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1. 发明申请

US20110135629A1 EYA2S As Modifiers of the PTEN/AKT Pathway and Methods of Use 审中-公开
标题翻译： EYA2S作为PTEN / AKT途径的修饰物和使用方法
公开(公告)号：US20110135629A1
公开(公告)日：2011-06-09
申请号：US11993130
申请日：2006-06-20
申请人： Arthur Brace , Margaret Lynn Bjerke , Susana Nieto-Bergman , Lori S. Friedman , Kevin Ward , Robert A. Blake
发明人： Arthur Brace , Margaret Lynn Bjerke , Susana Nieto-Bergman , Lori S. Friedman , Kevin Ward , Robert A. Blake
IPC分类号： A61K39/395 , A61K31/7088 , A61P35/00 , C12Q1/68 , C12N5/00 , C12Q1/48 , G01N33/53
CPC分类号： C12N9/14 , G01N33/574 , G01N33/6872 , G01N2333/4704 , G01N2333/9121 , G01N2500/04 , G01N2500/10 , G01N2510/00
摘要： Human MPTENAKT genes are identified as modulators of the PTEN/AKT pathway, and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT, comprising screening for agents that modulate the activity of MPTENAKT are provided.
摘要翻译：人类MPTENAKT基因被鉴定为PTEN / AKT途径的调节剂，因此是与缺陷性PTEN / AKT功能相关的病症的治疗靶点。提供了用于鉴定PTEN / AKT调节剂的方法，包括筛选调节MPTENAKT活性的试剂。

2. 发明申请

US20080193438A1 Eef2k as Modifiers of the Pten/Akt Pathway and Methods of Use 失效
标题翻译： Eef2k作为Pten / Akt途径的修饰物和使用方法
公开(公告)号：US20080193438A1
公开(公告)日：2008-08-14
申请号：US11908114
申请日：2006-03-10
申请人： Arthur Brace , Robert A. Blake , Lori S. Friedman , Lynn Margaret Bjerke , Kevin M. Ward , Susana Nieto-Bergman
发明人： Arthur Brace , Robert A. Blake , Lori S. Friedman , Lynn Margaret Bjerke , Kevin M. Ward , Susana Nieto-Bergman
IPC分类号： A61K39/395 , G01N33/53 , A61P35/00 , C12N5/00
CPC分类号： G01N33/5041
摘要： Human EEF2K genes are identified as modulators of the PTEN/AKT pathway and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT comprising screening for agents that modulate the activity of EEF2K are provided.
摘要翻译：人EEF2K基因被鉴定为PTEN / AKT途径的调节剂，因此是与缺陷型PTEN / AKT功能相关的疾病的治疗靶标。提供了用于鉴定PTEN / AKT调节剂的方法，包括筛选调节EEF2K活性的试剂。

3. 发明授权

US4766794A Rotary saw blade 失效
标题翻译：旋转锯片
公开(公告)号：US4766794A
公开(公告)日：1988-08-30
申请号：US899677
申请日：1986-08-25
申请人： Robert A. Blake
发明人： Robert A. Blake
IPC分类号： B23D61/02 , B23D61/04 , B27B33/08
CPC分类号： B23D61/04 , B23D61/021 , Y10T83/9348 , Y10T83/935 , Y10T83/9358
摘要： A radial saw blade is formed of a flat disc having peripheral edge including circular peripheral portions and recessed stepped peripheral portions. The peripheral edge includes spaced apart, radially inwardly extending notches. Each notch has a flat, plate-like insert brazed to an L-shaped seat in the notch facing the direction of rotation. Each insert has cutting edges formed on side edges of the inserts which extend axially from both sides of the disc and on a crown edge extending radially from the peripheral edge of the disc. The side and crown edges each have beveled surfaces extending away from the direction of rotation to define a relief angle. A first set of the notches are positioned about the circular peripheral portion of the peripheral edge. The inserts in the first set of notches make the primary cut in both linear and non-linear passes. A second set of notches are circumferentially spaced along the recessed peripheral portions, or stepped portions, of the blade and are located at different radial distances from the center of the disc. The side cutting edges of the inserts in the second set of notches radially overlap the side cutting edges of radially adjacent cutting inserts in the second set of notches. The inserts in the second set of notches plane the raw cut edges cut by the first set of inserts on straight cuts. The inserts in the second set of notches also cut in the axial direction relative to the disc for curved and diagonal cutting to prevent the blade from binding in the kerf by providing axial relief.
摘要翻译：径向锯片由具有圆周边缘和凹陷阶梯状周边部分的周缘的扁平盘形成。周缘包括间隔开的径向向内延伸的凹口。每个凹口具有平坦的板状插入件，其在面向旋转方向的凹口中钎焊到L形座。每个插入件具有形成在插入件的侧边缘上的切割刃，其从盘的两侧轴向延伸并且在从盘的周边边缘径向延伸的冠缘上形成。侧面和冠部边缘各自具有远离旋转方向延伸的倾斜表面，以限定一个仰角。第一组凹口围绕周边边缘的圆形周边部分定位。第一组凹口中的插入件在线性和非线性通道中进行初级切割。第二组凹口沿着刀片的凹陷的周边部分或阶梯部分周向间隔开并且位于与盘的中心不同的径向距离处。第二组凹口中的插入件的侧切割刃径向地与第二组凹口中径向相邻的切削刀片的侧切削刃重叠。第二组凹口中的插入物将由直线切口上的第一组插入物切割的原始切割刃平面。第二组凹口中的插入件也相对于盘沿轴向切割以进行弯曲和对角切割，以防止刀片通过提供轴向浮雕而在切口中结合。

4. 发明申请

US20100183583A1 GALK1S AS MODIFIERS OF THE PTEN/AKT PATHWAY AND METHODS OF USE 审中-公开
标题翻译： GALK1S作为PTEN / AKT途径的修饰者及其使用方法
公开(公告)号：US20100183583A1
公开(公告)日：2010-07-22
申请号：US11993191
申请日：2006-06-20
申请人： Arthur Brace , Margaret Lynn Bjerke , Susana Nieto-Bergman , Lori S. Friedman , Kevin Ward , Robert A. Blake
发明人： Arthur Brace , Margaret Lynn Bjerke , Susana Nieto-Bergman , Lori S. Friedman , Kevin Ward , Robert A. Blake
IPC分类号： A61K39/395 , G01N33/53 , C12Q1/68 , A01K67/00 , C12N5/02
CPC分类号： C12N9/14 , G01N33/574 , G01N33/6872 , G01N2333/4704 , G01N2333/9121 , G01N2500/04 , G01N2500/10 , G01N2510/00
摘要： Human GALK1 genes are identified as modulators of the PTEN/AKT pathway, and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT, comprising screening for agents that modulate the activity of GALK1 are provided.
摘要翻译：人GALK1基因被鉴定为PTEN / AKT途径的调节剂，因此是与缺陷型PTEN / AKT功能相关的疾病的治疗靶点。提供了用于鉴定PTEN / AKT调节剂的方法，包括筛选调节GALK1活性的试剂。

5. 发明授权

US07337672B2 Method for inspecting grinding wheels 失效
标题翻译：检查砂轮的方法
公开(公告)号：US07337672B2
公开(公告)日：2008-03-04
申请号：US11176981
申请日：2005-07-08
申请人： Robert A. Blake , Neville Whittle , Michelle M. Teichman
发明人： Robert A. Blake , Neville Whittle , Michelle M. Teichman
IPC分类号： G01N9/36 , B24B49/00
CPC分类号： G01N29/11 , G01N9/24 , G01N9/36 , G01N29/0609 , G01N29/223 , G01N29/27 , G01N29/4427 , G01N29/46 , G01N2203/0076 , G01N2291/02818 , G01N2291/02827 , G01N2291/048 , G01N2291/102 , G01N2291/2634 , G01N2291/2696
摘要： This invention discloses a method of evaluating the internal structure of a grinding wheel through ultrasonic inspection.
摘要翻译：本发明公开了一种通过超声波检查评估砂轮内部结构的方法。

6. 发明授权

US06777417B2 3-(4,5,6,7-tetrahydroindol-2-ylmethylidiene-2-indolinone derivatives as kinase inhibitors 失效
标题翻译：作为激酶抑制剂的3-（4,5,6,7-四氢吲哚-2-基亚甲基-2-二氢吲哚酮衍生物）
公开(公告)号：US06777417B2
公开(公告)日：2004-08-17
申请号：US10238051
申请日：2002-09-10
申请人： Congxin Liang , Huiping Guan , Peng Cho Tang , Robert A. Blake
发明人： Congxin Liang , Huiping Guan , Peng Cho Tang , Robert A. Blake
IPC分类号： A61K31495
CPC分类号： C07D401/12 , C07D209/34 , C07D401/14
摘要： The present invention relates to certain 3-(4,5,6,7-tetrahydroindol-2-yl-methylidene)-2-indolinone derivatives that inhibit kinases, in particular Src kinase. Pharmaceutical compositions comprising these compounds, methods of treating diseases mediated by kinases utilizing pharmaceutical compositions comprising these compounds, and methods of preparing them are also disclosed.
摘要翻译：本发明涉及抑制激酶，特别是Src激酶的某些3-（4,5,6,7-四氢吲哚-2-基 - 亚甲基）-2-二氢吲哚酮衍生物。还公开了包含这些化合物的药物组合物，使用包含这些化合物的药物组合物治疗由激酶介导的疾病的方法及其制备方法。

7. 发明申请

US20100122354A1 CDC6S AS MODIFIERS OF THE PTEN/AKT PATHWAY AND METHODS OF USE 审中-公开
标题翻译： CDC6S作为PTEN / AKT途径的修改者及其使用方法
公开(公告)号：US20100122354A1
公开(公告)日：2010-05-13
申请号：US11993122
申请日：2006-06-20
申请人： Arthur Brace , Margaret Lynn Bjerke , Susana Nieto-Bergman , Lori S. Friedman , Kevin Ward , Robert A. Blake
发明人： Arthur Brace , Margaret Lynn Bjerke , Susana Nieto-Bergman , Lori S. Friedman , Kevin Ward , Robert A. Blake
IPC分类号： G01N33/00 , C12Q1/68 , G01N33/53 , C12N5/02 , A01K67/00
CPC分类号： C12N9/14 , G01N33/574 , G01N33/6872 , G01N2333/4704 , G01N2333/9121 , G01N2500/04 , G01N2500/10 , G01N2510/00
摘要： Human CDC6 genes are identified as modulators of the PTEN/AKT pathway, and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT, comprising screening for agents that modulate the activity of CDC6 are provided.
摘要翻译：人CDC6基因被鉴定为PTEN / AKT途径的调节剂，因此是与缺陷型PTEN / AKT功能相关的病症的治疗靶点。提供了用于鉴定PTEN / AKT调节剂的方法，包括筛选调节CDC6活性的试剂。

8. 发明授权

US5740224A Cone beam synthetic arrays in three-dimensional computerized tomography 失效
标题翻译：锥形光束合成扫描仪阵列在三维计算机断层扫描
公开(公告)号：US5740224A
公开(公告)日：1998-04-14
申请号：US564854
申请日：1995-11-30
申请人： Martin Muller , Gonzalo R. Arce , Robert A. Blake, Jr.
发明人： Martin Muller , Gonzalo R. Arce , Robert A. Blake, Jr.
IPC分类号： G01N23/04 , G01N23/083
CPC分类号： G01N23/04 , Y10S378/901
摘要： The method of the present invention combines an ensemble of truncated partial cone beam projections to synthesize a complete virtual projection. The individual partial projections are obtained with CT scanners, where for each partial projection the investigated object is positioned at precise locations specified by formulas described in the present application (e.g., formulas (3), (4), (6) and (18) for linear cone beam synthetic scanner arrays or formulas (9)-(13), (20), (21) and (25)-(27) for circular cone beam synthetic scanner arrays). Prior to the actual reconstruction, the partial cone beam projections are combined to form a complete virtual projection, equivalent to a projection one would obtain by using a sufficiently large detector.
摘要翻译：本发明的方法组合了一组截锥部分锥形投影以合成完整的虚拟投影。用CT扫描器获得各个部分投影，其中对于每个部分投影，被调查物体位于由本申请中描述的公式指定的精确位置（例如公式（3），（4），（6）和（18）用于圆锥形束合成扫描器阵列的线性锥形束合成扫描器阵列或公式（9） - （13），（20），（21）和（25） - （27））。在实际重建之前，将部分锥形束投影组合以形成完整的虚拟投影，等同于通过使用足够大的检测器获得的投影。

9. 发明授权

US08679763B2 EEF2K as modifiers of the PTEN/AKT pathway and methods of use 失效
标题翻译： EEF2K作为PTEN / AKT途径的修饰剂和使用方法
公开(公告)号：US08679763B2
公开(公告)日：2014-03-25
申请号：US11908114
申请日：2006-03-10
申请人： Arthur Brace , Robert A. Blake , Lori S. Friedman , Lynn Margaret Bjerke , Kevin M. Ward , Susana Nieto-Bergman
发明人： Arthur Brace , Robert A. Blake , Lori S. Friedman , Lynn Margaret Bjerke , Kevin M. Ward , Susana Nieto-Bergman
IPC分类号： G01N33/53 , G01N33/58 , G01N33/15 , G01N33/487 , G01N33/577
CPC分类号： G01N33/5041
摘要： Human EEF2K genes are identified as modulators of the PTEN/AKT pathway and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT comprising screening for agents that modulate the activity of EEF2K are provided.
摘要翻译：人EEF2K基因被鉴定为PTEN / AKT途径的调节剂，因此是与缺陷型PTEN / AKT功能相关的疾病的治疗靶标。提供了用于鉴定PTEN / AKT调节剂的方法，包括筛选调节EEF2K活性的试剂。

10. 发明申请

US20080226154A1 SYSTEMS AND METHODS FOR PRODUCING CARBONACEOUS PASTES USED IN THE PRODUCTION OF CARBON ELECTRODES 审中-公开
标题翻译：用于生产碳电极中使用的碳酸钙的系统和方法
公开(公告)号：US20080226154A1
公开(公告)日：2008-09-18
申请号：US12046013
申请日：2008-03-11
申请人： Jay N. Bruggeman , Angelique Adams , David Coleman , Robert A. Blake
发明人： Jay N. Bruggeman , Angelique Adams , David Coleman , Robert A. Blake
IPC分类号： G06K9/00
CPC分类号： H05B7/09 , G01N21/84 , G06T7/0004 , G06T2207/30108
摘要： Systems and methods for producing a carbonaceous paste are provided. The systems and methods may include a paste control system that obtains an image of the carbonaceous paste and determines whether operational parameters associated with paste production require adjustment. One or more operational variables may be adjusted based on the obtained images to facilitate production of the carbonaceous paste.
摘要翻译：提供了生产碳质糊料的系统和方法。系统和方法可以包括获得碳质糊状物的图像的糊剂控制系统，并确定与糊剂生产相关的操作参数是否需要调整。可以基于所获得的图像来调整一个或多个操作变量以促进碳质糊料的生产。

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