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1. 发明授权

US07429587B2 Pyrrolidine derivatives as factor Xa inhibitors 失效
标题翻译：吡咯烷衍生物作为因子Xa抑制剂
公开(公告)号：US07429587B2
公开(公告)日：2008-09-30
申请号：US11548395
申请日：2006-10-11
申请人： Chuen Chan , Julie Nicole Hamblin , Henry Anderson Kelly , Nigel Paul King , Andrew McMurtrie Mason , Vipulkumar Kantibhai Patel , Stefan Senger , Gita Punjabhai Shah , Nigel Stephen Watson , Helen Elisabeth Weston , Caroline Whitworth , Robert John Young
发明人： Chuen Chan , Julie Nicole Hamblin , Henry Anderson Kelly , Nigel Paul King , Andrew McMurtrie Mason , Vipulkumar Kantibhai Patel , Stefan Senger , Gita Punjabhai Shah , Nigel Stephen Watson , Helen Elisabeth Weston , Caroline Whitworth , Robert John Young
IPC分类号： A61K31/5377 , C07D413/06
CPC分类号： C07D413/14 , A61K31/5377 , C07D207/12 , C07D413/06 , C07D417/14 , C07D495/04
摘要： The invention relates to compounds of formula (I) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.
摘要翻译：本发明涉及式（I）化合物的制备方法，含有它们的药物组合物及其在医药中的用途，特别是用于改善指定因子Xa抑制剂的临床病症。

2. 发明授权

US06355689B1 Nitric oxide synthase inhibitors 有权
标题翻译：一氧化氮合酶抑制剂
公开(公告)号：US06355689B1
公开(公告)日：2002-03-12
申请号：US09701473
申请日：2000-11-29
申请人： Paul John Beswick , Savvas Kleanthous , Robert John Young
发明人： Paul John Beswick , Savvas Kleanthous , Robert John Young
IPC分类号： A61K31155
CPC分类号： C07C323/58 , Y02P20/55
摘要： The present invention relates to novel amidino compounds of formula (I), or a salt, solvate, or physiologically functional derivative thereof; wherein R1 is selected from C1-4 alkyl, C3-4 cycloalkyl, C1-4 hydroxyalkyl, and C1-4 haloalkyl; to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use as selective inhibitors of inducible nitric oxide synthase.
摘要翻译：本发明涉及新的式（I）脒基化合物或其盐，溶剂化物或生理功能衍生物;其中R1选自C1-4烷基，C3-4环烷基，C1-4羟基烷基和C1-4 卤代烷基其制备方法，含有它们的药物组合物及其在治疗中的用途，特别是其作为诱导型一氧化氮合酶选择性抑制剂的用途。

3. 发明授权

US07517879B2 Pyrrolidine derivatives as factor Xa inhibitors 失效
标题翻译：吡咯烷衍生物作为因子Xa抑制剂
公开(公告)号：US07517879B2
公开(公告)日：2009-04-14
申请号：US11548402
申请日：2006-10-11
申请人： Chuen Chan , Julie Nicole Hamblin , Henry Anderson Kelly , Nigel Paul King , Andrew McMurtrie Mason , Vipulkumar Kantibhai Patel , Stefan Senger , Gita Punjabhai Shah , Nigel Stephen Watson , Helen Elisabeth Weston , Caroline Whitworth , Robert John Young
发明人： Chuen Chan , Julie Nicole Hamblin , Henry Anderson Kelly , Nigel Paul King , Andrew McMurtrie Mason , Vipulkumar Kantibhai Patel , Stefan Senger , Gita Punjabhai Shah , Nigel Stephen Watson , Helen Elisabeth Weston , Caroline Whitworth , Robert John Young
IPC分类号： A61K31/5377
CPC分类号： C07D413/14 , A61K31/5377 , C07D207/12 , C07D413/06 , C07D417/14 , C07D495/04
摘要： The invention relates to compounds of formula (I) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.
摘要翻译：本发明涉及式（I）化合物的制备方法，含有它们的药物组合物及其在医药中的用途，特别是用于改善指定因子Xa抑制剂的临床病症。

4. 发明授权

US07235544B2 3-sulfonylamino-pyrrolidine-2-one derivatives as inhibitors of factor Xa 失效
标题翻译： 3-磺酰基氨基 - 吡咯烷-2-酮衍生物作为因子Xa的抑制剂
公开(公告)号：US07235544B2
公开(公告)日：2007-06-26
申请号：US10561328
申请日：2004-06-17
申请人： Alan David Borthwick , John David Harling , Wendy Rebecca Irving , Savvas Kleanthous , Nigel Stephen Watson , Robert John Young
发明人： Alan David Borthwick , John David Harling , Wendy Rebecca Irving , Savvas Kleanthous , Nigel Stephen Watson , Robert John Young
IPC分类号： A61K31/5377 , A61K31/381 , A61K31/397 , A61K31/402 , C07D411/10 , C07D401/10 , C07D207/12
CPC分类号： C07D207/273 , C07D401/10 , C07D403/10 , C07D409/12
摘要： The invention relates to compounds of formula (I): wherein substituents are as defined.
摘要翻译：本发明涉及式（I）的化合物：其中取代基如所定义。

5. 发明授权

US6058843A Machine and method for printing on surfaces of edible substrates 失效
标题翻译：用于在可食用基材表面上印刷的机器和方法
公开(公告)号：US6058843A
公开(公告)日：2000-05-09
申请号：US930485
申请日：1997-09-30
申请人： Robert John Young
发明人： Robert John Young
IPC分类号： B41J2/01 , B41J3/407 , B41M1/26 , B41J2/175
CPC分类号： B41M5/0047 , B41J2/01 , B41J3/4073
摘要： A machine adapted to print an image as hereinbefore defined onto a surface of an edible substrate, the machine including a bubble-jet printer head assembly, and including a container for containing a liquid food colorant, a surface for supporting the said edible substrate, said surface and said head assembly being movable relative to each other, and a controller for controlling the said head assembly with printing instructions and for causing said relative movement in accordance with the desired image to be printed upon a edible substrate. This invention also included a method of printing an image onto an edible substrate.
摘要翻译： PCT No.PCT / GB96 / 00229 Sec。 371日期：1997年9月30日 102（e）1997年9月30日PCT 1996年2月2日PCT公布。第WO97 / 27759号公报日期1997年8月7日一种适于将如上文所定义的图像印刷到可食用基材的表面上的机器，该机器包括气泡喷墨打印机头部组件，并且包括用于容纳液体食品着色剂的容器，所述可食用基底，所述表面和所述头部组件可相对于彼此移动;以及控制器，用于通过打印指令控制所述头部组件，并根据要打印在可食用基底上的所需图像进行所述相对移动。本发明还包括将图像打印到可食用基底上的方法。

6. 发明授权

US07645338B2 Crystalline derivatives of (E)-2-(5-chlorothien-2-yl)-N-{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}ethenesulfonamide 失效
标题翻译：（E）-2-（5-氯噻吩-2-基）-N - {（3S）-1 - [（1S）-1-甲基-2-吗啉-4-基-2-氧代乙基] - -2-氧代吡咯烷-3-基}乙烯磺酰胺
公开(公告)号：US07645338B2
公开(公告)日：2010-01-12
申请号：US10537645
申请日：2003-12-04
申请人： Philip C. Dell 'Orco , Henry Anderson Kelly , Gita Punjabhai Shah , Nigel Stephen Watson , Robert John Young
发明人： Philip C. Dell 'Orco , Henry Anderson Kelly , Gita Punjabhai Shah , Nigel Stephen Watson , Robert John Young
IPC分类号： C30B29/54
CPC分类号： C07D409/12
摘要： The present invention includes (E)-2-(5-Chlorothien-2-yl)-N-{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}ethenesulfonamide in substantially crystalline form, pharmaceutical formulations thereof, processes for preparing it, and its use in medicine, particularly use in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.
摘要翻译：本发明包括（E）-2-（5-氯噻吩-2-基）-N - {（3S）-1 - [（1S）-1-甲基-2-吗啉-4-基-2-氧代乙基] -2-氧代吡咯烷-3-基}乙烯磺酰胺，其药物制剂，其制备方法及其在医药中的用途，特别用于改善指定因子Xa抑制剂的临床病症。

7. 发明申请

US20080306045A1 1-Benzazepine-3-Sulfonylamino-2-Pyrroridones as Factor Xa Inhibitors 审中-公开
标题翻译： 1-苯并氮杂-3-磺酰基氨基-2-吡咯烷酮作为因子Xa抑制剂
公开(公告)号：US20080306045A1
公开(公告)日：2008-12-11
申请号：US12094707
申请日：2006-11-22
申请人： Laure Camus , Reshma Chudasama , Caroline Jane Day , Deepali Deshmukh , John Gerald Gleason , John David Harling , Chao-Pin Lee , Paula Saklatvala , Stefan Senger , Sarah Vallance , John Watson , Nigel Stephen Watson , Robert John Young , Barbara Yuan
发明人： Laure Camus , Reshma Chudasama , Caroline Jane Day , Deepali Deshmukh , John Gerald Gleason , John David Harling , Chao-Pin Lee , Paula Saklatvala , Stefan Senger , Sarah Vallance , John Watson , Nigel Stephen Watson , Robert John Young , Barbara Yuan
IPC分类号： A61K31/55 , C07D409/14 , C07D403/10 , C07D403/14
CPC分类号： C07D409/14 , C07D403/04 , C07D403/14
摘要： The invention relates to chemical entities of formula (I): and/or pharmaceutically acceptable derivative(s) thereof. The invention also relates to processes for the preparation of compounds of formula (I), pharmaceutical compositions containing compounds of formula (I) and to the use of compounds of formula (I) in medicine, particularly in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.
摘要翻译：本发明涉及式（I）的化学实体：和/或其药学上可接受的衍生物。本发明还涉及制备式（I）化合物的方法，含有式（I）化合物的药物组合物和式（I）化合物在医药中的应用，特别是在改善临床病症方面指示因子Xa抑制剂。

8. 发明授权

US06495606B1 Nitric oxide synthase inhibitors 失效
公开(公告)号：US06495606B1
公开(公告)日：2002-12-17
申请号：US09994969
申请日：2001-11-26
申请人： Paul John Beswick , Savvas Kleanthous , Robert John Young
发明人： Paul John Beswick , Savvas Kleanthous , Robert John Young
IPC分类号： A61K3113
CPC分类号： C07C323/58 , Y02P20/55
摘要： The present invention relates to novel amidino compounds of formula (I), or a salt, solvate, or physiologically functional derivative thereof; wherein R1 is selected from C1-4 alkyl, C3-4 cycloalkyl, C1-4 hydroxyalkyl, and C1-4 haloalkyl; to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use as selective inhibitors of inducible nitric oxide synthase.

9. 发明授权

US07482374B2 Pyrrolidine-2-ones as Factor Xa inhibitors 失效
标题翻译：吡咯烷-2-酮作为因子Xa抑制剂
公开(公告)号：US07482374B2
公开(公告)日：2009-01-27
申请号：US10561414
申请日：2004-07-17
申请人： Alan David Borthwick , Henry Anderson Kelly , Nigel Stephen Watson , Robert John Young
发明人： Alan David Borthwick , Henry Anderson Kelly , Nigel Stephen Watson , Robert John Young
IPC分类号： A61K31/4178 , A61K31/4015 , C07D233/64 , C07D403/10 , C07D207/273
CPC分类号： C07D409/14
摘要： The invention relates to compounds of formula (I): wherein substituents are as defined.
摘要翻译：本发明涉及式（I）的化合物：其中取代基如所定义。

10. 发明授权

US07186717B2 Pyrrolidine derivatives as Factor Xa inhibitors 失效
标题翻译：吡咯烷衍生物作为因子Xa抑制剂
公开(公告)号：US07186717B2
公开(公告)日：2007-03-06
申请号：US10479545
申请日：2002-06-06
申请人： Chuen Chan , Julie Nicole Hamblin , Henry Anderson Kelly , Nigel Paul King , Andrew McMurtrie Mason , Vipulkumar Kantibhai Patel , Stefan Senger , Gita Punjabhai Shah , Nigel Stephen Watson , Helen Elisabeth Weston , Caroline Whitworth , Robert John Young
发明人： Chuen Chan , Julie Nicole Hamblin , Henry Anderson Kelly , Nigel Paul King , Andrew McMurtrie Mason , Vipulkumar Kantibhai Patel , Stefan Senger , Gita Punjabhai Shah , Nigel Stephen Watson , Helen Elisabeth Weston , Caroline Whitworth , Robert John Young
IPC分类号： A61K51/5377 , C07D413/414
CPC分类号： C07D413/14 , A61K31/5377 , C07D207/12 , C07D413/06 , C07D417/14 , C07D495/04
摘要： The invention relates to compounds of formula (I) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.
摘要翻译：本发明涉及式（I）化合物的制备方法，含有它们的药物组合物及其在医药中的用途，特别是用于改善指定因子Xa抑制剂的临床病症。

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