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1. 发明申请

US20210236542A1 NOVEL GOLD-BASED NANOCRYSTALS FOR MEDICAL TREATMENTS AND ELECTROCHEMICAL MANUFACTURING PROCESSES THEREFOR 有权
公开(公告)号：US20210236542A1
公开(公告)日：2021-08-05
申请号：US17223336
申请日：2021-04-06
申请人： Mark Gordon Mortenson , D. Kyle Pierce , David A. Bryce , Reed N. Wilcox , Anthony Lockett , Mikhail Merzliakov
发明人： Mark Gordon Mortenson , D. Kyle Pierce , David A. Bryce , Reed N. Wilcox , Anthony Lockett , Mikhail Merzliakov
IPC分类号： A61K33/24 , B22F1/00 , B22F9/00 , B82Y30/00 , C30B7/12 , C30B29/02 , C30B29/60 , A61K9/10 , A61K47/02 , A61K9/00 , A61K9/14 , A61K9/08
摘要： The present invention relates to novel gold nanocrystals and nanocrystal shape distributions that have surfaces that are substantially free from organic impurities or films. Specifically, the surfaces are “clean” relative to the surfaces of gold nanoparticles made using chemical reduction processes that require organic reductants and/or surfactants to grow gold nanoparticles from gold ions in solution.
The invention includes novel electrochemical manufacturing apparatuses and techniques for making the gold-based nanocrystals. The invention further includes pharmaceutical compositions thereof and the use of the gold nanocrystals or suspensions or colloids thereof for the treatment or prevention of diseases or conditions for which gold therapy is already known and more generally for conditions resulting from pathological cellular activation, such as inflammatory (including chronic inflammatory) conditions, autoimmune conditions, hypersensitivity reactions and/or cancerous diseases or conditions. In one embodiment, the condition is mediated by MIF (macrophage migration inhibiting factor).

2. 发明授权

US09603870B2 Gold-based nanocrystals for medical treatments and electrochemical manufacturing processes therefor 有权
公开(公告)号：US09603870B2
公开(公告)日：2017-03-28
申请号：US13382781
申请日：2010-07-08
申请人： Mark Gordon Mortenson , D. Kyle Pierce , David A. Bryce , Adam R. Dorfman , Reed N. Wilcox , Anthony Lockett , Mikhail Merzliakov
发明人： Mark Gordon Mortenson , D. Kyle Pierce , David A. Bryce , Adam R. Dorfman , Reed N. Wilcox , Anthony Lockett , Mikhail Merzliakov
IPC分类号： A61K33/24 , B22F1/00 , B22F9/00 , B82Y30/00 , C30B7/12 , C30B29/02 , C30B29/60 , A61K9/08 , A61K47/02 , A61K9/00 , A61K9/14 , A61K9/10
CPC分类号： A61K33/24 , A61K9/0095 , A61K9/08 , A61K9/10 , A61K9/14 , A61K47/02 , B22F1/0022 , B22F9/00 , B22F2001/0037 , B82Y30/00 , C30B7/12 , C30B29/02 , C30B29/60 , Y02A50/401 , Y02A50/411
摘要： The present invention relates to novel gold nanocrystals and nanocrystal shape distributions that have surfaces that are substantially free from organic impurities or films. Specifically, the surfaces are “clean” relative to the surfaces of gold nanoparticles made using chemical reduction processes that require organic reductants and/or surfactants to grow gold nanoparticles from gold ions in solution. The invention includes novel electrochemical manufacturing apparatuses and techniques for making the gold-based nanocrystals. The invention further includes pharmaceutical compositions thereof and the use of the gold nanocrystals or suspensions or colloids thereof for the treatment or prevention of diseases or conditions for which gold therapy is already known and more generally for conditions resulting from pathological cellular activation, such as inflammatory (including chronic inflammatory) conditions, autoimmune conditions, hypersensitivity reactions and/or cancerous diseases or conditions In one embodiment, the condition is mediated by MIF (macrophage migration inhibiting factor).

3. 发明授权

US07600817B2 Chair 有权
标题翻译：椅子
公开(公告)号：US07600817B2
公开(公告)日：2009-10-13
申请号：US11204609
申请日：2005-08-16
申请人： Kenneth L. Kramer , Marshall S. Dahneke , Reed N. Wilcox , David T. Schwanemann , John P. Biondo , Francis C. Ganance , Scott A. Schultz , Russell L. Hardy , Troy D. Acton
发明人： Kenneth L. Kramer , Marshall S. Dahneke , Reed N. Wilcox , David T. Schwanemann , John P. Biondo , Francis C. Ganance , Scott A. Schultz , Russell L. Hardy , Troy D. Acton
IPC分类号： B60N2/02
CPC分类号： A47C7/506 , A47C1/022 , A47C1/023 , A47C1/03 , A47C1/035 , A47C1/0352 , A47C3/38 , A47C7/54 , A47C7/62 , A47C7/70 , A47C7/72 , A47C7/725 , A47C7/748 , A47C31/008 , F16H25/16 , Y10S297/10 , Y10T74/18664
摘要： A chair with articulable support sections and an integrated lift system may have support sections mechanically linked such that a single actuation control device may articulate multiple sections. The chair includes configurable accessories directed to the comfort of an occupant of the chair. The support sections may include air cells to adjust firmness of support section surfaces.
摘要翻译：具有可铰接支撑部分和集成升降系统的椅子可以具有机械连接的支撑部分，使得单个致动控制装置可以铰接多个部分。椅子包括针对椅子乘员舒适的可配置配件。支撑部分可以包括气泡以调节支撑部分表面的坚固度。

4. 发明授权

US5562451A Craft art product including three-dimensional bead matrix designs 失效
标题翻译：工艺美术产品包括三维珠矩阵设计
公开(公告)号：US5562451A
公开(公告)日：1996-10-08
申请号：US272790
申请日：1994-07-08
申请人： Reed N. Wilcox , Richard L. George , William K. Thiess , John T. Loftus, Jr. , Timothy F. O'Meara , William H. Lichfield
发明人： Reed N. Wilcox , Richard L. George , William K. Thiess , John T. Loftus, Jr. , Timothy F. O'Meara , William H. Lichfield
IPC分类号： B44D2/00 , B44D3/00 , B44D3/22 , C09D5/28 , G09B11/00 , G09B11/10 , G09B19/00 , G09B19/10
CPC分类号： B44D2/00 , B44D3/00 , B44D3/003 , B44D3/22 , C09D5/28 , G09B11/00 , G09B11/10 , G09B19/0023 , G09B19/10
摘要： A novel craft art form product, system and method including patterns, paint, and applicators enables craft paint to form three-dimensional color bead matrix patterns having high degree of visual resolution and color saturation. Precisely located and closely spaced geometric shapes associated with a set of color symbols are used to form matrix designs in patterns. Each symbol represents an artistic expression which is assigned to a particular color. Each color symbol has a color darkness value which may also correspond to the darkness value of the assigned color. The craft paint material has the characteristics of forming a discrete substantially uniform and homogeneous, three-dimensional bead to overlay the color symbol associated with each geometric shape. The craft paint material can form discrete beads placed closely together without running together, yet retain sufficient fluidity to settle into smooth, substantially uniform beads. A fine tip applicator applies the craft paint material to each geometric shape.
摘要翻译：一种新颖的工艺艺术形式的产品，系统和方法，包括图案，油漆和涂布器，使工艺油漆形成具有高度视觉分辨率和色饱和度的三维色珠矩阵图案。使用与一组颜色符号相关联的精确定位和紧密间隔的几何形状来形成图案中的矩阵设计。每个符号表示分配给特定颜色的艺术表现。每个颜色符号具有也可以对应于所分配的颜色的暗度值的颜色深度值。工艺漆材料具有形成离散的基本均匀且均匀的三维珠粒以覆盖与每个几何形状相关联的颜色符号的特征。工艺油漆材料可以形成离散的珠子，紧密地放置在一起，而不会一起移动，但保持足够的流动性，以沉淀成光滑，基本均匀的珠子。精细的喷嘴施加器将工艺油漆材料应用于每个几何形状。

5. 发明授权

US10449217B2 Gold-based nanocrystals for medical treatments and electrochemical manufacturing processes therefor 有权
公开(公告)号：US10449217B2
公开(公告)日：2019-10-22
申请号：US15465092
申请日：2017-03-21
申请人： Mark Gordon Mortenson , D. Kyle Pierce , David A. Bryce , Reed N. Wilcox , Anthony Lockett , Mikhail Merzliakov
发明人： Mark Gordon Mortenson , D. Kyle Pierce , David A. Bryce , Reed N. Wilcox , Anthony Lockett , Mikhail Merzliakov
IPC分类号： A61K33/24 , B22F1/00 , B22F9/00 , B82Y30/00 , C30B7/12 , C30B29/02 , C30B29/60 , A61K9/08 , A61K47/02 , A61K9/00 , A61K9/14 , A61K9/10
摘要： The present invention relates to novel gold nanocrystals and nanocrystal shape distributions that have surfaces that are substantially free from organic impurities or films. Specifically, the surfaces are “clean” relative to the surfaces of gold nanoparticles made using chemical reduction processes that require organic reductants and/or surfactants to grow gold nanoparticles from gold ions in solution.The invention includes novel electrochemical manufacturing apparatuses and techniques for making the gold-based nanocrystals. The invention further includes pharmaceutical compositions thereof and the use of the gold nanocrystals or suspensions or colloids thereof for the treatment or prevention of diseases or conditions for which gold therapy is already known and more generally for conditions resulting from pathological cellular activation, such as inflammatory (including chronic inflammatory) conditions, autoimmune conditions, hypersensitivity reactions and/or cancerous diseases or conditions. In one embodiment, the condition is mediated by MIF (macrophage migration inhibiting factor).

6. 发明申请

US20170348350A1 Novel Gold-Based Nanocrystals for Medical Treatments and Electrochemical Manufacturing Processes Therefor 审中-公开
公开(公告)号：US20170348350A1
公开(公告)日：2017-12-07
申请号：US15465092
申请日：2017-03-21
申请人： Mark Gordon Mortenson , D. Kyle Pierce , David A. Bryce , Reed N. Wilcox , Anthony Lockett , Mikhail Merzliakov
发明人： Mark Gordon Mortenson , D. Kyle Pierce , David A. Bryce , Reed N. Wilcox , Anthony Lockett , Mikhail Merzliakov
IPC分类号： A61K33/24 , C30B29/02 , C30B7/12 , B82Y30/00 , A61K9/08 , A61K9/00 , B22F1/00 , A61K47/02 , A61K9/14 , A61K9/10 , C30B29/60 , B22F9/00
CPC分类号： A61K33/24 , A61K9/0095 , A61K9/08 , A61K9/10 , A61K9/14 , A61K47/02 , B22F1/0022 , B22F9/00 , B22F2001/0037 , B82Y30/00 , C30B7/12 , C30B29/02 , C30B29/60 , Y02A50/401 , Y02A50/411
摘要： The present invention relates to novel gold nanocrystals and nanocrystal shape distributions that have surfaces that are substantially free from organic impurities or films. Specifically, the surfaces are “clean” relative to the surfaces of gold nanoparticles made using chemical reduction processes that require organic reductants and/or surfactants to grow gold nanoparticles from gold ions in solution.The invention includes novel electrochemical manufacturing apparatuses and techniques for making the gold-based nanocrystals. The invention further includes pharmaceutical compositions thereof and the use of the gold nanocrystals or suspensions or colloids thereof for the treatment or prevention of diseases or conditions for which gold therapy is already known and more generally for conditions resulting from pathological cellular activation, such as inflammatory (including chronic inflammatory) conditions, autoimmune conditions, hypersensitivity reactions and/or cancerous diseases or conditions. In one embodiment, the condition is mediated by MIF (macrophage migration inhibiting factor).

7. 发明申请

US20130259903A1 Novel Gold-Based Nanocrystals for Medical Treatments and Electrochemical Manufacturing Processes Therefor 有权
标题翻译：用于医疗治疗和电化学制造工艺的新型金基纳米晶体
公开(公告)号：US20130259903A1
公开(公告)日：2013-10-03
申请号：US13382781
申请日：2010-07-08
申请人： Mark Gordon Mortenson , D. Kyle Pierce , David A. Bryce , Adam R. Dorfman , Reed N. Wilcox , Anthony Lockett , Mikhail Merzliakov
发明人： Mark Gordon Mortenson , D. Kyle Pierce , David A. Bryce , Adam R. Dorfman , Reed N. Wilcox , Anthony Lockett , Mikhail Merzliakov
IPC分类号： A61K33/24 , A61K9/08
CPC分类号： A61K33/24 , A61K9/0095 , A61K9/08 , A61K9/10 , A61K9/14 , A61K47/02 , B22F1/0022 , B22F9/00 , B22F2001/0037 , B82Y30/00 , C30B7/12 , C30B29/02 , C30B29/60 , Y02A50/401 , Y02A50/411
摘要： The present invention relates to novel gold nanocrystals and nanocrystal shape distributions that have surfaces that are substantially free from organic impurities or films. Specifically, the surfaces are “clean” relative to the surfaces of gold nanoparticles made using chemical reduction processes that require organic reductants and/or surfactants to grow gold nanoparticles from gold ions in solution. The invention includes novel electrochemical manufacturing apparatuses and techniques for making the gold-based nanocrystals. The invention further includes pharmaceutical compositions thereof and the use of the gold nanocrystals or suspensions or colloids thereof for the treatment or prevention of diseases or conditions for which gold therapy is already known and more generally for conditions resulting from pathological cellular activation, such as inflammatory (including chronic inflammatory) conditions, autoimmune conditions, hypersensitivity reactions and/or cancerous diseases or conditions In one embodiment, the condition is mediated by MIF (macrophage migration inhibiting factor).
摘要翻译：本发明涉及具有基本上不含有机杂质或膜的表面的新的金纳米晶体和纳米晶体形状分布。具体地说，相对于使用需要有机还原剂和/或表面活性剂的化学还原方法制备的金纳米颗粒的表面，表面是“干净的”，以从溶液中的金离子生长金纳米颗粒。本发明包括用于制造金基纳米晶体的新型电化学制造装置和技术。本发明还包括其药物组合物和金纳米晶体或其悬浮液或胶体用于治疗或预防已知金疗法的疾病或病症，更一般地，用于由病理性细胞活化引起的病症，例如炎性（包括慢性炎症）病症，自身免疫病症，超敏反应和/或癌性疾病或病症在一个实施方案中，该病症由MIF（巨噬细胞迁移抑制因子）介导。

8. 发明申请

US20120043794A1 Chair 有权
标题翻译：椅子
公开(公告)号：US20120043794A1
公开(公告)日：2012-02-23
申请号：US13286528
申请日：2011-11-01
申请人： Kenneth L. KRAMER , Marshall S. Dahneke , Reed N. Wilcox , David T. Schwanemann , John P. Biondo , Francis C. Ganance , Scott A. Schultz , Russell L. Hardy , Troy D. Acton
发明人： Kenneth L. KRAMER , Marshall S. Dahneke , Reed N. Wilcox , David T. Schwanemann , John P. Biondo , Francis C. Ganance , Scott A. Schultz , Russell L. Hardy , Troy D. Acton
IPC分类号： A47C7/02
CPC分类号： A47C7/506 , A47C1/022 , A47C1/023 , A47C1/03 , A47C1/035 , A47C1/0352 , A47C3/38 , A47C7/54 , A47C7/62 , A47C7/70 , A47C7/72 , A47C7/725 , A47C7/748 , A47C31/008 , F16H25/16 , Y10S297/10 , Y10T74/18664
摘要： A chair with articulable support sections and an integrated lift system may have support sections mechanically linked such that a single actuation control device may articulate multiple sections. The chair includes configurable accessories directed to the comfort of an occupant of the chair. The support sections may include air cells to adjust firmness of support section surfaces.
摘要翻译：具有可铰接支撑部分和集成升降系统的椅子可以具有机械连接的支撑部分，使得单个致动控制装置可以铰接多个部分。椅子包括针对椅子乘员舒适的可配置配件。支撑部分可以包括气泡以调节支撑部分表面的坚固度。

9. 发明授权

US6099378A Realistic doll head system and method therefor 失效
标题翻译：现实娃娃头系统及其方法
公开(公告)号：US6099378A
公开(公告)日：2000-08-08
申请号：US256795
申请日：1999-02-24
申请人： Richard L. George , Reed N. Wilcox , W. Kenn Thiess , Lane Anderson
发明人： Richard L. George , Reed N. Wilcox , W. Kenn Thiess , Lane Anderson
IPC分类号： A63H3/36
CPC分类号： A63H3/365
摘要： The present invention provides a system and method for producing realistic doll heads that have the facial appearance of particular children. The customer, using ten facial characteristics set forth in a chart, selects from among a predetermined number of facial characteristics those most closely resembling the facial appearance of the child. The facial characteristics that are selected comprise seven face shapes (rounded, oval, pear, rectangular, thinner rectangular, thinner heart, and wider heart); skin tone; eye color; eyelash color; eyebrow color, thickness, and shape; hair color, cut, length, and style; and birthmarks, moles, and/or freckles. The selected characteristics are then applied to the doll head to produce a one-of-a-kind doll closely resembling the child.
摘要翻译：本发明提供一种用于生产具有特定儿童的面部外观的逼真的玩偶头的系统和方法。使用图表中提出的十个面部特征的顾客从预定数量的面部特征中选出最类似于儿童的面部外观的面部特征。所选择的面部特征包括七个面部形状（圆形，椭圆形，梨形，矩形，较薄的矩形，较薄的心脏和更宽的心脏）; 肤色; 眼睛的颜色; 睫毛颜色眉毛颜色，厚度和形状; 头发颜色，剪裁，长度和风格; 和胎记，痣和/或雀斑。然后将所选择的特征应用于娃娃头以产生与儿童非常相似的独一无二的娃娃。

10. 发明授权

US5263787A Inverted cap for craft paint applicators 失效
标题翻译：工艺漆涂装机倒盖
公开(公告)号：US5263787A
公开(公告)日：1993-11-23
申请号：US888552
申请日：1992-05-22
申请人： Reed N. Wilcox , Richard L. George , William K. Thiess
发明人： Reed N. Wilcox , Richard L. George , William K. Thiess
IPC分类号： B43K23/00 , B43K23/08 , B43M11/00 , B65D41/04 , B65D51/24 , B43K9/00
CPC分类号： B65D41/04 , B43K23/002 , B43K23/08 , B43M11/00 , B65D51/249
摘要： A holder having a sealing cap portion for craft paint applicators. The holder includes a lower base portion with an interior cavity formed in the upper portion of the holder. A threaded portion is formed therein for mating engagement with a threaded portion on the applicator bottle. The interior cavity terminates in an end wall portion that seals the dispensing end of the applicator tip from air circulation and from leakage. The applicator is inserted in the interior cavity of the holder and twisted to lock the applicator tip in the holder so the applicator tip is sealed within the holder. This allows the base portion of the holder to support the applicator in a inverted position. Since the applicator is inverted, craft paint is always in fluid contact with the inner surfaces of the applicator tip. This prevents the craft paint from drying and clogging the applicator tip and also keeps any air in the applicator at the end of the applicator opposing the applicator tip to minimize the formation of air bubbles in the flow of the craft paint.
摘要翻译：具有用于工艺涂料器的密封盖部分的保持器。保持器包括下部基部，其具有形成在保持器的上部中的内部空腔。在其中形成有螺纹部分，用于与施加器瓶上的螺纹部分配合接合。内部空腔终止在端壁部分中，该端壁部分将施用器尖端的分配端部与空气循环和泄漏密封。涂抹器插入保持器的内腔中并扭曲以将施用器尖端锁定在保持器中，使得施用器尖端被密封在保持器内。这允许保持器的基部以倒置位置支撑施用器。由于涂抹器被倒置，工艺漆总是与施用器尖端的内表面流体接触。这防止工艺漆干燥并堵塞施用器尖端，并且还将施用器中的任何空气保持在施用器的与施加器尖端相对的端部，以最小化在工艺涂料流动中气泡的形成。

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