会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 2. 发明授权
    • Human neutralizing monoclonal antibodies to H5N1 influenza A virus
    • H5N1甲型流感病毒的人中和单克隆抗体
    • US07879326B2
    • 2011-02-01
    • US12140151
    • 2008-06-16
    • Steven FoungZhen-Yong KeckRichard Webby
    • Steven FoungZhen-Yong KeckRichard Webby
    • A61K39/42C07K16/10C12N15/13C12N5/24C12N5/10
    • C07K16/1018A61K2039/505C07K2317/21C07K2317/76
    • A panel of IgG1 human monoclonal antibodies (HMAbs) identified by hemagglutination inhibition (HI) assay has been produced from peripheral B cells of an individual immunized with prototype H5N1 vaccine. Sequence analysis of antibody clones showed three clusters of different HMAbs as represented by HMAbs designated as BF1-1, BF1-19 and BF1-10. BF1-1 and BF1-10 have distinct CDR 1, 2 and 3 regions of both heavy and light chains. BF1-19 has the same heavy chain as BF1-1 but the light chain of BF1-10. Antibody binding affinity, KD, studies showed all three HMAbs ranging from at least about 10−8 to at least about 10−9. In vivo protection studies showed that these antibodies afforded significant protection against infection. These findings demonstrate that the antibodies of the invention are cross-neutralizing and therapeutic.
    • 已经通过用原型H5N1疫苗免疫的个体的外周B细胞产生了通过血细胞凝集抑制(HI)测定鉴定的一组IgG1人单克隆抗体(HMAb)。 抗体克隆的序列分析显示由称为BF1-1,BF1-19和BF1-10的HMAb表示的三组不同HMAb。 BF1-1和BF1-10具有明显的重链和轻链CDR 1,2和3区。 BF1-19具有与BF1-1相同的重链,但BF1-10的轻链。 抗体结合亲和力KD研究显示所有三种HMAb在至少约10-8至至少约10-9之间。 体内保护研究表明,这些抗体提供了显着的抗感染保护。 这些发现证明本发明的抗体是交叉中和和治疗的。
    • 4. 发明申请
    • SYSTEMS, METHODS, AND COMPUTER PROGRAM PRODUCTS FOR GENERATING AND UPDATING A CACHE OF PRICE AND AVAILABILITY INFORMATION FOR TRAVEL PACKAGES AND COMPONENTS
    • 用于生成和更新旅行包和组件价格和可用性信息的系统,方法和计算机程序产品
    • US20080262878A1
    • 2008-10-23
    • US11736291
    • 2007-04-17
    • Richard WebbyJoshua HartmannDavid Yong
    • Richard WebbyJoshua HartmannDavid Yong
    • G06Q10/00
    • G06Q30/02G06Q10/02
    • Systems, methods, and computer program products are provided for generating, updating, and managing a cache of price and availability information for a plurality of travel packages and components. The cache of price and availability information may then be searched by an online travel planning service to provide customers with a list of available travel products. More particularly, embodiments of the present invention provide a cascading cache system including a cache of price and availability data related to travel components and a cache of price and availability data related to travel packages. Changes made to the component cache can affect information stored in the package cache, and changes made to the package cache can affect information stored in the component cache. Furthermore, the cache system updates the package and component caches based on information received from a purchase of a package or component, as well as by proactively polling one or more travel reservation systems.
    • 提供了系统,方法和计算机程序产品,用于生成,更新和管理多个旅行包和组件的价格和可用性信息的缓存。 然后可以通过在线旅行计划服务搜索价格和可用性信息的缓存,以向客户提供可用旅行产品的列表。 更具体地,本发明的实施例提供了一种级联缓存系统,其包括与旅行组件相关的价格和可用性数据的缓存以及与旅行包相关的价格和可用性数据的缓存。 对组件缓存所做的更改可能会影响存储在程序包缓存中的信息,并且对程序包缓存所做的更改可能会影响存储在组件缓存中的信息。 此外,缓存系统基于从购买包或组件接收到的信息以及主动地轮询一个或多个旅行预订系统来更新包和组件高速缓存。