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1. 发明专利

BR9917178A 未知
公开(公告)号：BR9917178A
公开(公告)日：2001-12-04
申请号：BR9917178
申请日：1999-12-14
申请人： ROLAND D GREEN
发明人： GREEN ROLAND D
IPC分类号： B65D35/22 , B65D1/04 , B65D81/32

2. 发明申请

US20090069197A1 Parallel Loading of Arrays 失效
标题翻译：数组并行加载
公开(公告)号：US20090069197A1
公开(公告)日：2009-03-12
申请号：US12269088
申请日：2008-11-12
申请人： Roland D. Green , Mark McCormick , Gary Barrett
发明人： Roland D. Green , Mark McCormick , Gary Barrett
IPC分类号： C40B50/14 , C40B60/00
CPC分类号： B01L3/50853 , B01J19/0046 , B01J2219/00369 , B01J2219/00414 , B01J2219/00418 , B01J2219/00421 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00619 , B01J2219/00637 , B01J2219/00662 , B01J2219/00677 , B01J2219/00691 , B01J2219/00722 , B01L3/0241 , B01L3/5025 , B01L3/563 , B01L2300/0636 , B01L2300/0819 , B01L2400/0406 , C40B40/06 , C40B60/14 , Y10T436/25 , Y10T436/2575
摘要： The present inventions provides an apparatus and method for the parallel loading of multiple samples in a microarray containing a plurality of sub-arrays. The method makes use of a microarray containing multiple sub-arrays, a loading channel array, and a fluid handling robot or an assembly robot or machine.
摘要翻译：本发明提供了一种用于在包含多个子阵列的微阵列中并行加载多个样本的装置和方法。该方法利用包含多个子阵列的微阵列，加载通道阵列和流体处理机器人或装配机器人或机器。

3. 发明授权

US07482170B2 Parallel loading of arrays 失效
标题翻译：数组并行加载
公开(公告)号：US07482170B2
公开(公告)日：2009-01-27
申请号：US10674768
申请日：2003-09-30
申请人： Roland D. Green , Mark McCormick , Gary Barrett
发明人： Roland D. Green , Mark McCormick , Gary Barrett
IPC分类号： G01N1/10
CPC分类号： B01L3/50853 , B01J19/0046 , B01J2219/00369 , B01J2219/00414 , B01J2219/00418 , B01J2219/00421 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00619 , B01J2219/00637 , B01J2219/00662 , B01J2219/00677 , B01J2219/00691 , B01J2219/00722 , B01L3/0241 , B01L3/5025 , B01L3/563 , B01L2300/0636 , B01L2300/0819 , B01L2400/0406 , C40B40/06 , C40B60/14 , Y10T436/25 , Y10T436/2575
摘要： The present inventions provides an apparatus and method for the parallel loading of multiple samples in a microarray containing a plurality of sub-arrays. The method makes use of a microarray containing multiple sub-arrays, a loading channel array, and a fluid handling robot or an assembly robot or machine.
摘要翻译：本发明提供了一种用于在包含多个子阵列的微阵列中并行加载多个样本的装置和方法。该方法利用包含多个子阵列的微阵列，加载通道阵列和流体处理机器人或装配机器人或机器。

4. 发明授权

US06315958B1 Flow cell for synthesis of arrays of DNA probes and the like 有权
标题翻译：用于合成DNA探针阵列等的流通池
公开(公告)号：US06315958B1
公开(公告)日：2001-11-13
申请号：US09437369
申请日：1999-11-10
申请人： Sangeet Singh-Gasson , Yongjian Yue , Roland D. Green
发明人： Sangeet Singh-Gasson , Yongjian Yue , Roland D. Green
IPC分类号： C12M100
CPC分类号： G01N35/0098 , B01J19/0046 , B01J2219/00281 , B01J2219/00351 , B01J2219/00527 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00722 , C40B40/06 , C40B60/14 , G01N2035/00158
摘要： A flow cell which can be used in the synthesis of DNA probes on an active surface of the substrate includes a base having a central window opening and a registration surface against which the substrate may be mounted. A gasket having a central opening defining an active area is mounted on the active surface of the substrate and has inlet and output extension openings which extend away from the central opening. A press block is engaged against the gasket to fully enclose an active volume between the press block, the peripheral walls of the central opening in the gasket, and the active surface of the substrate. A press is mounted to the base to selectively press the press block against the gasket and hold it in position. Channels in the press block extend to the extension openings in the gasket to allow flow of reagent into and out of the active volume, which is confined to the thickness of the gasket and can thus be minimized. The press may include a press screw which can be turned to engage against the press block to hold it into position, and which can be turned to release the press block from the gasket, allowing rapid and easy replacement of substrates.
摘要翻译：可用于合成DNA探针的流动池在基底的有效表面上包括具有中心窗口和对准表面的基底，该基底可安装在其上。具有限定有源区域的中心开口的垫圈安装在基板的有效表面上，并且具有远离中心开口延伸的入口和输出延伸开口。压块与垫圈接合以完全包围压块，衬垫中的中心开口的周壁和衬底的有效表面之间的有效体积。压力机安装到基座上以选择性地将压块压靠垫圈并将其保持在适当位置。压块中的通道延伸到垫圈中的延伸开口，以允许试剂流入和流出活性体积，这限制在垫圈的厚度上，因此可以最小化。压力机可以包括压力螺钉，其可以转动以与压块接合以将其保持在适当位置，并且可以转动以将压块从垫圈释放，从而允许快速且容易地更换基板。

5. 发明授权

US08129196B2 Parallel loading of arrays 失效
标题翻译：数组并行加载
公开(公告)号：US08129196B2
公开(公告)日：2012-03-06
申请号：US12269088
申请日：2008-11-12
申请人： Roland D Green , Mark McCormick , Gary Barrett
发明人： Roland D Green , Mark McCormick , Gary Barrett
IPC分类号： G01N1/10
CPC分类号： B01L3/50853 , B01J19/0046 , B01J2219/00369 , B01J2219/00414 , B01J2219/00418 , B01J2219/00421 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00619 , B01J2219/00637 , B01J2219/00662 , B01J2219/00677 , B01J2219/00691 , B01J2219/00722 , B01L3/0241 , B01L3/5025 , B01L3/563 , B01L2300/0636 , B01L2300/0819 , B01L2400/0406 , C40B40/06 , C40B60/14 , Y10T436/25 , Y10T436/2575
摘要： The present inventions provides an apparatus and method for the parallel loading of multiple samples in a microarray containing a plurality of sub-arrays. The method makes use of a microarray containing multiple sub-arrays, a loading channel array, and a fluid handling robot or an assembly robot or machine.
摘要翻译：本发明提供了一种用于在包含多个子阵列的微阵列中并行加载多个样本的装置和方法。该方法利用包含多个子阵列的微阵列，加载通道阵列和流体处理机器人或装配机器人或机器。

6. 发明授权

US07745118B2 Comparative genomic resequencing 失效
标题翻译：比较基因组重测序
公开(公告)号：US07745118B2
公开(公告)日：2010-06-29
申请号：US11101841
申请日：2005-04-08
申请人： Roland D Green , Steve Smith , Thomas Albert , Emile F. Nuwaysir
发明人： Roland D Green , Steve Smith , Thomas Albert , Emile F. Nuwaysir
IPC分类号： C12Q1/68 , C40B30/00
CPC分类号： C12Q1/689 , C12Q1/6827 , C12Q1/6837 , C12Q1/6869 , C12Q1/6874 , C12Q2600/156 , Y10S977/791 , Y10S977/795 , C12Q2565/515 , C12Q2539/101
摘要： The present invention is an improved method of resequencing DNA using microarrays to rapidly map and identify SNPs, deletions and amplification events present in the genome of an organism. The method is performed by hybridizing a reference and a test genome to two separate arrays with each array exhibiting a specific intensity pattern. The intensity differences between the reference and the test genome arrays are used to produce a mutation map. The mapped differences are resequenced on a set of resequencing arrays to identify specific genetic mutations.
摘要翻译：本发明是使用微阵列重新测序DNA以快速映射和鉴定存在于生物体基因组中的SNP，缺失和扩增事件的改进方法。该方法通过将参考和测试基因组杂交到具有每个阵列呈现特定强度模式的两个分离的阵列来进行。参考和测试基因组数组之间的强度差异用于产生突变图。映射的差异在一组重新排序数组上重新排列，以识别特定的遗传突变。

7. 发明授权

US06444175B1 Flow cell for synthesis of arrays of DNA probes and the like 有权
公开(公告)号：US06444175B1
公开(公告)日：2002-09-03
申请号：US10053368
申请日：2001-11-09
申请人： Sangeet Singh-Gasson , Yongjian Yue , Roland D. Green
发明人： Sangeet Singh-Gasson , Yongjian Yue , Roland D. Green
IPC分类号： B01L300
CPC分类号： G01N35/0098 , B01J19/0046 , B01J2219/00281 , B01J2219/00351 , B01J2219/00527 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00722 , C40B40/06 , C40B60/14 , G01N2035/00158
摘要： A flow cell which can be used in the synthesis of DNA probes on an active surface of the substrate includes a base having a central window opening and a registration surface against which the substrate may be mounted. A gasket having a central opening defining an active area is mounted on the active surface of the substrate and has inlet and output extension openings which extend away from the central opening. A press block is engaged against the gasket to fully enclose an active volume between the press block, the peripheral walls of the central opening in the gasket, and the active surface of the substrate. A press is mounted to the base to selectively press the press block against the gasket and hold it in position. Channels in the press block extend to the extension openings in the gasket to allow flow of reagent into and out of the active volume, which is confined to the thickness of the gasket and can thus be minimized. The press may include a press screw which can be turned to engage against the press block to hold it into position, and which can be turned to release the press block from the gasket, allowing rapid and easy replacement of substrates.

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