that a bond is formed between the functionalized polymer and the polymeric outer jacket. The elongated tubular member is cut to desired length to form the tubular medical device, and the core is removed from the device.
摘要翻译：在连续操作中形成加强管状医疗装置的方法以及通过连续方法形成的医疗装置。提供能够围绕一条线移动的细长芯。通过在功能化芯长度周围挤压官能化聚合物的涂层，沿着移动长度将功能化聚合物涂层的外表面施加加强构件，并且将聚合物外层沿着移动长度夹在官能化聚合物和增强构件上，使得在官能化聚合物和聚合物外护套之间形成结合。将细长管状构件切割成所需长度以形成管状医疗装置，并且将芯从装置移除。

4. 发明申请

WO2005025661A3 CATHETER HAVING AN OVERMOLDED HUB 审中-公开
标题翻译：带有一个扩展HUB的导管
公开(公告)号：WO2005025661A3
公开(公告)日：2005-06-16
申请号：PCT/US2004029484
申请日：2004-09-09
申请人： COOK INC , SABIN CORP , LESSARD DAVID R , EELLS SCOTT E , FRANKLAND GREGORY A , DREWES DAVID A JR
发明人： LESSARD DAVID R , EELLS SCOTT E , FRANKLAND GREGORY A , DREWES DAVID A JR
IPC分类号： A61M25/00 , A61M25/16 , B29C45/14
CPC分类号： A61M25/0009 , A61M25/0028 , A61M25/0032 , A61M25/0097 , A61M25/1036
摘要： Catheters having an overmolded hub are disclosed. The overmolded catheter hubs may include one or more access hubs that are overmolded with an overmold material. The catheter hub may also be formed as a single piece from the overmold material. The overmolded construction can result in a stronger bond between the catheter body and the hub and can provide for access hubs having sufficient clarity for the observation of air bubbles in a contained fluid. The disclosed catheter hubs may also demonstrate improved balloon deflation rates when utilized with a catheter body having a distal balloon.
摘要翻译：公开了具有包覆成型毂的导管。包覆模制的导管毂可以包括一个或多个通过包覆模制材料包覆成型的接入毂。导管毂也可以由包覆模制材料形成为单件。包覆成型结构可以导致导管主体和轮毂之间更强的结合，并且可以提供具有足够清晰度的进入轮毂以观察容纳流体中的气泡。当与具有远端球囊的导管本体一起使用时，公开的导管套管还可以证明改进的球囊收缩率。

5. 发明申请

WO0193787A2 HIGH PRESSURE INJECTION SYRINGE 审中-公开
标题翻译：高压注射器
公开(公告)号：WO0193787A2
公开(公告)日：2001-12-13
申请号：PCT/US0118348
申请日：2001-06-06
申请人： COOK INC , SABIN CORP
发明人： DIXON CHRISTOPHER G , FLAGLE JACOB A , HOFFA ANDREW K , LANE JOSEPH P
IPC分类号： A61B17/88 , A61F2/00 , A61F2/44 , A61F2/46
CPC分类号： A61B17/8827 , A61B17/8822 , A61F2/44 , A61F2/4601 , A61F2310/00353
摘要： A pressure injection syringe (10) with an actuator (100) that includes a plunger (102) for pressurizing viscous fluid material within a chamber (14). The plunger distal tip (112) includes a high pressure seal (110) defined by a seal member (118) within a seal seat (116). The high pressure seal (110) is viscoselective to permit air passage therepast for aspiration, and to prohibit viscous material passage therepast during actuation of the actuator wherein high pressure is applied to the material within the chamber (14). The viscoselective seal (110) may be defined for example by small axial openings (130) in the seal seat (116) that permit aspiration of air therepast during initial plunger insertion into the chamber, but fluid escape is prohibited by the seal member (118) when the seal member is pressed firmly against a collar (126) of the plunger (102) proximally adjacent the seal seat by initial engagement of the seal member with the viscous material, thus completely sealing the chamber (14) at the proximal end thereof.
摘要翻译：一种具有致动器（100）的压力注射器（10），其包括用于对腔室（14）内的粘性流体材料进行加压的柱塞（102）。柱塞远端尖端（112）包括由密封座（116）内的密封构件（118）限定的高压密封（110）。高压密封件（110）是粘性选择性的，以允许空气通过其吸入，并且在致动器期间禁止粘性材料通过，其中高压被施加到腔室（14）内的材料。粘性选择性密封件（110）可以例如通过密封座（116）中的小轴向开口（130）来限定，其允许在初始柱塞插入室期间吸入空气，但密封构件（118）禁止流体逸出）当密封构件通过密封构件与粘性材料的初始接合将密封构件紧紧地压靠在靠近密封座的凸柱（102）的套环（126）上时，从而在其近端处完全密封腔室（14）。

6. 发明申请

WO2011031827A3 MANUFACTURE OF EXTRACELLULAR MATRIX PRODUCTS USING SUPERCRITICAL OR NEAR SUPERCRITICAL FLUIDS 审中-公开
标题翻译：用超临界或近超临界流体制备细胞外基质产品
公开(公告)号：WO2011031827A3
公开(公告)日：2011-06-03
申请号：PCT/US2010048223
申请日：2010-09-09
申请人： COOK BIOTECH INC , SABIN CORP , LIU JIAN-LIN , DEMARS BRUCE J , SHAH BHAVIN
发明人： LIU JIAN-LIN , DEMARS BRUCE J , SHAH BHAVIN
IPC分类号： A61L27/36
CPC分类号： A61L27/50 , A61L27/3633 , A61L27/3683 , A61L2430/40
摘要： Described are methods for preparing extracellular matrix materials using treatment with a fluid under conditions at which the fluid is at least substantially supercritical. Preferred prepared extracellular matrix materials beneficially retain endogenous bioactive molecules and/or beneficial native mechanical properties even after treatment with the fluid. Also described are materials that can be prepared by such methods, and uses of such materials.
摘要翻译：描述了在流体至少基本上超临界的条件下使用流体处理制备细胞外基质材料的方法。优选制备的细胞外基质材料甚至在用流体处理之后有利地保留内源性生物活性分子和/或有益的天然机械性质。还描述了可以通过这些方法制备的材料以及这些材料的用途。

7. 发明申请

WO2011031882A2 METHODS OF MANUFACTURING DRUG-LOADED SUBSTRATES 审中-公开
标题翻译：制造药物载体基质的方法
公开(公告)号：WO2011031882A2
公开(公告)日：2011-03-17
申请号：PCT/US2010048300
申请日：2010-09-09
申请人： SABIN CORP , LIU JIAN-LIN , DEMARS BRUCE J
发明人： LIU JIAN-LIN , DEMARS BRUCE J
IPC分类号： A61L29/14
CPC分类号： A61M25/0009 , A61L29/04 , A61L29/085 , A61L29/14 , A61L2400/10
摘要： Described are methods for modifying a substrate by exposing the substrate to a densified fluid. The substrate may be a polymer or a metal alloy, and the densified fluid may be carbon dioxide. Uses of such substrate modification include impregnation of the substrate with one or more drugs, impregnation of microcellular particles, and formation of microcellular compositions.
摘要翻译：描述了通过将基底暴露于致密化流体来修饰基底的方法。基底可以是聚合物或金属合金，并且致密化的流体可以是二氧化碳。这种基质改性的用途包括用一种或多种药物浸渍底物，浸渍微细胞颗粒和形成微孔组合物。

8. 发明申请

WO2007095040A3 INLINE APPLICATION OF COATINGS 审中-公开
标题翻译：涂料的在线应用
公开(公告)号：WO2007095040A3
公开(公告)日：2007-11-08
申请号：PCT/US2007003310
申请日：2007-02-07
申请人： COOK INC , SABIN CORP , EELLS SCOTT E , LESSARD DAVID R
发明人： EELLS SCOTT E , LESSARD DAVID R
IPC分类号： B05D7/02 , A61L29/00
CPC分类号： B05D7/02 , B05D2254/00 , B05D2254/02 , B29C37/0092 , B29C47/0023 , B29C47/0066 , B29C47/021 , B29C47/065 , B29C47/882 , B29C47/8895 , B29C65/02 , B29C65/16 , B29C65/48 , B29C66/1142 , B29C66/5221 , B29C2035/046 , B29C2035/0827 , B29C2035/1616 , B29C2793/0027 , B29C2793/009 , B29D23/001 , B29K2027/06 , B29K2027/18 , B29K2075/00 , B29K2077/00 , B29K2079/08 , B29K2995/0092 , B29L2023/007 , B29L2031/7542 , C23C26/00 , B29C65/00
摘要： A method of forming a coated medical device is described. A coating may be applied inline to a continuous tubing formed by extrusion, prior to cutting and secondary operations. Thus, inefficient and labor-intensive steps associated with preparing individual tubes for coating may be avoided. The method may include forcing a flowable material through an exit port of an extruder, depositing a coating onto at least a portion of the continuous length of extruded tubing after the tubing is forced through the exit port, cutting the coated tubing to a desired length after depositing the coating, and performing one or more secondary operations on the coated tube at a temperature in the range of from about 15°C to about 375°C.
摘要翻译：描述形成涂覆的医疗装置的方法。在切割和二次操作之前，可以将涂层在线施加到由挤出形成的连续管道上。因此，可以避免与准备用于涂覆的各个管相关的低效和劳动密集的步骤。该方法可以包括迫使可流动材料通过挤出机的出口，在管被强制通过出口之后将涂层沉积在连续长度的挤压管道的至少一部分上，之后将涂覆的管道切割成所需长度沉积涂层，并在约15℃至约375℃的温度范围内对涂覆的管进行一次或多次二次操作。

9. 发明申请

WO2005097239B1 APPARATUS FOR AN IMPROVED HIGH PRESSURE MEDICINAL DISPENSER 审中-公开
标题翻译：用于改进的高压药物分配器的装置
公开(公告)号：WO2005097239B1
公开(公告)日：2005-12-22
申请号：PCT/US2005010036
申请日：2005-03-24
申请人： COOK INC , SABIN CORP , DIXON CHRIS G , PHILHOWER SCOTT , FRANKLAND GREGORY A , BURTON DAVID
发明人： DIXON CHRIS G , PHILHOWER SCOTT , FRANKLAND GREGORY A , BURTON DAVID
IPC分类号： A61B17/00 , A61B17/28 , A61B17/88 , A61F2/46 , A61M5/31 , A61M5/315 , A61M5/48 , B05C17/01
CPC分类号： A61B17/8822 , A61B2017/0042 , A61B2017/2925 , A61M5/31586 , A61M5/484 , A61M2005/3139 , B05C17/0133
摘要： An apparatus for an improved high pressure medicinal dispenser is disclosed. The high pressure dispenser may include a handle (26), a chamber (18), a threaded region, a threaded rod (14), and a knob (20). The high pressure dispenser may have at least one insert-molded component. A threaded insert providing the threaded region may be insert-molded into the handle or the threaded rod may be insert-molded into the knob, or both. The dispenser may have a handle made of hard plastic and overmolded soft rubber material. The dispenser also may have a ribbed knob having at least one longitudinal rectangular cavity. Furthermore, the dispenser may have a chamber that has an interior concave surface and an interior convex surface between the interior cylindrical surface of the chamber and a nozzle. The chamber may have at least one tab or notch dimensioned to engage with at least one corresponding notch or tab on the handle.
摘要翻译：公开了一种用于改进的高压药物分配器的装置。高压分配器可包括手柄（26），室（18），螺纹区域，螺杆（14）和旋钮（20）。高压分配器可具有至少一个插入模制部件。提供螺纹区域的螺纹插入件可以被嵌入模制到手柄中，或者螺纹杆可以被嵌入模制到旋钮中，或两者。分配器可以具有由硬塑料和包覆模制软橡胶材料制成的手柄。分配器还可以具有带有至少一个纵向矩形腔的肋状旋钮。此外，分配器可以具有腔室，该腔室具有内部凹入表面和腔室的内部圆柱形表面与喷嘴之间的内部凸出表面。腔室可具有至少一个突片或凹口，其尺寸被设计成与手柄上的至少一个对应的凹口或凸片接合。

10. 发明专利

AT509266T 未知
公开(公告)号：AT509266T
公开(公告)日：2011-05-15
申请号：AT08856250
申请日：2008-12-01
申请人： COOK INC , SABIN CORP
发明人： MAGNUSON MARK , LIU FRANK
IPC分类号： G01N25/48
摘要： A method of characterizing phase transformations of a shape memory material specimen entails recording data from the specimen during heating and cooling. The temperature of the specimen is changed in a first direction to a first temperature sufficient to define a first inflection and a second inflection in the data being recorded. The temperature of the specimen is changed in a second direction to a second temperature sufficient to define a third inflection in the data. The third inflection is formed by overlapping primary and secondary sub-inflections. The temperature of the specimen is changed in the first direction to a third temperature sufficient to define the first inflection but not sufficient to define the second inflection. The temperature of the specimen is then changed in the second direction to a fourth temperature sufficient to define the secondary sub-inflection in the data being recorded.

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