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    • 1. 发明授权
    • Controlled release oral drug delivery system
    • 控制释放口服药物输送系统
    • US06692766B1
    • 2004-02-17
    • US08750674
    • 1997-02-28
    • Abraham RubinsteinRaphael RadaiMichael FriedmanBoaz TiroshMuhammad BaluomTaher Nassar
    • Abraham RubinsteinRaphael RadaiMichael FriedmanBoaz TiroshMuhammad BaluomTaher Nassar
    • A61K910
    • A61K9/2027A61K9/2013Y10S514/944Y10S514/946
    • The present invention relates to a controlled release drug delivery system comprising a drug which is susceptible to enzymatic degradation by enzymes present in the intestinal tract; and a polymeric matrix which undergoes erosion in the gastrointestinal tract comprising a hydrogel-forming polymer selected from the group consisting of (a) polymers which are themselves capable of enhancing absorption of said drug across the intestinal mucosal tissues and of inbihiting degradation of said drug by intestinal enzymes; and (b) polymers which are not themselves capable of enhancing absorption of said drug across the intestinal mucosal tissues and of inhibiting degradation of said drug by intestinal enzymes; wherein when the matrix comprises a polymer belonging to group (b) the delivery system further comprises an agent which enhances absorption of said drug across the intestinal mucosal tissues and/or an agent which inhibits degradation of said drug by intestinal enzymes and when the matrix comprises a polymer belonging to group (a) the delivery system optionally further comprises an agent which enhances absorption of said drug across the intestinal mucosal tissues and/or an agent which inhibits degradation of said drug by intestinal enzymes.
    • 本发明涉及一种控释药物递送系统,其包含易于通过存在于肠道中的酶进行酶降解的药物; 以及在胃肠道中遭受侵蚀的聚合物基质,其包含选自以下的水凝胶形成性聚合物:(a)本身能够增强所述药物穿过肠粘膜组织的吸收的聚合物和所述药物的不利因素降解 肠酶; 和(b)本身不能增强所述药物穿过肠粘膜组织的吸收并且通过肠酶抑制所述药物降解的聚合物; 其中当所述基质包含属于组(b)的聚合物时,所述递送系统还包含增强所述药物穿过肠粘膜组织的吸收的试剂和/或通过肠酶抑制所述药物降解的药剂,并且当所述基质包含 属于(a)组的聚合物任选地还包含增强所述药物穿过肠粘膜组织的吸收的试剂和/或通过肠酶抑制所述药物降解的试剂。