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1. 发明授权

US07470441B2 Method for preparing Mucuna pruriens seed extract 有权
标题翻译： Mucuna pruriens种子提取物的制备方法
公开(公告)号：US07470441B2
公开(公告)日：2008-12-30
申请号：US10533135
申请日：2003-10-02
申请人： Rob Van Der Giessen , C. Warren Olanow , Andrew Lees , Hildebert Wagner
发明人： Rob Van Der Giessen , C. Warren Olanow , Andrew Lees , Hildebert Wagner
IPC分类号： A61K36/48
CPC分类号： A61K36/48
摘要： The present invention provides pharmaceutical compositions comprising Mucuna pruriens seeds or one or more Mucuna pruriens seed components, substances, fractions or mixtures or substances obtained therefrom. Furthermore, the invention relates to the use of Mucuna pruriens seed powder or one or more Mucuna pruriens components, substances, fractions or mixtures or substances obtained therefrom for the preparation of a pharmaceutical composition for preventing, alleviating or treating neurological diseases. Additionally, the invention relates to the use of Mucuna pruriens seeds for the preparation of a pharmaceutical composition for neuroprotection or neurostimulation and to methods of preparing extracts of Mucuna pruriens which can be used for the preparation of a pharmaceutical composition for treating neurological diseases. Finally, the invention relates to the use of Mucuna pruriens seeds for the preparation of a pharmaceutical composition for the treatment of Parkinson's Disease to obtain a broader therapeutic window in L-Dopa therapy, to delay a need for combination therapy, to obtain an earlier onset and longer duration of L-Dopa efficacy, and to prevent or alleviate acute and chronic L-Dopa toxicity.
摘要翻译：本发明提供了包含Mucuna pruriens种子或一种或多种Mucuna pruriens种子组分，从其获得的物质，级分或混合物或物质的药物组合物。此外，本发明涉及用于制备用于预防，减轻或治疗神经疾病的药物组合物的Mucuna pruriens种子粉或一种或多种Mucuna pruriens组分，物质，级分或由其获得的混合物或物质的用途。此外，本发明涉及Mucuna pruriens种子用于制备神经保护或神经刺激的药物组合物的用途，以及可用于制备用于治疗神经疾病的药物组合物的Mucuna pruriens的提取物的方法。最后，本发明涉及Mucuna pruriens种子用于制备用于治疗帕金森病的药物组合物以在L-多巴治疗中获得更广泛的治疗窗口，延迟联合治疗的需要以获得较早发病的用途延长持续时间的L-多巴功效，并预防或缓解急性和慢性左旋多巴的毒性。

2. 发明申请

US20060165822A1 Pharmaceutical compositions and uses comprising mucuna pruriens seed powder and extracts thereof in the treatment of neurological diseases 有权
标题翻译：药物组合物和用途，其包括粘液普鲁斯种子粉及其提取物在治疗神经疾病中的用途
公开(公告)号：US20060165822A1
公开(公告)日：2006-07-27
申请号：US10533135
申请日：2003-10-02
申请人： Rob Van Der Giessen , C Olanow , Andrew Lees , Hildebert Wagner
发明人： Rob Van Der Giessen , C Olanow , Andrew Lees , Hildebert Wagner
IPC分类号： A61K36/48
CPC分类号： A61K36/48
摘要： The present invention provides pharmaceutical compositions comprising Mucuna pruriens seeds or one or more Mucuna pruriens seed components, substances, fractions or mixtures or substances obtained therefrom. Furthermore, the invention relates to the use of Mucuna pruriens seed powder or one or more Mucuna pruriens components, substances, fractions or mixtures or substances obtained therefrom for the preparation of a pharmaceutical composition for preventing, alleviating or treating neurological diseases. Additionally, the invention relates to the use of Mucuna pruriens seeds for the preparation of a pharmaceutical composition for neuroprotection or neurostimulation and to methods of preparing extracts of Mucuna pruriens which can be used for the preparation of a pharmaceutical composition for treating neurological diseases. Finally, the invention relates to the use of Mucuna pruriens seeds for the preparation of a pharmaceutical composition for the treatment of Parkinson's Disease to obtain a broader therapeutic window in L-Dopa therapy, to delay a need for combination therapy, to obtain an earlier onset and longer duration of L-Dopa efficacy, and to prevent or alleviate acute and chronic L-Dopa toxicity.
摘要翻译：本发明提供了包含Mucuna pruriens种子或一种或多种Mucuna pruriens种子组分，从其获得的物质，级分或混合物或物质的药物组合物。此外，本发明涉及用于制备用于预防，减轻或治疗神经疾病的药物组合物的Mucuna pruriens种子粉或一种或多种Mucuna pruriens组分，物质，级分或由其获得的混合物或物质的用途。此外，本发明涉及Mucuna pruriens种子用于制备神经保护或神经刺激的药物组合物的用途，以及可用于制备用于治疗神经疾病的药物组合物的Mucuna pruriens的提取物的方法。最后，本发明涉及Mucuna pruriens种子用于制备用于治疗帕金森病的药物组合物以在L-多巴治疗中获得更广泛的治疗窗口，延迟联合治疗的需要以获得较早发病的用途延长持续时间的L-多巴功效，并预防或缓解急性和慢性左旋多巴的毒性。

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