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1. 发明公开

EP2413837A4 METHODS FOR TREATING MYOFASCIAL, MUSCLE, AND/OR BACK PAIN 审中-公开
标题翻译：方法肌筋膜，肌肉和背部疼痛治疗
公开(公告)号：EP2413837A4
公开(公告)日：2013-10-23
申请号：EP10759386
申请日：2010-04-01
申请人： ZHANG JIE , CROCKETT ANDREW , RIGBY LARRY
发明人： ZHANG JIE , CROCKETT ANDREW , RIGBY LARRY
IPC分类号： A61K9/00 , A61F7/02 , A61F7/03 , A61K9/70
CPC分类号： A61K9/0004 , A61F7/034 , A61F2007/0226 , A61F2007/0257 , A61F2007/0261 , A61K9/7084

2. 发明公开

EP2413837A1 METHODS FOR TREATING MYOFASCIAL, MUSCLE, AND/OR BACK PAIN 审中-公开
标题翻译：方法肌筋膜，肌肉和背部疼痛治疗
公开(公告)号：EP2413837A1
公开(公告)日：2012-02-08
申请号：EP10759386.5
申请日：2010-04-01
申请人： Zhang, Jie , Crockett, Andrew , Rigby, Larry
发明人： Zhang, Jie , Crockett, Andrew , Rigby, Larry
IPC分类号： A61F2/00
CPC分类号： A61K9/0004 , A61F7/034 , A61F2007/0226 , A61F2007/0257 , A61F2007/0261 , A61K9/7084
摘要： The present disclosure is drawn to methods for treating myofascial pain, muscle pain, back pain, or combinations of these pains. Specifically, a method for treating myofascial pain, muscle pain, back pain, or combinations thereof includes the application of an analgesic system to a skin surface of a subject experiencing the pain and maintaining the analgesic system on the skin surface for a period of time of at least 30 minutes. The analgesic system applied to the skin surface can include a heating component and a local anesthetic formulation which includes at least one local anesthetic. The heating component can be capable of heating the skin surface to a temperature of 36 0C to 42 0C.

3. 发明专利

CA2757302A1 METHODS FOR TREATING MYOFASCIAL, MUSCLE, AND/OR BACK PAIN 未知
公开(公告)号：CA2757302A1
公开(公告)日：2010-10-07
申请号：CA2757302
申请日：2010-04-01
申请人： CROCKETT ANDREW , ZHANG JIE , RIGBY LARRY
发明人： CROCKETT ANDREW , ZHANG JIE , RIGBY LARRY
IPC分类号： A61F2/00
摘要： The present disclosure is drawn to methods for treating myofascial pain, muscle pain, back pain, or combinations of these pains. Specifically, a method for treating myofascial pain, muscle pain, back pain, or combinations thereof includes the application of an analgesic system to a skin surface of a subject experiencing the pain and maintaining the analgesic system on the skin surface for a period of time of at least 30 minutes. The analgesic system applied to the skin surface can include a heating component and a local anesthetic formulation which includes at least one local anesthetic. The heating component can be capable of heating the skin surface to a temperature of 36 0C to 42 0C.

4. 发明申请

WO2011028542A2 METHODS OF TREATING PAIN ASSOCIATED WITH COMPLEX REGIONAL PAIN SYNDROME 审中-公开
标题翻译：治疗与复合区域疼痛综合征相关的疼痛的方法
公开(公告)号：WO2011028542A2
公开(公告)日：2011-03-10
申请号：PCT/US2010/046523
申请日：2010-08-24
申请人： ZARS PHARMA, INC. , ZHANG, Jie , CROCKETT, Andrew , RIGBY, Larry
发明人： ZHANG, Jie , CROCKETT, Andrew , RIGBY, Larry
IPC分类号： A61K31/245 , A61K31/24 , A61K31/165 , A61K31/167 , A61P17/00 , A61P29/00
CPC分类号： A61K45/06 , A61K31/165 , A61K31/167 , A61K31/24 , A61K31/245 , A61K2300/00
摘要： The present invention is drawn to methods for treating pain associated with complex regional pain syndrome. Specifically, a method for treating pain associated with complex regional pain syndrome includes the application of an analgesic system to a skin surface of a subject experiencing the pain and maintaining the analgesic system on the skin surface for a period of time of at least 30 minutes. The analgesic system applied to the skin surface can include a heating component and a local anesthetic formulation which includes at least one local anesthetic. The heating component can be capable of heating the skin surface to a temperature of 36°C to 42°C.
摘要翻译：本发明涉及用于治疗与复杂性区域性疼痛综合征相关的疼痛的方法。具体地说，用于治疗与复杂的局部疼痛综合征有关的疼痛的方法包括将镇痛系统施用于经历疼痛的受试者的皮肤表面，并将止痛系统保持在皮肤表面上至少30分钟的时间。应用于皮肤表面的镇痛系统可以包括加热组分和包括至少一种局部麻醉剂的局部麻醉剂制剂。加热组件能够将皮肤表面加热至36℃至42℃的温度。

5. 发明申请

WO2011028542A3 METHODS OF TREATING PAIN ASSOCIATED WITH COMPLEX REGIONAL PAIN SYNDROME 审中-公开
标题翻译：治疗与复合性局部疼痛综合征有关的疼痛的方法
公开(公告)号：WO2011028542A3
公开(公告)日：2011-07-21
申请号：PCT/US2010046523
申请日：2010-08-24
申请人： ZARS PHARMA INC , ZHANG JIE , CROCKETT ANDREW , RIGBY LARRY
发明人： ZHANG JIE , CROCKETT ANDREW , RIGBY LARRY
IPC分类号： A61K31/245 , A61K31/165 , A61K31/167 , A61K31/24 , A61P17/00 , A61P29/00
CPC分类号： A61K45/06 , A61K31/165 , A61K31/167 , A61K31/24 , A61K31/245 , A61K2300/00
摘要： The present invention is drawn to methods for treating pain associated with complex regional pain syndrome. Specifically, a method for treating pain associated with complex regional pain syndrome includes the application of an analgesic system to a skin surface of a subject experiencing the pain and maintaining the analgesic system on the skin surface for a period of time of at least 30 minutes. The analgesic system applied to the skin surface can include a heating component and a local anesthetic formulation which includes at least one local anesthetic. The heating component can be capable of heating the skin surface to a temperature of 36°C to 42°C.
摘要翻译：本发明涉及治疗与复杂区域性疼痛综合征相关的疼痛的方法。具体而言，用于治疗与复合区域性疼痛综合征相关的疼痛的方法包括将镇痛系统应用于经历疼痛的受试者的皮肤表面并将该镇痛系统维持在皮肤表面上至少30分钟的时间段。应用于皮肤表面的止痛系统可以包括加热部件和包含至少一种局部麻醉剂的局部麻醉剂。加热部件能够将皮肤表面加热至36℃至42℃的温度。

6. 发明申请

WO2010114973A1 METHODS FOR TREATING MYOFASCIAL, MUSCLE, AND/OR BACK PAIN 审中-公开
标题翻译：治疗肌肉，肌肉和/或背部疼痛的方法
公开(公告)号：WO2010114973A1
公开(公告)日：2010-10-07
申请号：PCT/US2010/029580
申请日：2010-04-01
申请人： ZHANG, Jie , CROCKETT, Andrew , RIGBY, Larry
发明人： ZHANG, Jie , CROCKETT, Andrew , RIGBY, Larry
IPC分类号： A61F2/00
CPC分类号： A61K9/0004 , A61F7/034 , A61F2007/0226 , A61F2007/0257 , A61F2007/0261 , A61K9/7084
摘要： The present disclosure is drawn to methods for treating myofascial pain, muscle pain, back pain, or combinations of these pains. Specifically, a method for treating myofascial pain, muscle pain, back pain, or combinations thereof includes the application of an analgesic system to a skin surface of a subject experiencing the pain and maintaining the analgesic system on the skin surface for a period of time of at least 30 minutes. The analgesic system applied to the skin surface can include a heating component and a local anesthetic formulation which includes at least one local anesthetic. The heating component can be capable of heating the skin surface to a temperature of 36 0C to 42 0C.
摘要翻译：本公开涉及用于治疗肌筋膜疼痛，肌肉疼痛，背部疼痛或这些疼痛的组合的方法。具体来说，治疗肌筋膜疼痛，肌肉疼痛，背部疼痛或其组合的方法包括将镇痛系统施用于经历疼痛的受试者的皮肤表面，并将止痛系统保持在皮肤表面上一段时间至少30分钟。应用于皮肤表面的镇痛系统可以包括加热组分和包括至少一种局部麻醉剂的局部麻醉剂制剂。加热组件能够将皮肤表面加热至36℃至42℃的温度。

7. 发明申请

WO2005120473A3 DERMAL PEEL-FORMING FORMULATION 审中-公开
标题翻译： DERMAL PEEL-FORMING制剂
公开(公告)号：WO2005120473A3
公开(公告)日：2006-05-11
申请号：PCT/US2005020099
申请日：2005-06-07
申请人： ZARS INC , ZHANG JIE , WARNER KEVIN S , ASHBURN MICHAEL A , RIGBY LARRY D , NIU SUYI
发明人： ZHANG JIE , WARNER KEVIN S , ASHBURN MICHAEL A , RIGBY LARRY D , NIU SUYI
IPC分类号： A61F13/00 , A61K9/70
CPC分类号： A61K9/7015 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/445 , A61K31/573 , A61K47/10 , A61K47/32
摘要： The present invention is drawn to adhesive peel-forming formulations for dermal delivery of a drug. The formulation can include a drug, a solvent vehicle, and a peel-forming agent. The solvent vehicle can include a volatile solvent system having one or more volatile solvent, and a non-volatile solvent system having one or more non-volatile solvent, wherein the non-volatile solvent system has a solubility for the drug that is within a window of operable solubility for the drug such that the drug can be delivered at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified peelable layer after at least a portion of the volatile solvent system is evaporated.
摘要翻译：本发明涉及用于药物真皮递送的粘合剂剥离形成制剂。制剂可以包括药物，溶剂载体和剥离形成剂。溶剂载体可以包括具有一种或多种挥发性溶剂的挥发性溶剂体系和具有一种或多种非挥发性溶剂的非挥发性溶剂体系，其中所述非挥发性溶剂体系对于在窗口内的药物具有溶解性对于药物具有可操作的溶解性，使得药物可以在持续的时间段内以治疗有效的速率递送。在挥发性溶剂体系蒸发之前，配方可以具有适用于皮肤表面的粘度。当施用于皮肤时，在挥发性溶剂系统的至少一部分蒸发之后，制剂可以形成固化的可剥离层。

8. 发明申请

WO2005120473A2 ADHESIVE PEEL-FORMING FORMULATIONS FOR DERMAL DELIVERY OF DRUGS AND METHODS OF USING THE SAME 审中-公开
标题翻译：用于药物递送的胶粘剂成型制剂及其使用方法
公开(公告)号：WO2005120473A2
公开(公告)日：2005-12-22
申请号：PCT/US2005/020099
申请日：2005-06-07
申请人： ZARS, INC. , ZHANG, Jie , WARNER, Kevin, S. , ASHBURN, Michael, A. , RIGBY, Larry, D. , NIU, Suyi
发明人： ZHANG, Jie , WARNER, Kevin, S. , ASHBURN, Michael, A. , RIGBY, Larry, D. , NIU, Suyi
IPC分类号： A61K9/70
CPC分类号： A61K9/7015 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/445 , A61K31/573 , A61K47/10 , A61K47/32
摘要： The present invention is drawn to adhesive peel-forming formulations for dermal delivery of a drug. The formulation can include a drug, a solvent vehicle, and a peel-forming agent. The solvent vehicle can include a volatile solvent system having one or more volatile solvent, and a non-volatile solvent system having one or more non-volatile solvent, wherein the non-volatile solvent system has a solubility for the drug that is within a window of operable solubility for the drug such that the drug can be delivered at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified peelable layer after at least a portion of the volatile solvent system is evaporated.
摘要翻译：本发明涉及用于药物真皮递送的粘合剂剥离形成制剂。制剂可以包括药物，溶剂载体和剥离形成剂。溶剂载体可以包括具有一种或多种挥发性溶剂的挥发性溶剂体系和具有一种或多种非挥发性溶剂的非挥发性溶剂体系，其中所述非挥发性溶剂体系对于在窗口内的药物具有溶解性对药物具有可操作的溶解性，使得药物可以在持续的时间段内以治疗有效的速率递送。在挥发性溶剂体系蒸发之前，配方可以具有适用于皮肤表面的粘度。当施用于皮肤时，在挥发性溶剂体系的至少一部分蒸发之后，制剂可以形成固化的可剥离层。

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