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1. 发明授权

US09193795B2 Method for making targeted therapeutic agents 有权
标题翻译：靶向治疗剂的制备方法
公开(公告)号：US09193795B2
公开(公告)日：2015-11-24
申请号：US13016576
申请日：2011-01-28
申请人： Richard B. Williams
发明人： Richard B. Williams
IPC分类号： C07K14/00 , C07K16/30 , G01N33/531 , G01N33/68
CPC分类号： C07K16/30 , C07K14/00 , C07K2319/30 , G01N33/531 , G01N33/6845
摘要： Provided herein are methods and kits for making a targeted therapeutic for treating a disease or condition. The therapeutic agents can be targeted to patient-specific disease markers. In one of these methods, the method includes obtaining a biological sample from a patient having the disease or condition, or who is at risk for developing the disease or condition. In this particular method, the sample includes a population of diseased cells, screening a library comprising proteins linked to their cognate mRNAs to identify mRNA-protein pairs that bind to the diseased cells, isolating one or more proteins from the identified mRNA-protein pairs, and conjugating the isolated protein(s) to a therapeutic agent. Some of the methods further include preparing a library with proteins linked to their cognate mRNAs. In certain of these methods, the preparation of the library includes providing at least two candidate mRNA molecules in which each of the mRNA molecules includes a cross-linker, translating at least two of the candidate mRNA molecules to generate at least one translated protein, and linking at least one of the candidate mRNA molecules to its corresponding translated protein via the cross-linker to form at least one cognate pair.
摘要翻译：本文提供了用于制备用于治疗疾病或病症的靶向治疗剂的方法和试剂盒。治疗剂可以靶向患者特异性疾病标记物。在这些方法之一中，该方法包括从具有疾病或病症的患者或患有发展疾病或病症风险的患者获得生物样品。在该特定方法中，样品包括患病细胞群，筛选包含与其同源mRNA相连的蛋白质的文库，以鉴定结合病变细胞的mRNA-蛋白质对，从鉴定的mRNA-蛋白质对分离一种或多种蛋白质，并将分离的蛋白质与治疗剂缀合。一些方法还包括用与其同源mRNA相连的蛋白质制备文库。在这些方法的某些中，文库的制备包括提供至少两个候选mRNA分子，其中每个mRNA分子包括交联剂，翻译候选mRNA分子中的至少两个以产生至少一个翻译的蛋白质，以及通过交联剂将候选mRNA分子中的至少一种与其相应的翻译蛋白连接以形成至少一个同源对。

2. 发明授权

US09080256B2 Generation of library of soluble random polypeptides linked to mRNA 有权
标题翻译：生成与mRNA连接的可溶性随机多肽的文库
公开(公告)号：US09080256B2
公开(公告)日：2015-07-14
申请号：US12525437
申请日：2008-02-12
申请人： Richard B Williams
发明人： Richard B Williams
IPC分类号： C40B50/06 , C40B40/02 , C07K14/00 , C12N15/10 , C40B10/00 , C40B40/08
CPC分类号： C40B40/02 , C07K14/003 , C12N15/1037 , C12N15/1062 , C12N15/1075 , C40B10/00 , C40B40/08 , C40B50/06
摘要： Methods and compositions are provided for producing libraries of soluble random polypeptides. In the methods, the fraction of hydrophilic residues in the polypeptide is controlled so as to maintain the solubility of the polypeptide constructs.
摘要翻译：提供了用于生产可溶性随机多肽文库的方法和组合物。在该方法中，控制多肽中亲水残基的分数，以维持多肽构建体的溶解度。

3. 发明授权

US4901732A Delta cuff 失效
标题翻译：三角袖口
公开(公告)号：US4901732A
公开(公告)日：1990-02-20
申请号：US144203
申请日：1988-01-15
申请人： Richard B. Williams
发明人： Richard B. Williams
IPC分类号： A61B5/022
CPC分类号： A61B5/02233
摘要： A sphygmomanometer which is constructed of an inflatable bladder having relatively converging sides arranged so that inflatable converging sides are held in place overlying an artery in the limb of a patient while the bladder may be inflated to measure the blood pressure of the patient.
摘要翻译：一种血压计，其由具有相对会聚侧面的可充气膀胱构成，其布置成使得充气的会聚侧保持在覆盖患者肢体中的动脉上方的位置，同时可以使膀胱膨胀以测量患者的血压。

4. 发明申请

US20110212119A1 METHODS FOR MAKING HIV VACCINES AND RELATED COMPOSITIONS 审中-公开
标题翻译：制备HIV疫苗的方法及相关成分
公开(公告)号：US20110212119A1
公开(公告)日：2011-09-01
申请号：US13126935
申请日：2009-10-22
申请人： Richard B. Williams
发明人： Richard B. Williams
IPC分类号： A61K39/385 , C40B30/04 , A61P31/18
CPC分类号： C12N15/1062 , A61K39/0005 , A61K39/12 , A61K39/21 , A61K2039/54 , A61K2039/55555 , C12N2740/16034 , G01N33/56988 , G01N33/6854 , G01N2333/162 , G01N2333/70514 , G01N2500/04
摘要： Provided herein are methods and kits for making a targeted therapeutic for prevent and treating HIV infection. In one of these methods, the method includes preparing a library of soluble peptides, and screening the library for proteins that bind to the region of CD4 that binds gp120. In this particular method, these proteins are used as the antigen to make the HIV vaccine.
摘要翻译：本文提供了用于制备预防和治疗HIV感染的靶向治疗剂的方法和试剂盒。在这些方法之一中，该方法包括制备可溶性肽文库，并筛选文库以结合结合gp120的CD4区域的蛋白质。在这种特定的方法中，使用这些蛋白质作为抗原来制备HIV疫苗。

5. 发明申请

US20100113302A1 GENERATION OF LIBRARY OF SOLUBLE RANDOM POLYPEPTIDES LINKED TO mRNA 有权
标题翻译：可溶性随机多肽连接到mRNA的库的生成
公开(公告)号：US20100113302A1
公开(公告)日：2010-05-06
申请号：US12525437
申请日：2008-02-12
申请人： Richard B Williams
发明人： Richard B Williams
IPC分类号： C40B40/02 , C40B40/06 , C40B50/10
CPC分类号： C40B40/02 , C07K14/003 , C12N15/1037 , C12N15/1062 , C12N15/1075 , C40B10/00 , C40B40/08 , C40B50/06
摘要： Methods and compositions are provided for producing libraries of soluble random polypeptides. In the methods, the fraction of hydrophilic residues in the polypeptide is controlled so as to maintain the solubility of the polypeptide constructs.
摘要翻译：提供了用于生产可溶性随机多肽文库的方法和组合物。在该方法中，控制多肽中亲水残基的分数，以维持多肽构建体的溶解度。

6. 发明申请

US20080199499A1 Method for Making Targeted Therapeutic Agents 审中-公开
标题翻译：制备靶向治疗剂的方法
公开(公告)号：US20080199499A1
公开(公告)日：2008-08-21
申请号：US11813849
申请日：2006-01-12
申请人： Richard B. Williams
发明人： Richard B. Williams
IPC分类号： A61K39/00 , C40B30/04
CPC分类号： C07K16/30 , C07K14/00 , C07K2319/30 , C12N15/1068 , C12N15/1075 , C12P19/34 , G01N33/531 , G01N33/6845
摘要： Provided herein are methods and kits for making a targeted therapeutic for treating a disease or condition. The therapeutic agents can be targeted to patient-specific disease markers. In one of these methods, the method includes obtaining a biological sample from a patient having the disease or condition, or who is at risk for developing the disease or condition. In this particular method, the sample includes a population of diseased cells, screening a library comprising proteins linked to their cognate mRNAs to identify mRNA-protein pairs that bind to the diseased cells, isolating one or more proteins from the identified mRNA-protein pairs, and conjugating the isolated protein(s) to a therapeutic agent. Some of the methods further include preparing a library with proteins linked to their cognate mRNAs. In certain of these methods, the preparation of the library includes providing at least two candidate mRNA molecules in which each of the mRNA molecules includes a cross-linker, translating at least two of the candidate mRNA molecules to generate at least one translated protein, and linking at least one of the candidate mRNA molecules to its corresponding translated protein via the cross-linker to form at least one cognate pair.
摘要翻译：本文提供了用于制备用于治疗疾病或病症的靶向治疗剂的方法和试剂盒。治疗剂可以靶向患者特异性疾病标记物。在这些方法之一中，该方法包括从具有疾病或病症的患者或患有发展疾病或病症风险的患者获得生物样品。在该特定方法中，样品包括患病细胞群，筛选包含与其同源mRNA相连的蛋白质的文库，以鉴定结合病变细胞的mRNA-蛋白质对，从鉴定的mRNA-蛋白质对分离一种或多种蛋白质，并将分离的蛋白质与治疗剂缀合。一些方法还包括用与其同源mRNA相连的蛋白质制备文库。在这些方法的某些中，文库的制备包括提供至少两个候选mRNA分子，其中每个mRNA分子包括交联剂，翻译候选mRNA分子中的至少两个以产生至少一个翻译的蛋白质，以及通过交联剂将候选mRNA分子中的至少一种与其相应的翻译蛋白连接以形成至少一个同源对。

7. 发明授权

US4159211A Dishwasher water temperature control system 失效
标题翻译：洗碗机水温控制系统
公开(公告)号：US4159211A
公开(公告)日：1979-06-26
申请号：US932665
申请日：1978-08-10
申请人： Robert E. Hoffman , Richard B. Williams , Carl J. Wright
发明人： Robert E. Hoffman , Richard B. Williams , Carl J. Wright
IPC分类号： A47L15/42 , B08B3/02
CPC分类号： A47L15/4287 , A47L15/4293 , Y10T137/6606
摘要： A domestic dishwasher is provided with a control system having circuitry including timer switch means adapted to insure automatic wash water at a normal set temperature for all cycles with the user having an option to preselect an elevated wash water temperature. During wash periods, power for the heater is provided through timer switch means connected through a first thermostat whereby if the water in the chamber is below its set temperature, the first thermostat will energize a heater to provide auxiliary heat to the wash water. The timer switch means is operative to stop the timer motor until the water is heated to said set temperature. Once the water reaches the minimum set temperature, or if the water supply is initially above said minimum setting the first thermostat will switch, deenergizing the heater. If an extra hot wash option is selected by an Options Selector Switch, and the water temperature is below a second thermostat's elevated set point, the timer switch means will stop the timer motor providing extended heating until the second thermostat closes upon the water reaching the elevated temperature.
摘要翻译：家用洗碗机具有控制系统，该控制系统具有包括计时器开关装置的电路，该定时开关装置适用于在用户具有预先选择升高的洗涤水温度的选项的情况下，确保在正常设定温度下进行所有循环的自动洗涤水。在洗涤期间，通过定时器开关装置提供加热器的功率，定时开关装置通过第一恒温器连接，由此如果室内的水低于其设定温度，则第一恒温器将给加热器供电以向洗涤水提供辅助热量。定时开关装置可操作以停止定时器马达，直到水被加热到所述设定温度。一旦水达到最低设定温度，或者如果供水最初高于所述最小设定值，则第一个恒温器将切换，使加热器断电。如果选件选择开关选择了额外的热洗选项，并且水温低于第二个恒温器升高的设定点，则定时开关装置将停止定时器电机提供延长的加热，直到第二个恒温器在水达到升高的位置时关闭温度。

8. 发明授权

US07488600B2 Compositions and methods for the identification and selection of nucleic acids and polypeptides 有权
标题翻译：用于鉴定和选择核酸和多肽的组合物和方法
公开(公告)号：US07488600B2
公开(公告)日：2009-02-10
申请号：US10960453
申请日：2004-10-07
申请人： Richard B. Williams
发明人： Richard B. Williams
IPC分类号： C12N15/01 , C12N15/09 , C12N15/11 , C12P19/34
CPC分类号： C12N15/1034 , C12N15/1062 , G01N33/58 , G01N33/6845 , G01N2458/10
摘要： This invention relates generally to systems and methods for identifying and selecting, desired proteins or nucleic acid molecules by linking mRNA, with known or unknown sequences, to its translated protein to form a cognate pair. The cognate pair is selected based upon desired properties of the protein or the nucleic acid. This method also includes the evolution of a desired protein or nucleic acid molecule by amplifying the nucleic acid portion of the selected cognate pair, introducing variation into the nucleic acid, translating the nucleic acid, attaching the nucleic acid to its protein to form a second cognate pair, and re-selecting this cognate pair based upon desired properties. Modified mRNAs operable to crosslink to tRNAs are also provided. Methods of producing a psoralen monoadduct or a crosslink are also provided.
摘要翻译：本发明一般涉及通过将mRNA与已知或未知序列连接到其翻译的蛋白质以形成同源对来鉴定和选择所需蛋白质或核酸分子的系统和方法。基于蛋白质或核酸的所需性质选择同源对。该方法还包括通过扩增所选择的同源对的核酸部分，引入核酸的变异，翻译核酸，将核酸连接到其蛋白质以形成第二个同源物，从而演化期望的蛋白质或核酸分子并且基于所需的属性重新选择该同源对。还提供了可操作以交联至tRNA的修饰的mRNA。还提供了补骨脂素单加成物或交联剂的制备方法。

9. 发明授权

US4545150A Combined gate and lock assembly 失效
标题翻译：组合门和锁组件
公开(公告)号：US4545150A
公开(公告)日：1985-10-08
申请号：US609713
申请日：1984-11-20
申请人： Richard B. Williams
发明人： Richard B. Williams
IPC分类号： E05B65/00 , E05C7/04
CPC分类号： E05B65/0007 , Y10T292/1025 , Y10T292/1028 , Y10T292/23 , Y10T70/7921
摘要： Disclosed is a combined gate and lock assembly of tubular construction comprising two horizontal female members fixed to two vertical posts pivotally mounted with respect to support structure. In the closed position, the longitudinal axes of the female members are aligned and receive coaxially in recipro cable relationship therein a male member having an eye engaged by the shackle of a padlock. In the open position, the male member is appropriately disengaged from one of the female members which are disposed in their open position by appropriate rotation of their vertical posts.
摘要翻译：公开了一种管状结构的组合门和锁组件，包括固定到相对于支撑结构枢转地安装的两个垂直柱的两个水平阴构件。在关闭位置，阴构件的纵向轴线对准并同轴地接合在其中，具有通过挂锁的钩环啮合的眼睛的阳构件。在打开位置，男性构件通过它们的垂直柱的适当旋转而被适当地从设置在其打开位置的女性构件中脱离。

10. 发明授权

US4484421A Traveling stage 失效
标题翻译：旅行阶段
公开(公告)号：US4484421A
公开(公告)日：1984-11-27
申请号：US427518
申请日：1982-09-29
申请人： Richard B. Williams , Thomas V. Janus
发明人： Richard B. Williams , Thomas V. Janus
IPC分类号： E04H3/28 , E04H3/26
CPC分类号： E04H3/28
摘要： A stage capable of rapid assembly and disassembly is provided for a traveling show. Through the use of appropriate vertical columns, main trusses and I-beams, a support structure is formed for the stage. Appropriate lighting and curtain structures are then supported from the I-beams. Collapsible tables provide a stage area.
摘要翻译：为旅行节目提供了能够快速组装和拆卸的舞台。通过使用适当的垂直柱，主桁架和I型梁，形成了支撑结构。然后从I型梁支撑适当的照明和窗帘结构。可折叠桌子提供舞台区域。

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