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1. 发明授权

US08772528B2 Method for producing aminothiazole derivative and production intermediate 有权
标题翻译：制备氨基噻唑衍生物和生产中间体的方法
公开(公告)号：US08772528B2
公开(公告)日：2014-07-08
申请号：US14066039
申请日：2013-10-29
申请人： Masaaki Nagasawa , Kazuyasu Asami , Ryu Nakao , Nobuyuki Tanaka , Yoshiyuki Aida
发明人： Masaaki Nagasawa , Kazuyasu Asami , Ryu Nakao , Nobuyuki Tanaka , Yoshiyuki Aida
IPC分类号： C07C65/05 , C07C51/377 , C07C51/347 , C07C67/08 , C07D277/56
CPC分类号： C07C69/92 , C07C51/347 , C07C51/377 , C07C67/08 , C07C205/60 , C07D277/46 , C07D277/56 , C07C65/05
摘要： Provided is a method for selectively demethylating a 2-methoxy group. Specifically provided is a production method of a compound represented by formula (7) below through the following reactions.
摘要翻译：提供了选择性使2-甲氧基脱甲基化的方法。具体提供的是下述通式（7）表示的化合物的制造方法。

2. 发明授权

US08329913B2 Carbazole derivative, solvate thereof, or pharmaceutically acceptable salt thereof 有权
标题翻译：咔唑衍生物，其溶剂化物或其药学上可接受的盐
公开(公告)号：US08329913B2
公开(公告)日：2012-12-11
申请号：US11666631
申请日：2005-10-28
申请人： Masakazu Murata , Yoshihiko Itokazu , Ryu Nakao
发明人： Masakazu Murata , Yoshihiko Itokazu , Ryu Nakao
IPC分类号： C07D293/00
CPC分类号： C07D413/12 , C07D413/14 , C07D417/12
摘要： An object of the present invention is to provide novel carbazole derivatives, solvates thereof, or pharmaceutically acceptable salts thereof having an excellent adipose tissue weight reducing effect, hypoglycemic effect, and hypolipidemic effect, which are useful as a preventive and/or therapeutic agent for fatty liver, obesity, lipid metabolism abnormality, visceral adiposity, diabetes, hyperlipemia, impaired glucose tolerance, hypertension, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, and the like.The above-mentioned object can be achieved by carbazole derivatives, solvates thereof, or pharmaceutically acceptable salts thereof, wherein the carbazole derivatives are represented by the following general formula (I): (In the formula (I), the ring A represents phenyl group or the like; X represents —O— or the like; Y represents ═N— or the like; a and b represent methylene group or the like; both V and Z represent —O— or the like; W represents a C1-C10 alkylene group whose 1 or 2 hydrogen atoms may be substituted by a phenyl group or a C1-C6 alkyl group; 1,2-phenylene group; 1,3-cyclohexyl group; or the like; R1 represents methyl group or the like; R2 represents methoxy group or the like; and R3 represents carboxy group or the like.).
摘要翻译：本发明的目的是提供具有优异的脂肪组织减重作用，降血糖作用和降血脂作用的新型咔唑衍生物，溶剂合物或其药学上可接受的盐，其可用作脂肪的预防和/或治疗剂肝脏，肥胖症，脂质代谢异常，内脏肥胖，糖尿病，高脂血症，葡萄糖耐量降低，高血压，非酒精性脂肪性肝病，非酒精性脂肪性肝炎等。上述目的可以通过其咔唑衍生物，溶剂化物或其药学上可接受的盐来实现，其中咔唑衍生物由以下通式（I）表示：（式（I）中，环A表示苯基 X表示-O-等; Y表示= N-等; a和b表示亚甲基等; V和Z均表示-O-等; W表示C1-C10 其1或2个氢原子可被苯基或C1-C6烷基取代的亚烷基; 1,2-亚苯基; 1,3-环己基;等; R1代表甲基等; R2 表示甲氧基等; R3表示羧基等。

3. 发明授权

US06197970B1 Process for producing 2-hydroxybenzamide derivatives 有权
标题翻译： 2-羟基苯甲酰胺衍生物的制备方法
公开(公告)号：US06197970B1
公开(公告)日：2001-03-06
申请号：US09446108
申请日：1999-12-23
申请人： Masaaki Nagasawa , Hiroyasu Nishioka , Takanori Suzuki , Eiichi Nagano , Katsuyuki Ishii , Ryu Nakao
发明人： Masaaki Nagasawa , Hiroyasu Nishioka , Takanori Suzuki , Eiichi Nagano , Katsuyuki Ishii , Ryu Nakao
IPC分类号： C07D27756
CPC分类号： C07D277/56
摘要： The present invention is directed to a process for producing 2-hydroxybenzamide derivatives (2) or (5) according to either one of the following reaction schemes.
摘要翻译：本发明涉及根据以下反应方案之一制备2-羟基苯甲酰胺衍生物（2）或（5）的方法。

4. 发明授权

US09096511B2 Method for producing 2-bromo-4,5-dialkoxy benzoic acid 有权
标题翻译： 2-溴-4,5-二烷氧基苯甲酸的制备方法
公开(公告)号：US09096511B2
公开(公告)日：2015-08-04
申请号：US13991242
申请日：2011-12-06
申请人： Ryu Nakao
发明人： Ryu Nakao
IPC分类号： C07C65/00 , C07C51/363 , C07C51/367
CPC分类号： C07C51/363 , C07C51/367 , C07C65/21
摘要： Provided is a method for effectively producing a 4,5-dialkoxy-2-hydroxybenzoic acid from an inexpensive raw material.A method for producing a 2-bromo-4,5-dialkoxybenzoic acid represented by the following formula (2): (wherein each of R1 and R2 represents a lower alkyl group), the method including causing a 3,4-dialkoxybenzoic acid represented by the following formula (1): (wherein R1 and R2 have the same meanings as defined above) to react with bromine in concentrated hydrochloric acid.
摘要翻译：提供从廉价的原料有效地制备4,5-二烷氧基-2-羟基苯甲酸的方法。由下式（2）表示的2-溴-4,5-二烷氧基苯甲酸的制造方法（其中R1和R2各自表示低级烷基），该方法包括使3,4-二烷氧基苯甲酸代表通过下式（1）表示：（其中R1和R2具有与上述相同的含义）与溴在浓盐酸中反应。

5. 发明申请

US20140046088A1 METHOD FOR PRODUCING AMINOTHIAZOLE DERIVATIVE AND PRODUCTION INTERMEDIATE 有权
标题翻译：生产氨基唑衍生物和生产中间体的方法
公开(公告)号：US20140046088A1
公开(公告)日：2014-02-13
申请号：US14066039
申请日：2013-10-29
申请人： Masaaki NAGASAWA , Kazuyasu Asami , Ryu Nakao , Nobuyuki Tanaka , Yoshiyuki Aida
发明人： Masaaki NAGASAWA , Kazuyasu Asami , Ryu Nakao , Nobuyuki Tanaka , Yoshiyuki Aida
IPC分类号： C07C51/347 , C07C67/08
CPC分类号： C07C69/92 , C07C51/347 , C07C51/377 , C07C67/08 , C07C205/60 , C07D277/46 , C07D277/56 , C07C65/05
摘要： Provided is a method for selectively demethylating a 2-methoxy group. Specifically provided is a production method of a compound represented by formula (7) below through the following reactions.
摘要翻译：提供了选择性使2-甲氧基脱甲基化的方法。具体提供的是下述通式（7）表示的化合物的制造方法。

6. 发明申请

US20080021221A1 Method For Producing Aminothiazole Derivative And Production Intermediate 有权
标题翻译：生产氨基噻唑衍生物和生产中间体的方法
公开(公告)号：US20080021221A1
公开(公告)日：2008-01-24
申请号：US11573409
申请日：2005-08-23
申请人： Masaaki Nagasawa , Kazuyasu Asami , Ryu Nakao , Nobuyuki Tanaka , Yoshiyuki Aida
发明人： Masaaki Nagasawa , Kazuyasu Asami , Ryu Nakao , Nobuyuki Tanaka , Yoshiyuki Aida
IPC分类号： C07D277/38 , C07C63/04 , C07C67/04 , C07C69/616
CPC分类号： C07C69/92 , C07C51/377 , C07C67/14 , C07D277/56 , C07C65/21
摘要： Provided is a method for selectively demethylating a 2-methoxy group. Specifically provided is a production method of a compound represented by formula (7) below through the following reactions
摘要翻译：提供了选择性使2-甲氧基脱甲基化的方法。具体提供的是下述通式（7）表示的化合物的制造方法

7. 发明申请

US20100286210A1 Carbazole derivative, solvate thereof, or pharmaceutically acceptable salt thereof 有权
标题翻译：咔唑衍生物，其溶剂化物或其药学上可接受的盐
公开(公告)号：US20100286210A1
公开(公告)日：2010-11-11
申请号：US11666631
申请日：2005-10-28
申请人： Masakazu Murata , Yoshihiko Itokazu , Ryu Nakao
发明人： Masakazu Murata , Yoshihiko Itokazu , Ryu Nakao
IPC分类号： A61K31/4439 , A61K31/427 , A61K31/422 , C07D413/14 , C07D417/12 , C07D413/12 , A61P29/00 , A61P3/04 , A61P3/10 , A61P3/06 , A61P9/12 , A61P1/16 , A61P3/00
CPC分类号： C07D413/12 , C07D413/14 , C07D417/12
摘要： An object of the present invention is to provide novel carbazole derivatives, solvates thereof, or pharmaceutically acceptable salts thereof having an excellent adipose tissue weight reducing effect, hypoglycemic effect, and hypolipidemic effect, which are useful as a preventive and/or therapeutic agent for fatty liver, obesity, lipid metabolism abnormality, visceral adiposity, diabetes, hyperlipemia, impaired glucose tolerance, hypertension, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, and the like.The above-mentioned object can be achieved by carbazole derivatives, solvates thereof, or pharmaceutically acceptable salts thereof, wherein the carbazole derivatives are represented by the following general formula (I): (In the formula (I), the ring A represents phenyl group or the like; X represents —O— or the like; Y represents ═N— or the like; a and b represent methylene group or the like; both V and Z represent —O— or the like; W represents a C1-C10 alkylene group whose 1 or 2 hydrogen atoms may be substituted by a phenyl group or a C1-C6 alkyl group; 1,2-phenylene group; 1,3-cyclohexyl group; or the like; R1 represents methyl group or the like; R2 represents methoxy group or the like; and R3 represents carboxy group or the like.)
摘要翻译：本发明的目的是提供具有优异的脂肪组织减重作用，降血糖作用和降血脂作用的新型咔唑衍生物，溶剂合物或其药学上可接受的盐，其可用作脂肪的预防和/或治疗剂肝脏，肥胖症，脂质代谢异常，内脏肥胖，糖尿病，高脂血症，葡萄糖耐量降低，高血压，非酒精性脂肪性肝病，非酒精性脂肪性肝炎等。上述目的可以通过其咔唑衍生物，溶剂化物或其药学上可接受的盐来实现，其中咔唑衍生物由以下通式（I）表示：（式（I）中，环A表示苯基 X表示-O-等; Y表示= N-等; a和b表示亚甲基等; V和Z均表示-O-等; W表示C1-C10 其1或2个氢原子可被苯基或C1-C6烷基取代的亚烷基; 1,2-亚苯基; 1,3-环己基;等; R1代表甲基等; R2 表示甲氧基等; R3表示羧基等。）

8. 发明申请

US20140058112A1 METHOD FOR PRODUCING AMINOTHIAZOLE DERIVATIVE AND PRODUCTION INTERMEDIATE 有权
公开(公告)号：US20140058112A1
公开(公告)日：2014-02-27
申请号：US14065862
申请日：2013-10-29
申请人： Masaaki NAGASAWA , Kazuyasu Asami , Ryu Nakao , Nobuyuki Tanaka , Yoshiyuki Aida
发明人： Masaaki NAGASAWA , Kazuyasu Asami , Ryu Nakao , Nobuyuki Tanaka , Yoshiyuki Aida
IPC分类号： C07D277/46
CPC分类号： C07C69/92 , C07C51/347 , C07C51/377 , C07C67/08 , C07C205/60 , C07D277/46 , C07D277/56 , C07C65/05
摘要： Provided is a method for selectively demethylating a 2-methoxy group. Specifically provided is a production method of a compound represented by formula (7) below through the following reactions.

9. 发明申请

US20140058104A1 METHOD FOR PRODUCING AMINOTHIAZOLE DERIVATIVE AND PRODUCTION INTERMEDIATE 审中-公开
公开(公告)号：US20140058104A1
公开(公告)日：2014-02-27
申请号：US14065947
申请日：2013-10-29
申请人： Masaaki NAGASAWA , Kazuyasu Asami , Ryu Nakao , Nobuyuki Tanaka , Yoshiyuki Aida
发明人： Masaaki NAGASAWA , Kazuyasu Asami , Ryu Nakao , Nobuyuki Tanaka , Yoshiyuki Aida
IPC分类号： C07C69/92 , C07C205/60
CPC分类号： C07C69/92 , C07C51/347 , C07C51/377 , C07C67/08 , C07C205/60 , C07D277/46 , C07D277/56 , C07C65/05
摘要： Provided is a method for selectively demethylating a 2-methoxy group. Specifically provided is a production method of a compound represented by formula (7) below through the following reactions.

10. 发明授权

US08586761B2 Method for producing aminothiazole derivative and production intermediate 有权
公开(公告)号：US08586761B2
公开(公告)日：2013-11-19
申请号：US11573409
申请日：2005-08-23
申请人： Masaaki Nagasawa , Kazuyasu Asami , Ryu Nakao , Nobuyuki Tanaka , Yoshiyuki Aida
发明人： Masaaki Nagasawa , Kazuyasu Asami , Ryu Nakao , Nobuyuki Tanaka , Yoshiyuki Aida
IPC分类号： C07C51/377 , C07C67/14 , C07C69/92 , C07C69/616 , C07C65/21 , C07C63/04 , C07C67/04 , C07D277/56 , C07D277/38
CPC分类号： C07C69/92 , C07C51/377 , C07C67/14 , C07D277/56 , C07C65/21
摘要： Provided is a method for selectively demethylating a 2-methoxy group. Specifically provided is a production method of a compound represented by formula (7) below through the following reactions.

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