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1. 发明授权

US5142045A Electroactive materials 失效
标题翻译：电活性材料
公开(公告)号：US5142045A
公开(公告)日：1992-08-25
申请号：US199764
申请日：1988-05-27
申请人： Robert Zand , Shinji Nezu , Selim Kusefoglu
发明人： Robert Zand , Shinji Nezu , Selim Kusefoglu
IPC分类号： C07D219/02 , C07D219/04 , C07D241/46 , C07D265/38 , C07D279/30 , C08F20/34 , C08F20/36 , C08F20/38 , C08G18/30 , C08G18/38 , C08L39/00 , C08L41/00 , C09D5/24 , C09K9/02 , G02F1/155 , H01B1/12
CPC分类号： C09D5/24 , C07D279/30 , C09K9/02 , H01B1/121 , G02F1/155
摘要： Novel polymers containing 6,6,6-tricyclic moieties pendant from the polymer backbone, their novel monomers, and novel conductive polymers formed by doping the novel polymers with an electron acceptor compound. The novel polymers are easily synthesized, are soluble in various solvents, and are more stable than conductive polymers having the tricyclics as repeating units in the polymer backbone. A preferred tricyclic is phenothiazine.
摘要翻译：包含从聚合物主链悬挂的6,6,6-三环部分的新型聚合物，它们的新型单体和通过用电子受体化合物掺杂新型聚合物形成的新型导电聚合物。新型聚合物易于合成，可溶于各种溶剂，并且比在聚合物骨架中具有三环作为重复单元的导电聚合物更稳定。优选的三环是吩噻嗪。

2. 发明申请

US20100035952A1 Radiosensitizer Formulations and Methods for Use 审中-公开
标题翻译：放射增敏剂配方和使用方法
公开(公告)号：US20100035952A1
公开(公告)日：2010-02-11
申请号：US12566208
申请日：2009-09-24
申请人： Richard H. Matthews , Nuran Ercal , Robert Zand
发明人： Richard H. Matthews , Nuran Ercal , Robert Zand
IPC分类号： A61K31/417 , A61P35/00
CPC分类号： A61K31/4172 , A61K9/0019 , A61K9/0024
摘要： The present invention provides radiosensitizer compositions, in controlled-release formulations or other acceptable formulations, particularly nitrohistidine radiosensitizer compositions, which may be administered by any suitable means including oral, intravenous, arterial infusion, intraperitoneal, intramuscular, subcutaneous, surgical, and topical. Optionally, radiosensitizer compositions may be formulated with other agents, including chemotherapy agents and agents that provide a synergistic radiosensitizing effect. Methods of potentiating radiotherapy cancer treatment of cancers in humans, particularly of astrocytomas, are also presented, wherein a radiosensitizer composition is administered and radiotherapy is directed to the site of the tumor. Chemotherapy regimens may also be used as adjuvant therapy.
摘要翻译：本发明提供了在控释制剂或其它可接受的制剂，特别是硝基组氨酸放射增敏剂组合物中的放射增敏剂组合物，其可以通过包括口服，静脉内，动脉输注，腹膜内，肌内，皮下，手术和局部的任何合适方式施用。任选地，放射增敏剂组合物可以与其它试剂配制，包括提供协同放射增敏作用的化疗剂和试剂。还提出了增强人类癌症，特别是星形细胞瘤的放射治疗癌症治疗的方法，其中施用放射增敏剂组合物，放射疗法指向肿瘤部位。化疗方案也可用作辅助治疗。

3. 发明授权

US07608612B2 Radiosensitizer formulations and methods for use 有权
标题翻译：放射增敏剂配方及使用方法
公开(公告)号：US07608612B2
公开(公告)日：2009-10-27
申请号：US11336419
申请日：2006-01-20
申请人： Richard H. Matthews , Nuran Ercal , Robert Zand
发明人： Richard H. Matthews , Nuran Ercal , Robert Zand
IPC分类号： A61K31/33 , A01N43/00
CPC分类号： A61K31/4172 , A61K9/0019 , A61K9/0024
摘要： The present invention provides radiosensitizer compositions, in controlled-release formulations or other acceptable formulations, particularly nitrohistidine radiosensitizer compositions, which may be administered by any suitable means including oral, intravenous, arterial infusion, intraperitoneal, intramuscular, subcutaneous, surgical, and topical. Optionally, radiosensitizer compositions may be formulated with other agents, including chemotherapy agents and agents that provide a synergistic radiosensitizing effect. Methods of potentiating radiotherapy cancer treatment of cancers in humans, particularly of astrocytomas, are also presented, wherein a radiosensitizer composition is administered and radiotherapy is directed to the site of the tumor. Chemotherapy regimens may also be used as adjuvant therapy.
摘要翻译：本发明提供了在控释制剂或其它可接受的制剂，特别是硝基组氨酸放射增敏剂组合物中的放射增敏剂组合物，其可以通过包括口服，静脉内，动脉输注，腹膜内，肌内，皮下，手术和局部的任何合适方式施用。任选地，放射增敏剂组合物可以与其它试剂配制，包括提供协同放射增敏作用的化疗剂和试剂。还提出了增强人类癌症，特别是星形细胞瘤的放射治疗癌症治疗的方法，其中施用放射增敏剂组合物，放射疗法指向肿瘤部位。化疗方案也可用作辅助治疗。

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