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1. 发明授权

US08236969B2 Method for preparing prostaglandin derivative 有权
公开(公告)号：US08236969B2
公开(公告)日：2012-08-07
申请号：US12762890
申请日：2010-04-19
申请人： Ryu Hirata , Tatsuya Matsukawa , Kazuhiro Masuzaki , Ryuji Ueno
发明人： Ryu Hirata , Tatsuya Matsukawa , Kazuhiro Masuzaki , Ryuji Ueno
IPC分类号： C07D309/12 , C07F7/18
CPC分类号： C07D307/93 , C07C405/0025 , C07D307/935 , C07D309/12 , C07D311/94
摘要： Disclosed is a method for preparing a prostaglandin derivative of formula (A): which comprises reacting an aldehyde represented by formula (1): with a 2-oxoalkyl phosphonate in a reaction solvent under the presence of alkali hydroxide as sole base. By carrying out the reaction using an alkali hydroxide as sole base in the reaction system, the desired prostaglandin derivative can be obtained by simple procedures and with high yield.

2. 发明申请

US20090218662A1 SEMICONDUCTOR DEVICE 审中-公开
标题翻译：半导体器件
公开(公告)号：US20090218662A1
公开(公告)日：2009-09-03
申请号：US12394862
申请日：2009-02-27
申请人： Shinji Kudoh , Ryu Hirata , Shinichi Miyazono
发明人： Shinji Kudoh , Ryu Hirata , Shinichi Miyazono
IPC分类号： H01L29/861 , H01L29/06
CPC分类号： H01L29/8613 , H01L29/0626 , H01L29/0657 , H01L29/861
摘要： A semiconductor device includes: a first semiconductor region of a first conductive type; a second semiconductor region of the first conductive type formed on an upper surface of the first semiconductor region and having a lower impurity concentration than that of the first semiconductor region; a third semiconductor region of the first conductive type formed on the upper surface of the first semiconductor region and having a higher impurity concentration than that of the second semiconductor region; and a fourth semiconductor region of a second conductive type different from the first conductive type formed on upper surfaces of the second semiconductor region and the third semiconductor region. A PN junction is formed between the second semiconductor region and third semiconductor region and the fourth semiconductor region. The second semiconductor region is formed to surround the third semiconductor region.
摘要翻译：半导体器件包括：第一导电类型的第一半导体区域; 所述第一导电类型的第二半导体区域形成在所述第一半导体区域的上表面上并且具有比所述第一半导体区域的杂质浓度低的杂质浓度; 第一导电类型的第三半导体区域形成在第一半导体区域的上表面上并且具有比第二半导体区域的杂质浓度更高的杂质浓度; 以及形成在第二半导体区域和第三半导体区域的上表面上的与第一导电类型不同的第二导电类型的第四半导体区域。在第二半导体区域和第三半导体区域与第四半导体区域之间形成PN结。第二半导体区域形成为围绕第三半导体区域。

3. 发明授权

US07321057B2 Method for manufacturing prostaglandin analogue 有权
标题翻译：前列腺素类似物的制备方法
公开(公告)号：US07321057B2
公开(公告)日：2008-01-22
申请号：US11193373
申请日：2005-08-01
申请人： Ryu Hirata , Tatsuya Matsukawa
发明人： Ryu Hirata , Tatsuya Matsukawa
IPC分类号： C07C61/06 , C07C49/00 , C07C35/06
CPC分类号： C07C51/373 , C07C405/00 , C07C59/353
摘要： The present invention provides a new method for manufacturing a prostaglandin analogue having one or more keto groups on the 5-membered ring and/or omega chain, which comprises the step of treating a corresponding hydroxyl group containing compound with a co-oxidizer under the presence of a tetramethylpyperidine-1-oxyl derivative to form the desired prostaglandin analogue. The method of the invention can be carried out easily under relatively mild conditions.
摘要翻译：本发明提供了一种制备在5元环和/或ω链上具有一个或多个酮基的前列腺素类似物的新方法，其包括在存在下用共氧化剂处理相应的含羟基化合物的步骤的四氢吡啶-1-氧基衍生物以形成所需的前列腺素类似物。本发明的方法可以在相对温和的条件下容易地进行。

4. 发明申请

US20070185206A1 Method for preparing 15-keto-prostaglandin E derivative 有权
标题翻译：制备15-酮 - 前列腺素E衍生物的方法
公开(公告)号：US20070185206A1
公开(公告)日：2007-08-09
申请号：US11703098
申请日：2007-02-07
申请人： Ryu Hirata , Tatsuya Matsukawa
发明人： Ryu Hirata , Tatsuya Matsukawa
IPC分类号： A61K31/557 , C07C59/147
CPC分类号： C07C405/00 , Y02P20/55
摘要： Disclosed is an improved method for preparing 15-keto-prostaglandin E derivative. According to the invention, the deprotection of protected hydroxy group required in manufacturing a 15-keto-prostaglandin derivative is conducted under the presence of a phosphoric acid compound.
摘要翻译：公开了一种制备15-酮 - 前列腺素E衍生物的改进方法。根据本发明，制备15-酮 - 前列腺素衍生物所需的被保护羟基的去保护在磷酸化合物的存在下进行。

5. 发明申请

US20050279210A1 Fuel vapor adsorption filters 有权
标题翻译：燃油蒸气吸附过滤器
公开(公告)号：US20050279210A1
公开(公告)日：2005-12-22
申请号：US11158310
申请日：2005-06-21
申请人： Ryu Hirata
发明人： Ryu Hirata
IPC分类号： B01D53/02 , B01D53/04 , F02M25/08 , F02M35/02 , F02M35/024
CPC分类号： B01D53/0415 , B01D2253/102 , B01D2253/25 , B01D2257/702 , B01D2257/708 , B01D2258/012 , B01D2259/4516 , F02M25/0854 , F02M35/02 , F02M35/024 , Y10S55/05
摘要： A fuel vapor adsorption filter includes a fuel vapor adsorption agent; a filter body containing the fuel vapor adsorption agent therein, and a frame formed to surround the filter body. The frame is adapted to be mounted within an intake air channel connected to an engine, so that the filter body is operable to adsorb a fuel vapor within the intake air channel when the engine has been stopped. Non-woven fabrics form the filter body. The non-woven fabrics have peripheral edge portions. Heat-pressing the peripheral edge portions of the non-woven fabrics forms the frame.
摘要翻译：燃料蒸汽吸附过滤器包括燃料蒸气吸附剂; 其中包含燃料蒸气吸附剂的过滤体和形成为围绕过滤体的框架。框架适于安装在与发动机连接的进气通道内，使得当发动机停止时，过滤器主体可操作地吸附进气通道内的燃料蒸气。无纺布形成过滤体。无纺布具有周缘部。热挤压无纺织物的周边部分形成框架。

6. 发明申请

US20110244037A1 PHARMACEUTICAL COMPOSITION COMPRISING A BI-CYCLIC COMPOUND AND METHOD FOR STABILIZING THE BI-CYCLIC COMPOUND 审中-公开
公开(公告)号：US20110244037A1
公开(公告)日：2011-10-06
申请号：US13161107
申请日：2011-06-15
申请人： Ryu HIRATA , Yasuhiro HARADA , Ryuji UENO
发明人： Ryu HIRATA , Yasuhiro HARADA , Ryuji UENO
IPC分类号： A61K9/64 , A61K31/352
CPC分类号： A61K9/4858 , A61K9/08 , A61K31/352 , A61K31/353 , A61K31/382 , A61K31/4741 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/26 , A61K47/36
摘要： Disclosed is a method for stabilizing a pharmaceutically active bi-cyclic compound of formula (I): comprising the step of: admixing the same with a polyol and/or a fatty acid ester other than glyceride and a composition obtained by the method. In addition a soft gelatin capsule formulation of the compound of formula (I) obtained by incorporating the compound in a soft gelatin capsule shell comprising gelatin and a polyol plasticizer.

7. 发明授权

US08026393B2 Soft-gelatin capsule formulation 有权
标题翻译：软明胶胶囊制剂
公开(公告)号：US08026393B2
公开(公告)日：2011-09-27
申请号：US11656476
申请日：2007-01-23
申请人： Yukiko Hashitera , Ryu Hirata , Yasuhiro Harada , Ryuji Ueno
发明人： Yukiko Hashitera , Ryu Hirata , Yasuhiro Harada , Ryuji Ueno
IPC分类号： C07C61/06 , C07C61/20
CPC分类号： A61K31/352 , A61K9/4816 , A61K9/4825 , A61K9/4858 , A61K31/557 , A61K31/5575
摘要： The present invention discloses a soft gelatin capsule formulation of a 15-keto-prostaglandin compound, which comprises: a soft gelatin capsule shell comprising gelatin and sugar alcohol as a plasticizer, and a mixture comprising a 15-keto-prostaglandin compound and a pharmaceutically acceptable vehicle which is filled in the shell. By encapsulating the 15-keto-prostaglandin compound in the specified soft gelatin capsule shell, stability of the compound is significantly improved.
摘要翻译：本发明公开了一种15-酮 - 前列腺素化合物的软明胶胶囊制剂，其包含：包含明胶和糖醇作为增塑剂的软明胶胶囊壳，以及包含15-酮前列腺素化合物和药学上可接受的混合物装在壳中的车辆。通过将15-酮 - 前列腺素化合物包封在指定的软明胶胶囊壳中，化合物的稳定性显着提高。

8. 发明授权

US07812182B2 Method for preparing prostaglandin derivative 有权
标题翻译：前列腺素衍生物的制备方法
公开(公告)号：US07812182B2
公开(公告)日：2010-10-12
申请号：US11703138
申请日：2007-02-07
申请人： Ryu Hirata , Tatsuya Matsukawa , Kazuhiro Masuzaki , Ryuji Ueno
发明人： Ryu Hirata , Tatsuya Matsukawa , Kazuhiro Masuzaki , Ryuji Ueno
IPC分类号： C07D311/94 , C07C69/608
CPC分类号： C07D307/93 , C07C405/0025 , C07D307/935 , C07D309/12 , C07D311/94
摘要： Disclosed is a method for preparing a prostaglandin derivative of formula (A): which comprises reacting an aldehyde represented by formula (1): with a 2-oxoalkyl phosphonate in a reaction solvent under the presence of alkali hydroxide as sole base. By carrying out the reaction using an alkali hydroxide as sole base in the reaction system, the desired prostaglandin derivative can be obtained by simple procedures and with high yield.
摘要翻译：公开了一种制备式（A）的前列腺素衍生物的方法：其包括在碱性氢氧化物作为唯一碱的存在下，在反应溶剂中使由式（1）表示的醛与2-氧代烷基膦酸酯反应。通过在反应体系中使用碱金属氢氧化物作为底物进行反应，可以通过简单的方法和高收率获得所需的前列腺素衍生物。

9. 发明申请

US20100204489A1 METHOD FOR PREPARING PROSTAGLANDIN DERIVATIVE 有权
公开(公告)号：US20100204489A1
公开(公告)日：2010-08-12
申请号：US12762917
申请日：2010-04-19
申请人： Ryu HIRATA , Tatsuya Matsukawa , Kazuhiro Masuzaki , Ryuji Ueno
发明人： Ryu HIRATA , Tatsuya Matsukawa , Kazuhiro Masuzaki , Ryuji Ueno
IPC分类号： C07D307/935 , C07D309/12
CPC分类号： C07D307/93 , C07C405/0025 , C07D307/935 , C07D309/12 , C07D311/94
摘要： Disclosed is a method for preparing a prostaglandin derivative of formula (A): which comprises reacting an aldehyde represented by formula (1): with a 2-oxoalkyl phosphonate in a reaction solvent under the presence of alkali hydroxide as sole base. By carrying out the reaction using an alkali hydroxide as sole base in the reaction system, the desired prostaglandin derivative can be obtained by simple procedures and with high yield.

10. 发明授权

US07416585B2 Fuel vapor adsorption filters 失效
标题翻译：燃油蒸气吸附过滤器
公开(公告)号：US07416585B2
公开(公告)日：2008-08-26
申请号：US11159823
申请日：2005-06-23
申请人： Ryu Hirata
发明人： Ryu Hirata
IPC分类号： B01D39/14 , F02M35/02
CPC分类号： B01D53/0415 , B01D2253/102 , B01D2253/25 , B01D2257/702 , B01D2257/708 , B01D2258/012 , B01D2259/4516 , F02M25/08 , F02M35/024
摘要： A fuel vapor adsorption filter for mounting within an intake air channel connected to an engine extends across the intake air channel in order to adsorb fuel vapor within the intake air channel when the engine has been stopped. The filter includes an adsorbing agent for adsorbing the fuel vapor. A holding layer is formed by a first non-woven fabric and serves to contain and hold the adsorbing agent. The first non-woven fabric is formed of thermoplastic resin fibers. A cover layer is made of a second non-woven fabric and serves to cover at least one side of the holding layer opposing the downstream side of the intake air channel. The second non-woven fabric is formed of thermoplastic resin fibers. The resin fibers forming the second non-woven fabric of the cover layer have an average diameter between 100 μm and 330 μm.
摘要翻译：用于安装在连接到发动机的进气通道内的燃料蒸汽吸附过滤器延伸穿过进气通道，以便当发动机停止时吸附进气通道内的燃料蒸气。该过滤器包括吸附燃料蒸气的吸附剂。保持层由第一无纺布形成，用于容纳和保持吸附剂。第一无纺布由热塑性树脂纤维形成。覆盖层由第二无纺布制成并且用于覆盖与进气通道的下游侧相对的保持层的至少一侧。第二无纺布由热塑性树脂纤维形成。形成覆盖层的第二无纺布的树脂纤维的平均直径为100μm〜330μm。

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