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1. 发明授权

US09770190B2 Method and apparatus for examining subjects for particular physiological conditions utilizing acoustic information 有权
公开(公告)号：US09770190B2
公开(公告)日：2017-09-26
申请号：US12994865
申请日：2009-05-26
申请人： Sarah Herscovici-Cohen , Robert P. Schnall
发明人： Sarah Herscovici-Cohen , Robert P. Schnall
IPC分类号： A61B7/00 , A61B5/08 , A61B5/00
CPC分类号： A61B5/08 , A61B5/4806 , A61B7/003 , A61B2560/0223
摘要： A method and apparatus for examining a subject for a particular physiological condition according to a technique which utilizes sounds generated by the subject and sensed at a predefined distance from the site of sound generation of the subject, by locating a first sound sensor, e.g., a sound level meter which measures the sound levels in decibels, on a particular region of the subject's body to produce an output corresponding to the sound level sensed thereby; modifying the output of the first sound level meter by a pre-calculated Transfer Function equating its output to that of a second sound level meter located at a predefined distance from the site of sound generation of the subject's body; and utilizing the modified output of the first sound level meter in determining the existence of the particular physiological condition.

2. 发明授权

US08696619B2 Drug delivery devices 有权
标题翻译：给药装置
公开(公告)号：US08696619B2
公开(公告)日：2014-04-15
申请号：US11658650
申请日：2005-08-10
申请人： Robert P. Schnall
发明人： Robert P. Schnall
IPC分类号： A61M37/00 , A61B17/20 , A61M5/00 , A61M5/32
CPC分类号： A61M37/0015 , A61M2037/003 , A61N1/303
摘要： A drug delivery device for delivering a drug to a preselected treatment site, includes a rupturable film capsule enclosing a quantity of the drug to be delivered; an array of micro-needles formed with passageways therethrough carried by the device; a covering layer overlying the capsule and forming a fluid-tight seal with the perimeter of the micro-needle array such that when the device is located with the micro-needles facing the treatment site, the application of pressure to the device causes the micro-needles to penetrate the treatment site and the capsule film to rupture to deliver the drug via the passageways to the treatment site; and an open mesh layer adjacent to the array of micro-needles effective, upon rupture of the capsule film, to uniformly distribute the drug to the micro-needles and also to reduce the possibility of clogging of the passageways.
摘要翻译：用于将药物递送到预选治疗部位的药物递送装置包括：包封一定量的药物的可破裂膜胶囊; 由该装置承载的通道形成的微针阵列; 覆盖在胶囊上的覆盖层，并与微型针阵列的周边形成流体密封的密封，使得当该装置位于微针面向治疗部位时，向该装置施加压力导致微型针针穿透处理部位和胶囊膜破裂，通过通道将药物输送到治疗部位; 并且与胶囊阵列相邻的开孔网层在胶囊膜破裂时有效，以将药物均匀分布到微针上，并且还降低了通道堵塞的可能性。

3. 发明申请

US20090118662A1 Drug delivery devices 有权
标题翻译：给药装置
公开(公告)号：US20090118662A1
公开(公告)日：2009-05-07
申请号：US11658650
申请日：2005-08-10
申请人： Robert P. Schnall
发明人： Robert P. Schnall
IPC分类号： A61M5/32 , A61M25/10 , A61B6/00 , A61J7/00 , A61N1/30 , A61M35/00
CPC分类号： A61M37/0015 , A61M2037/003 , A61N1/303
摘要： A drug delivery device for delivering a drug to a preselected treatment site, includes a rupturable film capsule enclosing a quantity of the drug to be delivered; an array of micro-needles formed with passageways therethrough carried by the device; a covering layer overlying the capsule and forming a fluid-tight seal with the perimeter of the micro-needle array such that when the device is located with the micro-needles facing the treatment site, the application of pressure to the device causes the micro-needles to penetrate the treatment site and the capsule film to rupture to deliver the drug via the passageways to the treatment site; and an open mesh layer adjacent to the array of micro-needles effective, upon rupture of the capsule film, to uniformly distribute the drug to the micro-needles and also to reduce the possibility of clogging of the passageways.
摘要翻译：用于将药物递送到预选治疗部位的药物递送装置包括：包封一定量的药物的可破裂膜胶囊; 由该装置承载的通道形成的微针阵列; 覆盖在胶囊上的覆盖层，并与微型针阵列的周边形成流体密封的密封，使得当该装置位于微针面向治疗部位时，向该装置施加压力导致微型针针穿透处理部位和胶囊膜破裂，通过通道将药物输送到治疗部位; 并且与胶囊阵列相邻的开孔网层在胶囊膜破裂时有效，以将药物均匀分布到微针上，并且还降低了通道堵塞的可能性。

4. 发明授权

US06319205B1 Method and apparatus for the non-invasive detection of medical conditions by monitoring peripheral arterial tone 有权
标题翻译：通过监测外周动脉音而无创检测医疗状况的方法和装置
公开(公告)号：US06319205B1
公开(公告)日：2001-11-20
申请号：US09214788
申请日：1999-01-12
申请人： Daniel A Goor , Robert P Schnall , Jacob Sheffy , Peretz Lavie
发明人： Daniel A Goor , Robert P Schnall , Jacob Sheffy , Peretz Lavie
IPC分类号： A61B502
CPC分类号： A61B5/6806 , A61B5/02007 , A61B5/02241 , A61B5/1073 , A61B5/6826 , A61B5/6838 , A61F2007/0036
摘要： A method and an apparatus for non-invasive detection of a physiological state or medical condition are disclosed. The method provides an indication of such state or condition such as myocardial ischemia or sleep apnea, by detecting the peripheral arterial tone's response to such state or condition, based on monitoring changes in peripheral arterial tone and determining that a change in the condition of the patient has occurred when a specific change in the peripheral arterial tone has been detected. A static pressure field is applied around the distal part of a digit of the subject. Peripheral arterial tone changes and related volume changes in the distal part of the digit are detected to thereby detect or monitor a physiological state or medical condition. The apparatus includes a finger probe (20), in the form of a tube (3) accommodating the patient's finger, which is designed to apply pressure, and a contiguous pressure cuff (40) which extends the boundary of the pressure field. The finger probe (2) either includes or is associated with a signal sensor/transducer (100, 101).
摘要翻译：公开了用于非侵入性检测生理状态或医疗状况的方法和装置。该方法通过基于监测外周动脉音调的变化来检测外周动脉血压对这种状态或状况的反应来提供诸如心肌缺血或睡眠呼吸暂停之类的状态或状况的指示，并确定患者状况的变化已经检测到外周动脉音的特定变化时发生。在受试者的数字的远端部分周围施加静压场。检测数字的远端部分的外周动脉音调变化和相关的体积变化，从而检测或监测生理状态或医疗状况。该装置包括一个指状探针（20），其形式为容纳患者手指的管（3），其被设计成施加压力;以及连续的压力袖带（40），其延伸了压力场的边界。手指探针（2）包括或与信号传感器/换能器（100,101）相关联。

5. 发明授权

US07374540B2 Non-invasive probe for detecting medical conditions 有权
标题翻译：用于检测医疗状况的无创探头
公开(公告)号：US07374540B2
公开(公告)日：2008-05-20
申请号：US10471580
申请日：2002-03-26
申请人： Robert P. Schnall
发明人： Robert P. Schnall
IPC分类号： A61B5/02 , A61B5/00
CPC分类号： A61B5/6826 , A61B5/0295 , A61B5/1073 , A61B5/6838
摘要： A non-invasive probe for application to a body part, such as a finger, toe or limb, for the detection of a medical condition of the subject includes a housing defining a compartment closed at one end and open at the opposite end for receiving the distal end of the subject's body part including its terminal-most extremity, a sensor for sensing a predetermined condition of the body part after being received within the compartment, and a removable liner lining the inner surface of the housing, to facilitate the insertion of the body part into the compartment. The described probe is one which senses changes in the peripheral arterial tone as manifested by changes in the pulsatile arterial blood volume and/or changes in the oxygen saturation level in a terminal extremity of a body part, and includes a number of other features particularly useful in such probes.
摘要翻译：用于应用于身体部位（例如手指，脚趾或肢体）以用于检测受试者的医疗状况的非侵入性探针包括限定在一端封闭并在相对端开放以接收受试者的外壳的壳体被检体的身体部分的远端包括其最末端，用于感测身体部分在容纳在隔室内的预定状态的传感器，以及衬在壳体的内表面上的可移除衬垫，以便于插入身体部分进入隔间。所描述的探针是通过身体部位的终末末端的脉动动脉血容积的变化和/或氧饱和度的变化来表示外周动脉音的变化的探针，并且包括许多特别有用的其它特征在这样的探针中。

6. 发明授权

US06916289B2 Pressure applicator devices particularly useful for non-invasive detection of medical conditions 有权
标题翻译：特别适用于非侵入性检测医疗条件的压力施加装置
公开(公告)号：US06916289B2
公开(公告)日：2005-07-12
申请号：US10851137
申请日：2004-05-24
申请人： Robert P. Schnall
发明人： Robert P. Schnall
IPC分类号： A61B5/022 , A61B5/103 , A61B5/02
CPC分类号： A61B5/6826 , A61B5/02007 , A61B5/1073 , A61B5/6838
摘要： A probe for application to a body part particularly a finger of a patent to detect a change in the physical condition of the patient includes a housing defining a compartment closed at one end and open at the opposite end for receiving the distal end of the patient's finger and a medium wholly self-contained within the probe for applying a static pressure field substantially uniformly around the distal end of the patient's finger, of a predetermined magnitude sufficient to substantially prevent distention of the venous vasculature, uncontrolled venous backflow, and retrograde shockwave propagation into the distal end, and to partially unload the wall tension of, but not to occlude, the arteries in the distal end when at heart level or below. A sensor senses changes in the distal end of the patient's finger related to changes in arterial blood volume therein.
摘要翻译：用于应用于身体部位，特别是用于检测患者的身体状况变化的专利手指的探针包括限定在一端封闭并在相对端开口以用于接收患者手指的远端的隔室的壳体以及在探头内完全独立包含的介质，用于基本上均匀地围绕患者手指的远端施加静态压力场，其具有足以基本上防止静脉血管扩张，不受控制的静脉回流和逆行冲击波传播的预定量值远端，并且在心脏水平或以下时部分地卸载远端的动脉的壁张力但不阻塞动脉。传感器感测与其中的动脉血容量的变化相关的患者手指的远端的变化。

7. 发明授权

US07621877B2 Body surface probe, apparatus and method for non-invasively detecting medical conditions 有权
标题翻译：身体表面探针，用于非侵入性检测医疗状况的装置和方法
公开(公告)号：US07621877B2
公开(公告)日：2009-11-24
申请号：US10520273
申请日：2003-07-15
申请人： Robert P. Schnall
发明人： Robert P. Schnall
IPC分类号： A61B5/02
CPC分类号： A61B5/02116 , A61B5/02007 , A61B5/02241 , A61B5/4035 , A61B5/6843
摘要： A probe for application to a selected area of a subject's skin covering a body part, which selected area serves as a measurement site for measuring changes in the pulsatile arterial blood volume thereat, includes: a base for application to the selected area of the subject's skin at the measurement site; a pressure applicator for applying a static pressure to the subject's skin at the measurement site; and a sensor for sensing changes in the pulsatile arterial blood volume at the measurement site. The pressure applicator is designed to apply to the measurement site a static pressure of a magnitude to partially unload the wall tension of, but not to occlude, the arteries. The pressure applicator is configured to substantially prevent venous distention and blood pooling at the measurement site by permitting free venous drainage through tissues surrounding the measurement site. This is done by configuring the pressure applicator to apply the static pressure to a relatively restricted area of the subject's skin, which area occupies a relatively small fraction of the surface perimeter of the respective body part at the measurement site, to thereby permit free venous drainage from the measurement site via a wide region of unrestricted passageways surrounding the measurement site.
摘要翻译：用于应用于被覆物体的选定区域的探针，所述选择区域用作用于测量其脉动动脉血容量变化的测量部位，包括：用于施用于受试者皮肤的选定区域的基底在测量点; 压力施加器，用于在所述测量部位处对所述受试者的皮肤施加静压; 以及用于感测测量部位的脉动动脉血容量的变化的传感器。压力施加器被设计成向测量部位施加一个大小的静态压力，以部分地卸载动脉的壁张力而不阻塞动脉。压力施加器被配置为通过允许通过围绕测量位置的组织的自由静脉引流来基本上防止在测量位置的静脉扩张和血液聚集。这通过配置压力施加器来将静压施加到受试者皮肤的相对受限的区域，该区域在测量部位占相应身体部位的表面周边的相对较小的一部分，从而允许自由静脉引流从测量地点通过围绕测量现场的无限制通道的广泛区域。

8. 发明授权

US06322515B1 Method and apparatus for the non-invasive detection of medical conditions by monitoring peripheral arterial tone 有权
标题翻译：通过监测外周动脉音而无创检测医疗状况的方法和装置
公开(公告)号：US06322515B1
公开(公告)日：2001-11-27
申请号：US09324529
申请日：1999-06-02
申请人： Daniel A. Goor , Robert P. Schnall , Jacob Sheffy , Peretz Lavie
发明人： Daniel A. Goor , Robert P. Schnall , Jacob Sheffy , Peretz Lavie
IPC分类号： A61B502
CPC分类号： A61B5/6806 , A61B5/02007 , A61B5/02241 , A61B5/1073 , A61B5/6826 , A61B5/6838 , A61F2007/0036
摘要： A method and apparatus for non-invasively determining a physiological condition. The method can include steps of monitoring peripheral arterial tone using an external sensor, detecting a change in the peripheral arterial tone, and determining the physiological condition when a specific change in the peripheral arterial tone has been detected. The physiological condition may be a cardiovascular disease state or endothelial dysfunction, for example. The apparatus can include a probe applied to a subject's digit for sensing peripheral arterial tone and outputting a corresponding signal, and a processor which processes the signal and provides an output from which the physiological condition can be determined or which determines the physiological condition based on the signal.
摘要翻译：一种用于非侵入性地确定生理状况的方法和装置。该方法可以包括使用外部传感器监测外周动脉音的步骤，检测外周动脉音的变化，以及当检测到外周动脉音的特定变化时确定生理状况。例如，生理状态可能是心血管疾病状态或内皮功能障碍。该装置可以包括应用于受试者的数字以用于感测外周动脉色调并输出相应信号的探针，以及处理器，其处理该信号并提供可以从其确定生理状态的输出或基于信号。

9. 发明申请

US20110092857A1 METHOD AND APPARATUS FOR EXAMINING SUBJECTS FOR PARTICULAR PHYSIOLOGICAL CONDITIONS UTILIZING ACOUSTIC INFORMATION 有权
标题翻译：用于检查使用声音信息的特殊生理条件的方法和装置
公开(公告)号：US20110092857A1
公开(公告)日：2011-04-21
申请号：US12994865
申请日：2009-05-26
申请人： Sarah Herscovici-Cohen , Robert P. Schnall
发明人： Sarah Herscovici-Cohen , Robert P. Schnall
IPC分类号： A61B7/00
CPC分类号： A61B5/08 , A61B5/4806 , A61B7/003 , A61B2560/0223
摘要： A method and apparatus for examining a subject for a particular physiological condition according to a technique which utilizes sounds generated by the subject and sensed at a predefined distance from the site of sound generation of the subject, by locating a first sound sensor, e.g., a sound level meter which measures the sound levels in decibels, on a particular region of the subject's body to produce an output corresponding to the sound level sensed thereby; modifying the output of the first sound level meter by a pre-calculated Transfer Function equating its output to that of a second sound level meter located at a predefined distance from the site of sound generation of the subject's body; and utilizing the modified output of the first sound level meter in determining the existence of the particular physiological condition.
摘要翻译：根据一种利用由被摄体产生的声音并且在距离被摄体的声音产生的位置的预定距离感测的技术的技术来检查特定生理条件的方法和装置，通过定位第一声音传感器，例如声级计，其测量对象身体的特定区域上的以分贝为单位的声级，以产生与由此感测的声级相对应的输出; 通过预先计算的传递函数来修改第一声级计的输出，将其输出等于位于距离被检体的声音产生位置预定义距离的第二声级计; 以及利用所述第一声级计的修改的输出来确定所述特定生理状况的存在。

10. 发明授权

US07819811B2 Detecting medical conditions with noninvasive body probes 有权
标题翻译：用无创身体探针检测医疗状况
公开(公告)号：US07819811B2
公开(公告)日：2010-10-26
申请号：US10533970
申请日：2003-11-06
申请人： Robert P. Schnall
发明人： Robert P. Schnall
IPC分类号： A61B5/00
CPC分类号： A61B5/026 , A61B5/02 , A61B5/02007 , A61B5/022 , A61B5/02241 , A61B5/1073 , A61B5/6826 , A61B5/6838 , A61B2560/0228
摘要： A method and apparatus for improving the diagnostic performance of a probe system (30) for detecting a medical condition in a patient by sensing volume changes in a monitored body part due to pulsatile arterial blood flow in the body part, characterized in calibrating the probe system (30) for the respective measurement site according to a predetermined characteristic of the monitored body part of the patient and quantifying the arterial pulsatile volume thereat. Such calibration is described with respect to probes including: (1) a pressure sensor (63), which senses pressure changes in a compressible fluid system to which the patient's body part (e.g., finger, toe or a distal portion of a limb) is subjected, which pressure changes are convertible to volume changes in the body part due to pulsatile arterial blood volume changes therein; and (2) an optical sensor (140), which senses optical density or transmissivity changes in the body part, which changes are also convertible to volume changes due to pulsatile arterial blood volume changes in the body part.
摘要翻译：一种用于通过感测由于身体部位中的脉动动脉血流引起的被监测身体部位的体积变化来检测患者的医疗状况的探针系统（30）的诊断性能的方法和装置，其特征在于，（30），用于根据患者的被监测身体部位的预定特征对各测量部位进行定量，并定量其动脉搏动体积。关于探头描述了这种校准，包括：（1）压力传感器（63），其感测患者的身体部分（例如，手指，脚趾或肢体的远端部分）可压缩的流体系统中的压力变化由于其中的脉动动脉血容量变化，哪个压力变化可转换成身体部位的体积变化; 以及（2）感测身体部位的光密度或透射率变化的光学传感器（140），其变化也可以由于体部的脉动动脉血容量变化而转换为体积变化。

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