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1. 发明申请

WO2012054195A2 DEVICES, SYSTEMS, AND METHODS FOR THE FABRICATION OF TISSUE 审中-公开
标题翻译：用于制造组织的装置，系统和方法
公开(公告)号：WO2012054195A2
公开(公告)日：2012-04-26
申请号：PCT/US2011/053515
申请日：2011-09-27
申请人： ORGANOVO, INC. , MURPHY, Keith , DORFMAN, Scott , SMITH, Nathan , BAUWENS, Larry , SOHN, Ian , MCDONALD, Tim , LEIGH-LANCASTER, Chris , LAW, Richard, Jin
发明人： MURPHY, Keith , DORFMAN, Scott , SMITH, Nathan , BAUWENS, Larry , SOHN, Ian , MCDONALD, Tim , LEIGH-LANCASTER, Chris , LAW, Richard, Jin
IPC分类号： B41J2/01 , B41J2/175 , G01N35/00
CPC分类号： A61L27/3808 , A61L27/3826 , B01L3/0268 , B28B1/001 , B29C64/106 , B29C64/112 , B29C64/118 , B29C64/20 , B33Y30/00 , B33Y50/02 , B33Y70/00 , B41J3/407 , C12M21/08 , C12M33/00
摘要： Described herein are bioprinters comprising: one or more printer heads, wherein a printer head comprises a means for receiving and holding at least one cartridge, and wherein said cartridge comprises contents selected from one or more of: bio-ink and support material; a means for calibrating the position of at least one cartridge; and a means for dispensing the contents of at least one cartridge. Further described herein are methods for fabricating a tissue construct, comprising: a computer module receiving input of a visual representation of a desired tissue construct; a computer module generating a series of commands, wherein the commands are based on the visual representation and are readable by a bioprinter; a computer module providing the series of commands to a bioprinter; and the bioprinter depositing bio-ink and support material according to the commands to form a construct with a defined geometry.
摘要翻译：本文描述的生物打印机包括：一个或多个打印头，其中打印头包括用于接收和保持至少一个盒的装置，并且其中所述盒包括从以下中的一个或多个选择的内容：生物油墨和支撑材料; 用于校准至少一个盒的位置的装置; 以及用于分配至少一个盒的内容物的装置。本文进一步描述的是用于制造组织结构的方法，包括：计算机模块，其接收所需组织结构的视觉表示的输入; 生成一系列命令的计算机模块，其中所述命令基于所述视觉表示，并且可由生物打印机读取; 为生物打印机提供一系列命令的计算机模块; 并且生物印刷机根据命令沉积生物油墨和支撑材料以形成具有确定的几何形状的构造。

2. 发明申请

WO2012054195A3 DEVICES, SYSTEMS, AND METHODS FOR THE FABRICATION OF TISSUE 审中-公开
标题翻译：用于组织制造的装置，系统和方法
公开(公告)号：WO2012054195A3
公开(公告)日：2012-06-21
申请号：PCT/US2011053515
申请日：2011-09-27
申请人： ORGANOVO INC , MURPHY KEITH , DORFMAN SCOTT , SMITH NATHAN , BAUWENS LARRY , SOHN IAN , MCDONALD TIM , LEIGH-LANCASTER CHRIS , LAW RICHARD JIN
发明人： MURPHY KEITH , DORFMAN SCOTT , SMITH NATHAN , BAUWENS LARRY , SOHN IAN , MCDONALD TIM , LEIGH-LANCASTER CHRIS , LAW RICHARD JIN
IPC分类号： B41J2/01 , B41J2/175 , G01N35/00
CPC分类号： A61L27/3808 , A61L27/3826 , B01L3/0268 , B28B1/001 , B29C64/106 , B29C64/112 , B29C64/118 , B29C64/20 , B33Y30/00 , B33Y50/02 , B33Y70/00 , B41J3/407 , C12M21/08 , C12M33/00
摘要： Described herein are bioprinters comprising: one or more printer heads, wherein a printer head comprises a means for receiving and holding at least one cartridge, and wherein said cartridge comprises contents selected from one or more of: bio-ink and support material; a means for calibrating the position of at least one cartridge; and a means for dispensing the contents of at least one cartridge. Further described herein are methods for fabricating a tissue construct, comprising: a computer module receiving input of a visual representation of a desired tissue construct; a computer module generating a series of commands, wherein the commands are based on the visual representation and are readable by a bioprinter; a computer module providing the series of commands to a bioprinter; and the bioprinter depositing bio-ink and support material according to the commands to form a construct with a defined geometry.
摘要翻译：本文描述的是生物打印机，其包括：一个或多个打印机头，其中打印机头包括用于接收和保持至少一个筒的装置，并且其中所述筒包括选自以下一种或多种的内容物：生物墨水和支撑材料; 用于校准至少一个盒的位置的装置; 以及用于分配至少一个筒的内容物的装置。本文进一步描述了用于制造组织构建体的方法，包括：接收期望组织构建体的视觉表示的输入的计算机模块; 产生一系列命令的计算机模块，其中所述命令基于所述可视表示并且可由生物打印机读取; 向生物打印机提供一系列命令的计算机模块; 并且生物打印机根据命令沉积生物墨水和支持材料以形成具有限定几何形状的构造。

3. 发明授权

US10060910B2 Multisignal reagents for labeling analytes 有权
公开(公告)号：US10060910B2
公开(公告)日：2018-08-28
申请号：US13556304
申请日：2012-07-24
申请人： Jack Coleman , Maciej Szczepanik , Richard Jin
发明人： Jack Coleman , Maciej Szczepanik , Richard Jin
IPC分类号： C12Q1/68 , G01N33/543 , G01N33/58
CPC分类号： G01N33/54306 , C12Q1/68 , G01N33/58
摘要： Provided is a composition comprising an analyte bound to a polymer where the analyte is less than about 2000 MW and the polymer further comprises more than one signal or first member of a second binding pair. Also provided is an assay for an analyte comprising combining a sample suspected of containing the analyte with the above-described composition and a binding agent that binds to the analyte; and detecting the signal or the first member of the second binding pair that is bound to the binding agent. Additionally provided is a multisignal labeling reagent comprising a first polymer covalently bound to (a) a reactive group or a first member of a first binding pair, and (b) more than one digoxigenin molecule.

4. 发明授权

US09680773B1 Integrated circuit with dynamically-adjustable buffer space for serial interface 有权
公开(公告)号：US09680773B1
公开(公告)日：2017-06-13
申请号：US13245790
申请日：2011-09-26
申请人： Zun Yang Tan , Tat Mun Lui , Boon Jin Ang , Chiang Wei Lee , Richard Jin Guan Saw , Want Sent Khor
发明人： Zun Yang Tan , Tat Mun Lui , Boon Jin Ang , Chiang Wei Lee , Richard Jin Guan Saw , Want Sent Khor
IPC分类号： H04L12/861 , G06F5/12 , G06F1/32 , G11C5/14
CPC分类号： H04L49/9005 , G06F1/3225 , G06F1/3243 , G06F1/3275 , G06F1/3278 , G06F1/3287 , G06F5/12 , G11C5/148 , Y02D10/14 , Y02D10/157
摘要： One embodiment relates to an integrated circuit which includes a method of dynamically adjusting a receive buffer in an integrated circuit. A fixed-size buffer circuit of the receive buffer is used to buffer data received by way of a serial interface circuit. The performance of the serial interface circuit are monitored. The receive buffer is dynamically extended based on said performance. Other embodiments, aspects, and features are also disclosed.

5. 发明授权

US09149952B2 Devices, systems, and methods for the fabrication of tissue 有权
公开(公告)号：US09149952B2
公开(公告)日：2015-10-06
申请号：US13246428
申请日：2011-09-27
申请人： Keith Murphy , Scott Dorfman , Nathan Smith , Larry Bauwens , Ian Sohn , Tim McDonald , Chris Leigh-Lancaster , Richard Jin Law
发明人： Keith Murphy , Scott Dorfman , Nathan Smith , Larry Bauwens , Ian Sohn , Tim McDonald , Chris Leigh-Lancaster , Richard Jin Law
IPC分类号： B41J2/015 , A61K35/12 , G06F19/00 , B28B1/00 , B41J3/407
CPC分类号： A61L27/3808 , A61L27/3826 , B01L3/0268 , B28B1/001 , B29C64/106 , B29C64/112 , B29C64/118 , B29C64/20 , B33Y30/00 , B33Y50/02 , B33Y70/00 , B41J3/407 , C12M21/08 , C12M33/00
摘要： Described herein are bioprinters comprising: one or more printer heads, wherein a printer head comprises a means for receiving and holding at least one cartridge, and wherein said cartridge comprises contents selected from one or more of: bio-ink and support material; a means for calibrating the position of at least one cartridge; and a means for dispensing the contents of at least one cartridge. Further described herein are methods for fabricating a tissue construct, comprising: a computer module receiving input of a visual representation of a desired tissue construct; a computer module generating a series of commands, wherein the commands are based on the visual representation and are readable by a bioprinter; a computer module providing the series of commands to a bioprinter; and the bioprinter depositing bio-ink and support material according to the commands to form a construct with a defined geometry.

6. 发明申请

US20140030787A1 MULTISIGNAL REAGENTS FOR LABELING ANALYTES 审中-公开
标题翻译：用于标签分析的多种试剂
公开(公告)号：US20140030787A1
公开(公告)日：2014-01-30
申请号：US13556304
申请日：2012-07-24
申请人： JACK COLEMAN , MACIEJ SZCZEPANIK , RICHARD JIN
发明人： JACK COLEMAN , MACIEJ SZCZEPANIK , RICHARD JIN
IPC分类号： C12N11/02 , C07K14/36 , C07H21/04
CPC分类号： G01N33/54306 , C12Q1/68 , G01N33/58
摘要： Provided is a composition comprising an analyte bound covalently or through a first binding pair to a polymer. In this composition, the analyte is less than about 2000 MW; the polymer further comprises more than one signal or first member of a second binding pair; and the analyte is not a member of the first binding pair or the second binding pair. Also provided is an assay for an analyte. The assay comprises: combining a sample suspected of containing the analyte with the above-described composition and a binding agent that binds to the analyte; and detecting the signal or the first member of the second binding pair that is bound to the binding agent. In this assay, the amount of the signal or the first member of the second binding pair bound to the binding agent is inversely proportional to the analyte in the sample. Additionally provided is a multisignal labeling reagent comprising a first polymer covalently bound to (a) a reactive group or a first member of a first binding pair, and (b) more than one digoxigenin molecule.
摘要翻译：提供了包含共价键合或通过第一结合对与聚合物结合的分析物的组合物。在该组合物中，分析物小于约2000MW; 聚合物还包含多于一个信号或第二结合对的第一个成员; 并且分析物不是第一结合对或第二结合对的成员。还提供了分析物的测定。该测定包括：将怀疑含有分析物的样品与上述组合物结合，和结合分析物的结合剂; 以及检测绑定到绑定剂的第二绑定对的信号或第一成员。在该测定中，与结合剂结合的信号或第二结合对的第一个成员的量与样品中的分析物成反比。另外提供了包含共价结合到（a）第一结合对的反应性基团或第一个成员的第一聚合物的多信号标记试剂，和（b）多于一个的地高辛分子。

7. 发明申请

US20110105606A1 Compositions and methods affecting the signaling pathways of LRP receptors 有权
标题翻译：影响LRP受体信号通路的组成和方法
公开(公告)号：US20110105606A1
公开(公告)日：2011-05-05
申请号：US12221863
申请日：2008-08-07
申请人： Elazar Rabbani , Xiaofeng Li , Dakai Liu , Yazhou Zhang , Richard Jin , Riddhi Bhattacharyya , Wei Cheng , James J. Donegan
发明人： Elazar Rabbani , Xiaofeng Li , Dakai Liu , Yazhou Zhang , Richard Jin , Riddhi Bhattacharyya , Wei Cheng , James J. Donegan
IPC分类号： A61K31/235 , A61P3/06 , A61P29/00 , A61P37/02 , A61P3/08 , A61P17/14 , A61K31/192 , A61K31/185 , C40B30/06 , C40B30/02 , C40B30/04
CPC分类号： A61K31/538 , A61K31/015 , A61K31/185 , A61K31/192 , A61K31/235 , A61K31/395 , A61K31/535 , A61K38/00 , G01N33/5011 , G01N33/5041 , G01N33/564 , G01N33/92 , G01N2333/705 , G01N2800/24
摘要： The present invention relates to the field of therapeutic methods, compositions and uses thereof, that affect, directly or indirectly, the behavior of LRP receptors. These compositions and methods result in the treatment of inflammatory, immunological and metabolic conditions. More particularly, the methods and compositions of the invention are directed to the identification of small molecules, drugs and/or pharmacological agents that affect the Wnt pathway by affecting normal complex formation among various signaling receptors, the LRP5 and LRP6 receptor, and related ligands.
摘要翻译：本发明涉及直接或间接影响LRP受体的行为的治疗方法，组合物和用途领域。这些组合物和方法导致治疗炎症，免疫和代谢疾病。更具体地，本发明的方法和组合物涉及通过影响各种信号传导受体（LRP5和LRP6受体）和相关配体之间的正常复合物形成来鉴定影响Wnt途径的小分子，药物和/或药理学试剂。

8. 发明申请

US20120116568A1 DEVICES, SYSTEMS, AND METHODS FOR THE FABRICATION OF TISSUE 有权
标题翻译：用于制造组织的装置，系统和方法
公开(公告)号：US20120116568A1
公开(公告)日：2012-05-10
申请号：US13246428
申请日：2011-09-27
申请人： Keith Murphy , Scott Dorfman , Nathan Smith , Larry Bauwens , Ian Sohn , Tim McDonald , Chris Leigh-Lancaster , Richard Jin Law
发明人： Keith Murphy , Scott Dorfman , Nathan Smith , Larry Bauwens , Ian Sohn , Tim McDonald , Chris Leigh-Lancaster , Richard Jin Law
IPC分类号： B05C5/00 , G06F17/00 , B65G47/24 , B05C11/00
CPC分类号： A61L27/3808 , A61L27/3826 , B01L3/0268 , B28B1/001 , B29C64/106 , B29C64/112 , B29C64/118 , B29C64/20 , B33Y30/00 , B33Y50/02 , B33Y70/00 , B41J3/407 , C12M21/08 , C12M33/00
摘要： Described herein are bioprinters comprising: one or more printer heads, wherein a printer head comprises a means for receiving and holding at least one cartridge, and wherein said cartridge comprises contents selected from one or more of: bio-ink and support material; a means for calibrating the position of at least one cartridge; and a means for dispensing the contents of at least one cartridge. Further described herein are methods for fabricating a tissue construct, comprising: a computer module receiving input of a visual representation of a desired tissue construct; a computer module generating a series of commands, wherein the commands are based on the visual representation and are readable by a bioprinter; a computer module providing the series of commands to a bioprinter; and the bioprinter depositing bio-ink and support material according to the commands to form a construct with a defined geometry.
摘要翻译：本文描述的生物打印机包括：一个或多个打印头，其中打印头包括用于接收和保持至少一个盒的装置，并且其中所述盒包括从以下中的一个或多个选择的内容：生物油墨和支撑材料; 用于校准至少一个盒的位置的装置; 以及用于分配至少一个盒的内容物的装置。本文进一步描述的是用于制造组织结构的方法，包括：计算机模块，其接收所需组织结构的视觉表示的输入; 生成一系列命令的计算机模块，其中所述命令基于所述视觉表示，并且可由生物打印机读取; 为生物打印机提供一系列命令的计算机模块; 并且生物印刷机根据命令沉积生物油墨和支撑材料以形成具有确定的几何形状的构造。

9. 发明申请

US20100298200A1 Compounds and assays for controlling Wnt activity 有权
标题翻译：用于控制Wnt活性的化合物和测定法
公开(公告)号：US20100298200A1
公开(公告)日：2010-11-25
申请号：US12454765
申请日：2009-05-22
申请人： Dakai Liu , Xiaofeng Li , Richard Jin , Yuaxin Liang , Wei Cheng , Riddhi Bhattacharyya , Guangrong Zhang
发明人： Dakai Liu , Xiaofeng Li , Richard Jin , Yuaxin Liang , Wei Cheng , Riddhi Bhattacharyya , Guangrong Zhang
IPC分类号： A61K38/02 , C07D265/38 , C07C309/53 , C07C235/56 , C07D251/70 , C07C229/66 , A61K31/538 , A61K31/196 , A61K31/185 , A61K31/277 , A61K31/53 , A61K31/245 , A61K31/366 , A61K31/12 , A61K31/165 , A61K31/167 , A61K31/505 , A61K31/122 , A61K31/235 , A61K31/05 , A61K31/365 , A61K31/343 , A61P31/12 , A61P25/00 , A61P19/00 , A61P35/00 , A61P3/08 , A61P3/06 , G01N33/00 , C12Q1/02 , C12Q1/68 , G01N33/53 , G01N33/542 , C40B30/04 , C40B30/02 , C12N5/10 , C12Q1/66
CPC分类号： G01N33/6845 , A61K31/536 , A61K31/538 , C07D265/28 , C07D265/34 , C07D265/38 , C40B30/02 , G01N2800/36
摘要： The present invention relates to the field of therapeutic methods to screen for compounds on the basis of their ability to influence Wnt activity. The screening process is applied to both a physical library of a series of compounds and a virtual library of compounds that affect Wnt activity. In one aspect, the virtual screening process could be carried out where a permutational library of small peptides is substituted for the small organic molecules. The inventive methods may be used to empirically test for effects on Wnt activity and may also be applied to any pair of proteins involved in protein-protein interactions.
摘要翻译：本发明涉及根据其影响Wnt活性的能力筛选化合物的治疗方法领域。筛选过程适用于一系列化合物的物理文库和影响Wnt活性的化合物的虚拟文库。在一个方面，虚拟筛选过程可以在小肽的置换文库替代小有机分子的地方进行。本发明的方法可用于经验性地测试对Wnt活性的影响，并且还可以应用于涉及蛋白质 - 蛋白质相互作用的任何一对蛋白质。

10. 发明授权

US09046537B2 Method for treating inflammation by administering a compound which binds LDL-receptor-related protein (LRP) ligand binding domain 有权
标题翻译：通过施用结合LDL-受体相关蛋白（LRP）配体结合结构域的化合物来治疗炎症的方法
公开(公告)号：US09046537B2
公开(公告)日：2015-06-02
申请号：US12221863
申请日：2008-08-07
申请人： Elazar Rabbani , Xiaofeng Li , Dakai Liu , Yazhou Zhang , Richard Jin , Riddhi Bhattacharyya , Wei Cheng , James J. Donegan
发明人： Elazar Rabbani , Xiaofeng Li , Dakai Liu , Yazhou Zhang , Richard Jin , Riddhi Bhattacharyya , Wei Cheng , James J. Donegan
IPC分类号： A01N43/00 , A61K31/33 , A01N61/00 , A61K31/00 , A61K31/535 , A01N43/02 , A61K31/335 , A01N43/16 , A61K31/35 , G01N33/92 , A61K31/015 , A61K31/395 , G01N33/50 , G01N33/564 , A61K38/00
CPC分类号： A61K31/538 , A61K31/015 , A61K31/185 , A61K31/192 , A61K31/235 , A61K31/395 , A61K31/535 , A61K38/00 , G01N33/5011 , G01N33/5041 , G01N33/564 , G01N33/92 , G01N2333/705 , G01N2800/24
摘要： The present invention relates to the field of therapeutic methods, compositions and uses thereof, that affect, directly or indirectly, the behavior of LRP receptors. These compositions and methods result in the treatment of inflammatory, immunological and metabolic conditions. More particularly, the methods and compositions of the invention are directed to the identification of small molecules, drugs and/or pharmacological agents that affect the Wnt pathway by affecting normal complex formation among various signaling receptors, the LRP5 and LRP6 receptor, and related ligands.
摘要翻译：本发明涉及直接或间接影响LRP受体的行为的治疗方法，组合物和用途领域。这些组合物和方法导致治疗炎症，免疫和代谢疾病。更具体地，本发明的方法和组合物涉及通过影响各种信号传导受体（LRP5和LRP6受体）和相关配体之间的正常复合物形成来鉴定影响Wnt途径的小分子，药物和/或药理学试剂。

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