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1. 发明申请

US20110213499A1 Methods, Systems, and Products for Conducting Droplet Operations 有权
标题翻译：用于进行液滴操作的方法，系统和产品
公开(公告)号：US20110213499A1
公开(公告)日：2011-09-01
申请号：US12596905
申请日：2009-08-13
申请人： Ryan A. Sturmer , Gregory F. Smith , Michael Fogleman , Keith R. Brafford , Sai Ram Rongali
发明人： Ryan A. Sturmer , Gregory F. Smith , Michael Fogleman , Keith R. Brafford , Sai Ram Rongali
IPC分类号： B01J19/08 , G06F17/50
CPC分类号： G06F19/00 , B01F13/0076 , B01L3/502715 , B01L3/502792 , B01L2300/0816 , B01L2300/0819 , B01L2300/089 , F04B17/00 , F04B19/006 , F04B49/065
摘要： The present invention provides modified droplet actuator systems, software, and software-executed methods for use in droplet actuator operation and droplet actuator systems that are configured and programmed to execute such software. An aspect of the software components of the invention is an interface description file for each hardware component of a microfluidics system that allows hardware components to be changed without modifying the program for performing droplet operations protocols. Another aspect of the software components of the invention is the establishment of electrode-to-electrode relationships and other aspects of droplet actuator configurations, which may be used when programming droplet operations protocols. Another aspect of the software components of the invention is a physical design library of predefined electrode elements that may be used by a droplet actuator designer when constructing a layout of electrodes. Another aspect of the software components of the invention is a droplet actuator description file that contains the physical and electrical description of the droplet actuator. Another aspect of the software components of the invention is a router component for determining routes of droplet operations in a droplet actuator. Another aspect of the software components of the invention is the use of tri-state vectors for programming sequences in a droplet actuator. Still other aspects are provided.
摘要翻译：本发明提供了用于在液滴致动器操作中使用的修改的液滴致动器系统，软件和软件执行方法以及配置和编程为执行这样的软件的液滴致动器系统。本发明的软件组件的一个方面是用于微流体系统的每个硬件组件的接口描述文件，其允许在不修改用于执行液滴操作协议的程序的情况下改变硬件组件。本发明的软件组件的另一方面是建立电极对电极关系和液滴致动器配置的其它方面，其可以在编程液滴操作协议时使用。本发明的软件组件的另一方面是预定电极元件的物理设计库，其可以在构建电极的布局时由液滴致动器设计者使用。本发明的软件组件的另一方面是液滴致动器描述文件，其包含液滴致动器的物理和电气描述。本发明的软件组件的另一方面是用于确定液滴致动器中的液滴操作路线的路由器组件。本发明的软件组件的另一方面是使用三态向量来在液滴致动器中编程序列。还提供了其他方面。

2. 发明申请

US20130293246A1 Capacitance Detection in a Droplet Actuator 审中-公开
标题翻译：滴液致动器中的电容检测
公开(公告)号：US20130293246A1
公开(公告)日：2013-11-07
申请号：US13988190
申请日：2011-11-15
申请人： Michael G. Pollack , Ryan A. Sturmer , Philip Y. Paik , Vamsee K. Pamula , Vijay Srinivasan
发明人： Michael G. Pollack , Ryan A. Sturmer , Philip Y. Paik , Vamsee K. Pamula , Vijay Srinivasan
IPC分类号： G01N27/22 , G01K7/34
CPC分类号： G01N27/221 , B01L3/502784 , B01L3/502792 , B01L2200/14 , B01L2300/0645 , B01L2300/0816 , B01L2300/089 , B01L2400/0427 , B41J2/04541 , B41J2/04555 , B41J2/0458 , G01K7/34
摘要： The embodiments described herein provide methods of measuring capacitance, detecting a droplet at a position, determining a thickness of an oil film and determining temperature in a droplet actuator. Specifically, the capacitance detection method may be used as a real-time verification tool in order to detect the absence, presence, and/or partial presence of a droplet at an electrode, analyze droplet properties, measure droplet size or volume, optimize the speed of droplet operation and detect air bubbles.
摘要翻译：本文所述的实施例提供了测量电容，检测位置处的液滴，确定油膜的厚度和确定液滴致动器中的温度的方法。具体地，可以将电容检测方法用作实时验证工具，以便检测电极处的液滴的不存在，存在和/或部分存在，分析液滴属性，测量液滴尺寸或体积，优化速度的液滴操作并检测气泡。

3. 发明申请

US20130217113A1 SYSTEM FOR AND METHODS OF PROMOTING CELL LYSIS IN DROPLET ACTUATORS 审中-公开
标题翻译：系统和方法促进滴液致动器中的细胞分析
公开(公告)号：US20130217113A1
公开(公告)日：2013-08-22
申请号：US13809762
申请日：2011-07-12
申请人： Vijay Srinivasan , William Craig Bauer , Gregory F. Smith , Ryan A. Sturmer , Zhishan Hua , Allen E. Eckhardt
发明人： Vijay Srinivasan , William Craig Bauer , Gregory F. Smith , Ryan A. Sturmer , Zhishan Hua , Allen E. Eckhardt
IPC分类号： C12M1/42
CPC分类号： C12M1/42 , B01L3/502792 , B01L2200/0647 , B01L2300/0672 , B01L2400/0427 , B01L2400/0439 , B01L2400/088 , C12M47/06 , C12N1/066 , C12N13/00
摘要： The invention relates to a droplet actuator for conducting droplet operations. The actuator includes a bottom substrate and a top substrate separated from the bottom substrate to form a gap. An arrangement of droplet operations electrodes may be located on a surface of the bottom substrate and/or top substrate. Optionally, a sample reservoir may hold a quantity of a sample fluid containing cells. A disruption device which can take various forms is used to lyse the cells in the sample or in a sample droplet to thereby conduct operations on samples having lysed cells therein.
摘要翻译：本发明涉及一种用于进行液滴操作的液滴致动器。致动器包括底部基板和与底部基板分离以形成间隙的顶部基板。液滴操作电极的布置可以位于底部基板和/或顶部基板的表面上。任选地，样品储存器可以容纳一定量的含有细胞的样品流体。可以采用各种形式的破坏装置来裂解样品或样品液滴中的细胞，从而对其中具有裂解细胞的样品进行操作。

4. 发明授权

US08364315B2 Methods, systems, and products for conducting droplet operations 有权
标题翻译：用于进行液滴操作的方法，系统和产品
公开(公告)号：US08364315B2
公开(公告)日：2013-01-29
申请号：US12596905
申请日：2009-08-13
申请人： Ryan A. Sturmer , Gregory F. Smith , Michael Fogleman , Keith R. Brafford , Sai Ram Rongali
发明人： Ryan A. Sturmer , Gregory F. Smith , Michael Fogleman , Keith R. Brafford , Sai Ram Rongali
IPC分类号： G05B21/00
CPC分类号： G06F19/00 , B01F13/0076 , B01L3/502715 , B01L3/502792 , B01L2300/0816 , B01L2300/0819 , B01L2300/089 , F04B17/00 , F04B19/006 , F04B49/065
摘要： The present invention provides modified droplet actuator systems, software, and software-executed methods for use in droplet actuator operation and droplet actuator systems that are configured and programmed to execute such software. An aspect of the software components of the invention is an interface description file for each hardware component of a microfluidics system that allows hardware components to be changed without modifying the program for performing droplet operations protocols. Another aspect of the software components of the invention is the establishment of electrode-to-electrode relationships and other aspects of droplet actuator configurations, which may be used when programming droplet operations protocols. Another aspect of the software components of the invention is a physical design library of predefined electrode elements that may be used by a droplet actuator designer when constructing a layout of electrodes. Another aspect of the software components of the invention is a droplet actuator description file that contains the physical and electrical description of the droplet actuator. Another aspect of the software components of the invention is a router component for determining routes of droplet operations in a droplet actuator. Another aspect of the software components of the invention is the use of tri-state vectors for programming sequences in a droplet actuator. Still other aspects are provided.
摘要翻译：本发明提供了用于在液滴致动器操作中使用的修改的液滴致动器系统，软件和软件执行方法以及配置和编程为执行这样的软件的液滴致动器系统。本发明的软件组件的一个方面是用于微流体系统的每个硬件组件的接口描述文件，其允许在不修改用于执行液滴操作协议的程序的情况下改变硬件组件。本发明的软件组件的另一方面是建立电极对电极关系和液滴致动器配置的其它方面，其可以在编程液滴操作协议时使用。本发明的软件组件的另一方面是预定电极元件的物理设计库，其可以在构建电极的布局时由液滴致动器设计者使用。本发明的软件组件的另一方面是液滴致动器描述文件，其包含液滴致动器的物理和电气描述。本发明的软件组件的另一方面是用于确定液滴致动器中的液滴操作路线的路由器组件。本发明的软件组件的另一方面是使用三态向量来在液滴致动器中编程序列。还提供了其他方面。

5. 发明授权

US07939021B2 Droplet actuator analyzer with cartridge 有权
标题翻译：液滴执行器分析仪带墨盒
公开(公告)号：US07939021B2
公开(公告)日：2011-05-10
申请号：US11838450
申请日：2007-08-14
申请人： Gregory F. Smith , Ryan A. Sturmer , Philip Y. Paik , Vijay Srinivasan , Michael G. Pollack , Vamsee K. Pamula , Keith R. Brafford , Richard M. West
发明人： Gregory F. Smith , Ryan A. Sturmer , Philip Y. Paik , Vijay Srinivasan , Michael G. Pollack , Vamsee K. Pamula , Keith R. Brafford , Richard M. West
IPC分类号： G01N33/00 , G01N15/06 , G01N27/00 , G01N21/00 , B65D35/00 , B65D35/28 , G05B21/00
CPC分类号： B01F13/0071 , B01F13/0076 , B01L3/502715 , B01L3/502792 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2200/0668 , B01L2200/148 , B01L2200/16 , B01L2300/024 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/089 , B01L2300/1827 , B01L2400/0406 , B01L2400/0415 , B01L2400/043 , B01L2400/0436 , B01L2400/0442 , B01L2400/0448 , B01L2400/0683 , G01N33/49
摘要： A droplet actuator with cartridge is provided. According to one embodiment, a sample analyzer is provided and includes an analyzer unit comprising electronic or optical receiving means, a cartridge comprising self-contained droplet handling capabilities, and a wherein the cartridge is coupled to the analyzer unit by a means which aligns electronic and/or optical outputs from the cartridge with electronic or optical receiving means on the analyzer unit. According to another embodiment, a sample analyzer is provided and includes a sample analyzer comprising a cartridge coupled thereto and a means of electrical interface and/or optical interface between the cartridge and the analyzer, whereby electrical signals and/or optical signals may be transmitted from the cartridge to the analyzer.
摘要翻译：提供带墨盒的液滴致动器。根据一个实施例，提供了样本分析器，并且包括分析器单元，其包括电子或光学接收装置，包括独立液滴处理能力的盒，以及其中所述盒通过使电子和 /或来自带有分析仪单元上的电子或光学接收装置的盒的光学输出。根据另一个实施例，提供了一个样本分析器，它包括一个样本分析器，该样本分析器包括与其相连接的盒，以及盒和分析器之间的电接口和/或光学接口的装置，由此电信号和/或光信号可以从墨盒进入分析仪。

6. 发明授权

US07822510B2 Systems, methods, and products for graphically illustrating and controlling a droplet actuator 有权
标题翻译：图形化显示和控制液滴执行器的系统，方法和产品
公开(公告)号：US07822510B2
公开(公告)日：2010-10-26
申请号：US11838388
申请日：2007-08-14
申请人： Philip Y. Paik , Michael G. Pollack , Ryan A. Sturmer , Gregory F. Smith , Keith R. Brafford , Vamsee K. Pamula
发明人： Philip Y. Paik , Michael G. Pollack , Ryan A. Sturmer , Gregory F. Smith , Keith R. Brafford , Vamsee K. Pamula
IPC分类号： G05D7/00 , G05D11/00 , G05D9/00 , G05B15/00 , G05B19/00
CPC分类号： B01L3/502792 , B01L2200/143 , B01L2300/027 , B01L2300/0816 , B01L2400/0427
摘要： Systems for controlling a droplet microactuator are provided. According to one embodiment, a system is provided and includes a controller, a droplet microactuator electronically coupled to the controller, and a display device displaying a user interface electronically coupled to the controller, wherein the system is programmed and configured to permit a user to effect a droplet manipulation by interacting with the user interface. According to another embodiment, a system is provided and includes a processor, a display device electronically coupled to the processor, and software loaded and/or stored in a storage device electronically coupled to the controller, a memory device electronically coupled to the controller, and/or the controller and programmed to display an interactive map of a droplet microactuator. According to yet another embodiment, a system is provided and includes a controller, a droplet microactuator electronically coupled to the controller, a display device displaying a user interface electronically coupled to the controller, and software for executing a protocol loaded and/or stored in a storage device electronically coupled to the controller, a memory device electronically coupled to the controller, and/or the controller.
摘要翻译：提供了用于控制液滴微致动器的系统。根据一个实施例，提供了一种系统，其包括电子耦合到控制器的控制器，液滴微致动器以及显示电子耦合到控制器的用户界面的显示设备，其中该系统被编程和配置为允许用户实现通过与用户界面交互来进行液滴操作。根据另一个实施例，提供了一种系统，包括处理器，电子耦合到处理器的显示设备，以及加载和/或存储在电子耦合到控制器的存储设备中的软件，电子耦合到控制器的存储设备，以及 /或控制器，并被编程以显示液滴微致动器的交互式地图。根据又一个实施例，提供了一种系统，其包括控制器，电子耦合到控制器的液滴微致动器，显示电子耦合到控制器的用户界面的显示设备，以及用于执行加载和/或存储在控制器中的协议的软件电子耦合到控制器的存储设备，电子耦合到控制器的存储设备和/或控制器。

7. 发明申请

US20100194408A1 Capacitance Detection in a Droplet Actuator 有权
标题翻译：滴液致动器中的电容检测
公开(公告)号：US20100194408A1
公开(公告)日：2010-08-05
申请号：US12527208
申请日：2008-02-15
申请人： Ryan A. Sturmer , Michael G. Pollack , Vamsee K. Pamula , Vijay Srinivasan , Philip Y. Paik
发明人： Ryan A. Sturmer , Michael G. Pollack , Vamsee K. Pamula , Vijay Srinivasan , Philip Y. Paik
IPC分类号： G01R27/26
CPC分类号： B01L3/50273 , B01L3/502715 , B01L3/502784 , B01L2200/0605 , B01L2300/0627 , B01L2300/0636 , B01L2300/0645 , B01L2300/0809 , B01L2400/0427 , G01N27/22 , G01N27/223 , G01N27/227 , G01N2203/00 , G01V3/02
摘要： A method, circuit and apparatus for detecting capacitance on a droplet actuator, inter alia, for determining the presence, partial presence or absence of a droplet at an electrode on a droplet actuator by: (a) providing a droplet actuator comprising: (i) a substrate comprising electrodes arranged on the substrate for conducting droplet operations on a surface of the substrate; (ii) a capacitance detection circuit for detecting capacitance at the droplet operations surface at one or more of the electrodes; (b) detecting capacitance at the droplet operations surface at one or more of the electrodes; and (c) determining from the capacitance the presence, partial presence or absence of a droplet at the droplet operations surface at the electrode.
摘要翻译：一种用于检测液滴致动器上电容的方法，电路和装置，特别是用于通过以下步骤确定液滴致动器上的电极处的液滴的存在，部分存在或不存在：（a）提供液滴致动器，其包括：（i）基板，其包括布置在所述基板上的电极，用于在所述基板的表面上进行液滴操作; （ii）电容检测电路，用于检测一个或多个电极处的液滴操作表面处的电容; （b）在一个或多个电极处检测液滴操作表面处的电容; 和（c）根据电容确定在电极处的液滴操作表面处的液滴的存在，部分存在或不存在。

8. 发明授权

US08872527B2 Capacitance detection in a droplet actuator 有权
标题翻译：液滴执行器中的电容检测
公开(公告)号：US08872527B2
公开(公告)日：2014-10-28
申请号：US12527208
申请日：2008-02-15
申请人： Ryan A. Sturmer , Michael G. Pollack , Vamsee K. Pamula , Vijay Srinivasan , Philip Y. Paik
发明人： Ryan A. Sturmer , Michael G. Pollack , Vamsee K. Pamula , Vijay Srinivasan , Philip Y. Paik
IPC分类号： G01R27/26 , G01N27/22
CPC分类号： B01L3/50273 , B01L3/502715 , B01L3/502784 , B01L2200/0605 , B01L2300/0627 , B01L2300/0636 , B01L2300/0645 , B01L2300/0809 , B01L2400/0427 , G01N27/22 , G01N27/223 , G01N27/227 , G01N2203/00 , G01V3/02
摘要： A method, circuit and apparatus for detecting capacitance on a droplet actuator, inter alia, for determining the presence, partial presence or absence of a droplet at an electrode on a droplet actuator by: (a) providing a droplet actuator comprising: (i) a substrate comprising electrodes arranged on the substrate for conducting droplet operations on a surface of the substrate; (ii) a capacitance detection circuit for detecting capacitance at the droplet operations surface at one or more of the electrodes; (b) detecting capacitance at the droplet operations surface at one or more of the electrodes; and (c) determining from the capacitance the presence, partial presence or absence of a droplet at the droplet operations surface at the electrode.
摘要翻译：一种用于检测液滴致动器上电容的方法，电路和装置，特别是用于通过以下步骤确定液滴致动器上的电极处的液滴的存在，部分存在或不存在：（a）提供液滴致动器，其包括：（i）基板，其包括布置在所述基板上的电极，用于在所述基板的表面上进行液滴操作; （ii）电容检测电路，用于检测一个或多个电极处的液滴操作表面处的电容; （b）在一个或多个电极处检测液滴操作表面处的电容; 和（c）根据电容确定在电极处的液滴操作表面处的液滴的存在，部分存在或不存在。

9. 发明申请

US20130168250A1 Droplet Actuator Systems, Devices and Methods 审中-公开
标题翻译：液滴致动器系统，装置和方法
公开(公告)号：US20130168250A1
公开(公告)日：2013-07-04
申请号：US13822990
申请日：2011-09-15
申请人： Michael Fogleman , Ryan A. Sturmer , Gregory F. Smith
发明人： Michael Fogleman , Ryan A. Sturmer , Gregory F. Smith
IPC分类号： B81B7/02
CPC分类号： B81B7/02 , B01L3/502792 , B01L2200/0605 , B01L2200/143 , B01L2300/0645 , B01L2300/0816 , B01L2300/089 , B01L2400/0424 , B01L2400/0427 , C12Q1/6825 , G01F22/00 , G01N35/10 , C12Q2527/107 , C12Q2563/159 , C12Q2565/629
摘要： The present invention is directed to droplet actuator systems, devices, and methods. In one embodiment, a microfluidic article of manufacture is provided. The microfluidic article of manufacture includes a first substrate; a second substrate separated from the first substrate to form a droplet operations gap; gap height setting spacers associated with the first and/or second substrate or situated between the first and second substrates; a spring forcing the second substrate against the gap height setting spacers, thereby establishing a substantially uniform gap height between the first and second substrates; and electrodes associated with the first and/or second substrate and configured to conduct droplet operations in the droplet operations gap.
摘要翻译：本发明涉及液滴致动器系统，装置和方法。在一个实施例中，提供微流体制造品。微流体制品包括第一基底; 从所述第一基板分离以形成液滴操作间隙的第二基板; 与第一和/或第二基板相关联或位于第一和第二基板之间的间隙高度设置间隔物; 弹簧迫使第二基板抵靠间隙高度设定间隔件，从而在第一和第二基板之间建立基本均匀的间隙高度; 以及与第一和/或第二基板相关联并且被配置为在液滴操作间隙中进行液滴操作的电极。

10. 发明申请

US20130018611A1 Systems and Methods of Measuring Gap Height 审中-公开
标题翻译：间隙高度测量系统和方法
公开(公告)号：US20130018611A1
公开(公告)日：2013-01-17
申请号：US13545716
申请日：2012-07-10
申请人： Ryan A. Sturmer
发明人： Ryan A. Sturmer
IPC分类号： G06F19/00
CPC分类号： G01B7/06 , B01L3/502707 , B01L3/502792 , B01L2200/143 , B01L2200/148 , B01L2300/0645 , B01L2300/0816 , G01B7/082
摘要： A method of determining a gap height in a droplet actuator including measuring an impedance between a droplet operations electrode of a first substrate in a droplet actuator and ground electrode of a second substrate in the droplet actuator, storing a lookup table that associates impedances to heights of gaps between the first substrate and the second substrate, querying the lookup table for the impedance measured between the droplet operations electrode of the first substrate and the ground electrode of the second substrate; and retrieving a height of a gap associated with the impedance.
摘要翻译：一种确定液滴致动器中的间隙高度的方法，包括测量液滴致动器中的第一基板的液滴操作电极与液滴致动器中的第二基板的接地电极之间的阻抗，存储将阻抗与高度相关联的查找表第一基板和第二基板之间的间隙，查询查找表，测量在第一基板的液滴操作电极和第二基板的接地电极之间测得的阻抗; 并且检索与阻抗相关联的间隙的高度。

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