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1. 发明授权

US07265244B2 Cyclopentyl derivatives 有权
标题翻译：环戊基衍生物
公开(公告)号：US07265244B2
公开(公告)日：2007-09-04
申请号：US10580366
申请日：2004-11-12
申请人： Piero Melloni , Cibele Maria Sabido David , Alessandra Restivo , Roberto Forlani , Patricia Salvati
发明人： Piero Melloni , Cibele Maria Sabido David , Alessandra Restivo , Roberto Forlani , Patricia Salvati
IPC分类号： C07C233/58 , C07C237/20
CPC分类号： C07C237/24 , C07C2601/08
摘要： This invention is related to novel cyclopentyl derivatives of the following general Formula (I), wherein X is methylene, oxygen, sulphur or a NR7 group; R1 is a straight or branched C1-C8 alkyl or C3-C8 alkenylene or C3-C8 alkynylene chain, optionally substituted with CF3, phenyl, phenoxy or naphthyl, the aromatic rings optionally substituted by one or more C1-C4 alkyl, halogens, trifluoromethyl, hydroxy or C1-C4 alkoxy groups; R2, R3 are independently hydrogen, a C1-C3 alkyl chain, halogen, trifluoromethyl, hydroxy or C1-C4 alkoxy groups; R4, R5,R6, R7 are independently hydrogen or C1-C6alkyl; and the pharmaceutically acceptable salts thereof that are active as sodium and/or calcium channel modulators and therefor useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to, neurological, psychiatric, cardiovascular, inflammatory, ophthalmic, urologic, metabolic and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role.
摘要翻译：本发明涉及以下通式（I）的新环戊基衍生物，其中X是亚甲基，氧，硫或NR 7基团; R 1是直链或支链C 1 -C 8烷基或C 3 -C 8烷基亚烷基或C 3 -C 8亚炔基链，任选被CF 3，苯基，苯氧基或萘基取代，芳环任选地被一个或多个C 1 -C 4烷基，卤素，三氟甲基，羟基或C 1 -C 4烷基取代，烷氧基; R 2，R 3，R 3独立地是氢，C 1 -C 3 - 烷基链，卤素，三氟甲基，羟基或C 1 -C 4烷氧基; R 4，R 5，R 6，R 7，R 7独立地是氢或C 1〜 C 1 -C 6烷基; 其作为钠和/或钙通道调节剂具有活性的药学上可接受的盐，并且可用于预防，减轻和治愈广泛范围的病症，包括但不限于神经性，精神病学，心血管疾病，炎症性，眼科，泌尿系统，代谢和胃肠道疾病，其中上述机制被描述为发挥病理作用。

2. 发明申请

US20070066688A1 Cyclopentyl derivatives 有权
标题翻译：环戊基衍生物
公开(公告)号：US20070066688A1
公开(公告)日：2007-03-22
申请号：US10580366
申请日：2004-11-12
申请人： Piero Melloni , Cibele Sabido David , Alessandra Restivo , Roberto Forlani , Patricia Salvati
发明人： Piero Melloni , Cibele Sabido David , Alessandra Restivo , Roberto Forlani , Patricia Salvati
IPC分类号： A61K31/165 , C07C237/20
CPC分类号： C07C237/24 , C07C2601/08
摘要： This invention is related to novel cyclopentyl derivatives of the following general Formula (I), wherein X is methylene, oxygen, sulphur or a NR7 group; R1 is a straight or branched C1-C8 alkyl or C3-C8 alkenylene or C3-C8 alkynylene chain, optionally substituted with CF3, phenyl, phenoxy or naphthyl, the aromatic rings optionally substituted by one or more C1-C4 alkyl, halogens, trifluoromethyl, hydroxy or C1-C4 alkoxy groups; R2, R3 are independently hydrogen, a C1-C3 alkyl chain, halogen, trifluoromethyl, hydroxy or C1-C4 alkoxy groups; R4, R5, R6, R7 are independently hydrogen or C1-C6 alkyl; and the pharmaceutically acceptable salts thereof that are active as sodium and/or calcium channel modulators and therefor useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to, neurological, psychiatric, cardiovascular, inflammatory, ophthalmic, urologic, metabolic and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role.
摘要翻译：本发明涉及以下通式（I）的新环戊基衍生物，其中X是亚甲基，氧，硫或NR 7基团; R 1是直链或支链C 1 -C 8烷基或C 3 -C 8烷基亚烷基或C 3 -C 8亚炔基链，任选被CF 3，苯基，苯氧基或萘基取代，芳环任选地被一个或多个C 1 -C 4烷基，卤素，三氟甲基，羟基或C 1 -C 4亚烷基取代 >烷氧基; R 2，R 3，R 3独立地是氢，C 1 -C 3 - 烷基链，卤素，三氟甲基，羟基或C 1 -C 4烷氧基; R 4，R 5，R 6，R 7，R 7独立地是氢或C 1〜 C 1 -C 6烷基; 其作为钠和/或钙通道调节剂具有活性的药学上可接受的盐，并且可用于预防，减轻和治愈广泛范围的病症，包括但不限于神经性，精神病学，心血管疾病，炎症性，眼科，泌尿系统，代谢和胃肠道疾病，其中上述机制被描述为发挥病理作用。

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