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1. 发明授权

US07897153B1 Chimera of human IgE receptor α-chain and avian constant immuno-globulin domains for the determination of serum IgE 有权
标题翻译：人类IgE受体α链和鸟类恒定免疫球蛋白结构域的嵌合体，用于测定血清IgE
公开(公告)号：US07897153B1
公开(公告)日：2011-03-01
申请号：US11581874
申请日：2006-10-17
申请人： Ingke Braren , Reinhard Bredehorst , Thomas Grunwald
发明人： Ingke Braren , Reinhard Bredehorst , Thomas Grunwald
IPC分类号： A61K39/00
CPC分类号： C07K16/4291 , C07K14/70535 , C07K2317/23 , C07K2317/24 , C07K2317/52 , C07K2319/30 , G01N33/6854
摘要： The instant application inter alia relates to chimeric fusion constructs comprising the extracellular portion of human FcεRIα and at least one avian constant immunoglobulin domain and the use thereof for in vitro diagnostic purposes.
摘要翻译：本申请尤其涉及包含人FcγRIα的细胞外部分和至少一种禽类恒定免疫球蛋白结构域的嵌合融合构建体及其用于体外诊断目的的用途。

2. 发明授权

US07696323B2 Bivalent IgY antibody constructs for diagnostic and therapeutic applications 失效
标题翻译：用于诊断和治疗应用的二价IgY抗体构建体
公开(公告)号：US07696323B2
公开(公告)日：2010-04-13
申请号：US11510329
申请日：2006-08-25
申请人： Reinhard Bredehorst , Kerstin Greunke , Thomas Grunwald , Edzard Spillner
发明人： Reinhard Bredehorst , Kerstin Greunke , Thomas Grunwald , Edzard Spillner
IPC分类号： C07K16/00 , A61K39/395
CPC分类号： C07K16/40 , C07K16/10 , C07K16/462 , C07K2317/23 , C07K2317/41 , C07K2317/622 , C07K2317/64
摘要： This invention relates to the field of recombinant antibody technology. It provides novel recombinant IgY antibody constructs for diagnostic and therapeutical applications. The bivalent antibody constructs display a heterotetrameric or homodimeric format stabilized by disulfide bonds. The constant heavy chain domains CH2-CH4 are partly or completely of avian origin, whereas the VH, VL, CL, and CH1 domains as well as the hinge region may be of avian origin or derived from any other species. The invention allows to combine the advantages of IgY antibodies with those of established mammalian monoclonal antibodies. IgY antibody constructs comprising nonglycosylated IgY constant heavy chain domains allow to reduce unwanted interactions with C-type lectins, e.g., in human sera. Furthermore, chimeric IgY antibody containing mammalian VH, VL, CL, and CH1 domains as well as a mammalian hinge region provide a higher molecular stability than IgY antibodies in acidic conditions and, thereby, are especially suited for peroral therapeutic applications.
摘要翻译：本发明涉及重组抗体技术领域。它提供用于诊断和治疗应用的新型重组IgY抗体构建体。二价抗体构建物显示通过二硫键稳定的异四聚体或同二聚体形式。恒定的重链结构域CH2-CH4部分或完全是鸟类来源的，而VH，VL，CL和CH1结构域以及铰链区可以是鸟类来源的或衍生自任何其它物种。本发明允许将IgY抗体的优点与已建立的哺乳动物单克隆抗体的优点相结合。包含非糖基化IgY恒定重链结构域的IgY抗体构建体允许减少与C型凝集素的不期望的相互作用，例如在人血清中。此外，含有哺乳动物VH，VL，CL和CH1结构域以及哺乳动物铰链区的嵌合IgY抗体在酸性条件下提供比IgY抗体更高的分子稳定性，因此特别适用于口服治疗应用。

3. 发明授权

US07553931B2 Complement depletion using recombinant human C3-derivatives 失效
标题翻译：使用重组人C3衍生物补体耗尽
公开(公告)号：US07553931B2
公开(公告)日：2009-06-30
申请号：US10884813
申请日：2004-07-02
申请人： Johanna Kölln , Edzard Spillner , Reinhard Bredehorst
发明人： Johanna Kölln , Edzard Spillner , Reinhard Bredehorst
IPC分类号： C07K1/00
CPC分类号： C07K14/472 , A61K38/00 , C07K2319/00
摘要： The invention provides isolated polypeptides having complement-modulating activity. Specifically, the invention resides in the provision of isolated polypeptides having complement-depleting properties, i.e. that effect an efficient consumption of complement in human serum. The current invention thus provides human C3-derivatives that are capable of forming C3-convertases exerting an extended CVF, Bb-like half-life of up several hours, compared to 1.5 minutes of the naturally occurring C3-convertases, thus escaping the physiological degradation mechanisms.
摘要翻译：本发明提供了具有补体调节活性的分离的多肽。具体地说，本发明在于提供具有补体消耗特性的分离的多肽，即在人血清中有效消耗补体。因此，本发明提供人类C3-衍生物，其能够与1.5分钟的天然存在的C3-转化酶相比，形成产生延长的CVF，类似Bb样的半衰期的C3-转化酶，从而逃避生理降解机制

4. 发明申请

US20070141049A1 Bivalent IgY antibody constructs for diagnostic and therapeutic applications 失效
标题翻译：用于诊断和治疗应用的二价IgY抗体构建体
公开(公告)号：US20070141049A1
公开(公告)日：2007-06-21
申请号：US11510329
申请日：2006-08-25
申请人： Reinhard Bredehorst , Kerstin Greunke , Thomas Grunwald , Edzard Spillner
发明人： Reinhard Bredehorst , Kerstin Greunke , Thomas Grunwald , Edzard Spillner
IPC分类号： A61K39/395 , C07K16/44
CPC分类号： C07K16/40 , C07K16/10 , C07K16/462 , C07K2317/23 , C07K2317/41 , C07K2317/622 , C07K2317/64
摘要： This invention relates to the field of recombinant antibody technology. It provides novel recombinant IgY antibody constructs for diagnostic and therapeutical applications. The bivalent antibody constructs display a heterotetrameric or homodimeric format stabilized by disulfide bonds. The constant heavy chain domains CH2-CH4 are partly or completely of avian origin, whereas the VH, VL, CL, and CH1 domains as well as the hinge region may be of avian origin or derived from any other species. The invention allows to combine the advantages of IgY antibodies with those of established mammalian monoclonal antibodies. IgY antibody constructs comprising nonglycosylated IgY constant heavy chain domains allow to reduce unwanted interactions with C-type lectins, e.g., in human sera. Furthermore, chimeric IgY antibody containing mammalian VH, VL, CL, and CH1 domains as well as a mammalian hinge region provide a higher molecular stability than IgY antibodies in acidic conditions and, thereby, are especially suited for peroral therapeutic applications.
摘要翻译：本发明涉及重组抗体技术领域。它提供用于诊断和治疗应用的新型重组IgY抗体构建体。二价抗体构建物显示通过二硫键稳定的异四聚体或同二聚体形式。恒定的重链结构域C H-2-C H 4部分或完全是鸟类来源的，而V H H， L，C L和C H 1结构域以及铰链区域可以是鸟类来源的或衍生自任何其它物种。本发明允许将IgY抗体的优点与已建立的哺乳动物单克隆抗体的优点相结合。包含非糖基化IgY恒定重链结构域的IgY抗体构建体允许减少与C型凝集素的不期望的相互作用，例如在人血清中。此外，含有哺乳动物V H，V L，C L和C H H 1结构域的嵌合IgY抗体为以及哺乳动物铰链区域在酸性条件下提供比IgY抗体更高的分子稳定性，因此特别适合于口服治疗应用。

5. 发明申请

US20190282692A1 SELECTIVE LOCAL INHIBITION OF TNFR1-MEDIATED FUNCTIONS AT THE SITE OF ANTIGEN/ALLERGEN PRESENTATION 审中-公开
公开(公告)号：US20190282692A1
公开(公告)日：2019-09-19
申请号：US15921945
申请日：2018-03-15
申请人： Reinhard Bredehorst , Thomas Grunwald , Markus Ollert , Carsten Schmidt-Weber , Edzard Spillner
发明人： Reinhard Bredehorst , Thomas Grunwald , Markus Ollert , Carsten Schmidt-Weber , Edzard Spillner
IPC分类号： A61K39/39 , A61K39/35 , A61K38/20 , C12N15/113 , A61K9/127 , A61K47/34 , A61K39/00 , A61K9/06 , A61K39/395 , A61K31/713
摘要： The invention relates to a pharmaceutical composition for the modulation of T cell and B cell responses made of one or more preparations and comprising a therapeutically effective dose of at least one inhibitor of TNFR1-mediated functions and of at least one antigen or allergen.

6. 发明授权

US07208077B1 Sensor arrangement with electrically controllable arrays 有权
标题翻译：具有电控阵列的传感器布置
公开(公告)号：US07208077B1
公开(公告)日：2007-04-24
申请号：US09958633
申请日：2000-04-14
申请人： Joerg Albers , Helmut Bernt , Reinhard Bredehorst , Rainer Hintsche , René Seitz
发明人： Joerg Albers , Helmut Bernt , Reinhard Bredehorst , Rainer Hintsche , René Seitz
IPC分类号： G01N27/403 , G01N27/327
CPC分类号： G01N27/3277
摘要： An electric sensor array which is provided with several sensor positions that each have at least two microelectrodes. Molecular substances can be detected electrochemically and charged molecules can be transported or handled using the array. Measuring procedures can be effected, especially using two addressing procedures, in which sensor positions can be individually addressed and electrochemically or electrically controlled by pairing or in groups for voltage or impedance measurements. For biomolecular assays, affinity-binding molecules can be immobilized at the sensor positions, between the microelectrodes, or on auxiliary surfaces.
摘要翻译：电传感器阵列具有多个传感器位置，每个传感器位置具有至少两个微电极。分子物质可以电化学检测，带电分子可以使用阵列进行运输或处理。可以实现测量程序，特别是使用两个寻址过程，其中传感器位置可以单独寻址，并通过配对或电压或电压控制电压或阻抗测量。对于生物分子测定，亲和力结合分子可以固定在传感器位置，微电极之间或辅助表面上。

7. 发明授权

US06881379B1 Method for producing detection systems with planar arrays 有权
标题翻译：具有平面阵列检测系统的方法
公开(公告)号：US06881379B1
公开(公告)日：2005-04-19
申请号：US09958807
申请日：2000-04-14
申请人： Reinhard Bredehorst , Rainer Hintsche , Rene Seitz , Walter Gumbrecht
发明人： Reinhard Bredehorst , Rainer Hintsche , Rene Seitz , Walter Gumbrecht
IPC分类号： B01J19/00 , G01N33/50
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00317 , B01J2219/00378 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00653 , B01J2219/00659 , B01J2219/00677 , B01J2219/00704 , G01N27/27 , G01N27/3276
摘要： The invention relates to a method for producing a detection system for detecting different analytes in a sample, characterised by the following steps: providing a planar or essentially planar substrate which has sensors for chemically, optically or electrically detecting the analytes; applying an already microstructured layer to the substrate or applying a continuous layer to the substrate and microstructuring said layer, the layer being applied in such a way in either case that the areas of the substrate that are separated from each other are not covered by the layer, the layer and substrate being sealingly interconnected at least around the uncovered areas; bringing at least some of the uncovered areas into contact with at least one liquid containing catcher molecules, in such a way that said catcher molecules are able to adhere or bond to the surface of the substrate and/or on the surface of the sensors; removing the non-adhering constituents of the liquid and removing the microstructured layer or parts thereof.
摘要翻译：本发明涉及一种生产用于检测样品中不同分析物的检测系统的方法，其特征在于以下步骤：提供具有用于化学，光学或电学检测分析物的传感器的平面或基本上平面的基底; 将已经微结构的层施加到基底上或向基底施加连续的层并且对所述层进行微结构化，所述层以这样的方式被施加，即在彼此分离的基底的区域不被层覆盖的情况下所述层和衬底至少围绕所述未覆盖区域密封地互连; 使至少一些未覆盖区域与至少一种含捕获剂分子的液体接触，使得所述捕获剂分子能够粘附或结合到所述基底的表面和/或所述传感器的表面上; 去除液体的不粘附成分并除去微结构的层或其部分。

8. 发明授权

US5965106A In vivo binding pair pretargeting 失效
标题翻译：体内结合对预靶向
公开(公告)号：US5965106A
公开(公告)日：1999-10-12
申请号：US461267
申请日：1995-06-05
申请人： Nicholas Pomato , Richard P. McCabe , Gregory A. Hawkins , Reinhard Bredehorst , Chong-Ho Kim , Carl-Wilhelm Vogel
发明人： Nicholas Pomato , Richard P. McCabe , Gregory A. Hawkins , Reinhard Bredehorst , Chong-Ho Kim , Carl-Wilhelm Vogel
IPC分类号： A61K47/48 , A61K51/10 , A61K39/395 , A61K51/00
CPC分类号： B82Y5/00 , A61K47/48746 , A61K51/1093 , A61K2121/00
摘要： A method for in-vivo targeting a functional moiety in a patient by administering a targeting moiety coupled to an affinity component, wherein the targeting moiety has affinity for binding sites in a target area, and administering a binding partner to the affinity component coupled to a functional moiety to localize the functional moiety in the target area. Preferably the targeting moiety is an antibody and the functional moiety is a radiometal when performing in vivo imaging or therapy. The affinity component may be a novel methotrexate analog. Preferably, the affinity component is thermo-stabilized.
摘要翻译：一种通过施用与亲和成分偶联的靶向部分来体内靶向患者功能部分的方法，其中所述靶向部分对靶区域中的结合位点具有亲和力，以及将结合配偶体施用于与功能部分以定位目标区域中的功能部分。优选地，靶向部分是抗体，并且当进行体内成像或治疗时，功能部分是放射性金属。亲和成分可以是新型甲氨蝶呤类似物。优选地，亲和性组分是热稳定的。

9. 发明授权

US5578289A In vivo binding pair pretargeting 失效
标题翻译：体内结合对预靶向
公开(公告)号：US5578289A
公开(公告)日：1996-11-26
申请号：US140186
申请日：1993-11-04
申请人： Nicholas Pomato , Richard P. McCabe , Gregory A. Hawkins , Reinhard Bredehorst , Chong-Ho Kim , Carl-Wilhelm E. Vogel
发明人： Nicholas Pomato , Richard P. McCabe , Gregory A. Hawkins , Reinhard Bredehorst , Chong-Ho Kim , Carl-Wilhelm E. Vogel
IPC分类号： A61K38/43 , A61K39/395 , A61K47/48 , A61K49/00 , A61K51/00 , A61K51/10
CPC分类号： B82Y5/00 , A61K47/48746 , A61K51/1093 , A61K2121/00
摘要： A method for in-vivo targeting a functional moiety in a patient by administering a targeting moiety coupled to an affinity component, wherein the targeting moiety has affinity for binding sites in a target area, and administering a binding partner to the affinity component coupled to a functional moiety to localize the functional moiety in the target area. Preferably the targeting moiety is an antibody and the functional moiety is a radiometal when performing in vivo imaging or therapy. The affinity component may be a novel methotrexate analog.
摘要翻译： PCT No.PCT / US93 / 01858 Sec。 371日期：1993年11月4日 102（e）日期1993年11月4日PCT 1993年3月3日PCT公布。出版物WO93 / 17707 日期1993年9月16日一种通过施用与亲和组分偶联的靶向部分来体内靶向患者功能部分的方法，其中靶向部分对靶区域中的结合位点具有亲和力，偶联至功能部分的亲和成分以定位目标区域中的功能部分。优选地，靶向部分是抗体，并且当进行体内成像或治疗时，功能部分是放射性金属。亲和成分可以是新型甲氨蝶呤类似物。

10. 发明授权

US5157123A S-(2-thiopyridyl)-L-cysteine, a heterobifunctional crosslinking reagent 失效
标题翻译： S-（2-噻吩基）-L- CYSTEINE，一种异构交联试剂
公开(公告)号：US5157123A
公开(公告)日：1992-10-20
申请号：US322214
申请日：1989-03-13
申请人： Jane J. Zara , Richard D. Wood , Reinhard Bredehorst , Carl-Wilhelm Vogel
发明人： Jane J. Zara , Richard D. Wood , Reinhard Bredehorst , Carl-Wilhelm Vogel
IPC分类号： C07C323/59 , C07D213/71 , G01N33/543
CPC分类号： C07D213/71 , C07C323/59 , G01N33/54353
摘要： Site-specific heterobifunctional crosslinkers of the formula:X--COCH(NH.sub.2)--Y--Zwhere X is a carbonyl reactive group, Y is a variable length spacer, and Z is a thiol reactive group, are useful for the specific labelling of biomolecules or bioaffecting molecules.
摘要翻译：具有下式的位点特异性异双功能交联剂：X-COCH（NH2）-YZ，其中X是羰基反应性基团，Y是可变长度的间隔基，Z是硫醇反应性基团，可用于生物分子或生物吸附的特异性标记分子。

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