专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20090246771A1 COMPOSITIONS AND METHODS COMPRISING BIOMARKERS OF SPERM QUALITY, SEMEN QUALITY AND FERTILITY 审中-公开
标题翻译：组合物和方法包括生物标志物质量，质量和品质
公开(公告)号：US20090246771A1
公开(公告)日：2009-10-01
申请号：US12264048
申请日：2008-11-03
申请人： Peter W. Laird , Sahar Houshdaran , Victoria Cortessis , Kimberly D. Siegmund , Rebecca Z. Sokol
发明人： Peter W. Laird , Sahar Houshdaran , Victoria Cortessis , Kimberly D. Siegmund , Rebecca Z. Sokol
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2523/125 , C12Q2600/136 , C12Q2600/154
摘要： Provided are compositions and methods for determining or diagnosing abnormal sperm or fertility, comprising: obtaining sperm DNA from a test subject; determining the methylation status of at least one CpG dinucleotide sequence of at least one gene sequence selected from HRAS, NTF3, MT1A, PAX8, DIRAS3, PLAGL1, SFN, SAT2CHRM1, MEST, RNR1, CYP27B1 and ICAM1; and thereby determining or diagnosing abnormal sperm or fertility. Provided are compositions and methods for identifying agents that cause spermatogenic deficits or abnormal sperm fertility, comprising: obtaining human ES-cell derived primordial germ cells; contacting the germ cells or descendants thereof, with a test agent; culturing the contacted cells; determining, using a genomic DNA of the sample, the methylation status of at least one CpG dinucleotide sequence of at least one gene sequence selected from the above group; and identifying at least one test agent that causes at least one of spermatogenic deficits, abnormal sperm, and abnormal fertility.
摘要翻译：提供了用于确定或诊断异常精子或生殖力的组合物和方法，包括：从测试对象获得精子DNA; 确定至少一个选自HRAS，NTF3，MT1A，PAX8，DIRAS3，PLAGL1，SFN，SAT2CHRM1，MEST，RNR1，CYP27B1和ICAM1的基因序列的至少一个CpG二核苷酸序列的甲基化状态; 从而确定或诊断异常精子或生育能力。提供了用于鉴定引起精子发生缺陷或异常精子生殖力的药剂的组合物和方法，其包括：获得人ES细胞衍生的原始生殖细胞; 使生殖细胞或其后代与测试剂接触; 培养接触细胞; 使用所述样品的基因组DNA确定至少一种选自上述基团的至少一个基因序列的至少一个CpG二核苷酸序列的甲基化状态; 并鉴定至少一种导致精子发生缺陷，异常精子和异常生育力中的至少一种的试剂。

2. 发明申请

US20100124747A1 COMPOSITIONS AND METHODS FOR DIAGNOSIS OR PROGNOSIS OF TESTICULAR CANCER 审中-公开
标题翻译：用于诊断或预防特发性癌症的组合物和方法
公开(公告)号：US20100124747A1
公开(公告)日：2010-05-20
申请号：US12611309
申请日：2009-11-03
申请人： Peter W. Laird , Sahar Houshdaran , Victoria Cortessis , Kimberly D. Siegmund , Rebecca Z. Sokol
发明人： Peter W. Laird , Sahar Houshdaran , Victoria Cortessis , Kimberly D. Siegmund , Rebecca Z. Sokol
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/154
摘要： Provided are compositions and methods for diagnosis or prognosis of testicular or male germ-cell derived cancer, comprising: obtaining sperm DNA from a test subject; determining the methylation status of at least one CpG dinucleotide sequence of at least one gene sequence selected from HRAS, NTF3, MT1A, PAX8, DIRAS3, PLAGL1, SFN, SAT2CHRM1, MEST, RNR1, CYP27B1 and ICAM1; and thereby determining or diagnosing testicular or male germ-cell derived cancer. Provided are compositions and methods for identifying agents that cause testicular or male germ-cell derived cancer, comprising: obtaining human ES-cell derived primordial germ cells; contacting the germ cells or descendants thereof, with a test agent; culturing the contacted cells; determining, using a genomic DNA of the sample, the methylation status of at least one CpG dinucleotide sequence of at least one gene sequence selected from the above group; and identifying at least one test agent that causes testicular or male germ-cell derived cancer.
摘要翻译：提供了用于睾丸或雄性生殖细胞衍生癌症的诊断或预后的组合物和方法，包括：从测试受试者获得精子DNA; 确定至少一个选自HRAS，NTF3，MT1A，PAX8，DIRAS3，PLAGL1，SFN，SAT2CHRM1，MEST，RNR1，CYP27B1和ICAM1的基因序列的至少一个CpG二核苷酸序列的甲基化状态; 从而确定或诊断睾丸或雄性生殖细胞衍生的癌症。提供用于鉴定导致睾丸或雄性生殖细胞衍生的癌症的药剂的组合物和方法，包括：获得人ES细胞衍生的原始生殖细胞; 使生殖细胞或其后代与测试剂接触; 培养接触细胞; 使用所述样品的基因组DNA确定至少一种选自上述基团的至少一个基因序列的至少一个CpG二核苷酸序列的甲基化状态; 并鉴定至少一种导致睾丸或雄性生殖细胞衍生的癌症的测试试剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式