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1. 发明授权

US5637323A Method of mobilizing pluripotential hematopoietic stem cells with IL-7 失效
标题翻译：用IL-7调动多能造血干细胞的方法
公开(公告)号：US5637323A
公开(公告)日：1997-06-10
申请号：US341399
申请日：1994-11-16
申请人： Robert H. Wiltrout , Francis Ruscetti , Krzysztof Grzegorzewski , Jonathan Keller , Kristin L. Komschlies-McConville
发明人： Robert H. Wiltrout , Francis Ruscetti , Krzysztof Grzegorzewski , Jonathan Keller , Kristin L. Komschlies-McConville
IPC分类号： A61K35/12 , A61K38/00 , A61K38/20 , C12N5/0789 , C12N15/85 , A61K35/14 , A01N63/00
CPC分类号： C12N5/0647 , A61K38/2046 , A61K2035/124
摘要： This invention provides a method of isolating an increased number of hematopoietic stem cells from a subject comprising a) administering interleukin-7 to the subject in an amount that mobilizes the hematopoietic stem cells to the peripheral blood; and, b) isolating a population of leukocytes enriched for hematopoietic stem cells from the peripheral blood. Also provided is a method of transplanting an increased number of hematopoietic stem cells from a donor to a recipient to enhance repopulation of the recipient's hematopoietic and immune cells comprising a) administering interleukin-7 to the donor in an amount that mobilizes the hematopoietic stem cells to the peripheral blood; b) isolating a population of leukocytes enriched for hematopoietic stem cells from the donor's peripheral blood; and, c) transplanting the isolated population of leukocytes enriched for hematopoietic stem cells to the recipient, thereby enhancing the repopulation of the recipient's hematopoietic and immune cells. Finally, the invention provides a method of improving engraftment of a bone marrow transplant or a peripheral blood leukocyte transplant from a donor to a recipient comprising administering interleukin-7 to the recipient following transplantation in an amount that enhances engraftment.
摘要翻译：本发明提供了从受试者中分离增加数目的造血干细胞的方法，其包括a）以将造血干细胞移植到外周血的量向受试者施用白细胞介素-7; 和b）从外周血中分离富含造血干细胞的白细胞群。还提供了将增加数量的造血干细胞从供体移植到受体以增强受体的造血细胞和免疫细胞的再增殖的方法，其包括a）以使动员造血干细胞的量向供体施用白细胞介素-7 外周血; b）从供体的外周血中分离富含造血干细胞的白细胞群; 并且c）将分离的富含造血干细胞的白细胞群体移植到受体，从而增强受体的造血细胞和免疫细胞的再增殖。最后，本发明提供了一种改善骨髓移植物或外周血白细胞移植物从供体到接受者的移植的方法，其包括以增强移植量的量将移植后的白细胞介素-7给予受体。

2. 依法登记的发明

USH1427H Substituted flavonoid compounds, their salts, their manufacture and their use in combination with interleukin-2 失效
标题翻译：取代的类黄酮化合物，其盐，其制备及其与白介素-2的组合使用
公开(公告)号：USH1427H
公开(公告)日：1995-04-04
申请号：US892706
申请日：1992-05-29
申请人： Phillipe Briet , Jean-Jacques Berthelon , Francois Collonges , Robert H. Wiltrout , Ronald L. Hornung
发明人： Phillipe Briet , Jean-Jacques Berthelon , Francois Collonges , Robert H. Wiltrout , Ronald L. Hornung
IPC分类号： A61K38/20 , C07D311/30 , A61K45/05 , A61K31/35 , C07D311/04
CPC分类号： C07D311/30 , A61K38/2013 , A61K31/35 , A61K2300/00
摘要： The use of substituted flavonoid compounds which have the immunomodulatory activity of (1) boosting natural killer activity in vivo and (2) inducing interferon, and (3) belong to the family of flavonoids of the formula (I): ##STR1## in conjunction with interleukin-2 in cancer therapy is disclosed.
摘要翻译：使用具有免疫调节活性的取代的类黄酮化合物（1）在体内促进自然杀伤活性，和（2）诱导干扰素，和（3）属于式（I）的类黄酮：[IMAGE] 公开了在癌症治疗中的白介素-2。

3. 发明授权

US5126129A Cancer therapy using interleukin-2 and flavone compounds 失效
标题翻译：使用白介素-2和黄酮化合物的癌症治疗
公开(公告)号：US5126129A
公开(公告)日：1992-06-30
申请号：US649182
申请日：1991-02-04
申请人： Robert H. Wiltrout , Ronald Hornung
发明人： Robert H. Wiltrout , Ronald Hornung
IPC分类号： A61K38/20
CPC分类号： A61K38/2013
摘要： Treatment of Cancer with Flavones and Interleukin 2.
摘要翻译：用黄酮和白细胞介素2治疗癌症。

4. 发明授权

US5096707A Flavone-8-acetic acid and interleukin-2 in a method of treating certain cancers 失效
标题翻译：黄酮-8-乙酸和白细胞介素-2在治疗某些癌症的方法
公开(公告)号：US5096707A
公开(公告)日：1992-03-17
申请号：US182222
申请日：1988-04-15
申请人： Robert H. Wiltrout , Ronald L. Hornung
发明人： Robert H. Wiltrout , Ronald L. Hornung
IPC分类号： A61K38/20
CPC分类号： A61K38/2013
摘要： A treatment regimen for cancers having cells which are susceptible to an interleukin-2 activated natural killer cell mediated anti-cancer effect, the method comprises administering to a patient an effective amount of a combination of interleukin 2 and flavone-8-acetic acid. The treatment regimen is particularly effective in the treatment of renal carcinoma. Synergistic pharmaceutical compositions are also provided. effective in the treatment of renal carcinoma. Synergistic pharmaceutical compositions are also provided.
摘要翻译：一种具有对白细胞介素-2激活的天然杀伤细胞介导的抗癌作用敏感的细胞的癌症的治疗方案，所述方法包括向患者施用有效量的白细胞介素2和黄酮-8-乙酸的组合。治疗方案在治疗肾癌方面特别有效。还提供了协同药物组合物。有效治疗肾癌。还提供了协同药物组合物。

5. 发明授权

US5061488A Flavone-8-acetic acid and interleukin-2 for cancer therapy 失效
标题翻译：黄酮-8-乙酸和白介素-2用于癌症治疗
公开(公告)号：US5061488A
公开(公告)日：1991-10-29
申请号：US533442
申请日：1990-06-05
申请人： Robert H. Wiltrout , Ronald L. Hornung
发明人： Robert H. Wiltrout , Ronald L. Hornung
IPC分类号： A61K38/20
CPC分类号： A61K38/2013
摘要： A treatment regimen for cancer comprises administering to a patient an effective amount of a combination of interleukin 2 and flavone-8-acetic acid. The treatment regime is particularly effective in the treatment of renal cracinoma.
摘要翻译：用于癌症的治疗方案包括向患者施用有效量的白细胞介素2和黄酮-8-乙酸的组合。治疗方案在治疗肾小管瘤方面特别有效。

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