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1. 发明授权

US06417183B1 1,4-diazacycloheptane derivatives 失效
标题翻译： 1,4-二氮杂环庚烷衍生物
公开(公告)号：US06417183B1
公开(公告)日：2002-07-09
申请号：US09581615
申请日：2000-06-15
申请人： Richard A Keith , Edward J Warawa , Thomas R Simpson
发明人： Richard A Keith , Edward J Warawa , Thomas R Simpson
IPC分类号： A61K3155
CPC分类号： C07D243/08
摘要： This invention provides substituted 1,2,3,4-tetrahydronaphthalene [3H]-emopamil binding site inhibitors useful in the treatment of neurological disorders. Such inhibitors are compounds of formula (I) wherein R, R1, m, R2 and n are as defined in the specification. The invention also provides pharmaceutical compositions containing such compounds, methods of using such compounds and methods of making such compounds
摘要翻译：本发明提供了可用于治疗神经障碍的取代的1,2,3,4-四氢化萘[3 H] - 孕霉素结合位点抑制剂。这样的抑制剂是式（I）的化合物，其中R，R 1，m，R 2和n如说明书中所定义。本发明还提供含有这些化合物的药物组合物，使用这些化合物的方法和制备这些化合物的方法

2. 发明授权

US5505680A Athletic grip strength training device 失效
标题翻译：运动握力训练装置
公开(公告)号：US5505680A
公开(公告)日：1996-04-09
申请号：US270606
申请日：1994-07-05
申请人： Richard A. Keith
发明人： Richard A. Keith
IPC分类号： A63B69/00 , A63B21/00
CPC分类号： A63B69/0071
摘要： An athletic training device is described for improving the grip strength and exercising other muscle groups of the user, comprised of a single strap secured together at three separate junctions so as to form two large loops and a small loop, with a clasping mechanism attached to the small loop. A method for using the device is also described, in which a user secures a basketball within the device and attaches the clasping device to any of a number of existing resistance devices, such as wieght training machines with cable and pulley systems, free weights, elastic cords, springs and athletic training machines employing some form of these resistance devices.
摘要翻译：描述了一种运动训练装置，用于提高抓握强度并锻炼使用者的其他肌群，包括在三个分开的连接处固定在一起的单个皮带，从而形成两个大的环和小的环，其中扣紧机构连接到小循环。还描述了一种使用该装置的方法，其中用户将该篮球固定在该装置内并且将该夹紧装置附接到多个现有的阻力装置中的任何一个，例如具有缆索和滑轮系统的自由训练机，自由重量，弹性线，弹簧和运动训练机采用某种形式的这些电阻装置。

3. 发明授权

US07982038B2 Ligands 失效
标题翻译：配体
公开(公告)号：US07982038B2
公开(公告)日：2011-07-19
申请号：US10573133
申请日：2004-09-24
申请人： Peter Dorff , John Gordon , John Richard Heys , Richard A Keith , Dennis J McCarthy , Mark A Smith , Eifion Phillips
发明人： Peter Dorff , John Gordon , John Richard Heys , Richard A Keith , Dennis J McCarthy , Mark A Smith , Eifion Phillips
IPC分类号： C07D413/04 , A61K31/44
CPC分类号： C07D491/22 , A61K51/0455 , C07B2200/05
摘要： A radioactive compound having the formula: and pharmaceutically-acceptable salts thereof, wherein R1 and Ar are as defined in the specification, enantiomers, in vivo-hydrolysable precursors, pharmaceutical compositions and formulations containing them, methods of using them to treat diseases and conditions either alone or in combination with other therapeutically-active compounds or substances, processes and intermediates used to prepare them and uses of them for diagnostic and analytic purposes.
摘要翻译：具有下式的放射性化合物及其药学上可接受的盐，其中R 1和Ar如说明书中所定义，对映异构体，体内可水解前体，药物组合物和含有它们的制剂，使用它们治疗疾病和病症的方法单独或与其他治疗活性化合物或物质，用于制备它们的方法和中间体以及它们用于诊断和分析目的的用途组合。

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