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1. 发明授权

US5187105A Process for determining thiols using chromogenic benzoisothiazolone derivatives 失效
标题翻译：使用显色苯并异噻唑啉酮衍生物测定硫醇的方法
公开(公告)号：US5187105A
公开(公告)日：1993-02-16
申请号：US659897
申请日：1991-02-25
申请人： James P. Albarella , David L. Garling , Robert P. Hatch
发明人： James P. Albarella , David L. Garling , Robert P. Hatch
IPC分类号： C07D275/04 , G01N31/22
CPC分类号： C07D275/04 , G01N31/22 , G01N31/221 , Y10T436/18 , Y10T436/182
摘要： A process for measuring the presence or appearance of thiols in aqueous system, the process involving contacting the aqueous system with a chromogenic thiol indicating benzoisothiazolone derivative and then observing chromophoric changes due to thiol mediated reduction of the benzoisothiazolone derivative wherein the changes are proportional to the amount or rate of appearance of the thiols in the aqueous system.
摘要翻译：一种测定水性体系中硫醇的存在或外观的方法，该方法包括使含水系统与显色苯并异噻唑酮衍生物的显色硫醇接触，然后观察由于硫醇介导的苯并异噻唑酮衍生物的还原产生的发色变化，其中变化与量或水溶液体系中硫醇的出现速率。

2. 发明授权

US5081044A Detection of hydrogen peroxide with optical indicator chalcogen compounds 失效
标题翻译：用光学指标硫属化合物检测过氧化氢
公开(公告)号：US5081044A
公开(公告)日：1992-01-14
申请号：US590226
申请日：1990-09-28
申请人： Robert T. Buckler , Robert P. Hatch
发明人： Robert T. Buckler , Robert P. Hatch
IPC分类号： C12Q1/28 , G01N33/00
CPC分类号： G01N33/0036 , C12Q1/28 , C12Q2326/00 , Y10T436/206664
摘要： Optical indicator chalcogen (selenide or sulfide) compounds responsive to oxidants, e.g., hydrogen peroxide, and a method for using such indicators. Upon oxidation the resulting intermediate undergoes spontaneous elimination of the chalcogen residue to yield a signal compound which provides an optical signal such as fluorescence. Preferred fluorogenic indicator compounds are 3-chalcogen-3,4-dihydrocoumarin derivatives and 3-chalcogen-3,4-dihydro-2-quinolone derivatives. Such indicator compounds provide highly fluorescent products upon oxidation by hydrogen peroxide and are useful in analytical systems which generate hydrogen peroxide in response to the analyte under determination.
摘要翻译：对氧化剂（例如过氧化氢）有响应的光学指示剂硫属化合物（硒化物或硫化物）以及使用这些指示剂的方法。氧化后，得到的中间体自发消除硫族元素残余物，产生提供光信号如荧光的信号化合物。优选的荧光指示剂化合物是3-硫族原-3,4-二氢香豆素衍生物和3-硫族原-3,4-二氢-2-喹诺酮衍生物。这种指示剂化合物在通过过氧化氢氧化时提供高度荧光的产物，并且可用于响应于待测分析物产生过氧化氢的分析系统。

3. 发明授权

US06872573B2 Fluorescent creatinine assay 失效
标题翻译：荧光肌酐测定
公开(公告)号：US06872573B2
公开(公告)日：2005-03-29
申请号：US10335718
申请日：2003-01-02
申请人： James P. Albarella , Robert P. Hatch
发明人： James P. Albarella , Robert P. Hatch
IPC分类号： C07C20060101 , C12Q1/28 , G01N33/00 , G01N33/58 , G01N33/70
CPC分类号： G01N33/582 , C12Q1/28 , G01N33/70 , Y10S436/80 , Y10T436/147777 , Y10T436/171538 , Y10T436/206664
摘要： A method of detecting creatinine in body fluids using an indicator which produces a fluorescent response when oxidized in the presence of a copperII/creatinine complex. A preferred indicator is 4-(1-methylhydrazino)-7-nitro benzooxadiazole (MNBDH).
摘要翻译：使用在铜/肌酸酐复合物存在下氧化时产生荧光反应的指示剂来检测体液中肌酐的方法。优选的指示剂是4-（1-甲基肼基）-7-硝基苯并恶二唑（MNBDH）。

4. 发明授权

US5250695A Use of specific counteranions to modify the solubility of tetrazolium salts 失效
标题翻译：使用特定的沉淀物来改变四唑盐的溶解度
公开(公告)号：US5250695A
公开(公告)日：1993-10-05
申请号：US898317
申请日：1992-06-15
申请人： Joel M. Blatt , Robert P. Hatch
发明人： Joel M. Blatt , Robert P. Hatch
IPC分类号： C07C309/04 , C07C309/30 , C07D257/04 , C07D405/04 , C07D417/04 , C07D417/14 , C07F9/11 , C07F9/12 , C07F9/38 , G01N33/52 , G01N33/66
CPC分类号： C07D257/04 , C07D417/04 , C07D417/14 , C07F9/11 , C07F9/12
摘要： Disclosed are sulfonate and phosphonate salts of tetrazolium compounds whose enhanced solubility in various solvents renders them particularly suitable for use as redox indicators in dry reagent, diagnostic test systems.

5. 发明授权

US06210978B1 Method and device for the detection of analyte in a fluid test sample 失效
标题翻译：用于检测流体测试样品中分析物的方法和装置
公开(公告)号：US06210978B1
公开(公告)日：2001-04-03
申请号：US09032884
申请日：1998-03-02
申请人： Robert P. Hatch , Meitak Teresa Yip
发明人： Robert P. Hatch , Meitak Teresa Yip
IPC分类号： G01N33548
CPC分类号： G01N33/54306 , G01N33/54366 , Y10S436/815
摘要： Disclosed is a method for the immobilization of an analyte such as deoxypyridinium (DPD) onto a solid support. The method involves binding an antigen-amino acid-deoxypyridinium complex to the support via an anti-antigen binding partner located in a capture zone of the solid support. Preferably, the support is nitrocellulose and the antigen has the fluorescein structure.
摘要翻译：公开了一种将分析物如脱氧吡啶鎓（DPD）固定在固体支持物上的方法。该方法包括通过位于固体支持物的捕获区域中的抗原抗原结合配偶体将抗原 - 氨基酸 - 脱氧吡啶络合物结合到载体上。优选地，载体是硝酸纤维素，抗原具有荧光素结构。

6. 发明授权

US6033918A Method and device for the detection of analyte in a fluid sample 失效
标题翻译：用于检测流体样品中分析物的方法和装置
公开(公告)号：US6033918A
公开(公告)日：2000-03-07
申请号：US967580
申请日：1997-11-10
申请人： Robert P. Hatch , Meitak Teresa Yip
发明人： Robert P. Hatch , Meitak Teresa Yip
IPC分类号： G01N33/53 , G01N33/543 , G01N33/548 , G01N33/553
CPC分类号： G01N33/54353 , Y10S436/815
摘要： Disclosed is an improvement to the technique for immobilizing an analyte onto a solid surface for use in a competitive immunoassay. The improvement involves immobilizing the analyte on the solid surface by reacting the analyte or derivative thereof with polyethylene glycol which has been functionalized with a group which is reactive with the analyte contacting the resulting conjugate with the solid surface to thereby immobilize the analyte.
摘要翻译：公开了用于将分析物固定在固体表面上用于竞争性免疫测定中的技术的改进。改进之处在于通过将分析物或其衍生物与聚乙二醇反应来固定分析物，所述聚乙二醇已经与被分析物反应的基团官能化，所述分析物与所得到的共轭物与固体表面接触，从而固定分析物。

7. 发明授权

US5130433A Chromogenic thiol indicators based on an isobenzothiazolone ring system 失效
标题翻译：基于ISOBENZOTHIAZOLONE环系统的色谱THIOL指示剂
公开(公告)号：US5130433A
公开(公告)日：1992-07-14
申请号：US546703
申请日：1990-07-02
申请人： James P. Albarella , David L. Garling , Robert P. Hatch
发明人： James P. Albarella , David L. Garling , Robert P. Hatch
IPC分类号： G01N31/00 , C07D275/04 , C09B29/039 , C09B57/00 , C09B69/00 , G01N31/22
CPC分类号： C07D275/04 , G01N31/22
摘要： Newly synthesized chromogenic thiol-indicating benzoisothiazolone derivatives having the structure: ##STR1## where R.sup.1, R.sup.2 and R.sup.3 are as defined in the specification, are useful in the detection of thiols, particularly in an aqueous system. This process comprises contacting the aqueous system with a chromogenic thiol-indicating benzoisothiazolone derivative as described herein. Chromophoric changes due to thiol-mediated reduction of the benzothiazolone derivative then occur. Such changes can be in a solution or on an indicator surface in contact or having been in contact with the aqueous system. The chromophoric changes, due to a bathochromic shift in characteristic light absorption upon reduction of the benzoisothiazolone derivative, are proportional to the amount or rate of appearance of thiols in the aqueous system.

8. 发明授权

US5128457A Chromogenic thiol indicators based on an isobenzothiazolone ring system 失效
标题翻译：基于异苯并噻唑酮环系的显色硫醇指示剂
公开(公告)号：US5128457A
公开(公告)日：1992-07-07
申请号：US802527
申请日：1991-12-05
申请人： James P. Albarella , David L. Garling , Robert P. Hatch
发明人： James P. Albarella , David L. Garling , Robert P. Hatch
IPC分类号： C07D275/04 , G01N31/22
CPC分类号： C07D275/04 , G01N31/22 , G01N31/221
摘要： Newly synthesized chromogenic thiol-indicating benzoisthiazolone derivatives having the structure: ##STR1## where R.sup.1, R.sup.2 and R.sup.3 are as defined in the specification, are useful in the detection of thiols, particularly in an aqueous system. This process comprises contacting the aqueous system with a chromogenic thiol-indicating benzoisothiazolone derivative as described herein. Chromophoric changes due to thiol-mediated reduction of the benzothiazolone derivative then occur. Such changes can be in a solution or on an indicator surface in contact or having been in contact with the aqueous system. The chromophoric changes, due to a bathochromic shift in characteristics light absorption upon reduction of the benzoisothiazolone derivative, are proportional to the amount or rate of appearance of thiols in the aqueous system.
摘要翻译：具有以下结构的新合成的显色硫醇指示苯并噻唑酮衍生物：其中R1，R2和R3如说明书中所定义，可用于检测硫醇，特别是在水系统中。该方法包括使含水系统与如本文所述的显色硫醇表示的苯并异噻唑酮衍生物接触。然后发生由于硫醇介导的苯并噻唑酮衍生物的还原引起的发色变化。这种变化可以在溶液中或与接触的或与水系统接触的指示剂表面上。由于苯并异噻唑酮衍生物还原后特征光吸收的红移发生的发色变化与水系中硫醇的出现量或速率成正比。

9. 发明授权

US5126275A Analytical method using tetrazolium salt indicators having a reflectance plateau 失效
标题翻译：使用具有反射率的四氯化钡盐指示剂的分析方法
公开(公告)号：US5126275A
公开(公告)日：1992-06-30
申请号：US584907
申请日：1990-09-19
申请人： Robert P. Hatch , Jurgen Kocher , Nan-Horng Lin , Scott Ruetten , Klaus Wehling
发明人： Robert P. Hatch , Jurgen Kocher , Nan-Horng Lin , Scott Ruetten , Klaus Wehling
IPC分类号： C07D417/04 , C12Q1/00 , G01N21/78 , G01N31/22 , G01N33/50 , G01N33/52
CPC分类号： C12Q1/008 , G01N33/52 , G01N33/521 , Y10S435/805
摘要： General classes of 2-thiazolyl tetrazolium salt compounds have been found to be characterized by a reflectance spectrum exhibiting an extended plateau above about 600-650 nm. Such compounds are useful as chromogenic indicators for reducing substances such as NADH. The reflectance plateau confers improved accuracy to analytical assays, particularly for the determination of analytes of medical diagnostic significance, in which a colorimetric response on a reagent carrier matrix is measured by reflectance.

10. 发明授权

US4895798A Test devices for determination of occult blood 失效
标题翻译：用于测定隐血的测试装置
公开(公告)号：US4895798A
公开(公告)日：1990-01-23
申请号：US119977
申请日：1987-11-13
申请人： Steven C. Charlton , Robert P. Hatch , Paul R. Hemmes
发明人： Steven C. Charlton , Robert P. Hatch , Paul R. Hemmes
IPC分类号： G01N33/50 , C07H15/04 , C12Q1/00 , C12Q1/26 , C12Q1/28 , C12Q1/54 , G01N33/72
CPC分类号： C12Q1/28 , C12Q1/54 , G01N33/725 , Y10S436/904 , Y10T436/104998 , Y10T436/144444
摘要： Test devices are disclosed which are useful for determining glucose or occult blood comprising a carrier matrix, glucose oxidase, an indicator system and a glucose derivative that upon addition of water hydrolizes to produce glucose.

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