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1. 发明授权

US09622480B2 Synergistic antimicrobial preparations containing chlorite and hydrogen peroxide 有权
公开(公告)号：US09622480B2
公开(公告)日：2017-04-18
申请号：US14718852
申请日：2015-05-21
申请人： S.K. PHARMACEUTICALS, INC.
发明人： Hampar L. Karagoezian
IPC分类号： A01N59/00 , A61K9/00 , A61K31/728 , A61K33/00 , A61K33/14 , A61K33/22 , A61K33/40 , A61K33/20
CPC分类号： A01N59/00 , A61K9/0014 , A61K9/0048 , A61K31/728 , A61K33/00 , A61K33/14 , A61K33/20 , A61K33/22 , A61K33/40 , A61L12/10 , A61L12/124 , A61K2300/00
摘要： An anti-microbial preservative for use in ophthalmic and dermatologic products. The preservative includes from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Additionally, the preservative does not generate chlorine dioxide within the pH range of 5.0-8.8. Also included are an antimicrobial ophthalmic and dermatologic compositions for direct application onto an eye or skin of a living being including from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Also included are methods for treating dryness of the eyes and skin disorders (e.g., wounds, burns, infections, ulcerations, psoriasis, etc.) and for disinfecting and cleansing contact lenses while in place upon an eye by applying the composition to the eye or to the contact lens.

2. 发明授权

US10010081B2 Synergistic antimicrobial preparations containing chlorite and hydrogen peroxide 有权
公开(公告)号：US10010081B2
公开(公告)日：2018-07-03
申请号：US15454859
申请日：2017-03-09
申请人： S.K. PHARMACEUTICALS, INC.
发明人： Hampar L. Karageozian
IPC分类号： A61K31/728 , A61K33/20 , A61K33/40 , A61K33/22 , A61K9/00 , A61L12/10 , A01N59/00 , A61L12/12 , A61K33/00 , A61K33/14
CPC分类号： A01N59/00 , A61K9/0014 , A61K9/0048 , A61K31/728 , A61K33/00 , A61K33/14 , A61K33/20 , A61K33/22 , A61K33/40 , A61L12/10 , A61L12/124 , A61K2300/00
摘要： An anti-microbial preservative for use in ophthalmic and dermatologic products. The preservative includes from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Additionally, the preservative does not generate chlorine dioxide within the pH range of 5.0-8.8. Also included are an antimicrobial ophthalmic and dermatologic compositions for direct application onto an eye or skin of a living being including from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Also included are methods for treating dryness of the eyes and skin disorders (e.g., wounds, burns, infections, ulcerations, psoriasis, etc.) and for disinfecting and cleansing contact lenses while in place upon an eye by applying the composition to the eye or to the contact lens.

3. 发明申请

US20150056272A1 Synergistic Antimicrobial Preparations Containing Chlorite and Hydrogen Peroxide 审中-公开
标题翻译：含有亚氯酸盐和过氧化氢的协同抗菌制剂
公开(公告)号：US20150056272A1
公开(公告)日：2015-02-26
申请号：US14482894
申请日：2014-09-10
申请人： S.K. Pharmaceuticals, Inc.
发明人： Hampar Karageozian
IPC分类号： A61K33/40 , A61K9/06 , A61K9/127 , A61K47/38 , A61K33/20 , A61K33/14
CPC分类号： A61K33/40 , A01N59/00 , A61K9/0014 , A61K9/0048 , A61K9/06 , A61K9/127 , A61K33/14 , A61K33/20 , A61K47/02 , A61K47/38 , Y10S424/13 , Y10S514/944 , Y10S514/964 , Y10S514/969 , Y10S514/97 , A01N2300/00 , A61K2300/00
摘要： Antimicrobial/pharmaceutical preparations (e.g., solutions, gels, ointments, creams, sustained release preparations, etc.) which comprise chlorite (e.g., a metal salt of a chlorite) in combination with a peroxy compound (e.g., hydrogen peroxide), and methods for using such preparations for disinfection of articles or surfaces (e.g., contact lenses, counter tops, etc.), antisepsis of skin or other body parts, prevention or deterrence of scar formation and/or treatment and prophylaxis of dermal (i.e., skin or mucous membrane) disorders (e.g., wounds, burns, infections, cold sores, ulcerations, psoriasis, acne, or other scar-forming lesions).
摘要翻译：包括亚氯酸盐（例如，亚氯酸盐的金属盐）与过氧化合物（例如，过氧化氢）组合的抗微生物剂/药物制剂（例如溶液，凝胶，软膏，霜剂，缓释制剂等）和方法使用这样的制品来消除物品或表面（例如隐形眼镜，台面等），皮肤或其他身体部位的消毒，防止或阻止瘢痕形成和/或治疗和预防皮肤（即，皮肤或粘膜）疾病（例如伤口，烧伤，感染，感冒，溃疡，牛皮癣，痤疮或其他瘢痕形成病变）。

4. 发明授权

US08784901B2 Synergistic antimicrobial preparations containing chlorite and hydrogen peroxide 有权
标题翻译：含有亚氯酸盐和过氧化氢的协同抗菌制剂
公开(公告)号：US08784901B2
公开(公告)日：2014-07-22
申请号：US14145126
申请日：2013-12-31
申请人： S.K. Pharmaceuticals, Inc.
发明人： Hampar L. Karagoezian
IPC分类号： A61K33/40 , A61K33/20
CPC分类号： A01N59/00 , A61K9/0014 , A61K9/0048 , A61K31/728 , A61K33/00 , A61K33/14 , A61K33/20 , A61K33/22 , A61K33/40 , A61L12/10 , A61L12/124 , A61K2300/00
摘要： An anti-microbial preservative for use in ophthalmic and dermatologic products. The preservative includes from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Additionally, the preservative does not generate chlorine dioxide within the pH range of 5.0-8.8. Also included are an antimicrobial ophthalmic and dermatologic compositions for direct application onto an eye or skin of a living being including from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Also included are methods for treating dryness of the eyes and skin disorders (e.g., wounds, burns, infections, ulcerations, psoriasis, etc.) and for disinfecting and cleansing contact lenses while in place upon an eye by applying the composition to the eye or to the contact lens.
摘要翻译：一种用于眼科和皮肤科产品的抗微生物防腐剂。防腐剂包括约0.005wt。％至约0.20wt。％亚氯酸盐化合物和约0.005重量％％至约0.05wt。％过氧化合物。此外，防腐剂在5.0-8.8的pH范围内不产生二氧化氯。还包括用于直接施用于生物的眼睛或皮肤的抗微生物眼科和皮肤病学组合物，其包含约0.005重量％％至约0.20wt。％亚氯酸盐化合物和约0.005重量％％至约0.05wt。％过氧化合物。还包括用于治疗眼睛和皮肤疾病（例如伤口，烧伤，感染，溃疡，银屑病等）的干燥和通过将组合物施用于眼睛而在眼睛处消毒和清洁隐形眼镜的方法，或到隐形眼镜。

5. 发明授权

US09072712B2 Synergistic antimicrobial preparations containing chlorite and hydrogen peroxide 有权
标题翻译：含有亚氯酸盐和过氧化氢的协同抗菌制剂
公开(公告)号：US09072712B2
公开(公告)日：2015-07-07
申请号：US14307706
申请日：2014-06-18
申请人： S.K. PHARMACEUTICALS, INC.
发明人： Hampar L. Karagoezian
IPC分类号： A01N59/00 , A61K33/20 , A61K9/00 , A61K31/728 , A61K33/00 , A61K33/14 , A61K33/22 , A61K33/40
CPC分类号： A01N59/00 , A61K9/0014 , A61K9/0048 , A61K31/728 , A61K33/00 , A61K33/14 , A61K33/20 , A61K33/22 , A61K33/40 , A61L12/10 , A61L12/124 , A61K2300/00
摘要： An anti-microbial preservative for use in ophthalmic and dermatologic products. The preservative includes from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Additionally, the preservative does not generate chlorine dioxide within the pH range of 5.0-8.8. Also included are an antimicrobial ophthalmic and dermatologic compositions for direct application onto an eye or skin of a living being including from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Also included are methods for treating dryness of the eyes and skin disorders (e.g., wounds, burns, infections, ulcerations, psoriasis, etc.) and for disinfecting and cleansing contact lenses while in place upon an eye by applying the composition to the eye or to the contact lens.
摘要翻译：一种用于眼科和皮肤科产品的抗微生物防腐剂。防腐剂包括约0.005wt。％至约0.20wt。％亚氯酸盐化合物和约0.005重量％％至约0.05wt。％过氧化合物。此外，防腐剂在5.0-8.8的pH范围内不产生二氧化氯。还包括用于直接施用于生物的眼睛或皮肤的抗微生物眼科和皮肤病学组合物，其包含约0.005重量％％至约0.20wt。％亚氯酸盐化合物和约0.005重量％％至约0.05wt。％过氧化合物。还包括用于治疗眼睛和皮肤疾病（例如伤口，烧伤，感染，溃疡，银屑病等）的干燥和通过将组合物施用于眼睛而在眼睛处消毒和清洁隐形眼镜的方法，或到隐形眼镜。

6. 发明申请

US20140127319A1 SYNERGISTIC ANTIMICROBIAL PREPARATIONS CONTAINING CHLORITE AND HYDROGEN PEROXIDE 有权
公开(公告)号：US20140127319A1
公开(公告)日：2014-05-08
申请号：US14145126
申请日：2013-12-31
申请人： S.K. PHARMACEUTICALS. INC.
发明人： Hampar L. Karagoezian
IPC分类号： A61K33/40 , A61K33/20
CPC分类号： A01N59/00 , A61K9/0014 , A61K9/0048 , A61K31/728 , A61K33/00 , A61K33/14 , A61K33/20 , A61K33/22 , A61K33/40 , A61L12/10 , A61L12/124 , A61K2300/00
摘要： An anti-microbial preservative for use in ophthalmic and dermatologic products. The preservative includes from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Additionally, the preservative does not generate chlorine dioxide within the pH range of 5.0-8.8. Also included are an antimicrobial ophthalmic and dermatologic compositions for direct application onto an eye or skin of a living being including from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Also included are methods for treating dryness of the eyes and skin disorders (e.g., wounds, burns, infections, ulcerations, psoriasis, etc.) and for disinfecting and cleansing contact lenses while in place upon an eye by applying the composition to the eye or to the contact lens.

7. 发明申请

US20130195995A1 SYNERGISTIC ANTIMICROBIAL PREPARATIONS CONTAINING CHLORITE AND HYDROGEN PEROXIDE 审中-公开
公开(公告)号：US20130195995A1
公开(公告)日：2013-08-01
申请号：US13658609
申请日：2012-10-23
申请人： S.K. PHARMACEUTICALS, INC.
发明人： Hampar L. Karagoezian
IPC分类号： A01N59/00
CPC分类号： A01N59/00 , A61K9/0014 , A61K9/0048 , A61K31/728 , A61K33/00 , A61K33/14 , A61K33/20 , A61K33/22 , A61K33/40 , A61L12/10 , A61L12/124 , A61K2300/00
摘要： An anti-microbial preservative for use in ophthalmic and dermatologic products. The preservative includes from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Additionally, the preservative does not generate chlorine dioxide within the pH range of 5.0-8.8. Also included are an antimicrobial ophthalmic and dermatologic compositions for direct application onto an eye or skin of a living being including from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Also included are methods for treating dryness of the eyes and skin disorders (e.g., wounds, burns, infections, ulcerations, psoriasis, etc.) and for disinfecting and cleansing contact lenses while in place upon an eye by applying the composition to the eye or to the contact lens.

8. 发明申请

WO2008070063A1 SYNERGISTIC ANTIMICROBIAL PREPARATIONS CONTAINING CHLORITE AND HYDROGEN PEROXIDE 审中-公开
标题翻译：含有氯化氢和过氧化氢的协同抗微生物制剂
公开(公告)号：WO2008070063A1
公开(公告)日：2008-06-12
申请号：PCT/US2007/024815
申请日：2007-12-04
申请人： S.K. PHARMACEUTICALS, INC. , KARAGOEZIAN, Hampar, L.
发明人： KARAGOEZIAN, Hampar, L.
IPC分类号： A01N39/00 , A61K33/40
CPC分类号： A01N59/00 , A61K9/0014 , A61K9/0048 , A61K31/728 , A61K33/00 , A61K33/14 , A61K33/20 , A61K33/22 , A61K33/40 , A61L12/10 , A61L12/124 , A61K2300/00
摘要： An anti-microbial preservative for use in ophthalmic and dermatologic products. The preservative includes from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Additionally, the preservative does not generate chlorine dioxide within the pH range of 5.0 - 8.8. Also included are an antimicrobial ophthalmic and dermatologic compositions for direct application onto an eye or skin of a living being including from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Also included are methods for treating dryness of the eyes and skin disorders (e.g., wounds, burns, infections, ulcerations, psoriasis, etc.) and for disinfecting and cleansing contact lenses while in place upon an eye by applying the composition to the eye or to the contact lens.
摘要翻译：一种用于眼科和皮肤科产品的抗微生物防腐剂。防腐剂包括约0.005wt。％至约0.20wt。％亚氯酸盐化合物和约0.005重量％％至约0.05wt。％过氧化合物。此外，防腐剂在5.0-8.8的pH范围内不产生二氧化氯。还包括用于直接施用于生物的眼睛或皮肤的抗微生物眼科和皮肤病学组合物，其包含约0.005重量％％至约0.20wt。％亚氯酸盐化合物和约0.005重量％％至约0.05wt。％过氧化合物。还包括用于治疗眼睛和皮肤疾病（例如伤口，烧伤，感染，溃疡，银屑病等）的干燥和通过将组合物施用于眼睛而在眼睛处消毒和清洁隐形眼镜的方法，或到隐形眼镜。

9. 发明申请

US20210128604A1 Stabilized Glycosaminoglycan Preparations and Related Methods 有权
公开(公告)号：US20210128604A1
公开(公告)日：2021-05-06
申请号：US17069429
申请日：2020-10-13
申请人： S.K. Pharmaceuticals, Inc.
发明人： Hampar L. Karageozian , John Park
IPC分类号： A61K31/737 , A61K31/765 , A61K31/728 , A61K31/726 , A61K31/717 , A61K31/721 , A61K31/734 , A61K47/10 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/42
摘要： Compositions comprising a glycosaminoglycan (e.g., a hyaluronan, hyaluronic acid, hyaluronate, sodium hyaluronate, dermatan sulfate, karatan sulfate, chondroitin 6-sulfate, heparin, etc.) in combination with at least one component selected from; i) polyglycols (e.g., polyethylene glycol), ii) long chain hydroxy polyanionic polysaccharides (e.g., dextran, sodium alginate, alginic acid, propylene glycol alginate, carboxymethyl cellulose and carboxyethyl cellulose, hydroxyl ethyl starch, hydroxyl propyl methyl cellulose, hydroxy propyl ethyl cellulose, hydroxy propyl cellulose, methyl cellulose, polylysine, polyhistidine, polyhydroxy proline, poly ornithine, polyvinyl pyrolidone, polyvinyl alcohol, chitosan, etc.) and iii) long chain Nitrogen containing polymers (e.g., Polylysine, Polyvinylpyrrolidone, and polyvinyl alcohol). The invention also includes methods for using such compositions (e.g., as substance delivery materials, tissue fillers or bulking agents, as moistening or hydrating agents, etc.)

10. 发明申请

US20170239287A1 Stabilized Glycosaminoglycan Preparations and Related Methods 审中-公开
公开(公告)号：US20170239287A1
公开(公告)日：2017-08-24
申请号：US15345166
申请日：2016-11-07
申请人： S.K. Pharmaceuticals, Inc.
发明人： Hampar Karageozian , John Park
IPC分类号： A61K31/737 , A61K47/36 , A61K47/32 , A61K47/42 , A61K47/10 , A61K31/728 , A61K47/38
CPC分类号： A61K31/737 , A61K31/717 , A61K31/721 , A61K31/726 , A61K31/728 , A61K31/734 , A61K31/765 , A61K47/10 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/42 , A61K2300/00
摘要： Compositions comprising a glycosaminoglycan (e.g., a hyaluronan, hyaluronic acid, hyaluronate, sodium hyaluronate, dermatan sulfate, karatan sulfate, chondroitin 6-sulfate, heparin, etc.) in combination with at least one component selected from; i) polyglycols (e.g., polyethylene glycol), ii) long chain hydroxy polyanionic polysaccharides (e.g., dextran, sodium alginate, alginic acid, propylene glycol alginate, carboxymethyl cellulose and carboxyethyl cellulose, hydroxyl ethyl starch, hydroxyl propyl methyl cellulose, hydroxy propyl ethyl cellulose, hydroxy propyl cellulose, methyl cellulose, polylysine, polyhistidine, polyhydroxy proline, poly ornithine, polyvinyl pyrolidone, polyvinyl alcohol, chitosan, etc.) and iii) long chain Nitrogen containing polymers (e.g., Polylysine, Polyvinylpyrrolidone, and polyvinyl alcohol). The invention also includes methods for using such compositions (e.g., as substance delivery materials, tissue fillers or bulking agents, as moistening or hydrating agents, etc.)

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