专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08124831B2 Transgenic mice carrying functional single nucleotide polymorphisms in brain-specific tryptophan hydroxylase 失效
标题翻译：在脑特异性色氨酸羟化酶中携带功能单核苷酸多态性的转基因小鼠
公开(公告)号：US08124831B2
公开(公告)日：2012-02-28
申请号：US11825202
申请日：2007-07-05
申请人： Marc G. Caron , Xiaodong Zhang , Martin Beaulieu , Raul R. Gainetdinov , Tatyana D. Sotnikova
发明人： Marc G. Caron , Xiaodong Zhang , Martin Beaulieu , Raul R. Gainetdinov , Tatyana D. Sotnikova
IPC分类号： A01K67/027 , G01N33/00
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0356 , C12N9/0071 , C12N15/8509 , C12N2800/30
摘要： Recombinant or transgenic non-human mammals are described having a mutant tryptophan hydroxylase 2 (Tph2) gene resulting in altered synthesis of 5-hydroxytryptophan and serotonin in the brain. In some embodiments the mutant tryptophan hydroxylase 2 gene contains mouse R439H and/or P447R functional mutations, or their corresponding mutations in other species. Congenic non-human mammals having mutant tryptophan hydroxylase 2 genes are also provided. Methods of screening a compound for serotonergic activity or activity in treating a serotonergic neurotransmission dysregulation disorder are provided, which include administering a test compound to a recombinant non-human mammal and then detecting the presence or absence of serotonergic activity, or activity in treating a serotonergic neurotransmission dysregulation disorder, in the mammal. A cell such as a nerve cell (e.g., a central nervous system neuron) isolated from a transgenic or congenic mammal is also disclosed, along with cell cultures containing these cells.
摘要翻译：描述了具有突变色氨酸羟化酶2（Tph2）基因的重组或转基因非人哺乳动物，导致脑中5-羟色胺和5-羟色胺的合成改变。在一些实施方案中，突变色氨酸羟化酶2基因含有小鼠R439H和/或P447R功能性突变或其他物种中相应的突变。还提供了具有突变色氨酸羟化酶2基因的同种非人哺乳动物。提供了筛选化合物用于治疗血清素能神经递质调节障碍的5-羟色胺能活性或活性的方法，其包括向重组非人哺乳动物施用测试化合物，然后检测血清素能活性的存在或不存在或治疗血清素能的活性神经传递异常调节障碍。还公开了从转基因或同基因哺乳动物分离的细胞例如分离自转基因或同种哺乳动物的神经细胞（例如中枢神经系统神经元）以及含有这些细胞的细胞培养物。

2. 发明授权

US08877802B2 Antiparkinsonian action of phenylisopropylamines 有权
标题翻译：苯异丙胺的抗帕金森病作用
公开(公告)号：US08877802B2
公开(公告)日：2014-11-04
申请号：US11460046
申请日：2006-07-26
申请人： Marc G. Caron , Tatyana D. Sotnikova , Raul R. Gainetdinov
发明人： Marc G. Caron , Tatyana D. Sotnikova , Raul R. Gainetdinov
IPC分类号： A61K31/36 , A61K31/135 , A61K31/137
CPC分类号： A61K31/137 , A61K31/198 , A61K31/36 , A61K31/55 , A61K45/06
摘要： A method of treating a subject for Parkinson's disease comprises administering said subject a phenylisopropylamine in an amount effective to treat said Parkinson's disease. In some embodiments the method is used to treat at least a motor symptom of Parkinson's disease; in some embodiments the method is used to treat at least a non-motor symptom of Parkinson's disease.
摘要翻译：一种治疗受试者帕金森病的方法包括以有效治疗所述帕金森病的量给予所述受试者苯基异丙胺。在一些实施方案中，该方法用于治疗帕金森病的至少一种运动症状; 在一些实施方案中，该方法用于治疗帕金森病的至少一种非运动性症状。

3. 发明申请

US20100256116A1 POLYMORPHISM IN TRYPTOPHAN HYDROXYLASE-2 CONTROLS BRAIN SEROTONIN SYNTHESIS 审中-公开
标题翻译： TRYPTOPHAN HYDROXYLASE-2控制脑多糖合成大豆蛋白合成
公开(公告)号：US20100256116A1
公开(公告)日：2010-10-07
申请号：US12510590
申请日：2009-07-28
申请人： Marc G. Caron , Xiaodong Zhang , Martin Beaulieu , Raul R. Gainetdinov , Tatiana D. Sotnikova , Ranga R. Krishnan , David A. Schwartz , Redford B. Williams , Lauranell Burch
发明人： Marc G. Caron , Xiaodong Zhang , Martin Beaulieu , Raul R. Gainetdinov , Tatiana D. Sotnikova , Ranga R. Krishnan , David A. Schwartz , Redford B. Williams , Lauranell Burch
IPC分类号： A61K31/55 , C12Q1/68 , A61K31/131 , A61K31/135 , A61K31/343 , A61K31/4525 , A61P25/24
CPC分类号： A61K45/06 , A61K31/137 , A61K31/14 , A61K31/343 , A61K31/405 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156
摘要： A method of screening a subject for a serotonergic neurotransmission dysregulation disorder comprises detecting the presence or absence of an Tph2 mutation in the subject; and then determining that the subject is at increased risk of a serotonergic neurotransmission dysregulation disorder due to the presence or absence of the Tph2 mutation.
摘要翻译：筛选受试者血清素能神经递质调节障碍的方法包括检测受试者中Tph2突变的存在或不存在; 然后确定由于存在或不存在Tph2突变，受试者处于血清素能神经传递失调障碍的风险增加。

4. 发明授权

US07763437B1 Methods for identifying compounds that regulate β-Arrestin signaling complexes 有权
标题翻译：鉴定化合物的方法 - 调节和抑制--Arrestin信号复合物
公开(公告)号：US07763437B1
公开(公告)日：2010-07-27
申请号：US11482277
申请日：2006-07-07
申请人： Marc G. Caron , Martin Beaulieu , Raul R. Gainetdinov , Tatiana D. Sotnikova , Sébastien Marion
发明人： Marc G. Caron , Martin Beaulieu , Raul R. Gainetdinov , Tatiana D. Sotnikova , Sébastien Marion
IPC分类号： G01N33/53
CPC分类号： G01N33/74 , G01N2333/726
摘要： A method of screening a candidate compound for βArrestin mediated anti-G protein coupled receptor signaling activity is comprises: (a) contacting said candidate compound to a βArrestin signaling complex or a constituent thereof, under conditions in which a signaling complex is formed; and then (b) detecting the presence or absence of disruption of said signaling complex, disruption of said complex indicating said compound has βArrestin mediated anti-G protein coupled receptor signaling activity. Compositions and kits for carrying out the method are also described.
摘要翻译：一种筛选候选化合物以控制Arrestin介导的抗G蛋白偶联受体信号传导活性的方法包括：（a）在信号传导复合体是在其下的条件下将所述候选化合物与一种Arrestin信号传导复合物或其组分接触形成然后（b）检测所述信号复合物的破坏的存在或不存在，指示所述化合物的所述复合物的破坏具有Arrestin介导的抗G蛋白偶联受体信号传导活性。还描述了用于实施该方法的组合物和试剂盒。

5. 发明授权

US07585627B2 Polymorphism in tryptophan hydroxylase-2 controls brain serotonin synthesis 有权
标题翻译：色氨酸羟化酶-2的多态性控制脑血清素的合成
公开(公告)号：US07585627B2
公开(公告)日：2009-09-08
申请号：US11133949
申请日：2005-05-20
申请人： Marc G. Caron , Xiaodong Zhang , Martin Beaulieu , Raul R. Gainetdinov , Tatiana D. Sotnikova , Ranga R. Krishnan , David A. Schwartz , Lauranell Burch , Redford B. Williams
发明人： Marc G. Caron , Xiaodong Zhang , Martin Beaulieu , Raul R. Gainetdinov , Tatiana D. Sotnikova , Ranga R. Krishnan , David A. Schwartz , Lauranell Burch , Redford B. Williams
IPC分类号： C12Q1/68 , G01N33/567 , C12P19/34
CPC分类号： A61K45/06 , A61K31/137 , A61K31/14 , A61K31/343 , A61K31/405 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156
摘要： A method of screening a subject for a serotonergic neurotransmission dysregulation disorder comprises detecting the presence or absence of an Tph2 mutation in the subject; and then determining that the subject is at increased risk of a serotonergic neurotransmission dysregulation disorder due to the presence or absence of the Tph2 mutation.
摘要翻译：筛选受试者血清素能神经递质调节障碍的方法包括检测受试者中Tph2突变的存在或不存在; 然后确定由于存在或不存在Tph2突变，受试者处于血清素能神经传递失调障碍的风险增加。

6. 发明授权

US07999075B2 Methods for identifying compounds that regulate beta-arrestin signaling complexes 有权
标题翻译：鉴定调节β-抑制蛋白信号复合物的化合物的方法
公开(公告)号：US07999075B2
公开(公告)日：2011-08-16
申请号：US12816764
申请日：2010-06-16
申请人： Marc G. Caron , Martin Beaulieu , Raul R. Gainetdinov , Tatiana D. Sotnikova , Sébastien Marion
发明人： Marc G. Caron , Martin Beaulieu , Raul R. Gainetdinov , Tatiana D. Sotnikova , Sébastien Marion
IPC分类号： C12N11/18 , C12N9/12 , C12N9/14 , C07K14/47
CPC分类号： G01N33/74 , G01N2333/726
摘要： A method of screening a candidate compound for βArrestin mediated anti-G protein coupled receptor signaling activity is comprises: (a) contacting said candidate compound to a βArrestin signaling complex or a constituent thereof, under conditions in which a signaling complex is formed; and then (b) detecting the presence or absence of disruption of said signaling complex, disruption of said complex indicating said compound has βArrestin mediated anti-G protein coupled receptor signaling activity. Compositions and kits for carrying out the method are also described.
摘要翻译：一种筛选候选化合物以控制Arrestin介导的抗G蛋白偶联受体信号传导活性的方法包括：（a）在信号传导复合体是在其下的条件下将所述候选化合物与一种Arrestin信号传导复合物或其组分接触形成然后（b）检测所述信号复合物的破坏的存在或不存在，指示所述化合物的所述复合物的破坏具有Arrestin介导的抗G蛋白偶联受体信号传导活性。还描述了用于实施该方法的组合物和试剂盒。

7. 发明申请

US20100255498A1 METHODS FOR IDENTIFYING COMPOUNDS THAT REGULATE BETA-ARRESTIN SIGNALING COMPLEXES 有权
标题翻译：用于鉴定化合物的方法，所述化合物调节β-阿霉素信号复合物
公开(公告)号：US20100255498A1
公开(公告)日：2010-10-07
申请号：US12816764
申请日：2010-06-16
申请人： Marc G. Caron , Martin Beaulieu , Raul R. Gainetdinov , Tatiana D. Sotnikova , Sebastien Marion
发明人： Marc G. Caron , Martin Beaulieu , Raul R. Gainetdinov , Tatiana D. Sotnikova , Sebastien Marion
IPC分类号： G01N33/53 , C07K19/00 , C12N9/12 , C12N9/16
CPC分类号： G01N33/74 , G01N2333/726
摘要： A method of screening a candidate compound for βArrestin mediated anti-G protein coupled receptor signaling activity is comprises: (a) contacting said candidate compound to a βArrestin signaling complex or a constituent thereof, under conditions in which a signaling complex is formed; and then (b) detecting the presence or absence of disruption of said signaling complex, disruption of said complex indicating said compound has βArrestin mediated anti-G protein coupled receptor signaling activity. Compositions and kits for carrying out the method are also described.
摘要翻译：一种筛选候选化合物以控制Arrestin介导的抗G蛋白偶联受体信号传导活性的方法包括：（a）在信号传导复合体是在其下的条件下将所述候选化合物与一种Arrestin信号传导复合物或其组分接触形成然后（b）检测所述信号复合物的破坏的存在或不存在，指示所述化合物的所述复合物的破坏具有Arrestin介导的抗G蛋白偶联受体信号传导活性。还描述了用于实施该方法的组合物和试剂盒。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式