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1. 发明授权

US07727178B2 Catheter with multiple ultrasound radiating members 有权
公开(公告)号：US07727178B2
公开(公告)日：2010-06-01
申请号：US11643471
申请日：2006-12-21
申请人： Richard R. Wilson , Robert L. Wilcox , Curtis Genstler , Tim Abrahamson , Wm. Gerrit Barrere , Amy Cohen , George Keilman , Leonard R. Oliver , Natalya Peskin
发明人： Richard R. Wilson , Robert L. Wilcox , Curtis Genstler , Tim Abrahamson , Wm. Gerrit Barrere , Amy Cohen , George Keilman , Leonard R. Oliver , Natalya Peskin
IPC分类号： A61B17/20
CPC分类号： A61M37/0092 , A61B17/2202 , A61B2017/22084 , A61B2017/22088 , A61M25/0029 , A61M25/0032 , A61N7/00 , A61N2007/0078
摘要： A catheter for delivering ultrasonic energy and therapeutic compounds to a treatment site within a patient's vasculature comprises a tubular body. The tubular body has a proximal region and a distal region opposite the proximal region. The catheter further comprises a plurality of fluid delivery lumens formed into the tubular body. The catheter further comprises an inner core configured for insertion into the tubular body. The inner core comprises an elongate electrical conductor having a plurality of flattened regions, each flattened region having a first flat side and a second flat side opposite the first flat side. The inner core further comprises a plurality of ultrasound radiating members mounted in pairs to the flattened regions of the elongate electrical conductor. A first ultrasound radiating member is mounted to the first flat side of the elongate electrical conductor, and a second ultrasound radiating member is mounted to the second flat side of the elongate electrical conductor. The catheter further comprises control electronics configured to apply a driving signal to at least two, but fewer than all, of the ultrasound radiating members.

2. 发明申请

US20140012248A1 APPARATUS AND METHOD FOR GASTRIC BYPASS SURGERY 审中-公开
标题翻译：胃旁路手术的装置及方法
公开(公告)号：US20140012248A1
公开(公告)日：2014-01-09
申请号：US13858776
申请日：2013-04-08
申请人： Stefan Josef Matthias Kraemer , Robert L. Wilcox , Thomas James Clement
发明人： Stefan Josef Matthias Kraemer , Robert L. Wilcox , Thomas James Clement
IPC分类号： A61F5/00 , A61B18/18
CPC分类号： A61F5/0076 , A61B17/00234 , A61B17/00491 , A61B17/1114 , A61B18/1492 , A61B18/18 , A61B34/73 , A61B90/361 , A61B90/39 , A61B2017/00026 , A61B2017/00039 , A61B2017/00066 , A61B2017/003 , A61B2017/00504 , A61B2017/00818 , A61B2017/00876 , A61B2017/1103 , A61B2017/1139 , A61B2017/22054 , A61B2018/00273 , A61B2018/00279 , A61B2018/00619 , A61B2034/2051 , A61B2090/061 , A61B2090/3954 , A61B2090/3987 , A61B2090/3991 , A61M25/0068 , A61M25/0082 , A61M25/0108 , A61M25/0662 , A61M29/02 , A61M2025/0086 , A61M2025/0092 , A61M2025/0681
摘要： A medical treatment device includes an elongate member having an internal volume, a proximal end, and a distal end, the internal volume extending from the proximal end to the distal end. The medical treatment device further includes a first coupler and a second coupler, the first coupler and the second coupler coupled to the internal volume of the elongate member; a first joining member and a second joining member, the first joining member coupled to the first coupler and the second joining member coupled to the second coupler. The first joining member is configured to attach to a first biological matter location, and the second joining member is configured to attach to a second biological matter location, the second location being distal to the first location. The second coupler is configured for manipulation to align relative the first coupler such that the second biological matter location relocates adjacent the first biological matter location. The first joining member and the second joining member are configured to join the first biological matter location to the second biological matter location.
摘要翻译：医疗处理装置包括具有内部容积，近端和远端的细长构件，内部容积从近端延伸到远端。医疗处理装置还包括第一联接器和第二联接器，第一联接器和第二联接器联接到细长构件的内部容积; 第一连接构件和第二接合构件，所述第一接合构件联接到第一联接器和联接到第二联接器的第二接合构件。第一连接构件被配置成附接到第一生物物质位置，并且第二连接构件被配置为附接到第二生物物质位置，第二位置远离第一位置。第二耦合器构造成用于操纵以相对于第一耦合器对准，使得第二生物物质位置重新定位在第一生物物质位置附近。第一接合构件和第二接合构件被构造成将第一生物物质位置连接到第二生物物质位置。

3. 发明授权

US08192363B2 Catheter with multiple ultrasound radiating members 有权
标题翻译：导管与多个超声波辐射构件
公开(公告)号：US08192363B2
公开(公告)日：2012-06-05
申请号：US11924482
申请日：2007-10-25
申请人： Azita Soltani , Robert L. Wilcox
发明人： Azita Soltani , Robert L. Wilcox
IPC分类号： A61B8/00
CPC分类号： A61N7/022 , A61B17/2202 , A61N2007/0078
摘要： A catheter system for delivering ultrasonic energy to a treatment site includes a tubular body having a proximal end, a distal end and a treatment zone located between the distal end and the proximal end. An ultrasonic assembly is positioned within the treatment zone and provides providing an average longitudinal power density between about 0.2 and about 1.0 W/cm within the treatment zone.
摘要翻译：用于将超声能量输送到治疗部位的导管系统包括具有近端，远端和位于远端和近端之间的治疗区的管状体。超声波组件位于处理区内并且在处理区域内提供约0.2至约1.0W / cm的平均纵向功率密度。

4. 发明授权

US08167831B2 Catheter with multiple ultrasound radiating members 有权
标题翻译：导管与多个超声波辐射构件
公开(公告)号：US08167831B2
公开(公告)日：2012-05-01
申请号：US12762254
申请日：2010-04-16
申请人： Richard R. Wilson , Robert L. Wilcox , Curtis Genstler , Tim Abrahamson , Wm. Gerrit Barrere , Amy Cohen , George Keilman , Leonard R. Oliver , Natalya Peskin
发明人： Richard R. Wilson , Robert L. Wilcox , Curtis Genstler , Tim Abrahamson , Wm. Gerrit Barrere , Amy Cohen , George Keilman , Leonard R. Oliver , Natalya Peskin
IPC分类号： A61B17/20
CPC分类号： A61M37/0092 , A61B17/2202 , A61B2017/22084 , A61B2017/22088 , A61M25/0029 , A61M25/0032 , A61N7/00 , A61N2007/0078
摘要： A method of delivery ultrasonic energy and a therapeutic compound to a treatment site and an ultrasonic catheter system are disclosed. The method comprises providing a catheter with a plurality of ultrasound radiating members, wherein the plurality of ultrasound radiating members are allocated into electrical groups comprising more than one ultrasound radiating member. The method further comprises independently driving each group of ultrasonic radiating members, and delivering the therapeutic compound through the catheter to the treatment site.
摘要翻译：公开了一种将超声能量和治疗化合物递送到治疗部位和超声波导管系统的方法。该方法包括提供具有多个超声辐射构件的导管，其中多个超声辐射构件被分配成包括多于一个超声波辐射构件的电组。该方法还包括独立地驱动每组超声辐射构件，并将治疗化合物通过导管输送到治疗部位。

5. 发明申请

US20110218476A1 APPARATUS AND METHOD FOR GASTRIC BYPASS SURGERY 审中-公开
标题翻译：胃旁路手术的装置及方法
公开(公告)号：US20110218476A1
公开(公告)日：2011-09-08
申请号：US13026087
申请日：2011-02-11
申请人： Stefan Josef Matthias Kraemer , Robert L. Wilcox , Thomas James Clement
发明人： Stefan Josef Matthias Kraemer , Robert L. Wilcox , Thomas James Clement
IPC分类号： A61F2/04
CPC分类号： A61F5/0076 , A61B17/00234 , A61B17/00491 , A61B17/1114 , A61B18/1492 , A61B18/18 , A61B34/73 , A61B90/361 , A61B90/39 , A61B2017/00026 , A61B2017/00039 , A61B2017/00066 , A61B2017/003 , A61B2017/00504 , A61B2017/00818 , A61B2017/00876 , A61B2017/1103 , A61B2017/1139 , A61B2017/22054 , A61B2018/00273 , A61B2018/00279 , A61B2018/00619 , A61B2034/2051 , A61B2090/061 , A61B2090/3954 , A61B2090/3987 , A61B2090/3991 , A61M25/0068 , A61M25/0082 , A61M25/0108 , A61M25/0662 , A61M29/02 , A61M2025/0086 , A61M2025/0092 , A61M2025/0681
摘要： A medical treatment device includes an elongate member having an internal volume, a proximal end, and a distal end, the internal volume extending from the proximal end to the distal end. The medical treatment device further includes a first coupler and a second coupler, the first coupler and the second coupler coupled to the internal volume of the elongate member; a first joining member and a second joining member, the first joining member coupled to the first coupler and the second joining member coupled to the second coupler. The first joining member is configured to attach to a first biological matter location, and the second joining member is configured to attach to a second biological matter location, the second location being distal to the first location. The second coupler is configured for manipulation to align relative the first coupler such that the second biological matter location relocates adjacent the first biological matter location. The first joining member and the second joining member are configured to join the first biological matter location to the second biological matter location.
摘要翻译：医疗处理装置包括具有内部容积，近端和远端的细长构件，内部容积从近端延伸到远端。医疗处理装置还包括第一联接器和第二联接器，第一联接器和第二联接器联接到细长构件的内部容积; 第一连接构件和第二接合构件，所述第一接合构件联接到第一联接器和联接到第二联接器的第二接合构件。第一连接构件被配置成附接到第一生物物质位置，并且第二连接构件被配置为附接到第二生物物质位置，第二位置远离第一位置。第二耦合器构造成用于操纵以相对于第一耦合器对准，使得第二生物物质位置重新定位在第一生物物质位置附近。第一接合构件和第二接合构件被构造成将第一生物物质位置连接到第二生物物质位置。

6. 发明申请

US20080319376A1 METHOD AND APPARATUS FOR TREATMENT OF INTRACRANIAL HEMORRHAGES 有权
标题翻译：用于治疗脑内HEMORRAGE的方法和装置
公开(公告)号：US20080319376A1
公开(公告)日：2008-12-25
申请号：US12143470
申请日：2008-06-20
申请人： Robert L. Wilcox , Ronald L. Haas
发明人： Robert L. Wilcox , Ronald L. Haas
IPC分类号： A61N7/00
CPC分类号： A61M25/00 , A61B17/2202 , A61B18/24 , A61B2017/00084 , A61B2017/00561 , A61B2017/12004 , A61B2090/064 , A61B2090/306 , A61B2090/309 , A61B2217/005 , A61B2217/007 , A61M1/0084 , A61M25/003 , A61M25/0032 , A61M25/007 , A61M2025/0002 , A61M2205/058
摘要： An ultrasound catheter with fluid delivery lumens, fluid evacuation lumens and a light source is used for the treatment of intracerebral hemorrhages. After the catheter is inserted into a blood clot in the brain, a lytic drug can be delivered to the blood clot via the fluid delivery lumens while applying ultrasonic energy to the treatment site. As the blood clot is dissolved, the liquefied blood clot can be removed by evacuation through the fluid evacuation lumens.
摘要翻译：具有流体输送腔的超声导管，流体排出腔和光源用于治疗脑内出血。在将导管插入脑中的血块之后，溶解药物可以通过流体输送腔输送到血块，同时向治疗部位施加超声波能量。当血块溶解时，可以通过排出流体排出腔排出液化血块。

7. 发明授权

US07220239B2 Catheter with multiple ultrasound radiating members 有权
公开(公告)号：US07220239B2
公开(公告)日：2007-05-22
申请号：US10309388
申请日：2002-12-03
申请人： Richard R. Wilson , Robert L. Wilcox , Curtis Genstler , Tim Abrahamson , Wm. Gerrit Barrere , Amy Cohen , George Keilman , Leonard R. Oliver , Natalya Peskin
发明人： Richard R. Wilson , Robert L. Wilcox , Curtis Genstler , Tim Abrahamson , Wm. Gerrit Barrere , Amy Cohen , George Keilman , Leonard R. Oliver , Natalya Peskin
IPC分类号： A61B17/20
CPC分类号： A61M37/0092 , A61B17/2202 , A61B2017/22084 , A61B2017/22088 , A61M25/0029 , A61M25/0032 , A61N7/00 , A61N2007/0078
摘要： A catheter for delivering ultrasonic energy and therapeutic compounds to a treatment site within a patient's vasculature comprises a tubular body. The tubular body has a proximal region and a distal region opposite the proximal region. The catheter further comprises a plurality of fluid delivery lumens formed into the tubular body. The catheter further comprises an inner core configured for insertion into the tubular body. The inner core comprises an elongate electrical conductor having a plurality of flattened regions, each flattened region having a first flat side and a second flat side opposite the first flat side. The inner core further comprises a plurality of ultrasound radiating members mounted in pairs to the flattened regions of the elongate electrical conductor. A first ultrasound radiating member is mounted to the first flat side of the elongate electrical conductor, and a second ultrasound radiating member is mounted to the second flat side of the elongate electrical conductor. The catheter further comprises control electronics configured to apply a driving signal to at least two, but fewer than all, of the ultrasound radiating members.

8. 发明授权

US06391010B1 Catheter movement control device and method 有权
标题翻译：导管运动控制装置及方法
公开(公告)号：US06391010B1
公开(公告)日：2002-05-21
申请号：US09810680
申请日：2001-03-19
申请人： Robert L. Wilcox
发明人： Robert L. Wilcox
IPC分类号： A61M3900
CPC分类号： A61M25/0111 , A61M25/002 , A61M2210/1089
摘要： A catheter movement control device is provided which allows forward, extending movement of the catheter tube contained within a flexible package to the exterior thereof as required during insertion. The method of use includes moving the catheter tube through the control device to exit the catheter package where it is inserted into the urethra. If resistance is encountered during insertion a stop member firmly engages the catheter tube to prevent rearward movement of the catheter tube under normal urging.
摘要翻译：提供了一种导管运动控制装置，其允许在插入期间根据需要将包含在柔性包装内的导管的向前，延伸的运动移动到其外部。使用的方法包括移动导管通过控制装置以离开导管包装，其中它被插入尿道。如果在插入期间遇到阻力，止动构件牢固地接合导管，以防止在正常推动下导管的向后移动。

9. 发明授权

US06332092B1 Optical probe having and methods for uniform light irradiation and/or light collection over a volume 失效
标题翻译：光学探头具有在体积上均匀的光照射和/或光收集的方法
公开(公告)号：US06332092B1
公开(公告)日：2001-12-18
申请号：US09111174
申请日：1998-07-08
申请人： Curtis K. Deckert , Roger L. Hildwein , Robert L. Wilcox
发明人： Curtis K. Deckert , Roger L. Hildwein , Robert L. Wilcox
IPC分类号： A61B107
CPC分类号： G02B23/2461 , G02B23/2469
摘要： A variety of optical probes and optical methods have utility in the examination of various materials, especially materials in the interior of cavities having restricted access through orifices or passageways. An optical probe useful, for example, in examining the epithelia and other tissues of anatomical structures within the body cavities and tubular organs and viscera of mammals is elongated and includes an optical window (240, 302, 1002), a light source (222, 312, 314, 510, 520, 1020, 1200, 1400, 1700), a spatial mixer (224, 304, 2004, 2104, 2204, 2304), and a light collector (210, 320, 720, 1120). The light from the light source is mixed in the spatial mixer, thereby removing any reflected images and irradiation artifacts to achieving uniform diffuse light in the vicinity of the optical window. The light collector receives light from the target through the spatial mixer, but the field of view of the light collector excludes any residual reflections and fluorescence from the spatial mixer. The optical probe may be made of two sections, a reusable section and a disposable section. Disposables (910, 2000, 2100, 2200, 2300) suitable for use with the reusable probe section (900) are elongated and contain a spatial mixing section utilizing an inside surface suitable for the spatial mixing of light, an elongated section extending from the spatial mixing section for mounting the disposable onto the reusable probe section, and a protective window or lens for sealing the reusable probe section from the target. Disposables may be constructed from various low cost materials.
摘要翻译：各种光学探针和光学方法可用于检查各种材料，特别是在具有通过孔或通道的限制进入的空腔内部的材料。例如，可用于检查体腔和哺乳动物的管状器官和内脏中的解剖结构的上皮和其他组织的光学探针是细长的，并且包括光学窗口（240,302,1002），光源（222,302） 312,314,510,520,1020,1200,1400,1700），空间混合器（224,304,204,2104,2204,2304）和光收集器（210,320,720,1120）。来自光源的光在空间混合器中混合，从而去除任何反射图像和照射伪像，以在光学窗口附近获得均匀的漫射光。光收集器通过空间混合器从目标物接收光，但是光收集器的视野不包括来自空间混合器的任何残余反射和荧光。光学探针可以由两部分组成，即可再利用部分和一次性部分。适合与可重复使用的探针部分（900）一起使用的一次性用品（910,2000,2100,2200,2300）是细长的并且包含利用适于空间混合光的内表面的空间混合部分，从空间用于将一次性物品安装到可重复使用的探针部分上的混合部分，以及用于将可重复使用的探针部分与目标物密封的保护窗或透镜。一次性物品可以由各种低成本材料构成。

10. 发明授权

US5540653A Preassembled bypass circuit 失效
标题翻译：预组装旁路电路
公开(公告)号：US5540653A
公开(公告)日：1996-07-30
申请号：US965438
申请日：1992-10-23
申请人： Robert B. Schock , Robert L. Wilcox
发明人： Robert B. Schock , Robert L. Wilcox
IPC分类号： A61M1/36 , A61M1/03
CPC分类号： A61M1/3643 , A61M1/3647 , A61M1/3667 , A61M1/3627 , A61M2209/06
摘要： A preassembled PBY circuit includes a blood pump, an oxygenator, a blood line, a filter/trap, a cannulae line subassembly, and a return line. The blood pump, oxygenator, blood line, filter/trap, cannulae line subassembly, and return line are serially arranged in a closed loop configuration, and a prime line is attached in fluid communication with the circuit. The cannulae line subassembly includes a first cannula line attached to the return line, a second cannula line attached to the filter/trap, and a removable connector for connecting the first and second cannulae lines in fluid communication. Each of the cannulae lines is prearranged in a helical configuration. The circuit is arranged for suspension, such that, when suspended, the filter/trap is located at a high point of the circuit, and the prime line is attached at a low point of the circuit. In this manner, priming fluid is introduced through the prime line, enters at a low point of the circuit, and fills the circuit in a bottom-to-top priming operation.
摘要翻译：预先组装的PBY电路包括血泵，氧合器，血液管线，过滤器/捕集器，插管管线组件和返回管线。血液泵，氧合器，血液管路，过滤器/捕集器，套管线组件和返回管线以闭环形式串联布置，并且主线路与电路流体连通地连接。插管线分组件包括附接到返回线的第一插管线，连接到过滤器/捕集器的第二插管线，以及用于连接第一和第二插管线以流体连通的可移除连接器。每个插管线被预先布置成螺旋状。电路被布置为悬架，使得当悬挂时，滤波器/陷波器位于电路的高点处，并且主线路连接在电路的低点处。以这种方式，引发流体通过主线引入，进入电路的低点，并且以底对顶起动操作填充电路。

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