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1. 发明授权

US07955559B2 Nanoelectronic electrochemical test device 有权
标题翻译：纳米电子电化学试验装置
公开(公告)号：US07955559B2
公开(公告)日：2011-06-07
申请号：US12146320
申请日：2008-06-25
申请人： Kanchan A. Joshi , Ray Radtkey , Christian Valcke
发明人： Kanchan A. Joshi , Ray Radtkey , Christian Valcke
IPC分类号： D01F9/12
CPC分类号： G01N27/3272 , A61B5/14532 , A61B5/14535 , A61B5/1486 , A61B5/14865 , B82Y10/00 , B82Y15/00 , C12Q1/006 , G01N27/4145 , G01N27/4146 , H01L51/0049 , H01L51/0093 , H01L51/0545 , Y10S977/723
摘要： Nanoelectronic devices for the detection and quantification of biomolecules are Provided. In certain embodiments, the devices are configured to detect and measure blood glucose levels. Also provided are methods of fabricating nanoelectronic devices for the detection of biomolecules.
摘要翻译：提供用于检测和定量生物分子的纳米电子器件。在某些实施例中，装置被配置为检测和测量血糖水平。还提供了制造用于检测生物分子的纳米电子器件的方法。

2. 发明申请

US20080185295A1 ELECTROCHEMICAL NANOSENSORS FOR BIOMOLECULE DETECTION 有权
标题翻译：用于生物分子检测的电化学纳米传感器
公开(公告)号：US20080185295A1
公开(公告)日：2008-08-07
申请号：US11868373
申请日：2007-10-05
申请人： Mikhail BRIMAN , Ray RADTKEY , Eugene TU , Christian VALCKE
发明人： Mikhail BRIMAN , Ray RADTKEY , Eugene TU , Christian VALCKE
IPC分类号： G01N27/327 , G01N27/26 , G01N27/40 , G01N27/30
CPC分类号： G01N27/026 , G01N27/3271 , G01N27/3275 , G01N27/3277 , G01N27/3278 , G01N33/5438
摘要： Sensor devices, methods and kits for detection of biomolecules are provided. According to various embodiments, the devices, methods and kits provide enhanced sensitivity through the measurement of electrochemical impedance and related properties. Certain embodiments employ nanostructured electrode elements including nanotubes, nanoparticles, nanowires, and nanocones. In a particular embodiment, single walled carbon nanotubes disposed in interconnected networks are used as electrodes. The device, methods and kits described herein have application for detection and measurement of biomolecular species including polynucleotides, proteins, polysaccharides and the like.
摘要翻译：提供了用于检测生物分子的传感器装置，方法和试剂盒。根据各种实施例，器件，方法和试剂盒通过测量电化学阻抗和相关性质提供增强的灵敏度。某些实施例采用包括纳米管，纳米颗粒，纳米线和纳米骨的纳米结构电极元件。在特定实施例中，布置在互连网络中的单壁碳纳米管用作电极。本文描述的装置，方法和试剂盒具有用于检测和测量生物分子物质的应用，包括多核苷酸，蛋白质，多糖等。

3. 发明申请

US20100268106A1 BREATH CONDENSATE SAMPLER AND DETECTOR AND BREATH/BREATH CONDENSATE SAMPLER AND DETECTOR 有权
标题翻译：呼吸冷凝器和探测器和呼吸器/呼吸器冷凝器和检测器
公开(公告)号：US20100268106A1
公开(公告)日：2010-10-21
申请号：US12761290
申请日：2010-04-15
申请人： Bradley N. Johnson , Kanchan Joshi , Ying-Lan Chang , Ray Radtkey
发明人： Bradley N. Johnson , Kanchan Joshi , Ying-Lan Chang , Ray Radtkey
IPC分类号： A61B5/097
CPC分类号： A61B5/097 , A61B5/0803 , A61B5/082 , A61B5/14539 , B82Y30/00 , G01N33/497 , G01N2001/2282
摘要： The present invention provides a direct sampler and detector for analytes found in exhaled breath condensate. Analytes in the breath condensate are detected instantaneously as they condense prior to reaching the sensor surface or condense directly on the sensor surface. Because the analysis or assay is performed immediately after patient exhalation, analyte stability is significantly improved providing accurate, reliable, consistent, and clinically applicable results. In certain embodiments, combined breath condensate/breath samplers and detectors are provided, enabling multiplexed analysis of condensed and vapor-phase analytes provided in a single sampling session. Breath is collected and directed to one or more subsystems. Within each subsystem, the breath portion is either condensed or prevented from condensing. The technique also allows real-time continuous monitoring, thus allowing immediate feedback to both medical professionals and additional hardware such as ventilators, anesthesia machines, drug infusion systems and cardiac pacemakers.
摘要翻译：本发明提供了一种用于呼出凝结水中分析物的直接取样器和检测器。呼吸冷凝液中的分析物在到达传感器表面之前凝结，或者直接凝结在传感器表面上瞬间被检测到。因为在患者呼气后立即进行分析或测定，所以分析物的稳定性得到显着改善，可提供准确，可靠，一致和临床适用的结果。在某些实施方案中，提供组合的呼吸冷凝物/呼吸取样器和检测器，使得能够对在单个采样会话中提供的冷凝和气相分析物进行复用分析。呼吸被收集并引导到一个或多个子系统。在每个子系统内，呼吸部分被冷凝或防止冷凝。该技术还允许实时连续监测，从而允许立即反馈医疗专业人员和附加硬件，如呼吸机，麻醉机，药物输注系统和心脏起搏器。

4. 发明申请

US20090084678A1 NANOELECTRONIC ELECTROCHEMICAL TEST DEVICE 有权
标题翻译：纳米电子电化学测试装置
公开(公告)号：US20090084678A1
公开(公告)日：2009-04-02
申请号：US12146320
申请日：2008-06-25
申请人： Kanchan A. Joshi , Ray Radtkey , Christian Valcke
发明人： Kanchan A. Joshi , Ray Radtkey , Christian Valcke
IPC分类号： G01N27/416 , C12N11/14 , B82B1/00
CPC分类号： G01N27/3272 , A61B5/14532 , A61B5/14535 , A61B5/1486 , A61B5/14865 , B82Y10/00 , B82Y15/00 , C12Q1/006 , G01N27/4145 , G01N27/4146 , H01L51/0049 , H01L51/0093 , H01L51/0545 , Y10S977/723
摘要： Nanoelectronic devices for the detection and quantification of biomolecules are Provided. In certain embodiments, the devices are configured to detect and measure blood glucose levels. Also provided are methods of fabricating nanoelectronic devices for the detection of biomolecules.
摘要翻译：提供用于检测和定量生物分子的纳米电子器件。在某些实施例中，装置被配置为检测和测量血糖水平。还提供了制造用于检测生物分子的纳米电子器件的方法。

5. 发明申请

US20120018301A1 NANOELECTRONIC ELECTROCHEMICAL TEST DEVICE 有权
标题翻译：纳米电子电化学测试装置
公开(公告)号：US20120018301A1
公开(公告)日：2012-01-26
申请号：US13092869
申请日：2011-04-22
申请人： Kanchan A. Joshi , Ray Radtkey , Christian Valcke
发明人： Kanchan A. Joshi , Ray Radtkey , Christian Valcke
IPC分类号： G01N33/66 , G01N27/327 , B05D5/12 , B82Y40/00 , B82Y5/00
CPC分类号： G01N27/3272 , A61B5/14532 , A61B5/14535 , A61B5/1486 , A61B5/14865 , B82Y10/00 , B82Y15/00 , C12Q1/006 , G01N27/4145 , G01N27/4146 , H01L51/0049 , H01L51/0093 , H01L51/0545 , Y10S977/723
摘要： Nanoelectronic devices for the detection and quantification of biomolecules are provided. In certain embodiments, the devices are configured to detect and measure blood glucose levels. Also provided are methods of fabricating nanoelectronic devices for the detection of biomolecules.
摘要翻译：提供了用于检测和定量生物分子的纳米电子器件。在某些实施例中，装置被配置为检测和测量血糖水平。还提供了制造用于检测生物分子的纳米电子器件的方法。

6. 发明申请

US20070020671A1 Method for detecting large mutations and duplications using control amplification comparisons to paralogous genes 审中-公开
标题翻译：使用对旁系同源基因的对照扩增比较检测大突变和重复的方法
公开(公告)号：US20070020671A1
公开(公告)日：2007-01-25
申请号：US11485167
申请日：2006-07-12
申请人： Ray Radtkey , Douglas Whitman , Graham Lidgard
发明人： Ray Radtkey , Douglas Whitman , Graham Lidgard
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6886 , C12Q1/6883 , C12Q2600/16 , C12Q2600/172
摘要： Methods for querying biological samples to detect genetic mutations, particularly insertions and deletions, by co-amplification of a gene of interest in conjunction with a paralogous gene. When the gene of interest and the corresponding paralogous gene are selected from the CYP450 family, the resulting ratios may predict how a particular patient metabolizes certain prescription drugs.
摘要翻译：通过与旁系同源基因共同扩增感兴趣的基因来查询生物样品以检测遗传突变，特别是插入和缺失的方法。当感兴趣的基因和相应的旁系同源基因选自CYP450家族时，所得到的比例可以预测特定患者如何代谢某些处方药物。

7. 发明授权

US08425745B2 Electrochemical nanosensors for biomolecule detection 有权
标题翻译：用于生物分子检测的电化学纳米传感器
公开(公告)号：US08425745B2
公开(公告)日：2013-04-23
申请号：US11868373
申请日：2007-10-05
申请人： Mikhail Briman , Ray Radtkey , Eugene Tu , Christian Valcke
发明人： Mikhail Briman , Ray Radtkey , Eugene Tu , Christian Valcke
IPC分类号： G01N27/416
CPC分类号： G01N27/026 , G01N27/3271 , G01N27/3275 , G01N27/3277 , G01N27/3278 , G01N33/5438
摘要： Sensor devices, methods and kits for detection of biomolecules are provided. According to various embodiments, the devices, methods and kits provide enhanced sensitivity through the measurement of electrochemical impedance and related properties. Certain embodiments employ nanostructured electrode elements including nanotubes, nanoparticles, nanowires, and nanocones. In a particular embodiment, single walled carbon nanotubes disposed in interconnected networks are used as electrodes. The device, methods and kits described herein have application for detection and measurement of biomolecular species including polynucleotides, proteins, polysaccharides and the like.
摘要翻译：提供了用于检测生物分子的传感器装置，方法和试剂盒。根据各种实施例，器件，方法和试剂盒通过测量电化学阻抗和相关性质提供增强的灵敏度。某些实施例采用包括纳米管，纳米颗粒，纳米线和纳米骨的纳米结构电极元件。在特定实施例中，布置在互连网络中的单壁碳纳米管用作电极。本文描述的装置，方法和试剂盒具有用于检测和测量生物分子物质的应用，包括多核苷酸，蛋白质，多糖等。

8. 发明授权

US07135283B1 Topoisomerase type II gene polymorphisms and their use in identifying drug resistance and pathogenic strains of microorganisms 有权
标题翻译：拓扑异构酶II型基因多态性及其在鉴定耐药性和微生物致病菌株中的应用
公开(公告)号：US07135283B1
公开(公告)日：2006-11-14
申请号：US09193291
申请日：1998-11-17
申请人： Michael Nerenberg , Ray Radtkey , Prashant Mehta , Dana Vollmer
发明人： Michael Nerenberg , Ray Radtkey , Prashant Mehta , Dana Vollmer
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04 , C12N9/90
CPC分类号： C12N9/90 , C12Q1/689 , C12Q2600/156
摘要： Novel polymorphisms of prokaryotic topoisomerase type II Gyr A, Gyr B and parC gene loci are provided. These polymorphisms differentiate very closely related organisms and provide a means to identify pathogenicity and drug resistance. For example, drug resistance such as resistance to methicillin, a drug which is not metabolically tied to topoisomerase function, may be determined by polymorphisms in the Gyrase A locus. Identification of such drug resistance by such unrelated loci is indicative of heretofore unrecognized [sub]species of Staphylococcus aureus.
摘要翻译：提供了原核型拓扑异构酶II型Gyr A，Gyr B和parC基因位点的新型多态性。这些多态性区分非常密切相关的生物体，并提供鉴定致病性和耐药性的手段。例如，耐药性如耐甲氧西林，一种不代表与拓扑异构酶功能相关的药物，可以通过Gyrase A基因座中的多态性来确定。通过这种不相关的基因座鉴定这种耐药性是迄今为止尚未被认识到的[金]金黄色葡萄球菌的指示。

9. 发明授权

US09357946B2 Breath condensate sampler and detector and breath/breath condensate sampler and detector 有权
标题翻译：呼吸冷凝取样器和检测器和呼吸/呼吸冷凝液取样器和检测器
公开(公告)号：US09357946B2
公开(公告)日：2016-06-07
申请号：US12761290
申请日：2010-04-15
申请人： Bradley N. Johnson , Kanchan Joshi , Ying-Lan Chang , Ray Radtkey
发明人： Bradley N. Johnson , Kanchan Joshi , Ying-Lan Chang , Ray Radtkey
IPC分类号： A61B5/08 , A61B5/097 , A61B5/145 , B82Y30/00 , G01N33/497 , G01N1/22
CPC分类号： A61B5/097 , A61B5/0803 , A61B5/082 , A61B5/14539 , B82Y30/00 , G01N33/497 , G01N2001/2282
摘要： The present invention provides a direct sampler and detector for analytes found in exhaled breath condensate. Analytes in the breath condensate are detected instantaneously as they condense prior to reaching the sensor surface or condense directly on the sensor surface. Because the analysis or assay is performed immediately after patient exhalation, analyte stability is significantly improved providing accurate, reliable, consistent, and clinically applicable results. In certain embodiments, combined breath condensate/breath samplers and detectors are provided, enabling multiplexed analysis of condensed and vapor-phase analytes provided in a single sampling session. Breath is collected and directed to one or more subsystems. Within each subsystem, the breath portion is either condensed or prevented from condensing. The technique also allows real-time continuous monitoring, thus allowing immediate feedback to both medical professionals and additional hardware such as ventilators, anesthesia machines, drug infusion systems and cardiac pacemakers.
摘要翻译：本发明提供了一种用于呼出凝结水中分析物的直接取样器和检测器。呼吸冷凝液中的分析物在到达传感器表面之前凝结，或者直接凝结在传感器表面上瞬间被检测到。因为在患者呼气后立即进行分析或测定，所以分析物的稳定性得到显着改善，可提供准确，可靠，一致和临床适用的结果。在某些实施方案中，提供组合的呼吸冷凝物/呼吸取样器和检测器，使得能够对在单个采样会话中提供的冷凝和气相分析物进行复用分析。呼吸被收集并引导到一个或多个子系统。在每个子系统内，呼吸部分被冷凝或防止冷凝。该技术还允许实时连续监测，从而允许立即反馈医疗专业人员和附加硬件，如呼吸机，麻醉机，药物输注系统和心脏起搏器。

10. 发明授权

US08993346B2 Magnetic carbon nanotube based biodetection 有权
标题翻译：基于磁性碳纳米管的生物检测
公开(公告)号：US08993346B2
公开(公告)日：2015-03-31
申请号：US13389247
申请日：2010-08-06
申请人： Ray Radtkey , Kanchan Joshi , Bradley N. Johnson , Ying-Lan Chang
发明人： Ray Radtkey , Kanchan Joshi , Bradley N. Johnson , Ying-Lan Chang
IPC分类号： G01N33/563 , G01N33/553 , G01N33/543 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B31/02 , G01N27/22
CPC分类号： G01N33/5438 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B32/16 , C01B32/162 , C01B32/174 , G01N27/226
摘要： Provided herein is a new hybrid material system, mCNT, including magnetic carbon nanotubes for biological and medical sensing applications. In certain embodiments, the systems include magnetic material on the interior of carbon nanotubes (CNTs). The amount of magnetic particles inside CNTs may be such that mCNT can respond to small, low cost, portable magnet. The exterior CNT surface is kept intact for biomolecular attachments or other functionalizations. Performance enhancement with this novel material includes improved sensitivity, reduced response time, and reduced sample volume. According to various embodiments, the mCNTs are substrates for the adherence of molecules participating in these assays or as active sensing elements. Also provided are methods of fabricating two-dimensional mCNT and CNT networks on printed electrodes.
摘要翻译：本文提供了一种新的混合材料系统，mCNT，包括用于生物和医学感测应用的磁性碳纳米管。在某些实施例中，系统包括在碳纳米管（CNT）内部的磁性材料。碳纳米管内的磁性颗粒的量可以使得mCNT可以响应于小型，低成本的便携式磁体。外部CNT表面保持完整，用于生物分子附着或其他功能化。这种新型材料的性能增强包括改进的灵敏度，减少的响应时间和减少的样品体积。根据各种实施方案，mCNT是用于粘附参与这些测定的分子或作为主动感测元件的底物。还提供了在印刷电极上制造二维mCNT和CNT网络的方法。

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