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1. 发明申请

US20110021906A1 Methods and Apparatus for Intraocular Brachytherapy 失效
标题翻译：眼内近距离放射疗法的方法与装置
公开(公告)号：US20110021906A1
公开(公告)日：2011-01-27
申请号：US12887996
申请日：2010-09-22
申请人： Richard A. Hillstead , Charles E. Larsen , Roelof Trip , Cory S. Anderson , Eberhard Fritz , Rainer Pintaske , John N. Hendrick , Benjamin W. Woodward
发明人： Richard A. Hillstead , Charles E. Larsen , Roelof Trip , Cory S. Anderson , Eberhard Fritz , Rainer Pintaske , John N. Hendrick , Benjamin W. Woodward
IPC分类号： A61N5/00 , A61B6/00
CPC分类号： A61N5/1017 , A61N5/1007 , A61N5/1049 , A61N2005/1058
摘要： Methods and apparatus for intraocular brachytherapy are disclosed in which a cannula is introduced into the eye for delivery of radiation to a target tissue. Techniques for properly locating the cannula with respect to the target tissue, for protecting non-target tissue, for regulating heat generated by x-ray emitters, and for combining therapies are disclosed.
摘要翻译：公开了用于眼内近距离放射治疗的方法和装置，其中将插管引入眼睛以将辐射递送至靶组织。公开了用于相对于目标组织适当地定位插管的技术，用于保护非目标组织，用于调节由x射线发射器产生的热量和用于组合疗法。

2. 发明授权

US07744520B2 Method and apparatus for intraocular brachytherapy 失效
标题翻译：眼内近距离放射疗法的方法和装置
公开(公告)号：US07744520B2
公开(公告)日：2010-06-29
申请号：US11056763
申请日：2005-02-11
申请人： Charles E. Larsen , Richard A. Hillstead , Roelof Trip , Eugene de Juan , Mark Humayun , Eberhard Fritz , Rainer Pintaske
发明人： Charles E. Larsen , Richard A. Hillstead , Roelof Trip , Eugene de Juan , Mark Humayun , Eberhard Fritz , Rainer Pintaske
IPC分类号： A61N5/00
CPC分类号： A61N5/1017
摘要： A method for performing intraocular brachytherapy and an apparatus for performing the same is disclosed. The apparatus preferably comprises a hand-held delivery device that advances a radiation source into an associated cannula or probe that is positioned adjacent the target tissue. The handpiece provides for shielded storage of the radiation source when retracted from the cannula and includes a slider mechanism for advancing and retracting the radiation source. The radiation source is mounted to a wire that has a flexible distal end and a relatively stiffer proximal end. A positioning system for the cannula is also disclosed.
摘要翻译：公开了一种用于进行眼内近距离放射治疗的方法及其执行装置。该装置优选地包括将辐射源前进到与靶组织相邻定位的相关套管或探针中的手持递送装置。所述手持件在从套管缩回时提供辐射源的屏蔽存储，并且包括用于前进和后退辐射源的滑块机构。辐射源安装到具有柔性远端和较硬的近端的导线上。还公开了用于套管的定位系统。

3. 发明授权

US07066872B2 Method and apparatus for treating a desired area in the vascular system of a patient 失效
公开(公告)号：US07066872B2
公开(公告)日：2006-06-27
申请号：US10411749
申请日：2003-04-11
申请人： Ron Waksman , Thomas D. Weldon , Richard A. Hillstead , Jonathan J. Rosen , Charles E. Larsen , Ian R. Crocker , Raphael F. Meloul
发明人： Ron Waksman , Thomas D. Weldon , Richard A. Hillstead , Jonathan J. Rosen , Charles E. Larsen , Ian R. Crocker , Raphael F. Meloul
IPC分类号： A61N5/00
CPC分类号： A61M25/1002 , A61M25/0028 , A61M25/003 , A61M25/0032 , A61M25/1006 , A61M2025/0034 , A61N5/1002 , A61N5/1007
摘要： Apparatus and method are described for delivery of a treating element, such as a radiation source, through a catheter to a desired site in the vascular system of a patient, such as a coronary artery, for inhibiting the formation of scar tissue such as may occur in restenosis following balloon angioplasty. The apparatus includes an elongated flexible catheter tube having proximal and distal end portions, with a lumen extending therebetween, and a diameter sufficiently small for insertion in to a patient's vascular system. One or more treating elements, such as a capsule or pellet containing radioactive material, is positionable within the lumen and movable between the proximal and distal end portions under the force of liquid flowing through the lumen. A method for using such apparatus, including a method for using such apparatus simultaneously with a balloon angioplasty procedure, is disclosed.

4. 发明授权

US06458070B1 Method and apparatus for treating a desired area in the vascular system of a patient 有权
标题翻译：用于治疗患者血管系统中所需区域的方法和装置
公开(公告)号：US06458070B1
公开(公告)日：2002-10-01
申请号：US09469103
申请日：1999-12-21
申请人： Ron Waksman , Thomas D. Weldon , Richard A. Hillstead , Jonathan J. Rosen , Charles E. Larsen , Ian R. Crocker , Raphael F. Meloul
发明人： Ron Waksman , Thomas D. Weldon , Richard A. Hillstead , Jonathan J. Rosen , Charles E. Larsen , Ian R. Crocker , Raphael F. Meloul
IPC分类号： A61N500
CPC分类号： A61M25/1002 , A61M25/0028 , A61M25/003 , A61M25/0032 , A61M25/1006 , A61M2025/0034 , A61N5/1002 , A61N5/1007
摘要： Apparatus and method are described for delivery of a treating element, such as a radiation source, through a catheter to a desired site in the vascular system of a patient, such as a coronary artery, for inhibiting the formation of scar tissue such as may occur in restenosis following balloon angioplasty. The apparatus includes an elongated flexible catheter tube having proximal and distal end portions, with a lumen extending therebetween, and a diameter sufficiently small for insertion in to a patient's vascular system. One or more treating elements, such as a capsule or pellet containing radioactive material, is positionable within the lumen and movable between the proximal and distal end portions under the force of liquid flowing through the lumen. A method for using such apparatus, including a method for using such apparatus simultaneously with a balloon angioplasty procedure, is disclosed.
摘要翻译：描述了用于通过导管将治疗元件（例如辐射源）递送到患者（例如冠状动脉）的血管系统中用于抑制形成瘢痕组织的可能发生的装置和方法在球囊血管成形术后再狭窄。该装置包括细长的柔性导管，其具有近端部分和远端部分，其间延伸有内腔，并且具有足够小的直径以插入患者血管系统中的直径。一个或多个处理元件，例如包含放射性物质的胶囊或丸粒，可定位在内腔内并且在液体流过内腔的力的作用下在近端部分和远端部分之间移动。公开了一种使用这种装置的方法，包括与球囊血管成形术程序同时使用这种装置的方法。

5. 发明授权

US5423762A Modular catheter sheath introducer 失效
标题翻译：模块导管鞘引导器
公开(公告)号：US5423762A
公开(公告)日：1995-06-13
申请号：US47847
申请日：1993-04-15
申请人： Richard A. Hillstead
发明人： Richard A. Hillstead
IPC分类号： A61M25/06 , A61M5/178
CPC分类号： A61M25/0662
摘要： A catheter sheath introducer comprises: a tubular body portion having opposed ends; a catheter sheath tube which is optionally replaceably carried on one of the body portion ends; and a slit, elastomeric hemostasis valve partition which is optionally replaceably carried on the other of the body portion ends.
摘要翻译：导管护套导引器包括：具有相对端的管状主体部分; 导管护套管，其任选地可替换地承载在所述主体部分端部之一上; 以及可选地可替代地承载在主体部分端部中的另一个上的狭缝，弹性止血阀分隔件。

6. 发明授权

US5054821A Sterile sleeve/connector assembly 失效
标题翻译：无菌套管/连接器总成
公开(公告)号：US5054821A
公开(公告)日：1991-10-08
申请号：US464554
申请日：1990-01-12
申请人： Richard A. Hillstead
发明人： Richard A. Hillstead
IPC分类号： B25B27/00 , B25B27/10 , H01R43/00 , H02G1/14
CPC分类号： B25B27/10 , B25B27/0028 , H01R43/005 , H02G1/14 , Y10T29/4987 , Y10T29/53657
摘要： The sterile sleeve/connector assembly includes a joint formed between a sterile sleeve and a connector. The sleeve is made of a tube of thin flexible material, the connector includes a hub having an annular groove therein, and the joint includes an O-ring which is positioned within a bight of an inwardly inverted end portion of the sleeve and within the groove of the connector hub. The apparatus used in forming the assembly comprises a barrel member having a lumen, a distal end and a proximal end. The barrel member has a diameter approximately equal to a diameter of the hub the connector and less than the diameter of the sleeve. The method for using the apparatus comprises the steps of (a) pushing the O-ring onto an outer surface of the barrel member at the distal end of the barrel member; (b) sliding a sleeve over the barrel member; (c) inverting an end portion of the sleeve into the distal end of the lumen of the barrel member; (d) sliding the hub of the connector into the inverted end portion of the sleeve at the distal end of the lumen; (e) forcing the O-ring off the distal end of the barrel member, into a bight of the inverted end portion of the sleeve and into the annular groove in the hub of the connector; and (f) removing the connector from within the barrel member and pulling on the connector until the entire sleeve is removed from over the barrel member.
摘要翻译：无菌套筒/连接器组件包括形成在无菌套管和连接器之间的接头。套筒由薄的柔性材料管制成，连接器包括其中具有环形槽的毂，并且接头包括O形环，该O形环位于套筒的向内倒置的端部的弯曲部内并且在凹槽内的连接器中心。用于形成组件的装置包括具有内腔，远端和近端的筒构件。筒构件的直径大致等于连接器的毂的直径，并且小于套筒的直径。使用该装置的方法包括以下步骤：（a）将O形环在筒构件的远端处推压到筒构件的外表面上; （b）将套筒滑动到所述筒体上; （c）将所述套筒的端部翻转到所述筒构件的内腔的远端; （d）将所述连接器的轮毂在所述内腔的远端处滑动到所述套筒的倒置端部; （e）将所述O形环从所述筒构件的远端推离到所述套筒的所述倒置端部的弯头中，并进入所述连接器的轮毂中的环形槽中; 以及（f）从筒体内取出连接器并拉动连接器，直到整个套筒从筒部件上方移除。

7. 发明授权

US4913141A Apparatus and method for placement of a stent within a subject vessel 失效
标题翻译：将支架放置在主体容器内的装置和方法
公开(公告)号：US4913141A
公开(公告)日：1990-04-03
申请号：US262831
申请日：1988-10-25
申请人： Richard A. Hillstead
发明人： Richard A. Hillstead
IPC分类号： A61F2/06 , A61F2/84 , A61F2/88
CPC分类号： A61F2/88 , A61F2/95 , A61F2002/9505 , A61F2002/9511
摘要： A stent delivery system and method. A stent is routed to a desired position within a vessel within a subject. A delivery wire is routed out an opening in a delivery catheter and looped over a portion of the stent and then routed back inside the delivery catheter. At an extreme distal end of the stent, the wire again exits the delivery catheter, reengages the stent and is pushed back into the catheter center passageway. This compresses the stent into a form whereby the delivery catheter can be maneuvered through a vessel to position the stent. To release the stent from the delivery catheter, the delivery wire is retracted so that its distal end passes out both pair of openings in the delivery catheter allowing the stent to expand into engagement with the vessel wall.
摘要翻译：一种支架输送系统及方法。支架被路由到受试者内的血管内的期望位置。输送线从输送导管中的开口排出并且环绕在支架的一部分上，然后在输送导管内返回。在支架的最远端，线再次离开输送导管，重新接合支架并被推回到导管中心通道中。这将支架压缩成一种形式，由此输送导管可以通过容器操纵以定位支架。为了从输送导管释放支架，输送线缩回，使得其远端排出输送导管中的两对开口，允许支架膨胀成与血管壁接合。

8. 发明申请

US20130006269A1 MEDICAL INSTRUMENT 有权
标题翻译：医用仪器
公开(公告)号：US20130006269A1
公开(公告)日：2013-01-03
申请号：US13612216
申请日：2012-09-12
申请人： Richard A. Hillstead , Bryan D. Knodel
发明人： Richard A. Hillstead , Bryan D. Knodel
IPC分类号： A61B19/00
CPC分类号： A61B17/07207 , A61B2017/00398 , A61B2017/00539 , A61B2017/00557 , A61B2017/07214 , A61B2017/2904 , A61B2017/2905 , A61B2017/2927
摘要： A hydraulically actuated medical instrument includes an elongated shaft having proximal and distal ends, a hydraulically actuated end effector at the distal end of the shaft and a fluid flow path extending through the shaft to the end effector. The end effector may be directly manually operated by way of a handle located at the proximal end of the shaft or remotely, for example, via robotic controller. Articulation joints may be provided along the shaft, between the shaft and end effector or handle, or elsewhere. The hydraulic actuation of the present invention permits multiple axis instrument articulation, miniaturization and simplified instrument fabrication.
摘要翻译：液压致动的医疗器械包括具有近端和远端的细长轴，在轴的远端处的液压致动的端部执行器和延伸穿过该轴到端部执行器的流体流动路径。端部执行器可以通过位于轴的近端处的手柄直接手动操作，或者远程例如通过机器人控制器手动操作。铰接接头可以沿着轴，在轴和端部执行器或手柄之间或其他地方设置。本发明的液压致动允许多轴仪器铰接，小型化和简化仪器制造。

9. 发明授权

US07922742B2 Medical instrument 有权
标题翻译：医疗仪器
公开(公告)号：US07922742B2
公开(公告)日：2011-04-12
申请号：US12055058
申请日：2008-03-25
申请人： Richard A. Hillstead , Bryan D. Knodel
发明人： Richard A. Hillstead , Bryan D. Knodel
IPC分类号： A61B17/3201 , A61B17/28
CPC分类号： A61B17/07207 , A61B2017/00398 , A61B2017/00539 , A61B2017/00557 , A61B2017/07214 , A61B2017/2904 , A61B2017/2905 , A61B2017/2927
摘要： A hydraulically actuated medical instrument includes an elongated shaft having proximal and distal ends, a hydraulically actuated end effector at the distal end of the shaft and a fluid flow path extending through the shaft to the end effector. The end effector may be directly manually operated by way of a handle located at the proximal end of the shaft or remotely, for example, via robotic controller. Articulation joints may be provided along the shaft, between the shaft and end effector or handle, or elsewhere. The hydraulic actuation of the present invention permits multiple axis instrument articulation, miniaturization and simplified instrument fabrication.
摘要翻译：液压致动的医疗器械包括具有近端和远端的细长轴，在轴的远端处的液压致动的端部执行器和延伸穿过该轴到端部执行器的流体流动路径。端部执行器可以通过位于轴的近端处的手柄直接手动操作，或者远程例如通过机器人控制器手动操作。铰接接头可以沿着轴，在轴和端部执行器或手柄之间或其他地方设置。本发明的液压致动允许多轴仪器铰接，小型化和简化仪器制造。

10. 发明授权

US07563222B2 Methods and apparatus for intraocular brachytherapy 失效
标题翻译：眼内近距离放射疗法的方法和装置
公开(公告)号：US07563222B2
公开(公告)日：2009-07-21
申请号：US11228030
申请日：2005-09-15
申请人： Charles E. Larsen , Richard A. Hillstead , Roelof Trip , Eugene deJuan , Mark Humayun , Eberhard Fritz , Rainer Pintaske
发明人： Charles E. Larsen , Richard A. Hillstead , Roelof Trip , Eugene deJuan , Mark Humayun , Eberhard Fritz , Rainer Pintaske
IPC分类号： A61N5/00
CPC分类号： A61N5/1017 , A61N5/1049 , A61N2005/1058
摘要： A method for performing intraocular brachytherapy and an apparatus for performing the same is disclosed. The apparatus preferably comprises a hand-held delivery device that advances a radiation source into an associated cannula or probe that is positioned adjacent the target tissue. The handpiece provides for shielded storage of the radiation source when retracted from the cannula and includes a slider mechanism for advancing and retracting the radiation source. The radiation source is mounted to a wire that has a flexible distal end and a relatively stiffer proximal end.
摘要翻译：公开了一种用于进行眼内近距离放射治疗的方法及其执行装置。该装置优选地包括将辐射源前进到与靶组织相邻定位的相关套管或探针中的手持递送装置。所述手持件在从套管缩回时提供辐射源的屏蔽存储，并且包括用于前进和后退辐射源的滑块机构。辐射源安装到具有柔性远端和较硬的近端的导线上。

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