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1. 发明专利

JP2007306926A Nucleic acid analog, diagnostic agent and use of the same in analysis method 审中-公开
标题翻译：核酸类似物，诊断试剂及其在分析方法中的应用
公开(公告)号：JP2007306926A
公开(公告)日：2007-11-29
申请号：JP2007147536
申请日：2007-06-01
申请人： Rolf Henrik Berg , Buchardt Dorte , Michael Egholm , Peter Eigil Nielsen , エグホルム、ミカエル , ニールセン、ピーター・アイギル , ブカルト、ドルテ , ベルク、ロルフ・ヘンリク
发明人： BUCHARDT OLE , EGHOLM MICHAEL , NIELSEN PETER EIGIL , BERG ROLF HENRIK
IPC分类号： A61K31/70 , C12N15/09 , A61K38/00 , A61K48/00 , A61P31/12 , A61P43/00 , C07H21/00 , C07H21/04 , C07K1/22 , C07K5/06 , C07K5/078 , C07K5/08 , C07K5/10 , C07K7/06 , C07K7/08 , C07K9/00 , C07K14/00 , C07K16/00 , C08G69/00 , C12Q1/68 , G01N30/88 , G01N33/53 , G01N33/58
CPC分类号： C07H21/00 , A61K38/00 , C07K5/06026 , C07K5/06139 , C07K7/06 , C07K7/08 , C07K14/003 , C12Q1/68 , C12Q1/6813 , C12Q1/6832 , C12Q1/6869 , C12Q2535/107 , C12Q2525/107
摘要： PROBLEM TO BE SOLVED: To obtain some nucleic acid analogs, e.g., for performing capture, recognition, detection, identification or quantification about one or more chemically or microbiologically individual units, in order to solve problems which can not be solved by conventional techniques in a field of diagnostic agents. SOLUTION: The nucleic acid homologs having a new structure and characteristics that have not been known such as a characteristic to form a hybrid with a conventionally known nucleic acid having a complementary sequence and enhancing stability in the Tm value of the hybrid higher than the hybrid formed by the conventionally known nucleic acid and/or a characteristic to enhance selectivity to a complementary sequence comparing with a sequence relating to a degree of mismatching of the known conventional nucleic acid, and applications of the nucleic acid homologs to diagnostic agents or analyses are provided. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：为了获得一些核酸类似物，例如用于对一个或多个化学或微生物学单个单元进行捕获，识别，检测，鉴定或定量，以解决常规的不能解决的问题技术在诊断剂领域。解决方案：具有新的结构和特征的核酸同系物，例如与常规已知的具有互补序列的核酸形成杂交体的特征，并提高混合物的Tm值的稳定性高于通过常规已知的核酸形成的杂合物和/或特征，以增强对互补序列的选择性与与已知的常规核酸的错配程度相关的序列以及核酸同系物与诊断试剂或分析的应用被提供。版权所有（C）2008，JPO＆INPIT

2. 发明专利

JP2008253251A Nucleic acid analog, diagnostic agent and method for using the same in analysis method 审中-公开
标题翻译：核酸类似物，诊断试剂及其在分析方法中的使用方法
公开(公告)号：JP2008253251A
公开(公告)日：2008-10-23
申请号：JP2008060342
申请日：2008-03-10
申请人： Rolf Henrik Berg , Buchardt Dorte , Michael Egholm , Peter Eigil Nielsen , エグホルム、ミカエル , ニールセン、ピーター・アイギル , ブカルト、ドルテ , ベルク、ロルフ・ヘンリク
发明人： BUCHARDT OLE , EGHOLM MICHAEL , NIELSEN PETER EIGIL , BERG ROLF HENRIK
IPC分类号： A61K31/70 , C12N15/09 , A61K38/00 , A61K48/00 , A61P31/12 , A61P43/00 , C07D519/00 , C07H21/00 , C07H21/04 , C07K1/22 , C07K5/06 , C07K5/078 , C07K5/08 , C07K5/10 , C07K7/06 , C07K7/08 , C07K9/00 , C07K14/00 , C07K16/00 , C08G69/00 , C12Q1/68 , G01N33/53
CPC分类号： C07H21/00 , A61K38/00 , C07K5/06026 , C07K5/06139 , C07K7/06 , C07K7/08 , C07K14/003 , C12Q1/68 , C12Q1/6813 , C12Q1/6832 , C12Q1/6869 , C12Q2535/107 , C12Q2525/107
摘要： PROBLEM TO BE SOLVED: To provide a nucleic acid analog for performing capture, recognition, detection, identification or quantification about chemically or microbiologically individual units. SOLUTION: The nucleic acid analogues provided are: (a) a PNA (peptide nucleic acid) including a polyamide backbone bearing a plurality of ligands at respective spaced locations along the backbone, where each ligand being bound directly or indirectly to a nitrogen atom in the backbone and the ligand bearing nitrogen atoms mainly being separated from one another in the backbone by 4-8 intervening atoms; (b) a nucleic acid analog capable of hybridizing to a nucleic acid of complementary sequence to form a hybrid which is more stable against denaturation by heat than a hybrid between the conventional deoxyribonucleotide and the nucleic acid; or (c) a nucleic acid analogue capable of hybridizing to double-stranded nucleic acid in which one strand has a sequence complementary to the analogue, so as to displace the other strand from one strand. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供用于进行关于化学或微生物学单个单元的捕获，识别，检测，鉴定或定量的核酸类似物。提供的核酸类似物是：（a）包含聚酰胺主链的PNA（肽核酸），其中所述聚酰胺主链在主链的相应间隔位置处具有多个配体，其中每个配体直接或间接地结合于氮骨架中的原子和带有氮原子的配体主要通过4-8个中间原子在骨架中彼此分离; （b）能够与互补序列的核酸杂交的核酸类似物，以形成与常规脱氧核糖核苷酸和核酸之间的杂交体相比对抗变性更稳定的杂交体; 或（c）能够与双链核酸杂交的核酸类似物，其中一条链具有与该类似物互补的序列，以便从一条链取代另一条链。版权所有（C）2009，JPO＆INPIT

3. 发明专利

JP2009069158A Nucleic acid analogue, diagnostic agent, and use of them in analyzing method 审中-公开
标题翻译：核酸类似物，诊断试剂及其在分析方法中的应用
公开(公告)号：JP2009069158A
公开(公告)日：2009-04-02
申请号：JP2008258890
申请日：2008-10-03
申请人： Rolf Henrik Berg , Buchardt Dorte , Michael Egholm , Peter Eigil Nielsen , エグホルム、ミカエル , ニールセン、ピーター・アイギル , ブカルト、ドルテ , ベルク、ロルフ・ヘンリク
发明人： BUCHARDT OLE , EGHOLM MICHAEL , NIELSEN PETER EIGIL , BERG ROLF HENRIK
IPC分类号： A61K31/70 , G01N33/531 , A61K38/00 , A61K48/00 , A61P31/12 , A61P43/00 , C07D239/47 , C07D239/54 , C07D473/18 , C07D473/34 , C07H21/00 , C07H21/04 , C07K1/22 , C07K5/06 , C07K5/078 , C07K5/08 , C07K5/10 , C07K7/06 , C07K7/08 , C07K9/00 , C07K14/00 , C07K16/00 , C08G69/00 , C12N15/09 , C12Q1/68 , G01N33/53 , G01N33/566
CPC分类号： C07H21/00 , A61K38/00 , C07K5/06026 , C07K5/06139 , C07K7/06 , C07K7/08 , C07K14/003 , C12Q1/68 , C12Q1/6813 , C12Q1/6832 , C12Q1/6869 , C12Q2535/107 , C12Q2525/107
摘要： PROBLEM TO BE SOLVED: To provide some nucleic acid analogues in order to perform capture, recognition, detection, identification or quantification about one or more chemically or microbiologically individual units for example. SOLUTION: The nucleic acid analogue with a new structure having characteristics that have not been conventionally known such as a characteristic to form a hybrid with a conventionally known nucleic acid having a complementary arrangement and to make stability in the Tm value of the hybrid higher than the hybrid formed by the conventionally known nucleic acid having an equivalent arrangement and/or a characteristic to make selectivity to the complementary arrangement compared with an arrangement relating to a degree of mismatching higher than the known conventional nucleic acid having the equivalent arrangement, and the method of using the nucleic acid analogues for diagnostic agents or analysis are provided. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一些核酸类似物以便例如关于一个或多个化学或微生物学个体单元的捕获，识别，检测，鉴定或定量。解决方案：具有新的结构的核酸类似物具有以往未知的特征，例如与具有互补排列的常规已知核酸形成杂交体的特征，并使混合物的Tm值稳定高于由具有等同排列和/或特征的常规已知核酸形成的杂交，以使得与相对于具有等同排列的已知常规核酸的错配程度相关的排列相比，对互补排列具有选择性;以及提供了使用核酸类似物进行诊断或分析的方法。版权所有（C）2009，JPO＆INPIT

4. 发明专利

AU674520B2 Use of nucleic acid analogues in the inhibition of nucleic acid amplification 未知
公开(公告)号：AU674520B2
公开(公告)日：1997-01-02
申请号：AU4323593
申请日：1993-06-07
申请人： DORTE BUCHARDT , PNA DIAGNOSTICS AS , MICHAEL EGHOLM , PETER EIGIL NIELSEN , ROLF HENRIK BERG
发明人： BUCHARDT OLE , EGHOLM MICHAEL , NIELSEN PETER EIGIL , BERG ROLF HENRIK , STANLEY CHRISTOPHER JOHN
IPC分类号： C12N15/09 , C07H21/04 , C12Q20060101 , C12Q1/68 , C12Q1/6848 , C12Q1/686 , G01N33/50 , G01N33/53 , G01N33/566
摘要： PCT No. PCT/EP93/01435 Sec. 371 Date Mar. 10, 1995 Sec. 102(e) Date Mar. 10, 1995 PCT Filed Jun. 7, 1993 PCT Pub. No. WO93/25706 PCT Pub. Date Dec. 23, 1993Nucleic acid analogues such as peptide-nucleic acids (PNAs) which hybridize strongly to nucleic acids are used to inhibit nucleic acid amplification procedures such as PCR. False positives in subsequent PCR assays are prevented by hybridizing a PNA to PCR amplification products. Assays capable of discriminating between single base mutants are conducted by using a PNA hybridizing to one of the two allelic forms to inhibit a PCR amplification of that form selectively. Asymmetric PCR amplifications are carried out by starting a PCR symmetrically using like quantities of forward and reverse primers, and, once the amplification is established, disabling one primer by hybridizing a PNA thereto.

6. 发明授权

US08785111B2 Hydrophilic nanoporous materials 失效
标题翻译：亲水纳米多孔材料
公开(公告)号：US08785111B2
公开(公告)日：2014-07-22
申请号：US13133701
申请日：2009-12-09
申请人： Li Li , Sokol Ndoni , Rolf Henrik Berg , Lars Schulte , Martin E. Vigild
发明人： Li Li , Sokol Ndoni , Rolf Henrik Berg , Lars Schulte , Martin E. Vigild
IPC分类号： G03F7/26
CPC分类号： C08J9/0071 , C08J9/26 , C08J9/36 , C08J2201/046 , C08J2300/00 , C08J2353/00
摘要： The present application discloses a method for preparing and rendering hydrophilic a nanoporous material of a polymer matrix which has a porosity of 0.1-90% (v/v), such that the ratio between the final water absorption (% (w/w)) and the porosity (% (v/v)) is at least 0.05, the method comprising the steps of: (a) preparing a precursor material comprising at least one polymeric component and having a first phase and a second phase; (b) removal of at least a part of the first phase of the precursor material prepared in step (a) so as to leave behind a nanoporous material of the polymer matrix; (c) irradiating at least a part of said nanoporous material with light of a wave length of in the range of 250-400 nm (or 200-700 nm) in the presence of oxygen and/or ozone. Corresponding hydrophilic nanoporous materials are also disclosed.
摘要翻译：本申请公开了一种制备和使亲水性的聚合物基质的纳米多孔材料的方法，其具有0.1-90％（v / v）的孔隙率，使得最终吸水率（％（w / w））并且孔隙率（％（v / v））至少为0.05，该方法包括以下步骤：（a）制备包含至少一种聚合物组分并具有第一相和第二相的前体材料; （b）除去在步骤（a）中制备的前体材料的至少一部分第一相，以留下聚合物基体的纳米多孔材料; （c）在存在氧和/或臭氧的情况下用波长为250-400nm（或200-700nm）的波长照射所述纳米多孔材料的至少一部分。还公开了相应的亲水纳米多孔材料。

7. 发明授权

US06376655B1 Physically functional materials 失效
标题翻译：物理功能材料
公开(公告)号：US06376655B1
公开(公告)日：2002-04-23
申请号：US08973179
申请日：1997-12-02
申请人： Rolf Henrik Berg , Søren Hvilsted , P. S. Ramanujam
发明人： Rolf Henrik Berg , Søren Hvilsted , P. S. Ramanujam
IPC分类号： C07C24508
CPC分类号： B82Y10/00 , C07C245/08 , C07C255/65 , C07D257/02 , G02F1/3611 , G03H2240/26 , G03H2240/52 , G03H2240/53 , G03H2260/35 , G11B7/00454 , G11B7/0065 , G11B7/244 , G11B9/149 , G11C13/042 , H01F1/42 , Y10S534/03
摘要： The invention relates to novel monodisperse or polydisperse compounds, in general named DNO (diamino acid N&agr;-substituted oligopeptides), preferably low molecular weight polypeptides, e.g., based on ornithine, lysine, diaminobutyric acid, diaminopropionic acid, aminoethylglycine or other amino acids or peptides having azobenzenes or other physicially functional groups, e.g., photoresponsive groups, as side chains. These compounds may be synthesized using solid phase peptide synthesis techniques. Materials, e.g., thin films, comprising such compounds may be used for optical storage of information (holographic data storage), nonlinear optics (NLO), as photoconductors, photonic band-gap materials, electrically conducting materials, electroluminescent materials, piezo-electric materials, pyroelectric materials, magnetic materials, ferromagnetic materials, ferroelectric materials, photorefractive materials, or materials in which light-induced conformational changes can be produced. Optical anisotropy may reversibly be generated with polarized laser light whereby a hologram is formed. First order diffraction efficiencies of up to around 80% have been obtained.
摘要翻译：本发明涉及新的单分散或多分散化合物，通常称为DNO（二氨基酸Nalpha取代的寡肽），优选低分子量多肽，例如基于鸟氨酸，赖氨酸，二氨基丁酸，二氨基丙酸，氨基乙基甘氨酸或其它氨基酸或肽具有偶氮苯或其它物理官能团，例如光响应基团，作为侧链。这些化合物可以使用固相肽合成技术合成。包括这种化合物的材料，例如薄膜可以用于光学存储信息（全息数据存储），非线性光学（NLO），作为光电导体，光子带隙材料，导电材料，电致发光材料，压电材料，热电材料，磁性材料，铁磁材料，铁电材料，光折射材料或可以产生光诱导构象变化的材料。光学各向异性可以用偏振激光可逆地产生，由此形成全息图。已获得高达约80％的一级衍射效率。

8. 发明授权

US5891625A Use of nucleic acid analogues in the inhibition of nucleic acid amplification 失效
标题翻译：核酸类似物在抑制核酸扩增中的应用
公开(公告)号：US5891625A
公开(公告)日：1999-04-06
申请号：US338535
申请日：1995-03-10
申请人： Ole Buchardt, deceased , Michael Egholm , Peter Eigil Nielsen , Rolf Henrik Berg , Christopher John Stanley
发明人： Ole Buchardt, deceased , Michael Egholm , Peter Eigil Nielsen , Rolf Henrik Berg , Christopher John Stanley
IPC分类号： C12N15/09 , C07H21/04 , C12Q20060101 , C12Q1/68 , G01N33/50 , G01N33/53 , G01N33/566 , C07H21/02 , C12P19/34
CPC分类号： C12Q1/6848 , C12Q1/686
摘要： Nucleic acid analogues such as peptide-nucleic acids (PNAs) which hybridize strongly to nucleic acids are used to inhibit nucleic acid amplification procedures such as PCR. False positives in subsequent PCR assays are prevented by hybridizing a PNA to PCR amplification products. Assays capable of discriminating between single base mutants are conducted by using a PNA hybridizing to one of the two allelic forms to inhibit a PCR amplification of that form selectively. Asymmetric PCR amplifications are carried out by starting a PCR symmetrically using like quantities of forward and reverse primers, and, once the amplification is established, disabling one primer by hybridizing a PNA thereto.
摘要翻译： PCT No.PCT / EP93 / 01435 Sec。 371 1995年3月10日 102（e）1995年3月10日PCT PCT 1993年6月7日PCT公布。公开号WO93 / 25706 日期1993年12月23日使用与核酸强烈杂交的核酸类似物如肽 - 核酸（PNA）来抑制核酸扩增程序如PCR。通过将PNA与PCR扩增产物杂交来防止后续PCR测定中的假阳性。能够区分单碱基突变体的测定通过使用与两种等位基因形式中的一种杂交的PNA进行，以选择性地抑制该形式的PCR扩增。通过使用类似量的正向引物和反向引物对称地进行PCR来进行不对称PCR扩增，一旦扩增成功，通过与PNA杂交就能使一个引物失活。

9. 发明授权

US5786461A Peptide nucleic acids having amino acid side chains 失效
公开(公告)号：US5786461A
公开(公告)日：1998-07-28
申请号：US847095
申请日：1997-05-01
申请人： Ole Buchardt, deceased , Michael Egholm , Peter Eigil Nielsen , Rolf Henrik Berg , Dorte Buchardt
发明人： Ole Buchardt, deceased , Michael Egholm , Peter Eigil Nielsen , Rolf Henrik Berg , Dorte Buchardt
IPC分类号： C07H21/00 , C07K5/078 , C07K14/00 , C12Q1/68 , C07K5/00
CPC分类号： C07H21/00 , C07K14/003 , C07K5/06139 , C12Q1/68 , C12Q1/6869
摘要： A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than the corresponding DNA or RNA strands, and exhibit increased sequence specificity and solubility. The peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone, and contain alkylamine side chains.

10. 发明申请

US20110305993A1 HYDROPHILIC NANOPOROUS MATERIALS 失效
标题翻译：水解纳米材料
公开(公告)号：US20110305993A1
公开(公告)日：2011-12-15
申请号：US13133701
申请日：2009-12-09
申请人： Li Li , Sokol Ndoni , Rolf Henrik Berg , Lars Schulte , Martin E. Vigild
发明人： Li Li , Sokol Ndoni , Rolf Henrik Berg , Lars Schulte , Martin E. Vigild
IPC分类号： G03F7/20 , B82B3/00
CPC分类号： C08J9/0071 , C08J9/26 , C08J9/36 , C08J2201/046 , C08J2300/00 , C08J2353/00
摘要： The present application discloses a method for preparing and rendering hydrophilic a nanoporous material of a polymer matrix which has a porosity of 0.1-90% (v/v), such that the ratio between the fmal water absorption (% (w/w)) and the porosity (% (v/v)) is at least 0.05, the method comprising the steps of: (a) preparing a precursor material comprising at least one polymeric component and having a first phase and a second phase; (b) removal of at least a part of the first phase of the precursor material prepared in step (a) so as to leave behind a nanoporous material of the polymer matrix; (c) irradiating at least a part of said nanoporous material with light of a wave length of in the range of 250-400 nm (or 200-700 nm) in the presence of oxygen and/or ozone. Corresponding hydrophilic nanoporous materials are also disclosed.
摘要翻译：本申请公开了一种制备和使亲水性的聚合物基质的纳米多孔材料的孔隙率为0.1-90％（v / v）的亲水性方法，使得吸水率（％（w / w））并且孔隙率（％（v / v））至少为0.05，该方法包括以下步骤：（a）制备包含至少一种聚合物组分并具有第一相和第二相的前体材料; （b）除去在步骤（a）中制备的前体材料的至少一部分第一相，以留下聚合物基体的纳米多孔材料; （c）在存在氧和/或臭氧的情况下用波长为250-400nm（或200-700nm）的波长照射所述纳米多孔材料的至少一部分。还公开了相应的亲水纳米多孔材料。

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