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1. 发明授权

US08623356B2 Demibodies: dimerization-activated therapeutic agents 失效
标题翻译：抗体：二聚激活治疗剂
公开(公告)号：US08623356B2
公开(公告)日：2014-01-07
申请号：US12095468
申请日：2006-11-29
申请人： Richard Ian Christopherson , Jacqueline Mary Matthews , Joel Peter MacKay
发明人： Richard Ian Christopherson , Jacqueline Mary Matthews , Joel Peter MacKay
IPC分类号： A61K38/00
CPC分类号： C07K16/2887 , C07K14/43595 , C07K16/289 , C07K2317/622 , C07K2317/732 , C07K2319/00 , C07K2319/30
摘要： The present invention relates generally to a set of synthetic immunointeractive molecules referred to herein as “demibodies” which are useful in targeting particular cells in a subject. More particularly, the present invention provides a set of demibodies wherein at least two molecules from within the set, each specific for a different antigen on a target cell, are required to interact together at the cell surface in order to form an active complex which directs demibody-mediated cellular or complement mediated cytotoxicity and/or reporter function and/or therapeutic activity. The demibodies of the present invention are useful in the targeting of particular cells such as cancer cells including leukemic cells, pathogens including malarial, bacterial and viral agents, and stem cells including embryonic and adult stem cells and pathogen cells. The present invention provides, therefore, methods of treatment, diagnosis and undertaking research and compositions comprising demibodies useful for same.
摘要翻译：本发明一般涉及本文称为“抗体”的一组合成免疫相互作用分子，其可用于靶向受试者中的特定细胞。更具体地说，本发明提供了一组抗体，其中需要来自组内的至少两个分子，每个特异于靶细胞上不同抗原的分子在细胞表面一起相互作用以形成活性复合物，抗体介导的细胞或补体介导的细胞毒性和/或报告物功能和/或治疗活性。本发明的抗体可用于靶向特定细胞，例如癌细胞，包括白血病细胞，包括疟疾，细菌和病毒剂的病原体，以及包括胚胎和成体干细胞和病原体细胞的干细胞。因此，本发明提供治疗，诊断和进行研究的方法以及包含对其有用的抗体的组合物。

2. 发明授权

US07560226B2 Assay to detect a binding partner 有权
公开(公告)号：US07560226B2
公开(公告)日：2009-07-14
申请号：US09888959
申请日：2001-06-25
申请人： Richard Ian Christopherson , Cristobal Guillermo Dos Remedios
发明人： Richard Ian Christopherson , Cristobal Guillermo Dos Remedios
IPC分类号： G01N33/48 , G01N33/574
CPC分类号： G01N33/543 , G01N33/574 , Y02A50/58
摘要： A method can identify a type of leukemia in a human subject. A biological sample from the human subject that contains CD antigens is obtained. The sample is contacted with an array of immunoglobulin molecules. Each immunoglobulin in the array, with the exception of one or more negative controls, is capable of interaction with a CD antigen on one or more types of leukemia cells. The pattern of interaction between the immunoglobulin molecules and the CD antigens in said sample is then determined, thereby providing an immunophenotype of the cells which is characteristic of the type of leukemia.

3. 发明申请

US20090130106A1 DEMIBODIES: DIMERIZATION-ACTIVATED THERAPEUTIC AGENTS 失效
标题翻译：体育活动：二维激活治疗剂
公开(公告)号：US20090130106A1
公开(公告)日：2009-05-21
申请号：US12095468
申请日：2006-11-29
申请人： Richard Ian Christopherson , Jacqueline Mary Matthews , Joel Peter MacKay
发明人： Richard Ian Christopherson , Jacqueline Mary Matthews , Joel Peter MacKay
IPC分类号： A61K39/395 , C07K16/00 , G01N33/53 , G01N33/574
CPC分类号： C07K16/2887 , C07K14/43595 , C07K16/289 , C07K2317/622 , C07K2317/732 , C07K2319/00 , C07K2319/30
摘要： The present invention relates generally to a set of synthetic immunointeractive molecules referred to herein as “demibodies” which are useful in targeting particular cells in a subject. More particularly, the present invention provides a set of demibodies wherein at least two molecules from within the set, each specific for a different antigen on a target cell, are required to interact together at the cell surface in order to form an active complex which directs demibody-mediated cellular or complement mediated cytotoxicity and/or reporter function and/or therapeutic activity. The demibodies of the present invention are useful in the targeting of particular cells such as cancer cells including leukemic cells, pathogens including malarial, bacterial and viral agents, and stem cells including embryonic and adult stem cells and pathogen cells. The present invention provides, therefore, methods of treatment, diagnosis and undertaking research and compositions comprising demibodies useful for same.
摘要翻译：本发明一般涉及本文称为“抗体”的一组合成免疫相互作用分子，其可用于靶向受试者中的特定细胞。更具体地说，本发明提供了一组抗体，其中需要来自组内的至少两个分子，每个特异于靶细胞上不同抗原的分子在细胞表面一起相互作用以形成活性复合物，抗体介导的细胞或补体介导的细胞毒性和/或报告物功能和/或治疗活性。本发明的抗体可用于靶向特定细胞，例如癌细胞，包括白血病细胞，包括疟疾，细菌和病毒剂的病原体，以及包括胚胎和成体干细胞和病原体细胞的干细胞。因此，本发明提供治疗，诊断和进行研究的方法以及包含对其有用的抗体的组合物。

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