专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06887669B1 Reagents for assays for ligands 有权
标题翻译：配体测定试剂
公开(公告)号：US06887669B1
公开(公告)日：2005-05-03
申请号：US09542445
申请日：2000-04-04
申请人： Mark A. Staples , Carolyn J. Haley , Richard F. Parrish , Wesley W. Zmolek
发明人： Mark A. Staples , Carolyn J. Haley , Richard F. Parrish , Wesley W. Zmolek
IPC分类号： G01N33/53 , G01N33/58 , G01N33/94 , G01N1/00 , G01N1/18 , G01N33/531 , G01N33/561
CPC分类号： G01N33/9493 , G01N33/53 , G01N33/5306 , G01N33/94 , Y10S435/961 , Y10S435/962 , Y10S436/825 , Y10T436/25 , Y10T436/25375
摘要： The present invention relates to a method for releasing a ligand from a complex of the ligand with an endogenous protein using a releasing agent.
摘要翻译：本发明涉及使用脱模剂从配体与内源蛋白质的配合物中释放配体的方法。

2. 发明授权

US06171801B2 Methods for releasing a ligand from a complex 失效
标题翻译：从配合物中释放配体的方法
公开(公告)号：US06171801B2
公开(公告)日：2001-01-09
申请号：US08896244
申请日：1997-07-17
申请人： Mark A. Staples , Carolyn J. Haley , Richard F. Parrish , Wesley W. Zmolek
发明人： Mark A. Staples , Carolyn J. Haley , Richard F. Parrish , Wesley W. Zmolek
IPC分类号： G01N3353
CPC分类号： G01N33/9493 , G01N33/53 , G01N33/5306 , G01N33/94 , Y10S435/961 , Y10S435/962 , Y10S436/825 , Y10T436/25 , Y10T436/25375
摘要： One aspect of the present invention relates to a method for releasing a ligand from a complex thereof. The method comprises contacting a medium suspected of containing such complex with an effective amount of a compound effective in releasing the ligand. Another aspect of the present invention is an improvement in a method for the determination of an analyte that is a member of a specific binding pair in a sample suspected of containing such analyte. The method comprises the steps of (a) providing in an assay medium the sample and a binding partner for the analyte and (b) detecting the binding of the binding partner to the analyte. The improvement comprises including in the assay medium a compound of the invention in an amount sufficient to enhance the accuracy of the determination. The invention has particular application to a method for releasing mycophenolic acid from a complex thereof. The method provides an improvement in a method for the determination of mycophenolic acid in a sample suspected of containing mycophenolic acid. The present invention also provides assay reagents as well as packaged kits useful for performing the methods of the invention.
摘要翻译：本发明的一个方面涉及从其络合物中释放配体的方法。该方法包括将怀疑含有此类复合物的培养基与有效释放配体有效量的化合物接触。本发明的另一方面是在怀疑含有这些分析物的样品中测定作为特异性结合对成员的分析物的方法的改进。该方法包括以下步骤：（a）在测定介质中提供样品和分析物的结合配偶体，和（b）检测结合配偶体与分析物的结合。改进包括在测定培养基中包含足以提高测定精度的本发明化合物。本发明特别适用于从其复合物中释放霉酚酸的方法。该方法提供了在怀疑含有霉酚酸的样品中测定霉酚酸的方法的改进。本发明还提供测定试剂以及用于实施本发明方法的包装试剂盒。

3. 发明授权

US6159698A Reagents for assays for mycophenolic acid 失效
标题翻译：霉酚酸测定试剂
公开(公告)号：US6159698A
公开(公告)日：2000-12-12
申请号：US895856
申请日：1997-07-17
申请人： Mark A. Staples , Richard F. Parrish
发明人： Mark A. Staples , Richard F. Parrish
IPC分类号： G01N33/53 , G01N33/564 , G01N33/94 , G01N1/00 , G01N33/531 , G01N33/543
CPC分类号： G01N33/9493 , G01N33/5306 , G01N33/94 , Y10S435/961 , Y10S435/975 , Y10S436/825 , Y10T436/25
摘要： One aspect of the present invention relates to assays for the detection of mycophenolic acid. The method comprises including in an assay medium suspected of containing mycophenolic acid a releasing agent for releasing mycophenolic acid from a complex with endogenous proteins. Another aspect of the present invention is an improvement in a method for the determination of mycophenolic acid in a sample suspected of containing such analyte. The method comprises the steps of (a) providing in combination in an assay medium the sample and a binding partner for the analyte and (b) detecting the binding of the binding partner to the analyte. The improvement comprises including in the assay medium a releasing agent for releasing mycophenolic acid from a complex with endogenous proteins. The present invention also provides assay reagents as well as packaged kits useful for performing the methods of the invention.
摘要翻译：本发明的一个方面涉及检测霉酚酸的测定法。该方法包括在疑似含有霉酚酸的测定介质中包含用于从内源蛋白质与复合物释放霉酚酸的释放剂。本发明的另一方面是在怀疑含有这些分析物的样品中测定霉酚酸的方法的改进。该方法包括以下步骤：（a）在测定介质中组合提供样品和分析物的结合配偶体，和（b）检测结合配偶体与分析物的结合。该改进包括在测定培养基中包括用于从与内源蛋白质的复合物中释放霉酚酸的释放剂。本发明还提供测定试剂以及用于实施本发明方法的包装试剂盒。

4. 发明授权

US07115383B2 Assays for amphetamine and methamphetamine 有权
标题翻译：苯丙胺和甲基苯丙胺的测定
公开(公告)号：US07115383B2
公开(公告)日：2006-10-03
申请号：US10806327
申请日：2004-03-22
申请人： Yi Feng Zheng , Richard F. Parrish , Johnny Valdez , Hshiou-ting Liu
发明人： Yi Feng Zheng , Richard F. Parrish , Johnny Valdez , Hshiou-ting Liu
IPC分类号： G01N33/535 , G01N33/531 , C07K16/00 , C07K17/02
CPC分类号： G01N33/946 , Y10S435/961 , Y10S435/975
摘要： Methods, compositions and kits are disclosed. The compounds disclosed comprise an amphetamine moiety and a methamphetamine moiety linked together by a first linking group. A second linking group depends from the first linking group and comprises a functional group. The distance of the amphetamine moiety and the methamphetamine moiety from the point of linkage of the second linking group to the first linking group is approximately the same. The compounds may be linked to labels and used in assays for the detection of amphetamine and/or methamphetamine in samples suspected of containing these drugs.
摘要翻译：公开了方法，组合物和试剂盒。所公开的化合物包括通过第一连接基团连接在一起的苯丙胺部分和甲基苯丙胺部分。第二连接基团取决于第一连接基团并且包含官能团。苯丙胺部分和甲基苯丙胺部分与第二连接基团与第一连接基团的连接点的距离大致相同。化合物可以与标记物连接，并用于检测疑似含有这些药物的样品中苯丙胺和/或甲基苯丙胺的检测。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式