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1. 发明申请

US20130052220A1 YEAST-HIV ANTIGEN COMPOSITIONS AND METHODS OF USING THE SAME 审中-公开
标题翻译： YEAST-HIV抗原组合物及其使用方法
公开(公告)号：US20130052220A1
公开(公告)日：2013-02-28
申请号：US13494193
申请日：2012-06-12
申请人： Richard C. Duke , Donald Bellgrau , Alex Franzusoff , Cara C. Wilson
发明人： Richard C. Duke , Donald Bellgrau , Alex Franzusoff , Cara C. Wilson
IPC分类号： A61K39/21 , A61P31/18 , A61P37/04
CPC分类号： A61K39/00 , A61K39/0011 , A61K39/12 , A61K39/39 , A61K2039/5154 , A61K2039/5158 , A61K2039/52 , A61K2039/523 , A61K2039/572 , C12N2740/16034
摘要： Disclosed is a vaccine that includes a dendritic cell loaded with a yeast vehicle and antigen. Also disclosed are methods of making the vaccine and using the vaccine to elicit cellular and humoral immune responses in a mammal. Additionally, a method to elicit an immune response by administration of a yeast vehicle and an antigen that is not complexed to the yeast vehicle is disclosed.
摘要翻译：公开了一种疫苗，其包含装载有酵母载体和抗原的树突状细胞。还公开了制备疫苗和使用疫苗在哺乳动物中引发细胞和体液免疫应答的方法。另外，公开了通过施用酵母载体和不与酵母载体复合的抗原来引发免疫应答的方法。

2. 发明申请

US20110256098A1 IMMUNOTHERAPY FOR CHRONIC HEPATITIS C VIRUS INFECTION 有权
标题翻译：慢性乙型肝炎病毒感染的免疫治疗
公开(公告)号：US20110256098A1
公开(公告)日：2011-10-20
申请号：US13119760
申请日：2009-09-18
申请人： David Apelian , Richard C. Duke , Alex Franzusoff
发明人： David Apelian , Richard C. Duke , Alex Franzusoff
IPC分类号： A61K38/21 , A61P31/14 , A61P37/04 , A61K39/29 , A61P1/16
CPC分类号： A61K39/29 , A61K38/21 , A61K39/12 , A61K2039/523 , C12N2770/24234 , A61K2300/00
摘要： Disclosed are uses of immunotherapeutic compositions in combination with Standard of Care (SOC), or interferon therapy combined with anti-viral therapy, for the improved treatment of chronic hepatitis C virus (HCV) infection and related conditions, including liver function. The compositions, kits and uses of the invention, as compared to the use of SOC therapy alone: improves the rate of early response to therapy as measured by early virologic markers (e.g., RVR and EVR), enlarges the pool of patients who will have sustained responses to therapy over the long term, offers shortened courses of therapy for certain patients, enables “rescue” of patients who are non-responders or intolerant to SOC therapy, improves liver function and/or reduces liver damage in patients, and enables the personalization of HCV therapy for a patient, which can result in dose sparing, improved patient compliance, reduced side effects, and improved long term therapeutic outcomes.
摘要翻译：公开了免疫治疗组合物与护理标准（SOC）或干扰素治疗联合抗病毒治疗结合用于改善治疗慢性丙型肝炎病毒（HCV）感染和相关病症（包括肝功能）的用途。与仅使用SOC治疗相比，本发明的组合物，试剂盒和用途与早期病毒学标志物（例如，RVR和EVR）一样，提高了对治疗的早期应答率，从而扩大了将有对长期治疗的持续反应，为某些患者提供了缩短的治疗疗程，使得“救援”无反应者或不耐受SOC治疗的患者，改善肝功能和/或减少患者的肝损伤，并使可以对患者进行HCV治疗的个性化，这可以导致剂量节省，改善患者依从性，减少副作用，并改善长期治疗结果。

3. 发明申请

US20100150963A1 Yeast-Based Therapeutic for Chronic Hepatitis C Infection 失效
标题翻译：基于酵母的慢性丙型肝炎感染治疗
公开(公告)号：US20100150963A1
公开(公告)日：2010-06-17
申请号：US12631039
申请日：2009-12-04
申请人： Richard C. Duke , Alex Franzusoff , Aurelia Haller , Thomas H. King
发明人： Richard C. Duke , Alex Franzusoff , Aurelia Haller , Thomas H. King
IPC分类号： A61K39/29 , A61P31/12
CPC分类号： A61K39/29 , A61K39/12 , A61K2039/521 , A61K2039/523 , A61K2039/5252 , C07K14/005 , C07K2319/35 , C12N2770/24222 , C12N2770/24234
摘要： Disclosed are compositions, including vaccines, and methods for vaccinating an animal against hepatitis C virus (HCV) and for treating or preventing hepatitis C viral infection in an animal. The invention includes a variety of novel HCV fusion proteins that can be used directly as a vaccine or in conjunction with a yeast-based vaccine vehicle to elicit an immune response against HCV in an animal. The invention also includes the use of the HCV fusion gene and protein described herein in any diagnostic or therapeutic protocol for the detection and/or treatment or prevention of HCV infection.
摘要翻译：公开了包括疫苗和疫苗接种丙型肝炎病毒（HCV）的组合物和用于治疗或预防动物中的丙型肝炎病毒感染的组合物。本发明包括可以直接用作疫苗或与基于酵母的疫苗载体一起使用以在动物中引发针对HCV的免疫应答的多种新型HCV融合蛋白。本发明还包括本文所述的HCV融合基因和蛋白质在任何诊断或治疗方案中用于检测和/或治疗或预防HCV感染的用途。

4. 发明授权

US10352936B2 Use of tumor Fas expression to determine response to anti-cancer therapy 有权
公开(公告)号：US10352936B2
公开(公告)日：2019-07-16
申请号：US14111448
申请日：2012-04-13
申请人： Jaime Modiano , Donald Bellgrau , Richard C. Duke
发明人： Jaime Modiano , Donald Bellgrau , Richard C. Duke
IPC分类号： A01N63/00 , A61K48/00 , G01N33/574 , C12Q1/6886 , C12Q1/6888 , G01N33/68 , A61K38/17 , A61K38/19
摘要： The invention provides methods for using expression levels of Fas to select individuals or subpopulation of individuals who can benefit from an anti-cancer therapy and for assessing whether an individual suspected of having or developing cancerous tumors will beneficially respond to an anticancer therapy. The invention additionally provides methods of treatment for individuals selected as likely to benefit from anti-cancer therapy based on Fas expression levels.

5. 发明申请

US20120220753A1 N-Terminal Dimerization Methods with Bis-Amindino Acid and Bis-Thioimidate Derivatives 审中-公开
标题翻译：双缩醛酸和双硫代酰亚胺衍生物的N-末端二聚方法
公开(公告)号：US20120220753A1
公开(公告)日：2012-08-30
申请号：US13392606
申请日：2010-08-26
申请人： Lajos Gera , Robert Hodges , Richard C. Duke
发明人： Lajos Gera , Robert Hodges , Richard C. Duke
IPC分类号： C07K1/04 , C07K1/00 , C07C327/42
CPC分类号： C07C327/42 , C07C257/14 , C07C327/58 , C07K7/18
摘要： The invention provides high-yield protein dimerization methods using highly reactive bis-thioimidates that may be used in the manufacture of a highly potent anti-cancer peptide dimers.
摘要翻译：本发明提供使用高活性双硫代亚氨酸酯的高产量蛋白质二聚方法，其可用于制备高效抗癌肽二聚体。

6. 发明申请

US20090304741A1 Yeast-Dendritic Cell Vaccines and Uses Thereof 有权
标题翻译：酵母树突状细胞疫苗及其用途
公开(公告)号：US20090304741A1
公开(公告)日：2009-12-10
申请号：US12539745
申请日：2009-08-12
申请人： RICHARD C. DUKE , DONALD BELLGRAU , ALEX FRANZUSOFF , CARA C. WILSON
发明人： RICHARD C. DUKE , DONALD BELLGRAU , ALEX FRANZUSOFF , CARA C. WILSON
IPC分类号： A61K39/00 , A61K39/12 , A61K39/21 , A61K39/29 , A61K39/02 , A61K39/07 , A61K39/002
CPC分类号： A61K39/00 , A61K39/0011 , A61K39/12 , A61K39/39 , A61K2039/5154 , A61K2039/5158 , A61K2039/52 , A61K2039/523 , A61K2039/572 , C12N2740/16034
摘要： Disclosed is a vaccine that includes a dendritic cell loaded with a yeast vehicle and antigen. Also disclosed are methods of making the vaccine and using the vaccine to elicit cellular and humoral immune responses in a mammal. Additionally, a method to elicit an immune response by administration of a yeast vehicle and an antigen that is not complexed to the yeast vehicle is disclosed.
摘要翻译：公开了一种疫苗，其包含装载有酵母载体和抗原的树突状细胞。还公开了制备疫苗和使用疫苗在哺乳动物中引发细胞和体液免疫应答的方法。另外，公开了通过施用酵母载体和不与酵母载体复合的抗原来引发免疫应答的方法。

7. 发明授权

US07625569B2 Yeast-based therapeutic for chronic hepatitis C infection 失效
标题翻译：基于酵母的慢性丙型肝炎感染治疗
公开(公告)号：US07625569B2
公开(公告)日：2009-12-01
申请号：US11618833
申请日：2006-12-31
申请人： Richard C. Duke , Alex Franzusoff , Aurelia Haller , Thomas H. King
发明人： Richard C. Duke , Alex Franzusoff , Aurelia Haller , Thomas H. King
IPC分类号： A61K39/29 , A61K39/00 , A61K45/00 , C12N1/00 , C12N1/19 , C12N15/09 , C12N15/51 , C12P21/00
CPC分类号： A61K39/29 , A61K39/12 , A61K2039/521 , A61K2039/523 , A61K2039/5252 , C07K14/005 , C07K2319/35 , C12N2770/24222 , C12N2770/24234
摘要： Disclosed are compositions, including vaccines, and methods for vaccinating an animal against hepatitis C virus (HCV) and for treating or preventing hepatitis C viral infection in an animal. The invention includes a variety of novel HCV fusion proteins that can be used directly as a vaccine or in conjunction with a yeast-based vaccine vehicle to elicit an immune response against HCV in an animal. The invention also includes the use of the HCV fusion gene and protein described herein in any diagnostic or therapeutic protocol for the detection and/or treatment or prevention of HCV infection.
摘要翻译：公开了包括疫苗和疫苗接种丙型肝炎病毒（HCV）的组合物和用于治疗或预防动物中的丙型肝炎病毒感染的组合物。本发明包括可以直接用作疫苗或与基于酵母的疫苗载体一起使用以在动物中引发针对HCV的免疫应答的多种新型HCV融合蛋白。本发明还包括本文所述的HCV融合基因和蛋白质在任何诊断或治疗方案中用于检测和/或治疗或预防HCV感染的用途。

8. 发明授权

US07439042B2 Yeast-based therapeutic for chronic hepatitis C infection 失效
标题翻译：基于酵母的慢性丙型肝炎感染治疗
公开(公告)号：US07439042B2
公开(公告)日：2008-10-21
申请号：US11254252
申请日：2005-10-18
申请人： Richard C. Duke , Alex Franzusoff , Aurelia Haller , Thomas H. King
发明人： Richard C. Duke , Alex Franzusoff , Aurelia Haller , Thomas H. King
IPC分类号： C12N15/33
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/523 , A61K2039/5252 , A61K2039/55516 , C12N2770/24222 , C12N2770/24234
摘要： Disclosed are compositions, including vaccines, and methods for vaccinating an animal against hepatitis C virus (HCV) and for treating or preventing hepatitis C viral infection in an animal. The invention includes a variety of novel HCV fusion proteins that can be used directly as a vaccine or in conjunction with a yeast-based vaccine vehicle to elicit an immune response against HCV in an animal. The invention also includes the use of the HCV fusion gene and protein described herein in any diagnostic or therapeutic protocol for the detection and/or treatment or prevention of HCV infection.
摘要翻译：公开了包括疫苗和疫苗接种丙型肝炎病毒（HCV）的组合物和用于治疗或预防动物中的丙型肝炎病毒感染的组合物。本发明包括可以直接用作疫苗或与基于酵母的疫苗载体一起使用以在动物中引发针对HCV的免疫应答的多种新型HCV融合蛋白。本发明还包括本文所述的HCV融合基因和蛋白质在任何诊断或治疗方案中用于检测和/或治疗或预防HCV感染的用途。

9. 发明授权

US06325999B1 Use of Fas ligand to suppress T-lymphocyte-mediated immune responses 失效
标题翻译：使用Fas配体抑制T淋巴细胞介导的免疫反应
公开(公告)号：US06325999B1
公开(公告)日：2001-12-04
申请号：US09087195
申请日：1998-05-29
申请人： Donald Bellgrau , Richard C. Duke
发明人： Donald Bellgrau , Richard C. Duke
IPC分类号： A01N6300
摘要： A method for inhibiting T-lymphocyte-mediated immune responses, including those directed against autologous and/or heterologous tissues, e.g., by a recipient mammal of a transplanted tissue, said method comprising providing the recipient mammal with Fas ligand. The Fas ligand may be provided to the recipient mammal by a variety of means, including by pump implantation or by transplantation of transgenic tissue expressing Fas ligand. Also provided is a method for diagnostic use of Fas ligand expression in improving transplantation success.
摘要翻译：一种抑制T淋巴细胞介导的免疫应答的方法，包括针对自体和/或异种组织的方法，例如由移植组织的受体哺乳动物，所述方法包括向受体哺乳动物提供Fas配体。 Fas配体可以通过各种方式提供给受体哺乳动物，包括通过泵植入或通过移植表达Fas配体的转基因组织。还提供了用于诊断使用Fas配体表达以改善移植成功的方法。

10. 发明授权

US5830463A Yeast-based delivery vehicles 失效
标题翻译：基于酵母的输送车
公开(公告)号：US5830463A
公开(公告)日：1998-11-03
申请号：US340185
申请日：1994-11-15
申请人： Richard C. Duke , Alex Franzusoff , Donald Bellgrau
发明人： Richard C. Duke , Alex Franzusoff , Donald Bellgrau
IPC分类号： G01N33/15 , A01N63/00 , A61K31/70 , A61K36/06 , A61K36/062 , A61K36/064 , A61K38/00 , A61K39/00 , A61K39/002 , A61K39/02 , A61K39/12 , A61K39/39 , A61K47/48 , A61K48/00 , A61P7/06 , A61P9/00 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/00 , A61P37/08 , C07H21/02 , C07H21/04 , C07K14/16 , C12N1/19 , C12N9/00 , C12N9/60 , C12N9/64 , C12N15/00 , C12N15/09 , C12N15/113 , C12N15/81 , C12N15/82 , C12Q1/00 , C12Q1/02 , C12Q1/37
CPC分类号： C12N15/8201 , A61K36/062 , A61K36/064 , A61K39/39 , A61K47/48776 , C07K14/005 , C12N15/1137 , C12N15/81 , C12N15/8279 , C12N9/60 , C12N9/6454 , C12Q1/025 , C12Q1/37 , A61K38/00 , C07K2319/00 , C12N2740/16122 , C12Q2337/22 , G01N2333/162 , G01N2333/395
摘要： The present invention includes yeast vehicles and their use as delivery vehicles. Yeast vehicles include a yeast portion and a heterologous compound. Such yeast vehicles can be used to protect animals from disease and to otherwise carry compounds to given cell types. Examples of yeast vehicles include gene delivery vehicles, drug delivery vehicles, and immunomodulatory vehicles. Immunomodulatory vehicles are capable of modulating an immune response. When stimulating an immune response, such yeast vehicles effect cell-mediated as well as humoral immunity.
摘要翻译：本发明包括酵母菌及其作为输送载体的用途。酵母载体包括酵母部分和异源化合物。这样的酵母载体可用于保护动物免受疾病和以其他方式携带化合物给予细胞类型。酵母载体的实例包括基因递送载体，药物递送载体和免疫调节载体。免疫调节载体能够调节免疫应答。当刺激免疫应答时，这种酵母载体会影响细胞介导以及体液免疫。

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