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1. 发明授权

US5797985A Banana starch production 失效
标题翻译：香蕉淀粉生产
公开(公告)号：US5797985A
公开(公告)日：1998-08-25
申请号：US824303
申请日：1997-03-26
申请人： Roy L. Whistler
发明人： Roy L. Whistler
IPC分类号： C08B30/04
CPC分类号： C08B30/04
摘要： A process is described for isolating granular starch from bananas by making use of sodium bisulfite and naturally occurring enzymes in the bananas to promote release of starch granules from the banana fruit.
摘要翻译：描述了通过利用亚硫酸氢钠和香蕉中的天然存在的酶从香蕉中分离颗粒淀粉以促进淀粉颗粒从香蕉果实中释放的方法。

2. 发明授权

US5298494A Monosaccharides having anti-proliferation and anti-inflammatory activity, compositions and uses thereof 失效
标题翻译：具有抗增殖和抗炎活性的单糖，其组合物和用途
公开(公告)号：US5298494A
公开(公告)日：1994-03-29
申请号：US83879
申请日：1993-06-30
申请人： Sudershan K. Arora , Roy L. Whistler , Albert V. Thomas
发明人： Sudershan K. Arora , Roy L. Whistler , Albert V. Thomas
IPC分类号： C07H9/04 , C07H11/00 , C07H13/04 , C07H15/04 , C07H15/10 , C07H15/12 , C07H15/14 , C07H15/18 , C07H15/26 , C07H19/01 , A61K31/00 , A61K31/70 , C07H15/00
CPC分类号： C07H9/04 , C07H11/00 , C07H13/04 , C07H15/04 , C07H15/10 , C07H15/12 , C07H15/14 , C07H15/18 , C07H15/26 , C07H19/01 , Y10S514/825 , Y10S514/861
摘要： Derivatives of simple monosaccharides which exhibit anti-proliferative and/or anti-inflammatory activity and are useful for treating mammals having inflammatory disorders and/or autoimmune disorders. This invention also encompasses pharmaceutical compositions containing these compounds and methods of treating inflammatory and/or autoimmune disorders.
摘要翻译：具有抗增殖和/或抗炎活性并且可用于治疗具有炎症性疾病和/或自身免疫性疾病的哺乳动物的简单单糖的衍生物。本发明还包括含有这些化合物的药物组合物和治疗炎性和/或自身免疫性疾病的方法。

3. 发明授权

US5843922A Preparation of oligosaccharides and products therefrom 失效
标题翻译：寡糖及其制品的制备
公开(公告)号：US5843922A
公开(公告)日：1998-12-01
申请号：US662201
申请日：1996-06-11
申请人： Roy L. Whistler , James N. BeMiller
发明人： Roy L. Whistler , James N. BeMiller
IPC分类号： C08B37/00 , C12N1/20 , A61K31/715 , C07H3/06
CPC分类号： C12N1/20 , C08B37/0051 , Y10S127/01 , Y10S514/892
摘要： The invention provides a method for preparation of a bifidobacteria-nourishing medium by subjecting a saccharide-based feedstock containing fructosyl units to flash flow conditions. The resulting shearform matrix is then treated to provide a medium having fructosyl-containing oligosaccharide. Preferably, the shearform matrix is treated by subjecting it to acid thermolysis conditions. Also provided is a method of nourishing mammalian alimentary tract for preferential growth of bifidobacteria. In addition, there is provided a medium for nourishing bifidobacteria and comestible products made therefrom.
摘要翻译：本发明提供了通过使含有果糖基单元的糖类原料经历闪蒸流动条件来制备双歧杆菌滋养培养基的方法。然后将所得剪切形式基质处理以提供含有果糖基寡糖的培养基。优选地，通过使剪切形式的基质经受酸热解条件处理。还提供了一种滋养哺乳动物消化道用于双歧杆菌优先生长的方法。此外，提供了用于滋养双歧杆菌和由其制成的食物的培养基。

4. 发明授权

US5403599A Method for preparing tamarind oligosaccharides 失效
标题翻译：罗望子寡糖的制备方法
公开(公告)号：US5403599A
公开(公告)日：1995-04-04
申请号：US165512
申请日：1993-12-10
申请人： Roy L. Whistler
发明人： Roy L. Whistler
IPC分类号： A21D2/18 , A21D13/08 , A23G3/34 , A23L1/05 , A23L1/0526 , A23L1/236 , A23L1/308 , C12P19/14 , A23L1/00
CPC分类号： C12Y302/01004 , A23L29/238 , A23L33/21 , Y10S426/804
摘要： A cellulase hydrolysate of tamarind polysaccharide is utilized as a substitute for a portion of metabolizable carbohydrates in processed foods to prepare reduced-calorie versions of said process foods having excellent organoleptic quality. The tamarind hydrolysate comprises DP 7 oligosaccharides, more typically, DP 7 and DP 9 oligosaccharides. The tamarind hydrolysate can be further processed utilizing yeast digestion and/or membrane filtration to remove monosaccharides and low DP (DP.ltoreq.6) oligosaccharides from the hydrolysate composition.
摘要翻译：罗望子多糖的纤维素酶水解物用作加工食品中可代谢的碳水化合物的一部分的替代品，以制备具有优良感官质量的所述加工食品的低热量型。罗望子水解产物包含DP 7寡糖，更典型的是DP 7和DP 9寡糖。可以利用酵母消化和/或膜过滤进一步处理罗望子水解产物，以从水解产物组合物中除去单糖和低DP（DP 6）寡糖。

5. 发明授权

US5064659A Reactive sugars for protection against cyanide adulteration 失效
标题翻译：防止氰化物反应的反应性糖
公开(公告)号：US5064659A
公开(公告)日：1991-11-12
申请号：US526175
申请日：1990-05-21
申请人： Michael J. Greenberg , Roy L. Whistler
发明人： Michael J. Greenberg , Roy L. Whistler
IPC分类号： A23G3/00 , A23G3/42 , A23G3/50 , A23G4/00 , A23G4/06 , A23G4/10 , A23L1/015 , A23L1/09
CPC分类号： A23G3/42 , A23G3/50 , A23G4/06 , A23G4/10 , A23L29/30 , A23L5/27 , A61K31/7004
摘要： Cyanide reactive reducing sugars, such as xylose, ribose, arabinose, glyceraldehyde and erythrose, are added to a food, drug or other oral composition to detoxify cyanide. The cyanide reacive reducing sugar is added in an amount in excess of about 1 weight percent. The cyanide reactive reducing sugar may be mixed into the composition or may be applied as a coating on a solid composition. The cyanide reactive reducing sugar is one of the edible components of the gum.
摘要翻译：向食品，药物或其他口服组合物中加入氰化物反应性还原糖，如木糖，核糖，阿拉伯糖，甘油醛和赤藓红，使氰化物解毒。氰化物还原糖的还原糖的添加量超过约1重量％。氰化物反应性还原糖可以混合到组合物中，或者可以作为涂料施用在固体组合物上。氰化物反应性还原糖是口香糖的可食用成分之一。

6. 发明授权

US4413120A Process for producing acosamine, daunosamine, 1-thioacosamine and related compounds 失效
标题翻译：生产盐酸胺，柔红霉素，1-硫代氨基甲酸和相关化合物的方法
公开(公告)号：US4413120A
公开(公告)日：1983-11-01
申请号：US251636
申请日：1981-04-06
申请人： Roy L. Whistler
发明人： Roy L. Whistler
IPC分类号： C07H15/04 , C07H15/14 , C07H1/00
CPC分类号： C07H15/14 , C07H15/04
摘要： A process for synthesizing acosamine, daunosamine and 1-thioacosamines from L-rhamnal is disclosed that can generally be characterized by Michael addition of an alkoxide or thioalkoxide to the enone formed by allylic oxidation of L-rhamnal to directly generate the 2-deoxy functionality, and stereospecific reduction of the oxime to the arabino compound which establishes configuration at C-3 and generates a compound which requires only epirmerization at C-4 to yield the desired product. The synthesis of anthracycline antibiotics incorporating these sugars or their derivatives by glycosidation of the glycone is also disclosed.
摘要翻译：公开了从L-鼠李糖合成α-淀粉胺，柔红霉素和1-硫代多糖的方法，其通常可以通过向通过L-鼠李糖的烯丙氧化形成的烯酮迈克尔加入醇盐或硫代烷氧化物来直接产生2-脱氧官能团，并将肟立体特异性还原成在C-3上构成的阿拉伯化合物，并产生仅需要在C-4表现出来产生所需产物的化合物。还公开了通过糖苷糖基化合成这些糖或其衍生物的蒽环类抗生素的合成。

7. 发明授权

US5453281A Compositions utilizing small granule starch 失效
标题翻译：使用小颗粒淀粉的组合物
公开(公告)号：US5453281A
公开(公告)日：1995-09-26
申请号：US852691
申请日：1992-03-17
申请人： Roy L. Whistler
发明人： Roy L. Whistler
IPC分类号： A61K8/04 , A61K8/73 , A61K9/20 , A61Q1/12 , A61K9/14 , A61K7/02 , A61K9/16
CPC分类号： A61K8/732 , A61K8/0241 , A61K9/2059 , A61Q1/12 , Y10S514/951
摘要： Small granule starch having a mean granule size of less than about 5 microns is substituted for binder excipients in tabletting compositions or the talc or granular starch ingredients of art recognized cosmetic/dusting powder compositions to provide improved compositions. Small granular starch is used as a binder with an orally active ingredient and other optional excipients to provide a tabletting mixture which can be compressed into tablets having excellent hardness and favorable disintegration characteristics. The use of small granule starches as a substitute for art-recognized starch and/or talc carriers in cosmetic/body powders provide compositions with enhanced coverage and a softer feel when applied to the skin.
摘要翻译：平均粒度小于约5微米的小颗粒淀粉取代了压片组合物中的粘合剂赋形剂或本领域公认的化妆品/粉尘粉末组合物的滑石粉或颗粒淀粉成分，以提供改进的组合物。使用小粒状淀粉作为具有口服活性成分和其它任选赋形剂的粘合剂，以提供可压制成具有优异硬度和有利的崩解特性的片剂的压片混合物。在化妆品/体内粉末中使用小颗粒淀粉作为本领域公认的淀粉和/或滑石载体的替代物，当施用于皮肤时，提供具有更高覆盖度和较柔软感觉的组合物。

8. 发明授权

US4985082A Microporous granular starch matrix compositions 失效
标题翻译：微孔颗粒淀粉基质组合物
公开(公告)号：US4985082A
公开(公告)日：1991-01-15
申请号：US123570
申请日：1987-11-20
申请人： Roy L. Whistler
发明人： Roy L. Whistler
IPC分类号： A01N25/10 , A61K8/04 , A61K8/73 , A61K9/16 , A61Q19/00 , C08B31/00 , C08L3/00 , C11D3/22 , C12P19/14
CPC分类号： A01N25/10 , A61K8/0279 , A61K8/732 , A61K9/1652 , A61K9/167 , A61Q19/00 , C08B31/00 , C08L3/00 , C11D3/222 , C11D3/225 , C12P19/14 , A61K2800/56 , A61K2800/654 , A61Q15/00
摘要： Amylase treated granular starches provide a microporous matrix material adapted for absorption and releasable containment of functional compositions. The microporous starch granules are chemically derivatized to enhance absorptive and structural properties. Absorbed functional substances are released from the microporous starch matrix under the influence of mechanical compression, by diffusion into a surrounding fluid or as a result of degradation of the granular starch matrix.
摘要翻译：淀粉酶处理的颗粒状淀粉提供适于吸收和释放的功能组合物的容纳物的微孔基质材料。化学衍生微孔淀粉颗粒以提高吸收性和结构性能。吸收的功能物质在机械压缩，通过扩散到周围的流体中或由于颗粒淀粉基质的降解的影响下从微孔淀粉基质释放。

9. 发明授权

US4420489A Sugars with sulfur replacing the ring oxygen atom as antiradiation agents 失效
标题翻译：硫磺替代环氧原子作为抗辐射剂
公开(公告)号：US4420489A
公开(公告)日：1983-12-13
申请号：US309280
申请日：1981-10-07
申请人： Roy L. Whistler
发明人： Roy L. Whistler
IPC分类号： C07H5/10 , A61K31/38
CPC分类号： C07H5/10
摘要： Simple sugars with sulfur replacing the ring oxygen atom protect normal healthy cells of animals from radiation or from any other reaction that produces free radicals and damages the cells through the action of the free radicals. To be effective, the thio-sugars must undergo transport to cells that may be adversely affected by free radicals. 6-Thio-D-fructose is an example of a sugar that is readily transported from the gastrointestinal tract to the cardiovascular system and thereby disseminated to cells throughout the body. As it is absorbed into the cells, it protects against all kinds of radiation that adversely affects cells through the creation of free radicals. It is believed to be effective against all high-energy radiation that produces free radicals in living material, and therefore is effective against radiation such as X-ray, gamma, alpha, pi mesons, neutrons, and ultraviolet light radiation. Therefore, it even offers protection against sunburn.
摘要翻译：用硫替代环氧原子的简单糖保护动物的正常健康细胞免受辐射或任何其他产生自由基的反应，并通过自由基的作用破坏细胞。为了有效，硫代糖必须运送到可能受自由基不利影响的细胞。 6-硫代-D-果糖是糖容易从胃肠道输送到心血管系统并由此分散到全身细胞的糖的实例。当它被吸收到细胞中时，它可以防止通过产生自由基对细胞产生不利影响的各种辐射。据信对于在生物材料中产生自由基的所有高能辐射是有效的，因此对于诸如X射线，γ，α，π介子，中子和紫外光辐射的辐射是有效的。因此，它甚至提供防晒霜。

10. 发明授权

US4332894A Conversion of guar gum to gel-forming polysaccharides by the action of .alpha.-galactosidase 失效
标题翻译：通过α-半乳糖苷酶的作用将瓜尔胶转化成凝胶形成多糖
公开(公告)号：US4332894A
公开(公告)日：1982-06-01
申请号：US178507
申请日：1980-08-15
申请人： Roy L. Whistler
发明人： Roy L. Whistler
IPC分类号： C12P19/14 , C12P19/04
CPC分类号： C12P19/14
摘要： Water-soluble polysaccharide guar gum, guaran, is altered to convert its properties from those of producing a highly viscous stable dispersion to enable production of a sequence of products that may be separately produced through the selective removal of D-galactopyranosyl side units so as to produce different lengths of molecular segments containing no derivatizing .alpha.-D-galactopyranosyl groups. The structure therefore yields a high viscosity polysaccharide with the ability to form gels of various strengths ranging from very weak gels to strong gels by appropriate selection of the extent to which the .alpha.-D-galactopyranosyl groups are removed.
摘要翻译：水溶性多糖瓜耳胶（guaran）被改变以将其性质从产生高粘度稳定分散体的性质转变为能够生产可以通过选择性除去D-吡喃半乳糖基侧基单独产生的一系列产物，以便产生不含衍生化α-D-吡喃半乳糖基团的不同长度的分子片段。因此，该结构产生高粘度多糖，通过适当选择去除α-D-吡喃半乳糖基的程度，能够形成从非常弱的凝胶到强凝胶的各种强度的凝胶。

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