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    • 3. 发明授权
    • Crosslinked hydrogel coatings
    • 交联水凝胶涂层
    • US5776611A
    • 1998-07-07
    • US746946
    • 1996-11-18
    • Richard EltonMargret Opolski
    • Richard EltonMargret Opolski
    • C08G18/48C09D175/02B32B27/00B32B27/40
    • C08G18/4833C09D175/02C08G2210/00Y10T428/31551Y10T428/31605
    • A hydrophilic, lubricious, durable, flexible, coating comprising a crosslinked polyurea matrix complexed with a hydrophilic polymer selected from the group consisting of poly (ethylene oxide) and polyvinylpyrrolidone, said crosslinked polymer formed from the reaction of an isocyanate and a compound having at least two active hydrogens per molecule selected from the group consisting of polyamines, polymercaptans, and polycarboxylates or compounds with NH, NH.sub.2, SH or COOH groups on same molecule in the presence of said hydrophilic polymer, with the total sum of the average isocyanate functionality plus the average active hydrogen functionality exceeding 4 and the molar ratio of total NCO groups to total active hydrogens being at least 0.8.
    • 一种亲水的,润滑的,耐用的,柔性的涂层,其包含与选自聚(环氧乙烷)和聚乙烯吡咯烷酮的亲水性聚合物络合的交联聚脲基质,所述交联聚合物由异氰酸酯和至少具有至少 选自多胺,多硫醇和多羧酸盐或在所述亲水性聚合物存在下在同一分子上具有NH,NH 2,SH或COOH基团的化合物的每个分子的两个活性氢,平均异氰酸酯官能度加上 平均活性氢官能度超过4,总NCO基团与总活性氢的摩尔比至少为0.8。
    • 7. 发明授权
    • Low friction guidewire with off-center core
    • 带偏心的低摩擦导丝
    • US06461311B2
    • 2002-10-08
    • US09784578
    • 2001-02-15
    • Tom DuBoisRichard EltonGary Teague
    • Tom DuBoisRichard EltonGary Teague
    • A61B500
    • A61M25/09A61L31/10A61M2025/09083A61M2025/09108A61L31/022C08L75/02C08L75/04A61L31/041C08L71/02C08L39/06C08L75/00
    • A flexible, kink-resistant, low-friction guidewire for positioning a medical instrument through tortuous passageways within a patient is disclosed. The guidewire includes a core wire which remains substantially free of any residual strain when it is positioned within the patient, a metal coil about the core wire and extending substantially the entire length of the core, a primer coating on the coil and a hydrophilic, lubricous coating on the primer coating. The core wire is preferably a superelastic metal alloy such as Nitinol. The metal coil is preferably formed from a wire with a rectangular cross section. The primer is preferably one which reacts with species of isocyanate or hydroxyl, and the hydrophilic, lubricous coating is preferably a cross-linked polymer selected from the group of polyurethane, polyurea, and polyurethaneurea, complexed with a hydrophilic complexing species such as poly(ethylene oxide) or polyvinylpyrrolidone. A method for manufacturing and coating such a guidewire is also disclosed.
    • 公开了一种用于通过患者内的曲折通道定位医疗器械的柔性,扭结的低摩擦导丝。 导线包括芯线,当其位于患者体内时基本上不存在任何残余应变,围绕芯线的金属线圈并且基本上延伸到芯的整个长度,线圈上的底漆涂层和亲水的,润滑的 涂底漆涂层。 芯线优选为镍钛诺超弹性金属合金。 金属线圈优选由具有矩形横截面的线形成。 底漆优选是与异氰酸酯或羟基物质反应的底漆,并且亲水性,润滑的涂料优选为选自聚氨酯,聚脲和聚氨酯脲的交联聚合物,其与亲水性络合物质如聚(乙烯 氧化物)或聚乙烯吡咯烷酮。 还公开了制造和涂覆这种导丝的方法。
    • 9. 发明授权
    • Flexible kink resistant, low friction guidewire with formable tip, and method for making same
    • 具有可弯曲的尖端的柔性抗扭结,低摩擦导丝及其制造方法
    • US06245030B1
    • 2001-06-12
    • US09257425
    • 1999-02-25
    • Tom DuBoisRichard EltonGary Teague
    • Tom DuBoisRichard EltonGary Teague
    • A61B500
    • A61M25/09A61L31/10A61M2025/09083A61M2025/09108A61L31/022C08L75/02C08L75/04A61L31/041C08L71/02C08L39/06C08L75/00
    • A flexible, kink-resistant, low-friction guidewire for positioning a medical instrument through tortuous passageways within a patient is disclosed. The guidewire includes a core wire which remains substantially free of any residual strain when it is positioned within the patient, a metal coil about the core wire and extending substantially the entire length of the core, a primer coating on the coil and a hydrophilic, lubricous coating on the primer coating. The core wire is preferably a superelastic metal alloy such as Nitinol. The metal coil is preferably formed from a wire with a rectangular cross section. The primer is preferably one which reacts with species of isocyanate or hydroxyl, and the hydrophilic, lubricous coating is preferably a cross-linked polymer selected from the group of polyurethane, polyurea, and polyurethaneurea, complexed with a hydrophilic complexing species such as poly(ethylene oxide) or polyvinylpyrrolidone. A method for manufacturing and coating such a guidewire is also disclosed.
    • 公开了一种用于通过患者内的曲折通道定位医疗器械的柔性,扭结的低摩擦导丝。 导线包括芯线,当其位于患者体内时基本上不存在任何残余应变,围绕芯线的金属线圈并且基本上延伸到芯的整个长度,线圈上的底漆涂层和亲水的,润滑的 涂底漆涂层。 芯线优选为镍钛诺超弹性金属合金。 金属线圈优选由具有矩形横截面的线形成。 底漆优选是与异氰酸酯或羟基物质反应的底漆,并且亲水性,润滑的涂料优选为选自聚氨酯,聚脲和聚氨酯脲的交联聚合物,其与亲水性络合物质如聚(乙烯 氧化物)或聚乙烯吡咯烷酮。 还公开了制造和涂覆这种导丝的方法。