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1. 发明授权

US09974953B2 Method and apparatus to provide safety checks for neural stimulation 有权
公开(公告)号：US09974953B2
公开(公告)日：2018-05-22
申请号：US13430356
申请日：2012-03-26
申请人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
发明人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
IPC分类号： A61N1/36 , A61N1/08 , A61N1/05
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/0551 , A61N1/08 , A61N1/36142 , A61N1/36185
摘要： An apparatus for controlling the stimulation of neural tissue which includes a neural stimulator, an input device for providing input to the neural stimulator for neural stimulation, at least one electrode electrically connected to and driven by the neural stimulator and suitable to stimulate neural tissue, a device capable of determining a charge per phase by calculating a discrete integral of the wave form of the input for the at least one electrode, a calculating device for comparing the charge per phase to a predetermined maximum and determining a reduced stimulation for the at least one electrode by the amount necessary not to exceed the predetermined maximum for the at least one electrode, and a current pulse generator for stimulating the neural tissue according to the reduced stimulation level.

2. 发明授权

US09078739B2 Fitting of brightness in a visual prosthesis 有权
标题翻译：在视觉假体中配合亮度
公开(公告)号：US09078739B2
公开(公告)日：2015-07-14
申请号：US12879979
申请日：2010-09-10
申请人： Robert Jay Greenberg , Ione Fine , Arup Roy , Matthew J. McMahon
发明人： Robert Jay Greenberg , Ione Fine , Arup Roy , Matthew J. McMahon
IPC分类号： A61N1/36 , A61N1/05 , A61F9/08
CPC分类号： A61F9/08 , A61N1/36046
摘要： The invention is a method of automatically adjusting an electrode array to the neural characteristics of an individual patient. The perceptual response to electrical neural stimulation varies from patient to patient and The response to electrical neural stimulation varies from patient to patient and the relationship between current and perceived brightness is often non-linear. It is necessary to determine this relationship to fit the prosthesis settings for each patient. It is advantageous to map the perceptual responses to stimuli. The method of mapping of the present invention is to provide a plurality of stimuli that vary in current, voltage, pulse duration, frequency, or some other dimension; measuring and recording the response to those stimuli; deriving a formula or equation describing the map from the individual points; storing the formula; and using that formula to map future stimulation.
摘要翻译：本发明是一种将电极阵列自动调整为单个患者的神经特征的方法。对电神经刺激的感知反应因患者而异，并且对电神经刺激的响应因患者而异，并且电流和感知亮度之间的关系通常是非线性的。需要确定这种关系以适应每个患者的假体设置。将感知反应映射到刺激是有利的。本发明的映射方法是提供在电流，电压，脉冲持续时间，频率或某些其他维度上变化的多个刺激; 测量和记录对这些刺激的反应; 从各个点得出描述地图的公式或方程; 存储公式; 并使用该公式来映射未来的刺激。

3. 发明申请

US20120330377A1 Visual Prosthesis Fitting 审中-公开
标题翻译：视觉假体拟合
公开(公告)号：US20120330377A1
公开(公告)日：2012-12-27
申请号：US13590011
申请日：2012-08-20
申请人： Matthew J. McMahon , Arup Roy , Scott Greenwald , Ione Fine , Alan Matthew Horsager , Avraham I. Caspi , Kelly Hobart McClure , Robert Jay Greenberg
发明人： Matthew J. McMahon , Arup Roy , Scott Greenwald , Ione Fine , Alan Matthew Horsager , Avraham I. Caspi , Kelly Hobart McClure , Robert Jay Greenberg
IPC分类号： A61F9/08 , A61N1/372
摘要： The present invention is a fitting system with a graphical interface with specific interface screens for specific functions. Methods and devices for fitting a visual prosthesis are described. In one of the methods, threshold levels and maximum levels for the electrodes of the prosthesis are determined and a map of brightness to electrode stimulation levels is later formed. A fitting system for a visual prosthesis is also discussed, together with a computer-operated system having a graphical user interface showing visual prosthesis diagnostic screens and visual prosthesis configuration screens.
摘要翻译：本发明是具有特定功能的特定接口屏幕的图形界面的拟合系统。描述了用于装配视觉假体的方法和装置。在其中一种方法中，确定假体电极的阈值水平和最大水平，并且稍后形成亮度与电极刺激水平的图。还讨论了用于视觉假体的装配系统，以及具有显示视觉假体诊断屏幕和视觉假体配置屏幕的图形用户界面的计算机操作系统。

4. 发明授权

US10780272B2 Visual prosthesis fitting 有权
公开(公告)号：US10780272B2
公开(公告)日：2020-09-22
申请号：US13590011
申请日：2012-08-20
申请人： Matthew J. McMahon , Arup Roy , Scott Greenwald , Ione Fine , Alan Matthew Horsager , Avraham I. Caspi , Kelly Hobart McClure , Robert Jay Greenberg
发明人： Matthew J. McMahon , Arup Roy , Scott Greenwald , Ione Fine , Alan Matthew Horsager , Avraham I. Caspi , Kelly Hobart McClure , Robert Jay Greenberg
IPC分类号： A61N1/36 , A61N1/372 , A61N1/05
摘要： The present invention is a fitting system with a graphical interface with specific interface screens for specific functions. Methods and devices for fitting a visual prosthesis are described. In one of the methods, threshold levels and maximum levels for the electrodes of the prosthesis are determined and a map of brightness to electrode stimulation levels is later formed. A fitting system for a visual prosthesis is also discussed, together with a computer-operated system having a graphical user interface showing visual prosthesis diagnostic screens and visual prosthesis configuration screens.

5. 发明授权

US09913985B2 Method and apparatus to provide safety checks for neural stimulation 有权
公开(公告)号：US09913985B2
公开(公告)日：2018-03-13
申请号：US11413771
申请日：2006-04-28
申请人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
发明人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/0551 , A61N1/08 , A61N1/36142 , A61N1/36185
摘要： In electrically stimulating neural tissue it is important to prevent over stimulation and unbalanced stimulation which would cause damage to the neural tissue, the electrode, or both. It is critical that neural tissue in not subjected to any direct current or alternating current above a safe threshold. Further, it is important to identify defective electrodes as continued use may result in neural and further electrode damage. The present invention presents system and stimulator control mechanisms to prevent damage to neural tissue.

6. 发明申请

US20120185015A1 Method and Apparatus to Provide Safety Checks for Neural Stimulation 有权
标题翻译：提供神经刺激安全检查的方法和装置
公开(公告)号：US20120185015A1
公开(公告)日：2012-07-19
申请号：US13430356
申请日：2012-03-26
申请人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
发明人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
IPC分类号： A61F9/08 , A61N1/36
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/0551 , A61N1/08 , A61N1/36142 , A61N1/36185
摘要： The present application deals generally with the stimulation of neural tissue by electronic means and specifically with controlling the level of electrical stimulation in order to prevent damage to the neural tissue. Methods presented in the disclosure include detecting current leakage via electrode impedance measurement, electrode capacitance measurement, and testing the electrode response to a test current pulse. Apparatus presented in the disclosure include circuitry and systems capable of performing the methods disclosed.
摘要翻译：本申请一般涉及通过电子手段刺激神经组织，特别是控制电刺激的水平以防止对神经组织的损伤。本公开中提出的方法包括通过电极阻抗测量，电极电容测量和测试电极对测试电流脉冲的响应来检测电流泄漏。本公开中提出的装置包括能够执行所公开的方法的电路和系统。

7. 发明申请

US20120004704A1 Retinal Prosthesis with Separate Electrode Array and Return Electrodes 有权
标题翻译：视网膜假体与独立的电极阵列和返回电极
公开(公告)号：US20120004704A1
公开(公告)日：2012-01-05
申请号：US13227132
申请日：2011-09-07
申请人： Robert Jay Greenberg , Mark S. Humayun
发明人： Robert Jay Greenberg , Mark S. Humayun
IPC分类号： A61F9/08 , A61N1/36
CPC分类号： A61N1/0543 , A61F9/08 , A61N1/36046
摘要： The artificial percept of light may be created by electrically stimulating the neurons of the retina. While a photolithographed array internal to the retina provides superior resolution, an array external to the retina provides easier implantation and improved manufacturability. Therefore it is advantageous to supply a high-resolution electrode array internal to the sclera, near the fovea and a lower-resolution electrode array eternal to the sclera near the periphery of the retina.It is advantageous to encourage current to flow through the retina by providing a physically separate and distinct electrode array and return electrode. The high-resolution electrode array and lower-resolution electrode array may be return electrodes for the other, or completely separate return electrodes may be provided.
摘要翻译：光的人造感知可以通过电刺激视网膜的神经元来产生。虽然在视网膜内部的光刻阵列提供优异的分辨率，但是视网膜外部的阵列提供更容易的植入和改进的可制造性。因此，在中央凹附近提供巩膜内部的高分辨率电极阵列和靠近视网膜周边的巩膜永久的较低分辨率的电极阵列是有利的。通过提供物理上分离和不同的电极阵列和返回电极来鼓励电流流过视网膜是有利的。高分辨率电极阵列和低分辨率电极阵列可以是另一个的返回电极，或者可以提供完全分离的返回电极。

8. 发明授权

US08068913B2 Visual prosthesis for improved circadian rhythms and method of improving the circadian rhythms 有权
标题翻译：视觉假体改善昼夜节律和改善昼夜节律的方法
公开(公告)号：US08068913B2
公开(公告)日：2011-11-29
申请号：US11293400
申请日：2005-12-01
申请人： Robert Jay Greenberg , Mark S. Humayun
发明人： Robert Jay Greenberg , Mark S. Humayun
IPC分类号： A61N1/32
CPC分类号： A61N1/0543 , A61N1/36046
摘要： Present invention is a method of improving circadian rhythms in blind people by stimulation the visual neural system. Ideally a retinal prosthesis of the type used to restore vision can be used to restore normal circadian rhythms. Additionally, brightness on the prosthesis can be increased in the morning and decreased in the evening to stimulate normal Circadian rhythms. Alternatively, if a retinal prosthesis is not preferable, the retina can be stimulated externally, during the day and not at night. While such eternal stimulation can not produced artificial vision, it can stimulate normal circadian rhythms.
摘要翻译：本发明是通过刺激视觉神经系统来改善盲人中的昼夜节律的方法。理想地，用于恢复视力的视网膜假体可用于恢复正常的昼夜节律。此外，假体上的亮度可以在早晨增加并在晚上减少以刺激正常的昼夜节律。或者，如果视网膜假体不是优选的，则视网膜可以在白天刺激，而不是在夜间刺激。虽然这种永恒的刺激不能产生人造视觉，但它可以刺激正常的昼夜节律。

9. 发明授权

US08060216B2 Method and apparatus to provide safety checks for neural stimulation 有权
标题翻译：提供神经刺激安全检查的方法和装置
公开(公告)号：US08060216B2
公开(公告)日：2011-11-15
申请号：US11796433
申请日：2007-04-27
申请人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
发明人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
IPC分类号： A61N1/18
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/0551 , A61N1/08 , A61N1/36142 , A61N1/36185
摘要： Electronic neural tissue stimulators for controlling the level of electrical stimulation in order to prevent damage to the neural tissue. Methods presented in the disclosure include detecting current leakage via electrode impedance measurement, electrode capacitance measurement, and testing the electrode response to a test current pulse. Apparatus presented in the disclosure include circuitry and systems capable of performing the methods disclosed.
摘要翻译：用于控制电刺激水平的电子神经组织刺激器，以防止损伤神经组织。本公开中提出的方法包括通过电极阻抗测量，电极电容测量和测试电极对测试电流脉冲的响应来检测电流泄漏。本公开中提出的装置包括能够执行所公开的方法的电路和系统。

10. 发明授权

US07818064B2 Fitting of brightness in a visual prosthesis 有权
标题翻译：在视觉假体中配合亮度
公开(公告)号：US07818064B2
公开(公告)日：2010-10-19
申请号：US11924334
申请日：2007-10-25
申请人： Robert Jay Greenberg , Ione Fine , Arup Roy , Matthew J. McMahon
发明人： Robert Jay Greenberg , Ione Fine , Arup Roy , Matthew J. McMahon
IPC分类号： A61N1/36
CPC分类号： A61F9/08 , A61N1/36046
摘要： The invention is a method of automatically adjusting an electrode array to the neural characteristics of an individual patient. The perceptual response to electrical neural stimulation varies from patient to patient and the response to electrical neural stimulation varies from patient to patient and the relationship between current and perceived brightness is often non-linear. It is necessary to determine this relationship to fit the prosthesis settings for each patient. It is advantageous to map the perceptual responses to stimuli. The method of mapping of the present invention is to provide a plurality of stimuli that vary in current, voltage, pulse duration, frequency, or some other dimension; measuring and recording the response to those stimuli; deriving a formula or equation describing the map from the individual points; storing the formula; and using that formula to map future stimulation.
摘要翻译：本发明是一种将电极阵列自动调整为单个患者的神经特征的方法。对电神经刺激的感知反应因患者而异，并且对电神经刺激的响应随病人而变化，并且电流和感知亮度之间的关系通常是非线性的。需要确定这种关系以适应每个患者的假体设置。将感知反应映射到刺激是有利的。本发明的映射方法是提供在电流，电压，脉冲持续时间，频率或某些其他维度上变化的多个刺激; 测量和记录对这些刺激的反应; 从各个点得出描述地图的公式或方程; 存储公式; 并使用该公式来映射未来的刺激。

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